Plasmodium vivax and Neisseria meningitidis co-infection in a newborn

2021 ◽  
pp. 004947552110174
Author(s):  
Karen Melissa Ordoñez Díaz ◽  
Juan José Gutiérrez Paternina
Keyword(s):  
Neisseria Meningitidis ◽  
Plasmodium Vivax ◽  
Indigenous Population ◽  
Age Group ◽  
Invasive Infections

Invasive infections due to Neisseria meningitidis in Colombia are unusual in newborns, in contrast to infections due to Plasmodium vivax which is one of the main pathogens related to the presentation of fever in this age group, especially in the indigenous population. We report a case of co-infection of these two microorganisms in a child.

scholarly journals Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999–2000

2002 ◽  
Vol 128 (1) ◽  
pp. 7-14 ◽  
Author(s):  
D. E. TRIBE ◽  
A. M. ZAIA ◽  
J. M. GRIFFITH ◽  
P. M. ROBINSON ◽  
H. Y. LI ◽  
...  
Keyword(s):  
Czech Republic ◽  
Dna Sequencing ◽  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Age Distribution ◽  
Housekeeping Gene ◽  
Restriction Pattern ◽  
The Novel ◽  
Age Group ◽  
The Czech Republic

In the years 1999–2000, there was an increase in the incidence of meningococcal disease in Victoria, largely caused by Neisseria meningitidis serogroup C. This change was associated with a shift in age distribution of cases, with relatively more disease appearing in the 15–29 year age group, and with 40/58 serogroup C isolates in 2000 exhibiting a new macrorestriction pattern (pattern A). Thirty-four of 52 pattern A isolates tested displayed the novel phenotype C:2a:P1.4, and were consistently porA VR type P1.7-2,4 by DNA sequencing. Nine of 10 representative pattern A isolates analysed displayed a housekeeping gene allele profile (ST-11) that is characteristic of the electrophoretic type (ET)-15 variant that has caused outbreaks in Canada, the Czech Republic and Greece. Meningococci belonging to the ST-11 complex that were isolated in Victoria prior to 1999 did not display either restriction pattern A or PorA VR type P1.7-2,4.

Surveillance of penicillin resistance of Neisseria meningitidis strains from invasive infections between 2013 and 2018 in Turkey

2020 ◽  
Vol 32 (4) ◽  
pp. 213-216
Author(s):  
Eda Karadag Oncel ◽  
Mehmet Ceyhan ◽  
Sevgen Tanir Basaranoglu ◽  
Venhar Gurbuz ◽  
Ahmet Emre Aycan ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Penicillin Resistance ◽  
Invasive Infections

scholarly journals Possible Impact of Wide-scale Vaccination Against Serogroup B Neisseria Meningitidis on Gonorrhea Incidence Rates in One Region of Quebec, Canada

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S734-S735 ◽  
Author(s):  
Jean Longtin ◽  
Rejean Dion ◽  
Marc Simard ◽  
Jean-Francois Betala Belinga ◽  
Yves Longtin ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Vaccine Coverage ◽  
Vaccination Campaign ◽  
Age Groups ◽  
Incidence Rates ◽  
Study Objective ◽  
Grant Recipient ◽  
Invasive Infections ◽  
Wide Scale ◽  
The Impact

Abstract Background Owing to a persistent increase of serogroup B Neisseria meningitidis (Nm) invasive infections in the Saguenay-Lac-Saint-Jean (SLSJ) region of the province of Quebec (Canada) since 2006, a wide-scale vaccination campaign of individuals aged 6 months to 20 years was conducted between May and December 2014 using the 4-component protein-based meningococcus serogroup B vaccine (4CMenB). Components of this vaccine have shown to potentially cross-react with Neisseria gonorrhoeae (Ng). The study objective was to assess the impact of the vaccination campaign on Ng incidence rate (IR). Methods Ng cases notified to public health authorities during prevaccination period (January 2006 to June 2014) and postvaccination period (July 2014 to June 2017) were analyzed. The impact of this mass campaign was estimated by a Poisson regression model, including the year (11 July–June categories), age (14–20 vs. 21 years and older), and the intervention (0 by default and 1 in those 14–20 years in the period of July 2014 to June 2017). Results Overall vaccine coverage was 82% in the target group. A total of 231 Ng cases were reported among persons 14 years and older (IR: 8.4/100,000 person-years) of the SLSJ region from January 2006 to June 2017. A decrease in the Ng number of cases and IR among individuals 14–20 years was observed during the post-vaccination period whereas it increased in those 21 years and older (figure). Estimate of vaccination impact was an Ng risk reduction of 59% (95% CI: −22% to 84%; P = 0.1). During the same period, Chlamydia trachomatis (Ct) infections increased among persons of both age groups in the SLSJ region. Conclusion Although the estimate of the impact of the campaign was not statistically significant, possibly due to limited size of the study population and the low incidence of the disease, it is congruent with results of a case–control study in New Zealand showing an OMV-MeNZB vaccine effectiveness of 31%. A higher effectiveness of 4CMenB is a plausible hypothesis as three additional proteins also found in Ng are included in the vaccine used in the SLSJ region. The results of this ecologic study suggest cross-protection of 4CMenB vaccine against Ng infections. Further studies on this topic are warranted. Disclosures P. De Wals, GlaxoSmithKline: Grant Investigator and Scientific Advisor, Grant recipient and travel expenses. Pfizer: Grant Investigator and Scientific Advisor, Grant recipient and travel expenses. Sanofi-Pasteur: Grant Investigator and Scientific Advisor, Grant recipient and travel expenses. Novartis: Grant Investigator and Scientific Advisor, Grant recipient and travel expenses.

