Adjustment of Serum Total Calcium for Albumin Concentration: Effects of Non-Linearity and of Regression Differences between Laboratories

1996 ◽  
Vol 33 (1) ◽  
pp. 55-58 ◽  
Author(s):  
J H Barth ◽  
J B Fiddy ◽  
R B Payne
Keyword(s):  
Clinical Significance ◽  
Albumin Concentration ◽  
Total Calcium ◽  
Concentration Effects ◽  
Computer Data ◽  
Serum Total Calcium ◽  
Wide Range ◽  
Hospital Patients ◽  
Computer Data Base ◽  
Low Prevalence

It has been reported that the relationship between serum total calcium and albumin concentrations in hospital patients deviates from linearity at low albumin concentrations. We searched a large laboratory computer data base for adult patients with discretionary requests for serum calcium analysis but with no other data suggestive of disturbances of calcium homeostasis, and collected a minimum of 100 calcium values at each of a wide range of albumin concentrations. We confirmed the earlier observation, but found that the use of a single regression to derive an adjustment of total calcium for albumin gave only small differences of no clinical significance. To investigate whether equations to adjust total calcium for albumin can be transferred between laboratories, three laboratory computers were searched for calcium requests from patients likely to have a low prevalence of calcium disturbances. The regressions of total calcium on albumin differed significantly between laboratories, but within each laboratory gave adjusted calcium values identical with those in health. Although the errors resulting from applying an equation from one laboratory to another were small and unlikely to be of major clinical significance, we recommend that where possible laboratories should derive adjustment equations from their own data.

Adjustment of Serum Total Calcium for Albumin Concentration: Values Change with Age in Women but Not in Men

1996 ◽  
Vol 33 (1) ◽  
pp. 59-62 ◽  
Author(s):  
R B Payne ◽  
J H Barth
Keyword(s):  
Serum Albumin ◽  
Albumin Concentration ◽  
Least Squares Regression ◽  
Total Calcium ◽  
Computer Data ◽  
Younger Women ◽  
Serum Total Calcium ◽  
Wide Range ◽  
Computer Data Base ◽  
Low Prevalence

A total of 669 women and 609 men were selected from a laboratory computer data base in such a way that they would be expected to have a low prevalence of disturbances of calcium homeostasis but a wide range of serum albumin concentrations. The least squares regression coefficients of total calcium on albumin did not differ between men and women, nor did they differ at different ages. Mean serum albumin-adjusted calcium concentrations did not change with age in men from 1 to 90 years, and values were similar in women aged 1–20 years. However, adjusted calcium concentrations were significantly lower in women aged 21–50 and higher in women aged 61–90 than in younger women and all men. The differences were small and are unlikely to affect clinical interpretation.

COMPARISON OF CYBER CRIME AWARENESS AMONG SCIENCE AND SOCIAL SCIENCE PERSPECTIVE TEACHERS

2017 ◽  
Vol 4 (36) ◽  
Author(s):  
Anupam Bansal
Keyword(s):  
Social Science ◽  
Automatic Control ◽  
Control Systems ◽  
Child Pornography ◽  
Cyber Crime ◽  
Computer Data ◽  
Automatic Control Systems ◽  
Living Things ◽  
Wide Range

“Cyber crime” has been used to describe a wide range of offences, including offences against computer data and systems (such as “Hacking”), computer related forgery and fraud (such as “phishing”), content offences (such as disseminating child pornography), and copyright offences (such as the dissemination of pirated content). The word “Cyber Crime” has been derived from the words “Cybernetic” which means the science of communication and automatic control systems in both machines and living things.

Effect of Hypocalcemia on Cardiac Function in Very-Low-Birth-Weight Preterm Neonates: Studies of Blood Ionized Calcium, Echocardiography, and Cardiac Effect of Intravenous Calcium Therapy

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 543-550
Author(s):  
Pankaja S. Venkataraman ◽  
Don A. Wilson ◽  
Roger E. Sheldon ◽  
Radhakrishna Rao ◽  
Michael K. Parker
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cardiac Function ◽  
Serum Calcium ◽  
Calcium Concentration ◽  
Very Low Birth Weight ◽  
Left Ventricular ◽  
Ionized Calcium ◽  
Total Calcium ◽  
Serum Total Calcium

Traditionally, in infants, a serum calcium value less than 7.0 mg/dL is considered to impair cardiac function. In very-low-birth-weight infants, we studied the hypotheses that decline in serum calcium to 6.0 mg/dL (1) would not impair cardiac function and (2) ionized calcium would remain greater than 3.0 mg/dL. We also evaluated the effect of calcium infusion on cardiac function. We studied 15 normokalemic and normonatremic infants whose birth weights were 822 to 1,450 g and were less than 32 weeks' gestation. When serum calcium declined to less than 6.0 mg/dL, 18 mg/kg of calcium as 5% calcium gluconate was infused for 10 minutes. Serum total calcium concentration, blood ionized calcium concentration, ECG, and M-mode echocardiogram were obtained on entry into the study, when the infants were hypocalcemic, immediately after treatment with calcium, and eight hours after treatment. Ionized calcium values were calculated based on serum total calcium and serum protein, and corrected calcium values were calculated based on serum total calcium, serum albumin, and blood pH. In all infants, serum calcium value declined to less than 7.0 and in eight infants to less than 6.0 mg/dL. Assessment of heart rate, systolic blood pressure, ejection fraction, left ventricular systolic time interval, right ventricular systolic time interval, fiber shortening index, and left ventricular mean velocity of circumferential fiber shortening showed no significant alteration from baseline during hypocalcemia or in association with intravenous slow bolus infusion of 18 mg/kg of calcium. In association with a decline in serum total calcium to as low as 6.0 mg/dL, whole blood ionized calcium was maintained at more than 3.0 mg/dL. Serum total calcium and calculated ionized calcium values correlated significantly with measured blood ionized calcium concentrations; however, these measures were not reliable predictors of blood ionized calcium. We speculate that the hypoproteinemia and hypoalbuminemia noted in these infants may result in relative protection of the blood ionized calcium in these infants. We suggest that in neonates with wide ranges in gestation, serum protein, and blood pH levels, total serum calcium and calculated ionized calcium values may be poor measures of derangement of calcium metabolism. Decline in total serum calcium concentration to 6.0 mg/dL was not associated with impaired cardiac function, and slow bolus calcium infusion in these hypocalcemic very-low-birth-weight infants neither improved nor impaired cardiac function.

