Abstract P286: ARTERIAL STIFFNESS IN OLDER FRAGILE PATINETS WITH ORTHOSTATIC HYPOTENSION

Aim: To study the relationship between orthostatic hypotension (OH) and arterial stiffness in older fragile adults with arterial hypertension (AH). Material and Methods: The study included 160 patients (77.2 ± 8.1 years) with verified hypertension. The actual intake of previously prescribed drugs was assessed. The patients were divided into three groups: group 1 of patients with frailty, group 2 - with pre-frailty, group 3 of patients without frailty. Arterial stiffness was assessed by volumetric sphygmometry (VaSera-VS-1500 device, FUKUDA DENSHI, Japan) with the determination of the Augmentation index (Aix index). The orthostatic test was considered positive, with a decrease in SBP by 20 and DADA by 10 mm Hg. Art. and more when moving to a vertical position for 1-3 minutes. Results: Orthostatic hypotension was present in 53 patients (33%). Patients with OH did not differ in age from patients without OH (77.9 ± 7.5 years vs. 76.8 ± 8.4 years; p = 0.418). The Aix index is higher in patients with OH, but these differences reach statistical significance only in the group of patients with frailty (11.0 ± 1.2 vs. 10.0 ± 1.6 p = 0.003). When analyzing the antihypertensive drugs taken, there were no significant differences in the total number of drugs within each group and between patients with OH and without OH (p = 0.95). The analysis for individual groups of drugs revealed an inverse relationship between the use of ACE inhibitors and OH in the group as a whole (ϕ = -0.205, p = 0.010), and in the group of patients with frailty, marginal significance (ϕ = -0.266, p = 0.05). Findings: OH is observed in 33% of patients 60 years and older with hypertension. Arterial stiffness increases with increasing “fragility” and concomitant OH in the group of patients 60 years and older. The progression of arterial stiffness in older adults is heterogeneous and depends on concomitant frailty.

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Antihypertensive and Vasoprotective Effects of Combined Pharmacotherapy in Patients with Arterial Hypertension and Prediabetes

Kardiologiia ◽

10.18087/cardio.2020.4.n1112 ◽

2020 ◽

Vol 60 (4) ◽

pp. 10-17

Author(s):

V. V. Skibitskiy ◽

S. R. Gutova ◽

A. V. Fendrikova ◽

A. V. Skibitskiy

Keyword(s):

Arterial Stiffness ◽

Arterial Hypertension ◽

Blood Pressure Monitoring ◽

Aortic Pressure ◽

Combination Drug ◽

Treatment Groups ◽

Group 3 ◽

Group 2 ◽

Group 1

Aim To evaluate effects of different types of combination drug therapy on indexes of 24-h blood pressure monitoring (24-h BPM), arterial stiffness, and central aortic pressure (CAP) in patients with arterial hypertension (AH) and prediabetes.Materials and methods The study included 120 patients with AH and prediabetes. After randomization using envelopes, three treatment groups were formed: group 1, patients receiving perindopril, indapamide SR, and metformin (n=40); group 2, patients receiving perindopril, moxonidin, and metformin (n=40); and group 3, patients receiving perindopril, indapamide SR, and amlodipine (n=40). 24-h BPM, determination of arterial stiffness, and measurement of CAP were performed for all patients.Results After 24 weeks of treatment, patients of all groups showed statistically significant improvements of most indexes of 24-h BPM, arterial stiffness, and CAP. In groups 2 and 3, the treatment was associated with significantly more pronounced beneficial changes in 24-BPM, arterial stiffness, and CAP compared to group 1. Antihypertensive and vasoprotective effects of the perindopril+moxonidin+metformin and perindopril+indopamide SR+amlodipine combinations were comparable.Conclusion The observed statistically significant antihypertensive and vasoprotective effects of the perindopril+moxonidin+metformin combination along with its known positive metabolic effect allow recommendation of this combination therapy to patients with AH and prediabetes as an effective strategy for BP control.

