A case report of sudden epileptic death linked to thermal water after mud therapy

We present the case of a 60-year-old male, with a long history of epilepsy, who was discovered submerged and unconscious in a small thermal whirlpool bath. The circumstances were forensically reviewed to include examination of clinical data and an autopsy with toxicological analysis. The conclusion was that “warm” hydro-therapy had contributed more than “hot” mud-therapy to the onset of epilepsy which led to accidental drowning, notwithstanding the deceased’s treatment with the long-lasting, poly-drug antiepileptic therapy. Further, we analysed the Italian medical indications of wellness centres for patients with epilepsy or other diseases.

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PROFILE OF HISTORY OF FEBRILE SEIZURE IN PATIENTS WITH EPILEPSY

MNJ (Malang Neurology Journal) ◽

10.21776/ub.mnj.2022.008.01.5 ◽

2022 ◽

Vol 8 (1) ◽

pp. 21-24

Author(s):

Rayhan Muhammad Basyarahil ◽

Wardah Rahmatul Islamiyah ◽

Prastiya Indra Gunawan

Keyword(s):

Febrile Seizure ◽

Age Of Onset ◽

Central Nervous System Infection ◽

Sampling Technique ◽

Febrile Seizures ◽

The Body ◽

Population Sampling ◽

History Of ◽

History Of Epilepsy ◽

Patients With Epilepsy

Background: Febrile seizure is convulsions with fever (temperature ³38°C) with no central nervous system infection that commonly found in children (6-60 months). Febrile seizures do not always mean the child has epilepsy. However, febrile seizures can be a possible long-term risk factor for epilepsy. Objective: The objective of this study is to know the profile of febrile seizure in patients with epilepsy. Methods: A retrospective descriptive study on 23 patients with epilepsy in the EEG Department of Neurology, Dr. Soetomo General Hospital, Surabaya, Indonesia in the period 2018-2019 based on inclusion and exclusion criteria. The total number of epilepsy patients is 849 patients, 216 of whom had a history of febrile seizure. Among 216 epilepsy patients who had a history of febrile seizures, 23 of them were qualified as the sample. The sampling technique used was total population sampling. The instrument of this research is the patients’ medical record. Data analysis is carried out descriptively. Results: The characteristics of the history of febrile seizures that found in patients with epilepsy are more patients are male, have the age of onset on less than 2 years old, have the body temperature more than 38.3°C, have the seizure duration less than 15 minutes, have focal seizures, have recurrent seizures in 24 hours, have a history of more than one febrile seizure, have accompanying neurological disorders, and have no family history of epilepsy. Conclusion: Febrile seizure is still becoming a concern because there is a possibility that it may develop into epilepsy. Even though, not all children who experience febrile seizure will generate epilepsy.

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Zollinger-Ellison Syndrome in a Nineyear -old Child: A Case Report and Review of this Entity in Childhood

PEDIATRICS ◽

10.1542/peds.47.3.594 ◽

1971 ◽

Vol 47 (3) ◽

pp. 594-598

Author(s):

Richard M. Buchta ◽

J. M. Kaplan

Keyword(s):

Abdominal Pain ◽

Case Report ◽

Clinical Data ◽

Islet Cell ◽

Islet Cell Tumor ◽

Cell Tumor ◽

Gastric Hypersecretion ◽

Zollinger Ellison Syndrome ◽

History Of ◽

Epigastric Abdominal Pain

In 1955, Zollinger and Ellison1 described a syndrome consisting of peptic ulceration, marked gastric hypersecretion, and non-beta islet cell tumor of the pancreas. Although there have been over 300 cases in the adult literature2-5 only 19 patients, 16 years old or younger have been reported. We add one more child to this growing list and review the clinical data of the known cases described. Case Report The patient (R.L.) was a 9-year-old Negro male with a 7-month history of intermittent episodes of mid-epigastric abdominal pain. The pain was somewhat relieved by eating, or the use of antispasmodics. During this period of time, the child had occasional episodes of vomiting, but no melena or hematemesis.

