Levo-Propionyl-Carnitine Improves the Effectiveness of Supervised Physical Training on the Absolute Claudication Distance in Patients With Intermittent Claudication

Angiology ◽  
2008 ◽  
Vol 59 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Giuseppe Maria Andreozzi ◽  
Alfredo Leone ◽  
Rita Laudani ◽  
Romeo Martin ◽  
Gregorio Deinit ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Physical Training ◽  
The Absolute ◽  
Propionyl Carnitine

scholarly journals Effects of Physical Rehabilitation on Spatiotemporal Gait Parameters and Ground Reaction Forces of Patients with Intermittent Claudication

2020 ◽  
Vol 9 (9) ◽  
pp. 2826
Author(s):  
Wioletta Dziubek ◽  
Małgorzata Stefańska ◽  
Katarzyna Bulińska ◽  
Katarzyna Barska ◽  
Rafał Paszkowski ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Physical Training ◽  
Lower Extremities ◽  
Gait Pattern ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Ground Reaction Forces ◽  
Nordic Walking ◽  
Lower Limb Pain ◽  
Reaction Forces

Chronic ischemia of the lower extremities often presents as intermittent claudication characterized by lower limb pain which subsides after a short break. This study aimed to provide an assessment of the spatiotemporal parameters of gait and ground reaction forces in patients with PAD participating in three forms of supervised physical training. A total of 80 subjects completed a three-month supervised physical rehabilitation program with three sessions per week. The subjects were assigned to one of three programs: group 1—standard walking training on a treadmill (TT); group 2—Nordic walking (NW) training; group 3—strength and endurance training comprised of NW with isokinetic resistance training (NW + ISO). Gait biomechanics tests (kinematic and kinetic parameters of gait) and a six-minute walk test were carried out before and after three months of physical training. Nordic walking training led to the greatest improvements in the gait pattern of patients with PAD and a significant increase in the absolute claudication distance and total gait distance. Combined training (NW + ISO) by strengthening the muscles of the lower extremities increased the amplitude of the general center of gravity oscillation to the greatest extent. Treadmill training had little effect on the gait pattern. Nordic walking training should be included in the rehabilitation of patients with PAD as a form of gait training, which can be conducted under supervised or unsupervised conditions.

Physical training for intermittent claudication: a comparison of structured rehabilitation versus home-based training

2002 ◽  
Vol 7 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Steve Degischer ◽  
Karl-Heinz Labs ◽  
Jacques Hochstrasser ◽  
Markus Aschwanden ◽  
Martin Tschoepl ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Physical Training ◽  
Home Based

scholarly journals Influence of the Physical Training on Muscle Function and Walking Distance in Symptomatic Peripheral Arterial Disease in Elderly

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Katarzyna Kropielnicka ◽  
Wioletta Dziubek ◽  
Katarzyna Bulińska ◽  
Małgorzata Stefańska ◽  
Joanna Wojcieszczyk-Latos ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Physical Training ◽  
Lower Limb ◽  
Training Group ◽  
Walking Distance ◽  
Nordic Walking ◽  
Group Iii ◽  
Exercise Rehabilitation ◽  
Force Velocity ◽  
Group Ii

Introduction. A typical symptom of chronic lower-limb ischaemia is lower-limb pain, which occurs during walking forcing the patient to stop, intermittent claudication (IC). Exercise rehabilitation is the basic form of treatment for these patients. Aim. The aim of this study was to compare the effectiveness of three types of physical training programmes conducted over a 12-week period in patients with chronic lower-limb arterial insufficiency. Materials and Methods. Ninety-five people qualified for the 3-month supervised motor rehabilitation programme, conducted three times a week. The respondents were assigned to three types of rehabilitation programmes using a pseudo-randomization method: Group I (TW), subjects undertaking treadmill walking training; Group II (NW), subjects undertaking Nordic walking training; Group III (RES+NW), subjects undertaking resistance and Nordic walking training. Treadmill test, 6 Minute Walk Test (6MWT), and isokinetic test were repeated after 3 months of rehabilitation, which 80 people completed. Results. Combined training (RES+NW) is more effective than Nordic walking alone and supervised treadmill training alone for improving ankle force-velocity parameters (p<0.05) in patients with intermittent claudication. Each of the proposed exercise rehabilitation programmes increased walking distance of patients with intermittent claudication (p<0.05), especially in 6MWT (p=0.001). Significant relationships of force-velocity parameters are observed in the maximum distance obtained in 6MWT, both in Group III (RES + NW) and in Group II (NW) at the level of moderate and strong correlation strength, which indicates that if the lower limbs are stronger the walking distance achieved in 6MWT is longer. Conclusions. Given both the force-velocity parameters and the covered distance, the training RES + NW gives the most beneficial changes compared to training TW alone and NW alone. All types of training increased walking distance, which is an important aspect of the everyday functioning of people with IC.

Effect of physical training on the metabolism of thyroid hormones in man

1975 ◽  
Vol 38 (2) ◽  
pp. 212-215 ◽  
Author(s):  
A. Balsam ◽  
L. E. Leppo
Keyword(s):  
Physical Training ◽  
Plasma Proteins ◽  
Degradation Rate ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Differential Impact ◽  
Before And After ◽  
The Absolute ◽  
Significant Change ◽  
Peripheral Metabolism

he effect of a 6-wk program of physical training (track running) on the peripheral metabolism of thyroxine (T4) and triiodothyronine (T3) was evaluated in a group of 11 men. Measurements were made of hormone turnover, urinay and fecal clearances, plasma hormone concentrations, and hormone binding by plasma proteins in all subjects before and after training, After training, metabolic clearance of T3 was increased 8.5% above the pretraining level due to an increased deiodinative clearance of this hormone. No significant change was observed in plasma T3 concentration. The absolute degradation of T3 increased 10.3% after training. In contrast, no significant change in the metabolic clearance of T4 was detected. Significantly decreased plasma concentration of total T4 after 4 and 6 wk of training was apparently not due to decreased hormone binding by plasma protein since no significant alteration in the dialyzable fraction of T4 was detected. The absolute degradation rate of T4 was decreased 8.8% after training. Possible implications of the observed differential impact of training on the degradation of T4 and T3 regarding thyroid hormone economy are discussed.

