Effect of physical training on the metabolism of thyroid hormones in man

1975 ◽  
Vol 38 (2) ◽  
pp. 212-215 ◽  
Author(s):  
A. Balsam ◽  
L. E. Leppo
Keyword(s):  
Physical Training ◽  
Plasma Proteins ◽  
Degradation Rate ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Differential Impact ◽  
Before And After ◽  
The Absolute ◽  
Significant Change ◽  
Peripheral Metabolism

he effect of a 6-wk program of physical training (track running) on the peripheral metabolism of thyroxine (T4) and triiodothyronine (T3) was evaluated in a group of 11 men. Measurements were made of hormone turnover, urinay and fecal clearances, plasma hormone concentrations, and hormone binding by plasma proteins in all subjects before and after training, After training, metabolic clearance of T3 was increased 8.5% above the pretraining level due to an increased deiodinative clearance of this hormone. No significant change was observed in plasma T3 concentration. The absolute degradation of T3 increased 10.3% after training. In contrast, no significant change in the metabolic clearance of T4 was detected. Significantly decreased plasma concentration of total T4 after 4 and 6 wk of training was apparently not due to decreased hormone binding by plasma protein since no significant alteration in the dialyzable fraction of T4 was detected. The absolute degradation rate of T4 was decreased 8.8% after training. Possible implications of the observed differential impact of training on the degradation of T4 and T3 regarding thyroid hormone economy are discussed.

EFFECTS OF OESTROGENS ON THYROXINE TURNOVER IN HYPERTHYROIDISM

1972 ◽  
Vol 71 (3) ◽  
pp. 491-497 ◽  
Author(s):  
Angel A. Zaninovich
Keyword(s):  
Degradation Rate ◽  
Control Period ◽  
The Other ◽  
Graves Disease ◽  
Oestrogen Therapy ◽  
Distribution Space ◽  
Oestrogen Treatment ◽  
Before And After ◽  
Peripheral Metabolism ◽  
Fractional Turnover

ABSTRACT The peripheral metabolism of thyroxine (T4) was studied before and after the administration of oestrogens in 21 patients with Graves' disease and in 5 subjects with thyrotoxicosis factitia. In addition, 6 patients with Graves' disease while receiving oestrogen treatment were given 600 mg of diphenylhydantoin (DPH) orally daily; the study on the peripheral metabolism of T4 was similarly performed. Oestrogens induced the following changes in T4 metabolism: a decrease in the concentration of free T4 in the serum, an increase in serum total T4, slowing of the fractional turnover, and contraction of the distribution space. The extrathyroidal T4 pool remained unchanged. These changes led to a decrease in daily T4 degradation rate from 469 μg in the control period to 348 μg during oestrogen therapy (P < 0.001). Fifteen of these patients showed apparent clinical improvement. The 2 subjects with T4-thyrotoxicosis factitia had decreased T4 degradation and remission of symptomatology following oestrogen administration; on the other hand, 3 subjects with T3-thyrotoxicosis factitia had no appreciable amelioration of their symptoms. The administration of DPH to oestrogen-treated patients with Graves' disease induced a slight acceleration of the absolute T4 turnover. It is concluded that the decreased T4 degradation induced by oestrogens in spontaneous and iatrogenic hyperthyroidism was mediated by an increase in T4-binding globulin capacity in the serum.

Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma

1981 ◽  
Vol 97 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Göran Fex ◽  
Göran Adielsson ◽  
Willy Mattson
Keyword(s):  
Plasma Proteins ◽  
Retinol Binding Protein ◽  
Sex Hormone Binding Globulin ◽  
Response To Treatment ◽  
Apolipoprotein Ai ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
Pregnancy Zone Protein ◽  
Apparent Relationship ◽  
Before And After

Abstract. The concentrations of 11 plasma proteins were determined by electroimmunoassay in 6 female and one male patient before and after treatment for 1–4 months with tamoxifen (30 mg/day) for advanced cancer. The concentrations of transcortin, sex hormone binding globulin, pregnancy zone protein, apolipoprotein AI and thyroxine binding globulin increased significantly. The concentrations of orosomucoid and haptoglobin decreased significantly. The concentrations of albumin, transferrin, prealbumin and retinol-binding protein showed no significant change. The changes after treatment with tamoxifen were thus similar to those which occur after the administration of oestrogens or during pregnancy although they were quantitatively less pronounced. There were also differences in the pattern of change between treatment with tamoxifen and during pregnancy. There was no apparent relationship between response to treatment and changes in concentration of plasma proteins.