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Arterial stiffness is a potential mechanism and promising indicator of orthostatic hypotension in the general population

VASA ◽

10.1024/0301-1526/a000389 ◽

2014 ◽

Vol 43 (6) ◽

pp. 423-432 ◽

Cited By ~ 11

Author(s):

Qingtao Meng ◽

Si Wang ◽

Yong Wang ◽

Shixi Wan ◽

Kai Liu ◽

...

Keyword(s):

General Population ◽

Arterial Stiffness ◽

Orthostatic Hypotension ◽

Operating Characteristic ◽

Pulse Wave ◽

Augmentation Index ◽

Multiple Logistic Regression Analysis ◽

The Elderly ◽

Baroreceptor Sensitivity ◽

Roc Curve Analysis

Background: Orthostatic hypotension (OH) is a disease prevalent among middle-aged men and the elderly. The association between arterial stiffness and OH is unclear. This study evaluates whether arterial stiffness is correlated with OH and tests the usefulness of brachial-ankle pulse wave velocity (baPWV), an arterial stiffness marker, with regard to identifying OH. Patients and methods: A sample of 1,010 participants was recruited from the general population (64.8 ± 7.7 years; 426 men) who attended health check-ups. BaPWV and the radial augmentation index (rAI) were both assessed as the arterial stiffness markers, and OH was determined using blood pressure (BP) measured in the supine position, as well as 30 seconds and 2 minutes after standing. Results: The prevalence of OH in this population was 4.9 %. Compared with the non-OH group, both baPWV (20.5 ± 4.5 vs 17.3 ± 3.7, p < 0.001) and rAI (88.1 ± 10.8 vs 84.2 ± 10.7, p < 0.05) were significantly higher in the OH group. In the multiple logistic regression analysis, baPWV (OR, 1.3; 95 % CI, 1.106–1.528; p < 0.05) remained associated with OH. Moreover, the degree of orthostatic BP reduction was related to arterial stiffness. In addition, increases in arterial stiffness predicted decreases in the degree of heart rate (HR) elevation. Finally, a receiver operating characteristic (ROC) curve analysis showed that baPWV was useful in discriminating OH (AUC, 0.721; p < 0.001), with the cut-off value of 18.58 m/s (sensitivity, 0.714; specificity, 0.686). Conclusions: Arterial stiffness determined via baPWV, rather than rAI, was significantly correlated with the attenuation of the orthostatic hemodynamic response and the resultant OH. The impaired baroreceptor sensitivity might be the mechanism. In addition, baPWV appears to be a relatively sensitive and reliable indicator of OH in routine clinical practice.

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

Blood Purification ◽

10.1159/000515639 ◽

2021 ◽

pp. 1-7

Author(s):

Emre Erdem ◽

Ahmet Karatas ◽

Tevfik Ecder

Keyword(s):

Serum Ferritin ◽

Hemodialysis Patients ◽

Rank Test ◽

Significant Difference ◽

All Cause Mortality ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin <800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

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POS0888 EPIDEMIOLOGICAL AND CLINICAL DIFFERENCES BETWEEN ANTI-MDA5 PHENOTYPES: DATA FROM A LARGE COHORT (MEDRA5) STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3837 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 700.1-700

Author(s):

E. Trallero-Araguás ◽

F. Romero ◽

I. Castellví ◽

V. Ortiz-Santamaria ◽

S. Castañeda ◽

...