scholarly journals Study on the Epidemiology of Typhoid Fever

1927 ◽  
Vol 27 (1) ◽  
pp. 14-31 ◽  
Author(s):  
I. J. Kligler
Keyword(s):  
Indigenous Population ◽  
Striking Difference ◽  
Age Group ◽  
Seasonal Incidence ◽  
Tel Aviv ◽  
Limited Experience ◽  
Group 15 ◽  
Two Measures ◽  
Second Year ◽  
Group 5

A study was made of the available statistical data bearing on the epidemiology of typhoid in Palestine. It apears from this analysis that:1. The typhiod epidemicity is not due to a single source such as contaminated water or food. The seasonal prevalence of the disease corresponds with the normal seasonal incidence of typhiod, and is, therefore, in the nature of a contact infection.2. There is no striking difference in age, sex or race susceptibility. In Tel Aviv the age group 5–14 shows a lower incidence than the corresponding age group in Jerusalem or the higher age group 15–29 in Jerusalem and Tel Aviv. There is, however, no difference in susceptibility between the age group 15–29 in Jerusalem and that in Tel Aviv.3. From a graphic comparisos, the calculation of the coefficient of correlation of the limited experience (six years), and a comparison of the prevalence of the disease in the immigrant and indigenous population, there appears to be a significant correlation between the net population increment and epidemicity. These results, if confirmed by a longer experience, are in accord with those obtained in the remarkable mice experiments conducted by the English and American investigators.4. Although, at the beginning, the morbidity and mortality is higher in the immigrant group, there is an evident tendency at equalisation, and in the second year the incidence in the indigenous population is the same as that among the immigrants.5. The above results indicate the path of control: (a) every immigrant, particularly those between the ages 5–29, should be properly vaccinated against typhoid. By raising the resistance of the new population, the possibility of epidemics among them, and consequently later among the resident population, will be averted; (b) the reduction of endemic typhoid can be brought about by reducing the dosage of the infectious microbes. This can only be brought about by concentration of effort on the early detection and isolation of cases and the vaccination of all contacts. These two measures would seem to offer a prompt and relatively simple solution to the typhoid problem in Palestine.

scholarly journals Sustained reduction in the carriage of Neisseria meningitidis as a result of a community meningococcal disease control programme

1998 ◽  
Vol 121 (3) ◽  
pp. 487-493 ◽  
Author(s):  
K. R. NEAL ◽  
D. J. IRWIN ◽  
S. DAVIES ◽  
E. B. KACZMARSKI ◽  
M. C. J. WALE
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Community Intervention ◽  
Economic Status ◽  
Age Groups ◽  
Control Programme ◽  
Age Group ◽  
Intervention Programme ◽  
Intervention Area ◽  
Sustained Reduction

The effect of a community intervention programme of antibiotics and meningitis vaccine on pharyngeal carriage of Neisseria meningitidis was investigated. Carriage rates were determined in pupils at both secondary schools (ages 11–18 years) included in the community intervention programme and compared with two schools outside the area matched for socio-economic status. A total of 1869 pupils were studied 6 months after the programmes, and 2457 pupils after 11 months.Six months after the programme was completed there was a 72% reduction in pharyngeal carriage of Neisseria meningitidis in pupils attending the schools in the intervention area compared with pupils in the control schools. After 11 months this difference persisted in the 11–14 age group but not in the 15–18 age group. No resistance to the antibiotics used in the programme was found.A community intervention programme of antibiotics and vaccine for the control of meningococcal disease led to a long-term reduction in Neisseria meningitidis carriage in some age groups.

TLR2–TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae

2014 ◽  
Vol 38 (6) ◽  
pp. 356-362
Author(s):  
J.J. Tellería-Orriols ◽  
A. García-Salido ◽  
D. Varillas ◽  
A. Serrano-González ◽  
J. Casado-Flores
Keyword(s):  
Streptococcus Pneumoniae ◽  
Neisseria Meningitidis ◽  
Invasive Infections

scholarly journals Species wise incidence of malaria in pediatric age group of Raichur district, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1334
Author(s):  
Abhishek Patel ◽  
Srinivasa K. ◽  
Manjunath G. A.
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Gold Standard ◽  
Malaria Diagnosis ◽  
Blood Film ◽  
Malarial Parasite ◽  
Careful Examination ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group

