scholarly journals Absence of Neisseria meningitidis Serogroup C-Specific Antibodies during the First Year of Life in The Netherlands: an Age Group at Risk?

2009 ◽  
Vol 16 (10) ◽  
pp. 1521-1523 ◽  
Author(s):  
Richarda M. de Voer ◽  
Fiona R. M. van der Klis ◽  
Laetitia E. M. Niers ◽  
Ger T. Rijkers ◽  
Guy A. M. Berbers
Keyword(s):  
At Risk ◽  
The Netherlands ◽  
Neisseria Meningitidis ◽  
Rapid Decline ◽  
First Year ◽  
Age Group ◽  
Specific Antibodies ◽  
Functional Antibodies ◽  
First Year Of Life

ABSTRACT In The Netherlands, a single meningococcal serogroup C conjugate (MenCC) vaccination is administered to children at the age of 14 months. Here, we report the levels of MenC polysaccharide-specific antibodies in children at birth and at 3, 11, and 12 months of age and the presence of functional antibodies at 11 months of age, before infants receive their MenCC immunization. We observed a rapid decline in polysaccharide-specific antibodies after birth and no induction of naturally elicited polysaccharide-specific antibodies. Furthermore, at 11 months of age, no bactericidal antibodies are observed. These data indicate that these infants may be at risk in the period prior to MenCC immunization, if Neisseria meningitidis serogroup C starts to (re)circulate.

scholarly journals Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 973
Author(s):  
Adrian Vlad ◽  
Viorel Serban ◽  
Romulus Timar ◽  
Alexandra Sima ◽  
Veronica Botea ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Background Information ◽  
First Year ◽  
Age Group ◽  
Newly Diagnosed ◽  
Β Cells ◽  
Specific Antibodies ◽  
Autoimmune Destruction ◽  
Geographical Regions

Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead to an increase in the incidence of type 1 diabetes. Material and Methods: The Romanian National Organization for the Protection of Children and Adolescents with Diabetes (ONROCAD) has collected information regarding new cases of type 1 diabetes in children aged 0 to 14 years from all over the country since 1996 and has computed the incidence of type 1 diabetes in this age group. Results: We observed a marked increase in the incidence of type 1 diabetes in the first year of the COVID-19 pandemic, with 16.9%, from 11.4/100,000 in 2019 to 13.3/100,000 in 2020, much higher compared to previous years (mean yearly increase was 5.1% in the period 1996–2015 and 0.8% in the interval 2015–2019). The proportion of newly diagnosed cases was significantly higher in the second half of 2020 compared to the second half of the previous years (57.8 vs. 51%, p < 0.0001). Conclusions: All these aspects suggest the role that SARS-CoV-2 could have in triggering pancreatic autoimmunity. To confirm this, however, collecting information from larger populations from different geographical regions, monitoring the incidence curves over a period of several years, and gathering background information on COVID-19 and/or data on COVID-19 specific antibodies are needed.

scholarly journals Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma.

2002 ◽  
Vol 110 (12) ◽  
Author(s):  
Janneane F Gent ◽  
Ping Ren ◽  
Kathleen Belanger ◽  
Elizabeth Triche ◽  
Michael B Bracken ◽  
...  
Keyword(s):  
At Risk ◽  
Respiratory Symptoms ◽  
First Year ◽  
First Year Of Life

scholarly journals Case Report: Recurrent Left Posterior Fascicular Ventricular Tachycardia in a Newborn

2021 ◽  
Vol 9 ◽  
Author(s):  
Lu Zhao ◽  
Lin Wu ◽  
Qu-ming Zhao ◽  
Xue-cun Liang
Keyword(s):  
Differential Diagnosis ◽  
Ventricular Tachycardia ◽  
Case Report ◽  
First Year ◽  
Age Group ◽  
Basic Principles ◽  
Left Posterior ◽  
Proper Diagnosis ◽  
First Year Of Life

Left posterior fascicular ventricular tachycardia (LPFVT) is extremely rare in neonates. We described a 17-day-old girl with LPFVT who was initially misdiagnosed as supraventricular tachycardia (SVT). Eventually, she was successfully treated by amiodarone infusion followed by oral amiodarone with propranolol for 9 months, and LPFVT spontaneously resolved after a 1-year follow-up. This case report illustrated the basic principles and caveats in differential diagnosis of LPFVT in the neonatal age group. With proper diagnosis and therapy, neonatal LPFVT might regress in the first year of life.