Keyword(s):

Internal Medicine ◽

Statistical Significance ◽

Disease Onset ◽

Amyopathic Dermatomyositis ◽

Clinically Amyopathic Dermatomyositis ◽

San Sebastian ◽

Group 3 ◽

Group 2 ◽

Hospital General ◽

Group 1

Background:Idiopathic inflammatory myopathies are a heterogenous group of systemic autoimmune diseases. Several phenotypes have been linked to specific autoantibodies. Clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease, the most severe form of ILD, is associated with the anti-MDA5 antibodies. However not all the patients with dermatomyositis and anti-MDA5 positive antibodies develop this severe condition.Objectives:We aim to define different phenotypes from a large cohort of patients diagnosed with dermatomyositis who were positive to anti-MDA5 antibodies.Methods:We retrospective analyzed the clinical and immunological data of 90 anti-MDA5 patients [50 female, 55.6%, mean (SD) age at diagnosis 47 (15.4) yrs.] with dermatomyositis recruited from a multicenter register in Spain (MEDRA5) including 30 hospitals. All the patients fulfill de International Myositis Classification Criteria (EULAR/ACR) for dermatomyositis (score >90%). Anti-MDA5 were detected by means of commercial immunoblot (EUROIMMUN©). The chi-square test was used to assess the relationships between qualitative variables. The Kruskal-Wallis test was used to compared medians between groups.Results:Sixty-six patients (73.3%) were diagnosed with clinically amyopathic dermatomyositis. Three different phenotypes linked with the anti-MDA5 antibody were identified. Group 1: patients with rapidly-ILD phenotype (28 patients, 31.1%), group 2: antisynthetase-like phenotype (23 patients, 25.5%), and group 3: non-ILD phenotype (39 patients, 43.3%). Clinical and immunological comparison between the groups disclosed that age at disease onset was higher (median, IQR) in patients from group 1 [53 (43-60)] vs. group 2 [46 (40-56)] or group 3 [42(41-51)] (p=0.01); disease onset was more frequent in spring in patients from group 1 (46.5%) than in the rest of the groups (21.7% and 28.9%) (p<0.01). Cancer was detected in 7 patients, only associated with myositis in 3 cases (3 years interval between cancer and dermatomyositis) without significant differences between phenotypes. Vasculitis (one case ANCA positive) was detected in 9 cases (6 limited to skin, 1 renal and 1 intestinal), 6 of them in the group 3 (statistical significance, in comparison with group 1 and 2, p<0.01). Mortality rate was higher in group 1 (51.9%, 16 out of 17 due to refractory respiratory failure) vs group 2 (12.5%) or 3 (0%) (p<0.001). Anti Ro52 positivity was more frequent in group 1 (65.4%) vs. group 2 (25%) or 3 (35.5%) (p<0.017), although it did not reach statistical significance in terms of mortality (p=0.173) or patients admitted in the intensive care unit (p=0.173). Mechanic hands were more frequent in group 2 (40.6%) than in groups 1 (25%) and 3 (34.4%) (p=0.05). Fever was significantly most frequent in group 1(52.6%) than in group 2 (21.1%) and 3 (26.3%) (p=0.001). Other clinical or immunological features such as arthritis, myositis, or the number of characteristic skin lesions among others were not more frequent in one group or another.Conclusion:Three different phenotypes of patients positive to anti-MDA5 were identified. The presence or not of ILD, or the different type (rapidly progressive or not) of ILD were the main feature that allow to differentiate these phenotypes, which are relevant in clinical practice.References:[1]Allenbach Y, Uzunhan Y, Toquet S, et al; French Myositis Network. Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases. Neurology. 2020;95: e70-e78.Acknowledgements:List of contributors of MEDRA5 group: Aguilar-García J (Internal Medicine, Hospital Costa del Sol, Marbella), Carrión-Barberá I (Rheumatology, Hospital del Mar, Barcelona), Cobo-Ibañez T (Rheumatology, Hospital Infanta Sofía, San Sebastián de los Reyes), de Escalante-Yangüela B (Internal Medicine, Hospital Clínico Lozano Blesa, Zaragoza), Fonseca-Aizpuru EM (Internal Medicine, Hospital de Cabueñes, Gijón), González-Cubillo L (Intensive Medicine, Hospital Universitario de Cruces, Barakaldo), González-Gay MA (Rheumatology, Hospital Marqués de Valdecilla, Santander), Prieto-González S (Internal Medicine, Hospital Clinic, Barcelona), Ruiz-Román A (Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla), Calero-Paniagua I (Internal Medicine, Hospital Virgen de la Luz, Cuenca), Callejas-Rubio JL (Internal Medicine, Hospital Clínico San Cecilio, Granada), Gil-Vila A (Internal Medicine, Hospital Vall d’Hebron, Barcelona), de Miguel-Campo B (Internal Medicine, Hospital Doce de Octubre, Madrid), García-Sevilla R (Pneumology, Hospital General Universitario de Alicante, Alicante), Iriarte-Fuster A (Internal Medicine, Hospital de Bellvitge, Hospitalet de Llobregat), Jovani-Casano V (Rheumatology, Hospital General Universitario de Alicante, Alicante), Lozano-Rivas N (Rheumatology, Hospital Virgen de la Arritxaca, Murcia), Martín-Gascón M (Internal Medicine, Hospital Morales Meseguer, Murcia), Martinez-González O (Rheumatology, Hospital Universitario de Salamanca, Salamanca), Monteagudo-Jiménez M (Internal Medicine, Hospital Parc Taulí, Sabadell), Mora-Ortega GM (Pneumology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes), Moral-Moral Pedro (Internal Medicine, Hospital Universitari i Politecnic La Fe, Valencia), Pérez-De Pedro I (Interna Medicine, Hospital Regional Universitario de Málaga, Málaga), Picazo-Talavera MR (Rheumatology, Hospital del Sureste, Madrid), Rubio-Rivas M (Internal Medicine, Hospital de Bellvitge, Hospitalet de Llobregat)Disclosure of Interests:None declared