ENDOCRINE CHANGES BEFORE AND AFTER THE MENARCHE

1973 ◽  
Vol 74 (4) ◽  
pp. 685-694 ◽  
Author(s):  
B.-A. Lamberg ◽  
R.-L. Kantero ◽  
P. Saarinen ◽  
O. Widholm
Keyword(s):  
Binding Proteins ◽  
Maturation Process ◽  
Hormone Binding ◽  
Maximal Level ◽  
Continuous Increase ◽  
Mean Values ◽  
Thyroxine Binding Globulin ◽  
Before And After ◽  
Free Thyroxine Index ◽  
Level 1

ABSTRACT In an endocrine survey of healthy girls aged 8 to 20 years before and after the menarche, the serum thyroxine (T4), uptake of triiodothyronine by Sephadex (T3U), and the binding capacities of thyroxine binding globulin (TBG) and pre-albumin (TBPA) were measured, and a free thyroxine index (FTI = T4 × T3U) was calculated. The subjects were grouped according to skeletal age (SA) until the menarche and after this in the post-menarcheal age (PMA), expressed in years. T4 and FTI increased concomitantly and reached peak values of 8.40 μg/100 ml and 8.40, respectively, at 2–3 years PMA. The corresponding mean values for post-menarcheal girls (7.74 μg/100 ml and 7.51) differed statistically significantly from the means before the menarche (7.03 μg/ 100 ml and 6.75). The TBG remained virtually unchanged during the whole period, whereas the TBPA showed a continuous increase and reached a maximal level 1–2 years after the menarche. The maturation process in girls in some way involves an increase in the total and free T4 level which is not dependent on hormone binding proteins.

scholarly journals Resilience and vulnerability of maternity services in Zimbabwe: a comparative analysis of the effect of Covid-19 and lockdown control measures on maternal and perinatal outcomes, a single-centre cross-sectional study at Mpilo Central Hospital

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Clare Shakespeare ◽  
Handsome Dube ◽  
Sikhangezile Moyo ◽  
Solwayo Ngwenya
Keyword(s):  
Perinatal Outcomes ◽  
Control Measures ◽  
Central Hospital ◽  
Cross Sectional ◽  
Maternity Services ◽  
Before And After ◽  
The Mean ◽  
Significant Change ◽  
The Impact ◽  
Mpilo Central Hospital

Abstract Background On the 27th of March 2020 the Zimbabwean government declared the Covid-19 pandemic a ‘national disaster’. Travel restrictions and emergency regulations have had significant impacts on maternity services, including resource stock-outs, and closure of antenatal clinics during the lockdown period. Estimates of the indirect impact of Covid-19 on maternal and perinatal mortality was expected it to be considerable, but little data was yet available. This study aimed to examine the impact of Covid-19 and lockdown control measures on non-Covid outcomes in a government tertiary level maternity unit in Bulawayo, Zimbabwe, by comparing maternal and perinatal morbidity and mortality before, and after the lockdown was implemented. Methods This was a retrospective, observational study, using a cross-sectional design to compare routine monthly maternal and perinatal statistics three months before and after Covid-19 emergency measures were implemented at Mpilo Central Hospital. Results Between January-March and April-June 2020, the mean monthly deliveries reduced from 747.3 (SD ± 61.3) in the first quarter of 2020 to 681.0 (SD ± 17.6) during lockdown, but this was not statistically significant, p = 0.20. The Caesarean section rates fell from a mean of 29.8% (SD ± 1.7) versus 28.0% (SD ± 1.7), which was also not statistically significant, p = 0.18. During lockdown, the percentage of women delivering at Mpilo Central Hospital who were booked at the hospital fell from a mean of 41.6% (SD ± 1.1) to 35.8% (SD ± 4.3) which was statistically significant, p = 0.03. There was no significant change, however, in maternal mortality or severe maternal morbidity (such as post-partum haemorrhage (PPH), uterine rupture, and severe preeclampsia/eclampsia), stillbirth rate or special care baby unit admission. There was an increase in the mean total number of early neonatal deaths (ENND) (mean 18.7 (SD ± 2.9) versus 24.0 (SD ± 4.6), but this was not statistically significant, p = 0.32. Conclusions Overall, maternity services at Mpilo showed resilience during the lockdown period, with no significant change in maternal and perinatal adverse outcomes, with the same number of man-hours worked before and during the lockdown Maternal and perinatal outcomes should continue to be monitored to assess the impact of Covid-19 and the lockdown measures as the pandemic in Zimbabwe unfolds. Further studies would be beneficial to explore women’s experiences and understand how bookings and deliveries at local clinics changed during this time.