scholarly journals Causes of violation of vaccination schedule in young children

2019 ◽  
Vol 10 (3) ◽  
pp. 31-36
Author(s):  
Tatyana M. Chernova ◽  
Vladimir N. Timchenko ◽  
Nadezhda A. Myskina ◽  
Maria A. Lapina ◽  
Anna E. Orekhova ◽  
...  
Keyword(s):  
Young Children ◽  
Infectious Diseases ◽  
High Frequency ◽  
Maternity Hospital ◽  
Vaccination Schedule ◽  
First Year ◽  
Age Group ◽  
Immunization Schedule ◽  
Significant Delay ◽  
First Year Of Life

The high frequency of severe and complicated forms of infectious diseases in young children, with the possibility of death, confirms the importance of timely specific protection of this age group. In order to identify the causes of violation of the terms of vaccination of young children, 469 histories of children from 0 to 12 months of life were studied. The analysis showed that only 77% of the observed children in the first year of life were vaccinated according to the immunization schedule, whereas in 23% of cases, violations of the vaccination status were found. In 45% of children, the time of immunization was violated already at the stage of the maternity hospital: only every fifth child was not vaccinated because of health reasons, while 79% of children did not receive prophylactic vaccinations due to the mother’s refusal. Medical abductions prevailed in the structure of violations of vaccination terms in the сhildren’s оutpatient: 39% of children were vaccinated with deviations from the schedule due to temporary contraindications, 22% were vaccinated later than terms due to unreasonable medical leads. In 39% of cases of violation of vaccine status is associated with a misunderstanding of the parents of the risk of infectious diseases and the effectiveness of the child’s protection through immunization. Of these, 22% of children were denied, 10% of children were vaccinated with a significant delay, 7% of children did not reach the сhildren’s оutpatient during the year without an explanation of the reasons. Thus, the analysis showed that the majority of the observed children (57%) did not receive timely protection against infectious diseases due to attitudes towards vaccinations of parents, 43% of children were not vaccinated due to medical abductions.

Tracheotomy in the Preschool Population: Indications and Outcomes

2007 ◽  
Vol 137 (2) ◽  
pp. 280-283 ◽  
Author(s):  
Lesley C. French ◽  
Christopher T. Wootten ◽  
Robert G. Thomas ◽  
Wallace W. Neblett ◽  
Jay A. Werkhaven ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Direct Result ◽  
First Year ◽  
Care Hospital ◽  
Age Group ◽  
First Year Of Life

OBJECTIVE: Although more tracheotomy procedures are performed within the first year of life than in any other age group, preschool-aged children requiring tracheotomy remain understudied. We characterize the indications and outcomes for patients between the ages of 3 and 6 years undergoing tracheotomy. METHODS: Out of 480 pediatric tracheotomy procedures performed at a tertiary-care hospital between 1988 and 2004, 15 patients underwent primary tracheotomy between 3 and 6 years of age. RESULTS: Most (60%) procedures were performed for pulmonary toilet. Upper-airway obstruction represented the second most common indication (40%), and trauma necessitated tracheotomy procedures more often than had been predicted (40%). The decannulation rate was 40%; 2 patients died. CONCLUSION: Trauma contributed to both upper-airway obstruction as well as requirements for pulmonary toilet. These procedures performed secondary to trauma will likely continue to increase. SIGNIFICANCE: Tracheotomy procedures in the preschool population remain uncommon; however, nearly half of those studied were performed as a direct result of otherwise preventable trauma.

scholarly journals Mothers' perceptions of their premature infant's communication: A description of two cases

2016 ◽  
Vol 21 ◽  
pp. 143-154
Author(s):  
Michelle Pascoe ◽  
Divya Bissessur ◽  
Pat Mayers
Keyword(s):  
At Risk ◽  
Premature Infants ◽  
Developmental Delays ◽  
Survival Rates ◽  
Physical Contact ◽  
First Year ◽  
Communication Development ◽  
Early Communication ◽  
Communication Difficulties ◽  
First Year Of Life

Background: Survival rates of premature infants have increased due to advances in medicine. Premature infants however, remain at risk for developmental delays including communication difficulties. The bonding and attachment experiences of premature infants and their parents are often challenged, further placing these infants at risk for communication difficulties. This study firstly aimed to explore mothers' perceptions of their premature infants' communication. The second aim was to explore the mothers' perceptions of their own role in the communication development of their infants.Methods: A descriptive, longitudinal study was conducted with two mother—infant dyads.Three visits took place in the first year of life. Subjective maternal reports were obtained through semi-structured interviews.Results: Differences in the two mothers' perceptions were noted. The mothers described helping their infants to communicate through physical contact and talking. Risk and protective factors for early communication development are discussed in relation to the findings.Conclusion: The findings support the need for a healthy mothereinfant relationship in the first few months of life. Health professionals should support premature infants and their families after discharge in order to help them interact with their infants and encourage attachment and bonding.

scholarly journals Respiratory infections in the first year of life in children at risk of developing atopy.