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Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

International Journal of Otolaryngology ◽

10.1155/2010/137128 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Çiğdem Tepe Karaca ◽

Erdoğan Gültekin ◽

M. Kürşat Yelken ◽

Ayşenur Akyıldız İğdem ◽

Mehmet Külekçi

Keyword(s):

Cancer Patients ◽

Nasal Mucosa ◽

Laryngeal Cancer ◽

Total Laryngectomy ◽

Group 3 ◽

Histopathologic Changes ◽

Group 2 ◽

The Relationship ◽

Histopathologic Findings

Objective. To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation.Material and Method. Biopsies were taken from the inferior turbinates of 11 laryngeal cancer patients after total laryngectomy. Specimens were stained with hematoksilen-eosin and several histopathologic parameters were examined under light microscopy.Results. All of the patients demonstrated at least one histopathologic abnormality (100%,n=11). Goblet destruction and stromal fibrosis were the most common findings (81%,n=9), followed by focal epithelial atrophy and subepithelial seromusinous gland destruction (45%,n=5), neovascularization and congestion (36%,n=4), complete epithelial atrophy and mixoid degeneration (27%,n=3). According to the duration between laryngectomy and biopsy, patients were grouped in to three: group 1; less than 12 months (36%,n=4), group 2; 12–36 months (18%,n=2), and group 3; more than 36 months (45%,n=5). Only congestion was found to be decreased as the duration increased (P<.005).Conclusion. In laryngeal cancer patients histopathologic changes occur in nasal mucosa eventuate due to the cessation of air current stimulation, however there was no relation between progression of the histopathologic findings and the duration of cessation.

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Corresponding erdosteine changes autophagy genes expression in hippocampus on Rhinitis medicamentosa model

Genetika ◽

10.2298/gensr1503091d ◽

2015 ◽

Vol 47 (3) ◽

pp. 1091-1098

Author(s):

Recep Dokuyucu ◽

Bulent Gogebakan ◽

Cengiz Cevik

Keyword(s):