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Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

Children ◽

10.3390/children8111063 ◽

2021 ◽

Vol 8 (11) ◽

pp. 1063

Author(s):

Chien-Heng Lin ◽

Sheng-Shing Lin ◽

Syuan-Yu Hong ◽

Chieh-Ho Chen ◽

I-Ching Chou

Keyword(s):

Drug Reaction ◽

Case Report ◽

Skin Rash ◽

Stable Condition ◽

Anticonvulsant Drug ◽

Dress Syndrome ◽

Life Threatening ◽

History Of ◽

History Of Epilepsy ◽

Systemic Symptoms

Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

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A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity

BMC Pharmacology and Toxicology ◽

10.1186/s40360-019-0366-y ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 2

Author(s):

Xiaonian Han ◽

Jinping Wang

Keyword(s):

Adverse Drug Reaction ◽

Drug Reaction ◽

Case Report ◽

Creatine Phosphokinase ◽

Combination Therapies ◽

Drug Reactions ◽

Unique Case ◽

Case Presentation ◽

History Of ◽

History Of Epilepsy

Abstract Background The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. Case presentation A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase. The patient is currently bedridden and unable to take care of herself. Conclusion Clinicians should be vigilant of the possibility of myotoxicity induced by clonazepam, especially in specific populations such as polio patients or when clonazepam is used in combination therapies.

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Lamotrigine induced DRESS syndrome in a child: a case report and literature review

10.21203/rs.3.rs-151612/v1 ◽

2021 ◽

Author(s):

Chien-Heng Lin ◽

Sheng-Shing Lin ◽

Syuan-Yu Hong ◽

Chieh-Ho Chen ◽

I-Ching Chou

Keyword(s):

Drug Reaction ◽

Case Report ◽

Literature Review ◽

Skin Rash ◽

Anticonvulsant Drug ◽

Dress Syndrome ◽

Life Threatening ◽

History Of ◽

History Of Epilepsy ◽

Systemic Symptoms

Abstract BackgroundLamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).Case presentationHere, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in stable condition.ConclusionAnticonvulsant drugs such as lamotrigine among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

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Structural Abnormalities on MRI in Cases with Epilepsy

Asian Journal of Medical Radiological Research ◽

10.47009/ajmrr.2020.8.2.3 ◽

2020 ◽

Vol 8 (2) ◽

pp. 18-22

Author(s):

Gaurav Kaushik ◽

Madan Manmohan

Keyword(s):

Vascular Malformations ◽

Age Groups ◽

The Elderly ◽

Common Finding ◽

Weber Syndrome ◽

History Of ◽

Sturge Weber Syndrome ◽

History Of Epilepsy ◽

Mri Study ◽

Patients With Epilepsy

Introduction: Many treatable anatomical abnormalities of the brain can cause seizures. The present study was done to determine the role of MRI for evaluation of patients with epilepsy. Subjects and Methods: Patients who presented to our hospital with history of epilepsy. i.e two or more episodes of unproved seizures 24 hours apart, underwent MRI study to assess for abnormalities. Patients of either gender and all age groups who were referred to our department for MRI study were included. Results: Generalized tonic clonic seizures were present in 86% of the population and rest had partial seizures. Using MRI, we arrived at a diagnosis as a cause of seizure in 51.3% of the patients and rest of the 48.7% had a normal MRI study. The most common pathology detected on MRI was infarct with gliosis (24.7%). Less common pathology detected were neurocysticercosis (6.7%), brain atrophy (5.3%), tuberculoma (3.3%), venous thrombosis (2.7%), developmental malformations (2.7%), glioma (1.3%), cavernoma (1.3%), tuberous sclerosis (1.3%), meningioma (0.7%), cerebral abscess (0.7%) and Sturge Weber syndrome (0.7%). Abnormality on MRI was not significantly associated with gender or type of seizure. MR abnormality was observed maximum in patients between 1 to 30 years (30 out of 70 patients i.e. 42.8%) while all the elderly cases showed abnormal MRI, with infract with gliosis being the most common finding. Conclusions : MR imaging should be the first investigation of choice in epileptic syndrome, cerebrovascular disease with seizure, developmental cortical malformations, and vascular malformations.

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A Case Series on Tramadol Induced-Seizures

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2017.v03i01.03 ◽

2017 ◽

Vol 3 (1) ◽

pp. 253-255

Author(s):

Neethu Poulose ◽

Sreelakshmi Sreedhar ◽

Aswini B

Keyword(s):

Case Series ◽

The Other ◽

Racemic Mixture ◽

Synthetic Analogue ◽

Precipitating Factors ◽

History Of ◽

History Of Epilepsy ◽

Patients With Epilepsy

Tramadol is a synthetic analogue of codeine which has been in the market since 1995. It is a racemic mixture in which the each of the enantiomer is responsible for each of its dual analgesic mechanism. The seizure inducing effect of tramadol is widely studied and reported. The tramadol can provoke seizure in patients with epilepsy and those with no history of epilepsy even with the recommended doses. The other precipitating factors are excessive doses or co-administration with other seizure inducing drugs.