Thyroid Hormone-Binding Plasma Proteins

1986 ◽  
pp. 97-101
Author(s):  
Georg Hennemann ◽  
Eric P. Krenning ◽  
Roelof Docter
Keyword(s):  
Thyroid Hormone ◽  
Plasma Proteins ◽  
Hormone Binding

Effects of training on lactate production and removal during progressive exercise in humans

1992 ◽  
Vol 72 (5) ◽  
pp. 1649-1656 ◽  
Author(s):  
H. S. MacRae ◽  
S. C. Dennis ◽  
A. N. Bosch ◽  
T. D. Noakes
Keyword(s):  
Endurance Training ◽  
Lactate Production ◽  
Metabolic Clearance ◽  
O2 Uptake ◽  
Lower Blood ◽  
Peak Lactate ◽  
Progressive Exercise ◽  
Before And After ◽  
Power Outputs ◽  
Exercise In Humans

To determine whether the reduced blood lactate concentrations [La] during submaximal exercise in humans after endurance training result from a decreased rate of lactate appearance (Ra) or an increased rate of lactate metabolic clearance (MCR), interrelationships among blood [La], lactate Ra, and lactate MCR were investigated in eight untrained men during progressive exercise before and after a 9-wk endurance training program. Radioisotope dilution measurements of L-[U-14C]lactate revealed that the slower rise in blood [La] with increasing O2 uptake (VO2) after training was due to a reduced lactate Ra at the lower work rates [VO2 less than 2.27 l/min, less than 60% maximum VO2 (VO2max); P less than 0.01]. At power outputs closer to maximum, peak lactate Ra values before (215 +/- 28 mumol.min-1.kg-1) and after training (244 +/- 12 mumol.min-1.kg-1) became similar. In contrast, submaximal (less than 75% VO2max) and peak lactate MCR values were higher after than before training (40 +/- 3 vs. 31 +/- 4 ml.min-1.kg-1, P less than 0.05). Thus the lower blood [La] values during exercise after training in this study were caused by a diminished lactate Ra at low absolute and relative work rates and an elevated MCR at higher absolute and all relative work rates during exercise.

scholarly journals Effect of growth hormone on fibrinogen synthesis

1970 ◽  
Vol 119 (2) ◽  
pp. 243-249 ◽  
Author(s):  
K. N. Jeejeebhoy ◽  
A. Bruce-Robertson ◽  
U. Sodtke ◽  
M. Foley
Keyword(s):  
Growth Hormone ◽  
Plasma Proteins ◽  
Bovine Growth Hormone ◽  
Absolute Rate ◽  
Albumin Synthesis ◽  
The Absolute

A method described by McFarlane (1963a) for the measurement of the absolute rate of synthesis of liver-made plasma proteins was used to show that, within a few hours of giving bovine growth hormone to rats, fibrinogen synthesis increased significantly without a change in albumin synthesis.