Control Group ◽

Gene Expressions ◽

Autophagy Gene ◽

Genes Expression ◽

Left Hippocampus ◽

Antioxidant Agent ◽

Group 3 ◽

Group 2 ◽

Rhinitis Medicamentosa

In our study, rats were subjected to Oxymetazoline hydrochloride treatment and Rhinitis medicamentosa (RM) was formed and then autophagy gene expression levels were determined after the application of an antioxidant agent erdosteine (ED). The rats were divided into three groups; Group 1 was the control group. Group 2 (RM) and group 3 (RM+ED) rats received two spray puffs of 0.05% oxymetazoline into the nasal cavities three times daily for eight weeks. After determination of RM in the rats, the RM group were killed. The ED+RM group received 10 mg/kg of an ED suspension. At the end of seven days, these rats were also killed. All groups? hippocampus tissues were obtained for the measurement of autophagy gene expressions. In rhinitis medicamentosa group Atg5, Atg7 and Atg10 gene expressions in the left hippocampus were reduced as compared to control group (p=0.01, p>0.05, p=0.01, respectively). Also, erdosteine treatments were restored mRNA expression of autophagy genes. In right hippocampus of rhinitis medicamentosa group, Atg5 and Atg10 gene expressions was found to be down-regulated as compared to control group (p>0.05, p<0.05, respectively). Both BECN1 and ULK genes expression were found to be reduced in left hippocampus of rhinitis medicamentosa group. Erdosteine applications was restored the expression of these genes (p=0.03, p=0.03, respectively). Additionally, in right hippocampus, Erdosteine application was restored the expression of ULK gene (p=0.01). This is the first report that evaluated the expression autophagy genes in RM rat models and the changes observed after erdosteine applications.

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CARACTERIZAÇÃO HIDRÁULICA DO MICROASPERSOR DAN SPRINKLERS GRUPO MODULAR

Irriga ◽

10.15809/irriga.2001v6n1p13-18 ◽

2001 ◽

Vol 6 (1) ◽

pp. 13-18 ◽

Cited By ~ 1

Author(s):

Marcio Antonio Vilas Boas ◽

Eurides Kuster Macedo Júnior ◽

Silvio Cesar Sampaio ◽

Melânia Inês Valiati

Keyword(s):

Production Process ◽

Power Function ◽

Characteristic Equation ◽

State University ◽

The West ◽

Potential Equation ◽

Group 2 ◽

The Relationship

CARACTERIZAÇÃO HIDRÁULICA DO MICROASPERSOR DAN SPRINKLERS GRUPO MODULAR Márcio Antônio Vilas BoasEurides Kuster Macedo JuniorSilvio César SampaioMelânia Inês ValiatiUNIOESTE - Universidade Estadual do Oeste do ParanáCEP: 85814-110 - Cascavel – PR - Brasil - Cx. Postal 711Fone: (045) 225 -2100 (R-249) - Fax : (045) [email protected] 1 RESUMO Este trabalho teve como objetivo avaliar as características hidráulicas do microaspersor DAN SPRINKLERS do grupo modular de fabricação da DAN SPRINKLERS - ISRAEL, de uso recente no Oeste do Paraná. Os ensaios foram realizados no Laboratório de Hidráulica do Departamento de Engenharia da Universidade Estadual do Oeste do Paraná – UNIOESTE. Na avaliação dos microaspersores estudou-se, a variação decorrente do processo de fabricação e a determinação da equação característica da relação vazão–pressão. Os microaspersores do Grupo modular com diâmetros de bocais 0,94; 1,16;1,41;1,92 e 2,34 mm, foram submetidos às pressões de 100, 150, 200, 250, 300 e 350 kPa. As equações características determinadas indicaram que o microaspersor testado não é auto-compensante , tolerante a sensibilidade de variações de pressões e que a equação potencial se ajusta bem aos dados. Os coeficientes de variação de fabricação obtidos foram menores que 5%, classificando-se, de acordo com a Norma ISO, como de categoria A. UNITERMOS: Microaspersão, coeficiente de variação, modelo potencial. VILAS BÔAS, M. A., MACEDO JUNIOR, E. K. HYDRAULIC CHARACTERIZATION OF MICROSPRINKLER DAN SPRINKLER - MODULATE GROUP 2 ABSTRACT This work had as objective to evaluate the characteristics hydraulic of the microsprinklers of the group to modulate of production of DAN SPRINKLERS - ISRAEL, of recent use in the West of Paraná. The tests was accomplished in the Laboratory of Hydraulics of the Department of Engineering of the State University of the West of Paraná - UNIOESTE. In the evaluation of the microasprinklers it was studied such characteristics as, the variation due to the production process and the determination of the characteristic equation of the relationship vazão-pressure. The microsprinklers of the Group to modulate with diameters of nozzle 0,94; 1,16;1,41;1,92 and 2,34 mm, the pressures were submitted 100, 150, 200, 250, 300 and 350 kPa. The certain characteristic equations showed that the tested microsprinklers is not solemnity-compensante and that the potential equation was fit well to the data. The obtained coefficients of production variation were everybody below 5% being able to not this way to classify them in agreement with for ISO category as A. KEYWORDS: Microsprinkler, coefficient variation, power function.

