scholarly journals Hearing Disorders and Sensorineural Aging

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Alessandra Fioretti ◽  
Otello Poli ◽  
Theodoros Varakliotis ◽  
Alberto Eibenstein
Keyword(s):  
Hearing Loss ◽  
Organ Of Corti ◽  
Physiological Age ◽  
Hearing Disorders ◽  
Hearing Sensitivity ◽  
Age Related ◽  
Loss Of Autonomy ◽  
Central Auditory Function ◽  
Central Auditory Pathways ◽  
Age Related Hearing Loss

The physiological age-related hearing loss is defined as presbycusis and it is characterized by reduced hearing sensitivity and problems in understanding spoken language especially in a noisy environment. In elderly the reduced speech recognition is generally caused by a reduction of the cochlear cells in the organ of Corti and degeneration of the central auditory pathways. In order to have a complete management strategy of central and peripheral presbycusis the diagnostic evaluation should include clinical ENT examination, standard audiological tests, and tests of central auditory function. Treatment should include not only the appropriate instruments for peripheral compensation but also auditory rehabilitative training and counseling to prevent social isolation and loss of autonomy. Other common hearing disorders in elderly are tinnitus and hyperacusis which are often undervalued. Tinnitus is characterized by the perception of a “phantom” sound due to abnormal auditory perception. Hyperacusis is defined as a reduced tolerance to ordinary environmental sounds. Furthermore auditory, visual, nociceptive, and proprioceptive systems may be involved together in a possible context of “sensorineural aging.” The aim of this review is to underline the presence of hearing disorders like tinnitus and hyperacusis which in many cases coexist with hearing loss in elderly.

scholarly journals Promoting healthy hearing over the lifespan

2021 ◽  
Author(s):  
James W. Hall III
Keyword(s):  
Health Care ◽  
Hearing Loss ◽  
Test Battery ◽  
Patient Specific ◽  
Comorbid Conditions ◽  
Specific Test ◽  
Age Related ◽  
Central Auditory Function ◽  
Hearing Health ◽  
Age Related Hearing Loss

Background and Aim: Comorbid conditions and unhealthy lifestyles are risk factors for auditory dysfunction, including age-related hearing loss. With a focus on adults, this paper describes a new approach to hearing health care that aims to prevent or mitigate hearing loss and related disorders, like tinnitus. Accurate diagnosis and effective management of hearing loss is best achieved with a patient-specific test battery that includes sensitive measures of peripheral and central auditory function. Background and Aim: Comorbid conditions and unhealthy lifestyles are risk factors for auditory dysfunction, including age-related hearing loss. With a focus on adults, this paper describes a new approach to hearing health care that aims to prevent or mitigate hearing loss and related disorders, like tinnitus. Accurate diagnosis and effective management of hearing loss is best achieved with a patient-specific test battery that includes sensitive measures of peripheral and central auditory function. Conclusion: The traditional model for hearing health care service delivery relies on a rather outdated and simplistic protocol for evaluating and describing hearing loss, and a technologyfocused approach for management. This paper offers an evidence-based rationale for expanding the test battery for diagnosing hearing loss, and a multidisciplinary intervention approach.   Keywords: Comorbid conditions; smoking; diet; value-added tests

scholarly journals Role of Oxidative Stress in the Senescence Pattern of Auditory Cells in Age-Related Hearing Loss

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1497
Author(s):  
Luz del Mar Rivas-Chacón ◽  
Sofía Martínez-Rodríguez ◽  
Raquel Madrid-García ◽  
Joaquín Yanes-Díaz ◽  
Juan Ignacio Riestra-Ayora ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Molecular Mechanisms ◽  
Morphological Changes ◽  
Cell Damage ◽  
Stria Vascularis ◽  
Organ Of Corti ◽  
Age Related ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL) is an increasing and gradual sensorineural hearing dysfunction. Oxidative stress is an essential factor in developing ARHL; additionally, premature senescence of auditory cells induced by oxidative stress can produce hearing loss. Hydrogen peroxide (H2O2) represents a method commonly used to generate cellular senescence in vitro. The objective of the present paper is to study H2O2-induced senescence patterns in three auditory cell lines (House Ear Institute-Organ of Corti 1, HEI-OC1; organ of Corti, OC-k3, and stria vascularis, SV-k1 cells) to elucidate the intrinsic mechanisms responsible for ARHL. The auditory cells were exposed to H2O2 at different concentrations and times. The results obtained show different responses of the hearing cells concerning cell growth, β-galactosidase activity, morphological changes, mitochondrial activation, levels of oxidative stress, and other markers of cell damage (Forkhead box O3a, FoxO3a, and 8-oxoguanine, 8-oxoG). Comparison between the responses of these auditory cells to H2O2 is a helpful method to evaluate the molecular mechanisms responsible for these auditory cells’ senescence. Furthermore, this in vitro model could help develop anti-senescent therapeutic strategies for the treatment of AHRL.

