scholarly journals Occurrence of linezolid induced thrombocytopenia and its association with the risk factors: a review article

2018 ◽  
Vol 7 (12) ◽  
pp. 2483 ◽  
Author(s):  
Radha A. ◽  
Anuradha H. V. ◽  
Radhika K.
Keyword(s):  
Risk Factors ◽  
English Language ◽  
Cross Sectional Study ◽  
Albumin Concentration ◽  
Cross Sectional ◽  
Baseline Platelet Count ◽  
Gram Positive Bacteria ◽  
Search Terms ◽  
Wide Range ◽  
Linezolid Therapy

Linezolid is the oxazolidinone group of antibiotic with wide range of activity against the gram positive bacteria including methicillin resistant staphylococcus aureus and penicillin resistant pneumococci and vancomycin resistant enterococci. Patients who are on linezolid were reported to have reversible myelosuppression especially thrombocytopenia and anaemia. Since there are less number of studies regarding the occurrence of thrombocytopenia and the risk factors associated with it, this study was undertaken to evaluate the occurrence of linezolid induced thrombocytopenia and its association with risk factors. It was a systematic review with synthesis of available literature in English language. Articles were retrieved using search terms included “linezolid”, “and”, “or”, “thrombocytopenia” from Clinical key and PubMed, published during 2000 - 2017. Out of 16 studies retrieved, only 7 studies were analysed based on inclusion and exclusion criteria; of them, 3 were found to be prospective and retrospective cohort each and only one was retrospective cross-sectional study. The occurrence of linezolid induced thrombocytopenia range from 18-50% with normal renal function and 57% of incidence associated with renal insufficiency patients. The risk factors were found to be dose of linezolid >18-27mg/kg, body weight of subjects <55kg, creatinine clearance <88.39 to 60ml/min/1.73m2 and baseline platelet count <200*103/mm3, serum albumin concentration, serum creatinine, concomitant caspofungin therapy and duration of linezolid therapy.

scholarly journals Asthma and Keratoconus: An analysis of the risk factors association with the severity of keratoconus

2020 ◽  
Author(s):  
Srujana Sahebjada ◽  
Elsie Chan ◽  
Jing Xie ◽  
Grant Snibson ◽  
Mark Daniel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Wide Range ◽  
Multivariable Regression

Abstract Background: A cross-sectional study was undertaken in Australia to explore a wide range of risk factors associated with keratoconus. A questionnaire addressing age, gender, educational background, ocular and medical history, smoking and alcohol consumption, and physical examination comprising anthropometric measurements was collected; eye examination was undertaken. The associations between a range of risk factors and keratoconus was determined using univariate and multivariable linear regression analyses.Main Text: A total of 260 keratoconus subjects were included in this study. Mean age of subject was 35.5 (SD= 14.8) years and the majority of the subjects were European 171 (68.2%). Initial univariate regression analysis identified the following risk factors at the p<0.1 level with keratoconus: higher body mass index, smoking cigarettes, diabetes, rheumatoid arthritis and asthma were associated with increased severity of keratoconus, whereas eczema was associated with less severe keratoconus. Following multivariable regression analysis, only asthma remained as a significant risk factor associated with 2.2 diopters (D) steeper average mean keratometry compared to keratoconus subjects having no asthma [p = 0.03; β= 2.18; 95% confidence intervals: 1.22, 4.14].Conclusion: Our study describes the comprehensive assessment of all the known risk factors in a large keratoconus cohort recruited in Australia. Our study has reported asthma as the only risk factor found to be significantly associated with keratoconus. The results of this study allow us to better understand the aetiology of keratoconus and such a knowledge could be useful in instigate systemic management of patients to slow or prevent keratoconus.

scholarly journals Bacterial and Fungal Profile, Drug Resistance Pattern and Associated Factors of Isolates Recovered From Blood Samples of Patients Referred to Ethiopian Public Health Institute: Cross-Sectional Study

2021 ◽  
Author(s):  
Etsehiwot Adamu Tsegaye ◽  
Dejenie Shiferaw Teklu ◽  
Zelalem Tazu Bonger ◽  
Abebe Assefa Negeri ◽  
Tesfaye Legesse Bedada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Burkholderia Cepacia ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Gram Positive Bacteria ◽  
Blood Specimens

Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby-Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candidia krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (p = 0.007), age (p < 0.001) and use of invasive medical devices (p = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to Burkholderia cepacia and non-Candidia albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.

scholarly journals Risk factors for linezolid-associated thrombocytopenia and negative effect of carbapenem combination

2019 ◽  
Vol 13 (10) ◽  
pp. 886-891
Author(s):  
Esra Kaya Kılıç ◽  
Cemal Bulut ◽  
Meliha Çağla Sönmezer ◽  
Özlem Ozel ◽  
Çiğdem Ataman Hatipoğlu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Platelet Count ◽  
Combination Therapy ◽  
Univariate Analysis ◽  
Treatment Combination ◽  
Baseline Platelet Count ◽  
Gram Positive Bacteria ◽  
Platelet Level ◽  
Negative Effect ◽  
Linezolid Therapy