Computer data-base organization

1978 ◽  
Vol 14 (6) ◽  
pp. 486-487
Author(s):  
William H. Jepson
Keyword(s):  
Data Base ◽  
Computer Data ◽  
Computer Data Base

scholarly journals Occurrence of linezolid induced thrombocytopenia and its association with the risk factors: a review article

2018 ◽  
Vol 7 (12) ◽  
pp. 2483 ◽  
Author(s):  
Radha A. ◽  
Anuradha H. V. ◽  
Radhika K.
Keyword(s):  
Risk Factors ◽  
English Language ◽  
Cross Sectional Study ◽  
Albumin Concentration ◽  
Cross Sectional ◽  
Baseline Platelet Count ◽  
Gram Positive Bacteria ◽  
Search Terms ◽  
Wide Range ◽  
Linezolid Therapy

Linezolid is the oxazolidinone group of antibiotic with wide range of activity against the gram positive bacteria including methicillin resistant staphylococcus aureus and penicillin resistant pneumococci and vancomycin resistant enterococci. Patients who are on linezolid were reported to have reversible myelosuppression especially thrombocytopenia and anaemia. Since there are less number of studies regarding the occurrence of thrombocytopenia and the risk factors associated with it, this study was undertaken to evaluate the occurrence of linezolid induced thrombocytopenia and its association with risk factors. It was a systematic review with synthesis of available literature in English language. Articles were retrieved using search terms included “linezolid”, “and”, “or”, “thrombocytopenia” from Clinical key and PubMed, published during 2000 - 2017. Out of 16 studies retrieved, only 7 studies were analysed based on inclusion and exclusion criteria; of them, 3 were found to be prospective and retrospective cohort each and only one was retrospective cross-sectional study. The occurrence of linezolid induced thrombocytopenia range from 18-50% with normal renal function and 57% of incidence associated with renal insufficiency patients. The risk factors were found to be dose of linezolid >18-27mg/kg, body weight of subjects <55kg, creatinine clearance <88.39 to 60ml/min/1.73m2 and baseline platelet count <200*103/mm3, serum albumin concentration, serum creatinine, concomitant caspofungin therapy and duration of linezolid therapy.

scholarly journals Contagious diseases in the Belgrade region

Stanovnistvo ◽  
1998 ◽  
Vol 36 (1-2) ◽  
pp. 125-143 ◽  
Author(s):  
Marko Kovacevic ◽  
Veljko Djerkovic ◽  
Dusan Pokorni
Keyword(s):  
Age Groups ◽  
Population Migration ◽  
Computer Data ◽  
Chicken Pox ◽  
Contagious Diseases ◽  
Computer Data Base ◽  
The City ◽  
Insight Into ◽  
Individual Disease ◽  
Public Health Institute

Data from records on population affected by contagious diseases in the period from 1991 to 1996 are entered in the computer data base and are managed by the Epidemiology corps of the City Public Health Institute. These data are used to serve the operative needs of the epidemiological corps in order to control contagious diseases within the district. They are analysed to obtain an insight into the problem of contagious diseases in general, and each individual disease in particular, while monitoring the distribution of diseases by gender, age and commune. In the period from 1991 to 1996 no person in Belgrade was down with a particularly dangerous contagious disease. The lowest number of the diseased was registered in 1991 (14788) and the highest in 1994 (27368). In 1996, the number of the diseased was higher by 33% than in 1991. Among the most widely spread contagious diseases was chicken pox (its share ranging from 22.5% to 54.6%), contagious diarrhea (from 7.4% to 17.3%), salmonellosis (from 2.9% to 6.1%), angina (from 2.6% to 5.6%). In the period reviewed, the above four diseases were among the ten most frequently incurred contagious diseases. In the course of 1993, measles fell within the group of ten and acquired epidemic proportions. The disease affected 3524 inhabitants of Belgrade (44. 7% children below 14 years of age and 32% young people from 15 to 19 years of age). The epidemic was caused by the discontinuation of regular vaccination of children against measles caused by the shortage of imported vaccination and by population migration. In the same year, the epidemic of rubella also broke out. The epidemic extended to 1994 and 1995. A breakdown of the diseased by gender ranged from 51.0% to 52.9% for males and from 47.1 % to 49.0% for females. Majority of the diseased were in the age groups 5-9 and 0-4 years while the least number of the diseased were among the aged. The youngest population was most frequently affected by chicken pox (from 35.6% to 69.4% of the overall number of those stricken by the disease), contagious diarrhea (from 4.5% to 17.5%), salmonellosis (from 3.1% to 7.4% ), angina (from 3.4% to 9.7%) and scarlet fever (from 3.1% to 7.3%). During the period reviewed, 69 people died from contagious diseases. Mortality from contagious diseases was lowest in 1992 and 1993 (3.1 and 3.4 per 1,000,000). It gradually rose to reach the highest value in 1996 (12.6% per 1,000,000). The largest number of people affected was reported in the communes of Novi Beograd, Zemun and Cukarica.

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