scholarly journals Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature

Geriatrics ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 48 ◽  
Author(s):  
Michelle Lycke ◽  
Tessa Lefebvre ◽  
Lieselot Cool ◽  
Koen Van Eygen ◽  
Tom Boterberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Older Patients ◽  
Cumulative Effect ◽  
Screening Methods ◽  
Hearing Sensitivity ◽  
Patients With Cancer ◽  
Age Related ◽  
Age Related Hearing Loss

As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient’s quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient’s ability to deal properly with all aspects of their disease, and may have a cumulative effect on their already decreased quality of life. Therefore, the proper screening of those conditions is essential in order to optimise the patient’s comfort during and after treatment. This review article aims at providing a concise image of the nature of age-related hearing loss, and provides an overview of the screening methods that could be used in older patients with cancer.

scholarly journals Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Chisato Fujimoto ◽  
Tatsuya Yamasoba
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dysfunction ◽  
Stria Vascularis ◽  
Spiral Ganglion ◽  
Organ Of Corti ◽  
The Elderly ◽  
Laboratory Animals ◽  
Age Related ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.

scholarly journals Presbycusis and the Aging of Eye Movement: Common Attention Mechanisms

2022 ◽  
Vol 12 (1) ◽  
pp. 107
Author(s):  
Martin Chavant ◽  
Zoï Kapoula
Keyword(s):  
Hearing Loss ◽  
Eye Movement ◽  
Speech Processing ◽  
Aging Population ◽  
Saccade Latency ◽  
Physiological Age ◽  
Major Health Problem ◽  
Age Related ◽  
Underlying Mechanisms ◽  
Age Related Hearing Loss

Presbycusis, physiological age-related hearing loss, is a major health problem because it is the most common cause of hearing impairment, and its impact will grow in the coming years with the aging population. Besides auditory consequences, the literature recently found an association between hearing loss and cognitive decline over the last two decades, emphasizing the importance of the early detection of presbycusis. However, the current hearing tests are not sufficient to detect presbycusis in some cases. Furthermore, the underlying mechanisms of this association are still under discussion, calling for a new field of research on that topic. In that context, this study investigates for the first time the interaction between presbycusis, eye movement latency and Stroop scores for a normal aging population. Hearing abilities, eye movement latency and the Stroop Victoria test were measured for 69 elderly (mean 66.7 ± 8.4) and 30 young (mean 25.3 ± 2.7) participants. The results indicated a significant relationship between saccade latency and speech audiometry in the silence score, independently from age. These promising results suggest common attentional mechanisms between speech processing and saccade latency. The results are discussed regarding the relationship between hearing and cognition, and regarding the perspective of expanding new tools for presbycusis diagnosis.

scholarly journals Hidden age-related hearing loss and hearing disorders: current knowledge and future directions

2018 ◽  
Vol 16 (2) ◽  
pp. 74-82 ◽  
Author(s):  
Richard Salvi ◽  
Dalian Ding ◽  
Haiyan Jiang ◽  
Guang-Di Chen ◽  
Antonio Greco ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Current Knowledge ◽  
Hearing Disorders ◽  
Future Directions ◽  
Age Related ◽  
Age Related Hearing Loss

Audiological and Temporal Bone Findings in Myxedema

1986 ◽  
Vol 95 (3) ◽  
pp. 278-283 ◽  
Author(s):  
A. Parving ◽  
B. Ostri ◽  
J. M. Hansen ◽  
P. Bretlau ◽  
H.-H. Parving
Keyword(s):  
Hearing Loss ◽  
Structural Changes ◽  
Morphological Changes ◽  
The Elderly ◽  
Hearing Sensitivity ◽  
Age Related ◽  
Before And After ◽  
Temporal Bones ◽  
Age Related Hearing Loss ◽  
Observation Period

Fifteen patients with confirmed myxedema at a median age of 48 years (range 32 to 60 years) were referred for audiological evaluation before and after treatment with levothyroxine. The median interval between the pretreatment and posttreatment investigations was 18 months (range 9 to 27 months). In addition, 13 patients at a median age of 78 years (range 64 to 95 years) were audiologically reexamined after long-standing levothyroxine treatment. The observation period upon treatment with levothyroxine was 40 months (range 32 to 46 months). No improvement in hearing sensitivity could be demonstrated either in the younger patients or in the elderly. When compared to an age- and sex-matched unscreened population, the myxedematous patients did not demonstrate any different degree of hearing loss. Histological investigation of the temporal bones from an 83-year-old woman with myxedema, however, showed no morphological changes or deposition of glycosaminoglycans, changes which are compatible with true age-related hearing loss. It is concluded that no association exists between myxedema and hearing impairment and that no morphological or structural changes due to myxedema can be demonstrated in the temporal bones.

scholarly journals Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62786 ◽  
Author(s):  
Qian Zhang ◽  
Huizhan Liu ◽  
JoAnn McGee ◽  
Edward J. Walsh ◽  
Garrett A. Soukup ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Organ Of Corti ◽  
Age Related ◽  
Age Related Hearing Loss
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