Treatment of Intermittent Claudication With Physical Training, Smoking Cessation, Pentoxifylline, or Nafronyl

1999 ◽  
Vol 159 (4) ◽  
pp. 337 ◽  
Author(s):  
Bruno Girolami ◽  
Enrico Bernardi ◽  
Martin H. Prins ◽  
Jan Wouter ten Cate ◽  
Rohan Hettiarachchi ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Intermittent Claudication ◽  
Physical Training

scholarly journals Experimental Models of Chronic Lower Extremity Arterial Occlusive Disease: Lessons for Drug Development

1996 ◽  
Vol 1 (1) ◽  
pp. 43-49 ◽  
Author(s):  
CD Nicholson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Intermittent Claudication ◽  
Physical Training ◽  
Muscle Blood Flow ◽  
Lower Limbs ◽  
Peripheral Vascular ◽  
Vascular Insufficiency

Peripheral vascular disease is the result of chronic vascular insufficiency. As the vascular insufficiency of the lower limbs progressively deteriorates, the condition progresses from intermittent claudication (pain upon exercise) to pain at rest and gangrene. In very severe cases amputation of the leg may be necessary. Whilst dieting, cessation of smoking and physical exercise all beneficially affect the progression of the disorder, the available drug therapy is of limited benefit. Very effective pharmacological agents capable of alleviating the symptoms of chronic peripheral vascular disease have not been developed. In order to mimic the vascular insufficiency of intermittent claudication, an animal model was developed in rats. This involves short-term and long-term 6–10 weeks ligation of the femoral artery of the rat. As demonstrated using measurements of hindlimb skeletal muscle, blood flow, pO2, metabolism and function, a model of intermittent claudication was produced. Using this model, the beneficial effects of physical training was demonstrated. Physical training induced an increase in blood flow and a greater capacity for aerobic metabolism in the partially ischaemic skeletal muscle. The effect of vasodilators has also been examined in this model; in contrast to agents such as Ca2+ antagonists, K+ channel openers appear to improve nutritional blood flow and metabolism in the afflicted skeletal muscle. This model can also be utilized to demonstrate the effects of haemorrheological interventions and of agents modulating muscle metabolism. However, additional effort is required to develop models for the evaluation of efficacy of antiatherothrombotic drugs.

Efficacy and safety of a new pneumatic compression device for peripheral arterial disease with intermittent claudication

Phlebologie ◽  
2014 ◽  
Vol 43 (01) ◽  
pp. 5-11 ◽  
Author(s):  
A. Zelikovski ◽  
Z. Loberman ◽  
G. Rauh ◽  
F. X. Breu
Keyword(s):  
Treatment Group ◽  
Intermittent Claudication ◽  
Study Groups ◽  
Walking Distance ◽  
Control Group ◽  
Medication Treatment ◽  
Walking Exercise ◽  
The Mean ◽  
The Absolute ◽  
Peripheral Arterial

SummaryBackground: The primary objective of the study was to demonstrate that Intermittent Pneumatic Compression (IPC) with the new ANGIO PRESS™ IPC device can significantly improve the walking distance, i.e. pain free initial intermittent claudication distance (ICD) and the absolute claudication distance (ACD) in patients with stage II peripheral arterial occlusive disease (PAD) compared to control treatment.Patients and methods: A total of 67 patients were screened and randomized into the study in four clinical centers based in Israel and Germany. Patients were randomized to one of the two study groups: 1. Medication treatment with ASS / Clopidogrel and standardized walking exercise with additional IPC treatment, two times per day for 1.5 hours for three months. 2. Medication treatment and standardized walking exercise alone. The safety and efficacy of the ANGIO PRESS™ device was determined for the treatment of symptoms of PAD Fontaine stage IIb by measuring the pain free walking distance, the absolute walking distance, the ankle-brachial-index (ABI) and the walking pain. Additionally the quality of life (QOL) of each subject was assessed according to the SF-36 questionnaire. Subjects were followed up at six weeks and 3 months.Results: No statistical differences were observed in any of the demographic characteristics and baseline scores. A significant difference was found between the treatment and control group in the ACD and the walking pain scale. Subjects in the treatment group improved their total walking distance in 54 meters, an improvement of 40% compared to their baseline distance. The walking pain improved by 1.89 points in the treatment group. Despite the fact that the difference in the ICD between the study groups were not found significantly different, the mean change from baseline in ICD score at the three month visit in the treatment group of 37 m was found statistically significant (p=0.0002), whereas the mean change of 20.7 m in the control group was not found significantly different. No changes were found between the study groups in the ABI and the QOL. The treatment was easy to tolerate and most patients suffered no side-effects, nor complained of any significant discomfort. Two subjects suffered from SAEs which were determined as not related to the study treatment.Conclusion: The ANGIO PRESS™ is a non-invasive, easy to use, home treatment which is safe and moderately effective for the treatment of intermittent claudication. The ability of subjects to improve their absolute walking distance and reduce the walking pain on the same time may offer a significant value for patients at early stages of PAD who are not indicated for an invasive treatment.

Sign in / Sign up

Export Citation Format

Share Document