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Epilepsy in children with cerebral palsy

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2001000100008 ◽

2001 ◽

Vol 59 (1) ◽

pp. 35-39 ◽

Cited By ~ 31

Author(s):

Isac Bruck ◽

Sérgio Antônio Antoniuk ◽

Adriane Spessatto ◽

Ricardo Schmitt de Bem ◽

Romeu Hausberger ◽

...

Keyword(s):

Cerebral Palsy ◽

Family History ◽

First Year ◽

Neonatal Seizures ◽

Tertiary Center ◽

History Of ◽

History Of Epilepsy ◽

First Year Of Life ◽

Patients With Epilepsy

OBJECTIVE: To describe the prevalence and characteristics of epilepsy in patients with cerebral palsy in a tertiary center. METHODS: a total of 100 consecutive patients with cerebral palsy were retrospectively studied. Criteria for inclusion were follow-up period for at least 2 years. Types and incidence of epilepsy were correlated with the different forms of cerebral palsy. Other factors associated with epilepsy such as age of first seizure, neonatal seizures and family history of epilepsy were also analysed. RESULTS: follow-up ranged between 24 and 151 months (mean 57 months). The overall prevalence of epilepsy was 62%. Incidence of epilepsy was predominant in patients with hemiplegic and tetraplegic palsies: 70.6% and 66.1%, respectively. First seizure occurred during the first year of life in 74.2% of patients with epilepsy. Generalized and partial were the predominant types of epilepsy (61.3% and 27.4%, respectively). Thirty-three (53.2%) of 62 patients were seizure free for at least 1 year. Neonatal seizures and family history of epilepsy were associated with a higher incidence of epilepsy. CONCLUSIONS: epilepsy in cerebral palsy can be predicted if seizures occur in the first year of life, in neonatal period and if there is family history of epilepsy.

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Risk and outcomes of diabetes in patients with epilepsy

Scientific Reports ◽

10.1038/s41598-021-98340-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chun-Cheng Li ◽

Chuen-Chau Chang ◽

Yih-Giun Cherng ◽

Chao-Shun Lin ◽

Chun-Chieh Yeh ◽

...

Keyword(s):

Adverse Events ◽

Cohort Analysis ◽

Sociodemographic Factors ◽

Susceptible Population ◽

Cox Proportional Hazard ◽

Hazard Ratios ◽

History Of ◽

Cox Proportional Hazard Models ◽

History Of Epilepsy ◽

Patients With Epilepsy

AbstractThe risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propensity-score matching by sociodemographic factors and medical conditions, we selected 22,832 people without epilepsy as a non-exposed cohort for comparison. Follow-up events of diabetes from January 1, 2000 until December 31, 2013 were ascertained from medical claims. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with epilepsy were calculated using multiple Cox proportional hazard models. In the diabetes admission analysis, we identified 92,438 hospitalized diabetes patients, 930 of whom had a history of epilepsy. Adjusted odds ratios (ORs) and 95% CIs of adverse events after diabetes associated with previous epilepsy were calculated using multiple logistic regressions. The adjusted HR of diabetes in the cohort with epilepsy was 1.31 (95% CI 1.14–1.50) compared to the non-epilepsy cohort. Previous epilepsy was associated with post-diabetes adverse events, such as pneumonia (OR 1.68, 95% CI 1.37–2.07), urinary tract infection (OR 1.83, 95% CI 1.55–2.16), and septicemia (OR 1.34, 95% CI 1.09–1.65). In conclusion, epilepsy was associated with higher risk of diabetes and adverse post-diabetes outcomes. Diabetes prevention and attention to post-diabetes adverse events are needed for this susceptible population.

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Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽

10.1024/0301-1526/a000101 ◽

2011 ◽

Vol 40 (3) ◽

pp. 251-255 ◽

Cited By ~ 4

Author(s):

Gruber-Szydlo ◽

Poreba ◽

Belowska-Bien ◽

Derkacz ◽

Badowski ◽

...

Keyword(s):

Case Report ◽

Magnetic Resonance Angiography ◽

Popliteal Artery ◽

Doppler Ultrasonography ◽

Histopathological Examination ◽

Previous History ◽

Plain Radiography ◽

Artery Thrombosis ◽

History Of ◽

The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

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