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Inverse Relationship between Adenoid Size and Asthma or Atopy in Children: A Preliminary Study

Korean Journal of Otorhinolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2019.00913 ◽

2020 ◽

Vol 63 (9) ◽

pp. 409-414

Author(s):

Yangseop Noh ◽

Ji-Eun Choi ◽

Kyung Eun Lee ◽

Seung-Kyu Chung ◽

Sang Duk Hong ◽

...

Keyword(s):

Medical Center ◽

Allergic Sensitization ◽

Allergic Diseases ◽

Adenoid Hypertrophy ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Diagnosis Criteria ◽

The Relationship ◽

Group 1

Background and Objectives One of the most common surgical procedures in children is adenoidectomy, but the causes of adenoid hypertrophy are not fully understood. Some studies have found that allergies can be a risk factor for adenoid hypertrophy, asthma being one of these allergic diseases. This study aimed to investigate the relationship between adenoid size and asthma in a group of children.Subjects and Method This study reviewed a total of 2063 pediatric patients with or without atopy and asthma who visited the Otorhinolaryngology and Pediatric unit at a tertiary medical center from January 2011 to June 2016. We classified these patients into 4 groups according to the presence of asthma or atopy and randomly selected 100 patients from each group (to a total of 400 pts): group 1 (asthma-, atopy-); group 2 (asthma-, atopy+); group 3 (asthma+, atopy-) and group 4 (asthma+, atopy+). The presence of allergic sensitization (atopy) was evaluated by CAP test and total IgE. Asthma was diagnosed according to the diagnosis criteria in the Korean guideline for asthma. Adenoid size was evaluated with the adenoidal-nasopharyngeal ratio (A/N ratio) by the adenoid view.Results The four groups did not differ from each other significantly in age or sex. There was a negative correlation between adenoid size and atopic and asthmatic condition. Group 1 had a significantly larger A/N ratio than the other groups (group 1=0.534±0.138; group 2=0.469± 0.140; group 3=0.476±0.135; group 4=0.482±0.128, p<0.05). However, group 4 showed nearly identical results to groups 2 and 3, despite the combination of asthma and atopy in group 4.Conclusion Large adenoids were negatively associated with atopy and asthma. This finding may be explained by a decrease in adenoid stimulation by nasal obstruction and a difference in the immune system, including allergic immune reactions. Further studies are needed.

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Interaction Between Age and Change in Velocity During a Baseball Training Program

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120927939 ◽

2020 ◽

Vol 8 (6) ◽

pp. 232596712092793

Author(s):

Christopher Antonacci ◽

Thomas R. Atlee ◽

Peter N. Chalmers ◽

Christopher Hadley ◽

Meghan E. Bishop ◽

...