Introduction: Linezolid is a synthetic antimicrobial agent with a broad spectrum of activity against virtually all Gram-positive bacteria. Although linezolid is generally well tolerated, the prolonged use of linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia. The aim of this study was investigating the risk factors for thrombocytopenia in patients who received linezolid therapy. Methodology: This retrospective study was performed on patients who received linezolid therapy between July 2007 and December 2017. Thrombocytopenia was defined as either a platelets count of < 100×109/L or a 25% reduction from the baseline platelet count. Results: A total of 371 patients, (198 (53%) male and 173(47%) female were included into the study. Mean duration of therapy was 12.81 ± 5.19 days. Linezolid-induced thrombocytopenia was detected in a total of 111 patients. Using the univariate analysis advanced sex, serum urea concentration, baseline platelet level and low eGFR value were found to be risk factors for linezolid associated thrombocytopenia (p < 0.05). According to a multivariate analysis, patients undergoing carbapenem treatment combination therapy (p = 0.003) and with a baseline platelet level of < 200×109/L (p = 0.00) were found to have a high risk of developing thrombocytopenia. Conclusions: Several factors may influence of linezolid associated thrombocytopenia. Platelet count should be monitored during therapy and thrombocytopenia should be kept in mind in patients with baseline platelet level of < 200×109/L, low eGFR, linezolid-carbapenem combination therapy.

scholarly journals Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Etsehiwot Adamu Tsegaye ◽  
Dejenie Shiferaw Teklu ◽  
Zelalem Tazu Bonger ◽  
Abebe Aseffa Negeri ◽  
Tesfaye Legesse Bedada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Blood Specimens

Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby–Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candida krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (P = 0.007), age (P < 0.001) and use of invasive medical devices (P = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to B. cepacia and non-C. albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.

PRRSV: Risikofaktoren und Herdenprävalenz in Deutschland

2019 ◽  
Vol 47 (02) ◽  
pp. 132-132
Author(s):  
Sebastian Ganz
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Respiratory Syndrome Virus ◽  
Sectional Study ◽  
Cross Sectional ◽  
Klinische Symptome

Nathues C, Janssen E, Duengelhoef A et al. Cross-sectional study on risk factors for Porcine Reproductive and Respiratory Syndrome virus sow herd instability in German breeding herds. Acta Vet Scand 2018; 60 (1): 1–8 In mit PRRSV (Porcine Reproductive and Respiratory Syndrom Virus) infizierten Schweinebeständen zeigen die Tiere oftmals ernsthafte klinische Symptome. Die Schwere der Symptomatik hängt von der Virulenz der jeweiligen Virusstämme ab. Deshalb ist die Impfung gegen diesen Erreger sinnvoll und wird empfohlen, auch wenn sie nicht immer klinische Fälle verhindert bzw. das Virus vollends eliminiert. Aufgrund dessen rückt die Prävention durch Verbesserung der innerbetrieblichen Abläufe zunehmend in den Fokus. Um solche Maßnahmen erfolgreich etablieren zu können, ist es wichtig, den epidemiologischen Status der Herde und mögliche Risikofaktoren zu kennen. Ziel der Studie war deshalb, die Prävalenz der Infektion in Sauenbetrieben in Norddeutschland zu eruieren und verschiedene Arbeitsabläufe hinsichtlich des Risikos der Erregerverbreitung zu untersuchen.

Obesity in relation to risk factors and socioeconomic conditions among school-age children at Khartoum State 2011/2012

2019 ◽  
Vol 9 (5) ◽  
pp. 413-416
Author(s):  
Dr. Suzan Ail Yousif Abo* ,Dr. ALI abdalazez Salih
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
School Age Children ◽  
Anthropometric Measurement ◽  
Socioeconomic Conditions ◽  
Cross Sectional ◽  
School Year ◽  
Prevalence Of Obesity ◽  
Class Room ◽  
Watching Tv

This is a descriptive cross-sectional study that was carried out at Khartoum Stateduring the school year 20112/2012 to estimate the prevalence of obesity among schoolchildren aged 6-15 years and to investigate the relationship between BMI (Body MassIndex) and socioeconomic status and life style factors. Two hundred and fifty pupilsparticipated in this study. The researcher took the anthropometric measurement insidethe class room and gave the questionnaire the students to be answered by one of child’sparents. The data was analyzed using the Statistical Package for the Social Sciences(SPSS Version 13.0).In this study, prevalence of obesity was found to be (48%) of them 18% males and 30%females. Income of the family, number of high caloric carbonated beverages/week, wayof transportation to school, length of daily playing outside the home, and time spentin watching TV and video games were significantly correlated with student’s BMI.While parent’s BMI was not having significant correlation with student’s BMI.This study is considered as the first study in its field regarding this age category inKhartoum State, and it is promoting future researches in obesity and its determinant.Key words: Obesity in relation to risk factors and socioeconomic conditions amongschool-age children

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