Long-term mild jogging increases insulin action despite no influence on body mass index or VO2 max

1989 ◽  
Vol 66 (5) ◽  
pp. 2206-2210 ◽  
Author(s):  
Y. Oshida ◽  
K. Yamanouchi ◽  
S. Hayamizu ◽  
Y. Sato
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Clearance Rate ◽  
Insulin Action ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Before And After ◽  
Plasma Insulin Levels ◽  
Improve Glucose Tolerance

Physical training has been shown to improve glucose tolerance and insulin sensitivity. In the present study, insulin action was determined using the euglycemic clamp technique in six untrained nonobese subjects before, during, and after long-term mild regular jogging. After 1 yr of jogging, steady-state plasma insulin levels (I) decreased significantly, and the metabolic clearance rate of insulin was increased by 87%, although insulin infusion rate during the clamp was constant for each individual. The amount of glucose infused (glucose metabolism, M) tended to increase from 6.16 +/- 0.94 to 8.15 +/- 1.94 mg.kg-1.min-1 after regular jogging for 1 yr, although that was not statistically significant. However, M/I increases significantly from 0.060 +/- 0.012 to 0.184 +/- 0.056 (P less than 0.05) after 1 yr. The concentrations of plasma free fatty acids during the hyperinsulinemic clamp decreased more significantly after 1 yr of jogging (P less than 0.05). The concentrations of plasma glycerol decreased gradually before and after long-term regular jogging, showing only a 50–60% reduction in 120 min. Therefore, long-term mild regular jogging, which did not influence either body mass index or maximal O2 uptake, appears to improve insulin action in both carbohydrate and lipid metabolism and to increase the metabolic clearance rate of insulin.

scholarly journals CLINICAL EVALUATION OF THE EFFICACY OF LEKHANBASTI AND MEDOHARAVIDANGADILAUHA IN THE MANAGEMENT OF DYSLIPIDEMIA

2021 ◽  
Vol 9 (7) ◽  
pp. 1362-1365
Author(s):  
Noor Sayeda Shabnam Ahmed ◽  
Om Prakash Gupta ◽  
Bishnu Prasad Sarma
Keyword(s):  
Lipid Profile ◽  
Clinical Evaluation ◽  
Oral Intake ◽  
Before And After ◽  
Significant Change ◽  
Ethical Clearance

This study was conducted to evaluate the efficacy of lekhanbasti and medoharavidangadilauha in the management of dyslipidemia. Consent from all the selected patients was taken before the study after explaining to them about the disease and the procedure. Ethical clearance was accredited by the ethical committee of Government Ayurvedic College and Hospital Guwahati, Assam. Patients from IPD and OPD of the department of Kayachikitsa of the aforesaid institute were chosen. Lekhanbasti niruha and tiltaila anuvasana on alternate days was administered for 8 days Follow up was done at an interval of 30,60 and 90 days. Oral intake of medoharavidangadilauha was advised during these 90 days. The basti was repeated in the follow-up period. After comparing the fasting lipid profile before and after treatment it was found that there was a significant change in it. Keywords: Dyslipidemia, Lekhanbasti, Medoharavidangadilauha, Medoroga, Fasting lipid profile.

Immediate and late acute effect of moderate continuous and high intensity interval training on hypertension stage I: case report

2021 ◽  
Vol 1 (4) ◽  
pp. 50-56
Author(s):  
Ana Luísa Freitas Siqueira ◽  
Gabriela Souza Faria ◽  
Pedro De Oliveira Neto ◽  
Maria Paula Fabrício de Andrade ◽  
Bruna Pereira Molina Cruz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Physical Training ◽  
High Intensity ◽  
Interval Training ◽  
Hypotensive Effect ◽  
Acute Effect ◽  
High Intensity Interval Training ◽  
Before And After ◽  
High Intensity Interval ◽  
Training Modalities

Physical training is used in the control of arterial hypertension (AH), especially in patients with higher levels of blood pressure (BP). However, there are still few studies on the effects of physical training on AH in less advanced stages of the disease. The aim of the present study was to assess the immediate and late acute effects of continuous moderate physical training (CMT) and high intensity interval training (HIIT) in patients with mild AH, and to assess which training method induces a greater hypotensive effect. A female patient, 43 years old, sedentary, diagnosed with mild AH (stage 1), taking Losartana 50 mg twice a day was studied. She underwent one CMT and one HIIT session, one week apart. BP measurements were taken before and after each session, as well as 24 hours before and after the sessions. After the physical training sessions, we observed a drop in the patient's BP that lasted up to 60 minutes, and a reduction in blood pressure levels on the day after the training. We conclude that both training modalities were efficient in reducing the BP of the patient with mild acute immediate and delayed hypertension.

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