Keyword(s):

Training Program ◽

Age Groups ◽

Maximum Velocity ◽

Age Group ◽

Significant Difference ◽

Group 3 ◽

Baseball Pitchers ◽

Group 2 ◽

The Relationship ◽

Group 1

Background: Pitching velocity is one of the most important metrics used to evaluate a baseball pitcher’s effectiveness. The relationship between age and pitching velocity after a lighter ball baseball training program has not been determined. Purpose/Hypothesis: The purpose of this study was to examine the relationship between age and pitching velocity after a lighter ball baseball training program. We hypothesized that pitching velocity would significantly increase in all adolescent age groups after a lighter baseball training program, without a significant difference in magnitude of increase based on age. Study Design: Cohort study; Level of evidence, 2. Methods: Baseball pitchers aged 10 to 17 years who completed a 15-week training program focused on pitching mechanics and velocity improvement were included in this study. Pitchers were split into 3 groups based on age (group 1, 10-12 years; group 2, 13-14 years; group 3, 15-17 years), and each group trained independently. Pitch velocity was assessed at 4 time points (sessions 3, 10, 17, and 25). Mean, maximum, and mean change in pitch velocity between sessions were compared by age group. Results: A total of 32 male baseball pitchers were included in the analysis. Mean/maximum velocity increased in all 3 age groups: 3.4/4.8 mph in group 1, 5.3/5.5 mph in group 2, and 5.3/5.2 mph in group 3. While mean percentage change in pitch velocity increased in all 3 age groups (group 1, 6.5%; group 2, 8.3%; group 3, 7.6%), the magnitude of change was not significantly different among age groups. Program session number had a significant effect on mean and maximum velocity, with higher mean and maximum velocity seen at later sessions in the training program ( P = .018). There was no interaction between age and program session within either mean or maximum velocity ( P = .316 and .572, respectively). Conclusion: Age had no significant effect on the magnitude of increase in maximum or mean baseball pitch velocity during a velocity and mechanics training program in adolescent males.

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Determination of alpha 2-macroglobulin-trypsin complex with a new synthetic substrate.

Clinical Chemistry ◽

10.1093/clinchem/35.11.2169 ◽

1989 ◽

Vol 35 (11) ◽

pp. 2169-2172 ◽

Cited By ~ 6

Author(s):

K Kuroiwa ◽

S Nakatsuyama ◽

K Katayama ◽

T Nagasawa

Keyword(s):

Healthy Subjects ◽

Colorimetric Assay ◽

Colorimetric Method ◽

Pancreatic Disease ◽

Chromogenic Substrate ◽

Standard Curve ◽

Group 3 ◽

Group 2 ◽

Group 1

Abstract We have developed a colorimetric assay for quantifying alpha 2-macroglobulin-trypsin complex (alpha 2M-TRY) in human serum, based on use of a new chromogenic substrate D-gamma-tert-butyloxy-Glu-Gly-Arg-3-carboxy-4-hydroxyanilide dihydrochloride (PS-3001). Within-run CVs by this assay were 4.76%, 1.57%, and 0.83% for trypsin complex concentrations of 3.1, 12.2, and 48.1 U/L, respectively (n = 10 each). Between-day CVs were 5.38%, 3.12%, and 2.20% at each concentration, respectively (n = 7). Mean analytical recoveries of alpha 2M-TRY added to serum were 100%, 105%, and 101% for 9.2, 15.1, and 46.3 U/L, respectively (n = 2). The standard curve obtained was linear up to 330 U/L. We applied this method to the study of alpha 2M-TRY activity in sera from 97 healthy subjects (group 1), from 27 patients with acute pancreatitis (group 2), and from 25 patients with other chylopoietic diseases (group 3); results ranged from 0 to 1.2 U/L (mean = 0.5, SD = 0.3), from 1.2 to 77.4 U/L (mean = 14.6, SD = 19.0), and from 0 to 1.3 U/L (mean = 0.4, SD = 0.3), respectively. Concentrations of enzymatically active alpha 2M-TRY were significantly greater in sera from group 2 than in groups 1 and 3. The determination of serum alpha 2M-TRY activity by this simple, rapid, colorimetric method may be useful for the diagnosis and evaluation of pancreatic disease.

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