Background: The incidence of malaria is on the raise in Raichur district of Karnataka in the recent years and there is not much studies on malaria from this region. A hospital and community-based study was conducted to know the species wise incidence of malaria in pediatric age group of Raichur district and to know the efficacy of rapid diagnostic test for the diagnosis of malaria, against the gold standard ‘Microscopic examination’ of thick and thin smear.Methods: Blood samples from 676 children with clinical suspicion of malaria were tested by PBS study and RDT. Differentiation of malaria parasite is based on antigenic differences between pLDH isoforms. Results from the RDT were compared to those obtained by PBS.Results: A total of 302 (44.67%) samples were positive by PBS method of which 54 (8.0%) are Plasmodium falciparum, 248 (36.9%) are Plasmodium vivax and, while 218 (32.2%) were positive by RDT 37 (5.5%) Plasmodium falciparum, 181 (26.8%) Plasmodium vivax.  In present study the overall incidence of Plasmodium vivax in Raichur district is 36.69% and Plasmodium falciparum incidence is 7.99% and none of the samples have tested positive for Plasmodium malariae and Plasmodium ovale species among the study group.   The RDT showed sensitivities of 53.70% and 66.13% and specificities of 98.71% and 96.03%, respectively for the detection of Plasmodium falciparum and Plasmodium vivax.Conclusions: Plasmodium vivax species remains the most common malarial parasite among the positive case by PBS method in Raichur district, but the incidence of plasmodium falciparum is on the rise which is a matter of concern. The RDT method has a low sensitivity and specificity for the diagnosis of malaria since the identification of the four-parasite species is not possible. The careful examination of a well-prepared and well-stained blood film currently remains the "gold standard" for malaria diagnosis.

scholarly journals Polymorphism of some genes of bone tissue metabolism (VDR Bsm1 c.IVS7G>A, LCT 13910 T>C, COL1A 12046 G->T) among the representatives of Russian and Buryat nationalities

2017 ◽  
Vol 20 (1) ◽  
pp. 3-6
Author(s):  
Svetlana V. Verkhoturova ◽  
Svetlana U. Tsarenok ◽  
Vladimir V. Gorbunov ◽  
Tatyana A. Aksenova
Keyword(s):  
Indigenous Population ◽  
Statistical Significance ◽  
Receptor Gene ◽  
Venous Blood ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Control Group ◽  
Collagen Gene ◽  
Age Group ◽  
Lactase Gene

Aim: to study the frequency of genotypes of the polymorphous markers of bone remodeling (vita-min D receptor gene Bsm1 c.IVS7G> A, the lactase gene LCT 13910 T> C and collagen gene COL1A 12046 G-> T) in healthy people and patients with osteopo-rosis (OP) among the indigenous population of Trans-baikalia of Russian and Buryat nationalities. Methods: 97 women with OP were examined: 49 Russian and 48 Buryat women aged from 50 to 80 years. 123 healthy women of the same age group were included in the control group. DNA sam-ples for molecular genetic analysis were taken from peripheral venous blood. Results: The recessive allele A of the VDR – Bsm1c.IVS7G> A polymorphism was accumulated in women of Buryat nationality, but the statistical significance was not observed (OR = 1.04, CI [0 68, 1.6]). C al-lele of LCT -13910 T> C polymorphism was associated with the development of OP among the representa-tives of Buryat nationality. Conclusion: The gene allele VDR Bsm1 c.IVS7G> Aand the LCT -13910 T>C leads to a higher risk of OP in women of Buryat nationality. The genotypes G/Tand T/T of COL1A12046 G-> T are associated with the development of OP in people of both nationalities.

scholarly journals Absence of Neisseria meningitidis Serogroup C-Specific Antibodies during the First Year of Life in The Netherlands: an Age Group at Risk?

2009 ◽  
Vol 16 (10) ◽  
pp. 1521-1523 ◽  
Author(s):  
Richarda M. de Voer ◽  
Fiona R. M. van der Klis ◽  
Laetitia E. M. Niers ◽  
Ger T. Rijkers ◽  
Guy A. M. Berbers
Keyword(s):  
At Risk ◽  
The Netherlands ◽  
Neisseria Meningitidis ◽  
Rapid Decline ◽  
First Year ◽  
Age Group ◽  
Specific Antibodies ◽  
Functional Antibodies ◽  
First Year Of Life

ABSTRACT In The Netherlands, a single meningococcal serogroup C conjugate (MenCC) vaccination is administered to children at the age of 14 months. Here, we report the levels of MenC polysaccharide-specific antibodies in children at birth and at 3, 11, and 12 months of age and the presence of functional antibodies at 11 months of age, before infants receive their MenCC immunization. We observed a rapid decline in polysaccharide-specific antibodies after birth and no induction of naturally elicited polysaccharide-specific antibodies. Furthermore, at 11 months of age, no bactericidal antibodies are observed. These data indicate that these infants may be at risk in the period prior to MenCC immunization, if Neisseria meningitidis serogroup C starts to (re)circulate.

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