BMJ ◽  
1982 ◽  
Vol 284 (6321) ◽  
pp. 1011-1013 ◽  
Author(s):  
J J Cogswell ◽  
D F Halliday ◽  
J R Alexander
Keyword(s):  
At Risk ◽  
Respiratory Infections ◽  
First Year ◽  
Children At Risk ◽  
First Year Of Life

Regional Underreporting of Associated Congenital Anomalies in Cleft Patients in the Netherlands

2006 ◽  
Vol 43 (6) ◽  
pp. 710-714 ◽  
Author(s):  
F. J. C. van der Veen ◽  
J. M. van Hagen ◽  
J. Berkhof ◽  
J. P. W. Don Griot
Keyword(s):  
The Netherlands ◽  
Birth Cohort ◽  
Congenital Anomalies ◽  
Cleft Lip ◽  
First Year ◽  
Medical File ◽  
Early Registration ◽  
First Year Of Life

Objective: The Dutch Cleft Palate Association (DCPA) registers all patients with cleft lip or palate and associated congenital anomalies in the Netherlands. The aim of this study was to assess if early registration of cleft patients leads to underreporting of associated congenital anomalies and, if so, whether reregistration is necessary. Methods: The DCPA registration of the birth cohort 1997 to 2001 was compared with the medical files of these cleft patients for prevalence, type, and moment of registration of associated congenital anomalies. To assess possible long-term underregistration, a second birth cohort of 1990 to 1991 was analyzed. Results: The percentage of cleft patients with associated congenital anomalies was 26% in the DCPA database and 33% in the retrospective medical file review. A syndrome, sequence, or association was recognized in 8% of the cleft patients by the DCPA compared with 13% in our medical file review. Of all associated congenital anomalies diagnosed during a follow-up of 12 years, 53% were diagnosed in the first year of life. The cumulative percentage was 59% after 2 years, 62% after 3 years, 80% after 6 years, and 97% after 10 years. Conclusion: Early registration of cleft patients leads to underreporting of other associated anomalies. For a complete registration of associated congenital anomalies in cleft patients, reregistration at a later age is necessary.

Relationship-based intervention with at-risk mothers: Outcome in the first year of life

1999 ◽  
Vol 20 (4) ◽  
pp. 349-374 ◽  
Author(s):  
C.M. Heinicke ◽  
N.R. Fineman ◽  
G. Ruth ◽  
S.L. Recchia ◽  
D. Guthrie ◽  
...  
Keyword(s):  
At Risk ◽  
First Year ◽  
First Year Of Life

scholarly journals Study of Appearances of Ossification Centers in the Carpal Bones in 3 – 14 Years Age Group in a Teaching Hospital in Telangana

2020 ◽  
Vol 7 (48) ◽  
pp. 2811-2814
Author(s):  
Uday Kiran B ◽  
Divya Pothati
Keyword(s):  
Prospective Observational Study ◽  
Skeletal Maturity ◽  
Carpal Bones ◽  
First Year ◽  
X Rays ◽  
Age Group ◽  
Medical College ◽  
One Year ◽  
Ossification Centers ◽  
First Year Of Life

BACKGROUND Study of ossification of carpal bones in children indicates the level of structural maturity and age estimation. For the assessment of skeletal maturity in children, radiologists often use hand and wrist radiograph because of low level of radiation. Carpals are the most commonly used bones for determining the age of a child. We wanted to study the appearance of ossification centers in the carpal bones in age group of 3 - 14 years. METHODS This is a prospective observational study of one-year duration conducted between January 2019 and December 2020 in the Department of Forensic Medicine and Toxicology at Maheshwara Medical College and Hospital, Patancheru, Telangana. Children 3 to 14 years of age from nearby schools were randomly selected, and X-rays of the carpal bones were taken. Appearance of carpal bones and ossification were studied to estimate the age. RESULTS The study included 70 school children. We found that capitate and hamate carpals ossified during the first year of life in children of both sexes. Triquetral and lunate appeared at 3 - 4 years, trapezium, trapezoid and scaphoid carpals appeared between 5 and 8 years. Pisiform appeared at 9 years of age in females and at 13 years in males. CONCLUSIONS Capitate and hamate ossify at an early age. Triquetral and lunate carpals appear after capitate and hamate. Their appearance is slightly earlier in females than in males. KEYWORDS Ossification, Carpal Bones, Capitate, Hamate

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