scholarly journals Plasma and Lipoprotein Lipids and Apolipoproteins AI, AII and B in Patients with Chronic Airflow Limitation

1989 ◽  
Vol 82 (2) ◽  
pp. 91-92 ◽  
Author(s):  
C H Bolton ◽  
E Mulloy ◽  
J Harvey ◽  
L G Downs ◽  
M Hartog
Keyword(s):  
Body Mass Index ◽  
Heart Disease ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Airflow Limitation ◽  
Cholesterol Concentration ◽  
Apolipoprotein Ai ◽  
Lipoprotein Lipids ◽  
Normal Controls

Plasma and lipoprotein cholesterol and triglycerides, and plasma apolipoproteins AI, AII and B were compared in patients with chronic airflow limitation, and normal controls matched for body mass index. The controls were non-smokers, and free from respiratory disease. High-density lipoprotein (HDL) cholesterol concentration was significantly elevated in the patients, due mainly to a raised HDL2 cholesterol level. HDL triglyceride was significantly lower in the patients. All other lipids were not different from normal. Apolipoprotein AI levels were significantly raised in the patients but other apolipoproteins were unchanged. The changes found may account in part for the fact that patients with chronic airflow limitation have a lower incidence of atherosclerotic heart disease.

High-density lipoprotein composition and paraoxonase activity in Type I diabetes

2001 ◽  
Vol 101 (6) ◽  
pp. 659-670 ◽  
Author(s):  
Jonathan VALABHJI ◽  
Avril J. McCOLL ◽  
Michael SCHACHTER ◽  
Surinder DHANJIL ◽  
William RICHMOND ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Particle Density ◽  
Type I Diabetes ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Cholesterol Concentration ◽  
Pon1 Activity ◽  
Type I ◽  
Carotid Imt

Type I diabetes is associated with a high incidence of coronary heart disease (CHD), despite a normal or even increased concentration of high-density lipoprotein (HDL) cholesterol. This paradox may be explained by changes in the antioxidant capacity of HDL, related to paraoxonase (PON1) activity. HDL compositional changes in subjects with Type I diabetes may result in changes in PON1 activity that are associated with a higher incidence of CHD. Single-vertical-spin density-gradient ultracentrifugation was used to isolate seven HDL fractions from serum according to density. PON1 activity was measured in serum and in the HDL fractions using phenyl acetate as substrate. The mean recovery of PON1 activity in the HDL fractions was 87% (S.D. 12%). CHD risk was assessed using B-mode ultrasound to measure carotid artery intima-media thickness (IMT). Groups of 35 subjects with Type I diabetes {duration of diabetes 18 years (12-32 years) [median (interquartile range)]; glycated haemoglobin 7.67% (1.17%)} and 24 non-diabetic control subjects were studied. Carotid IMT was greater in the diabetic subjects [0.60 (0.55-0.70) compared with 0.55 (0.45-0.64) mm; P = 0.042] and HDL cholesterol concentration was higher [1.53 (0.36) compared with 1.32(0.34)mmol/l; P = 0.031]. There were qualitative differences in HDL in subjects with Type I diabetes: HDL particles were triacylglycerol-deplete, and there were greater numbers of the larger, more buoyant HDL particles. These properties were not those found to determine PON1 activity. PON1 activity increased as HDL particle density increased and particle size decreased; the increase in PON1 activity was associated with an increase in the ratio of the two HDL surface lipid components, phospholipid and unesterified cholesterol, as particle density increased. PON1 activity was similar in diabetic and non-diabetic subjects [121 (28) and 120 (36)μmolċmin-1ċml-1 respectively; P = 0.887]. PON1 activity was not associated with carotid IMT in either group. Our results suggest that the PON1 activities of HDL particles relate to the density, size and composition of the particles. However, PON1 activity does not appear to contribute to the greater risk of CHD in subjects with Type I diabetes.

Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin

1983 ◽  
Vol 104 (2) ◽  
pp. 253-256 ◽  
Author(s):  
R. F. Heller ◽  
M. J. Wheeler ◽  
J. Micallef ◽  
N. E. Miller ◽  
B. Lewis
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding

Abstract. A cross-sectional study was performed to see if the previously described association between high density lipoprotein (HDL) cholesterol and plasma total testosterone concentration reflected a relationship with free testosterone or with sex hormone binding globulin (SHBG). In 295 employed middle-aged men, measurements were made of total testosterone and SHBG in serum and of testosterone in saliva, and also of plasma total and HDL cholesterol, plasma triglycerides and other factors which might influence HDL cholesterol levels such as body mass index, alcohol and smoking habits and thyroid hormone levels. In a multiple regression analysis using the GLIM package programme total testosterone concentrations had a persistent positive association with HDL cholesterol (t = 3.5, P < 0.001) – this association was independent of SHBG (which had a negative association with HDL: t = −1.8, P <0.07. The association of HDL cholesterol with testosterone was independent of and stronger than the association of HDL cholesterol with body mass index, alcohol intake and cigarette smoking. Salivary testosterone (a measure of the circulating free hormone) also had a positive independent association with HDL cholesterol. The relationship between HDL cholesterol and testosterone thus appears to reflect an association with circulating hormone levels rather than with the hormone binding globulin.

scholarly journals Hepatic Lipase, Genetically Elevated High-Density Lipoprotein, and Risk of Ischemic Cardiovascular Disease

2009 ◽  
Vol 94 (4) ◽  
pp. 1264-1273 ◽  
Author(s):  
Trine Holm Johannsen ◽  
Pia R. Kamstrup ◽  
Rolf V. Andersen ◽  
Gorm B. Jensen ◽  
Henrik Sillesen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
High Density Lipoprotein ◽  
Genetic Variants ◽  
Hepatic Lipase ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ischemic Cerebrovascular Disease

Abstract Context: Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease). Objective: We tested the hypothesis that genetic variation in the hepatic lipase genetic variants V73M, N193S, S267F, L334F, T383M, and −480c&gt;t influence levels of lipids, lipoproteins, and apolipoproteins and risk of ICD. Design: For the cross-sectional study, we genotyped 9003 individuals from the Copenhagen City Heart Study; hereof were 8971 individuals included in the prospective study, 1747 of whom had incident ICD during 28 yr of follow-up. For the case-control studies, 2110 ischemic heart disease patients vs. 4899 controls and 769 ischemic cerebrovascular disease patients vs. 2836 controls, respectively, were genotyped. Follow-up was 100% complete. Results: HDL cholesterol was higher by 0.21 mmol/liter in S267F heterozygotes, by 0.06 mmol/liter in −480c&gt;t heterozygotes, and by 0.13 mmol/liter in −480c&gt;t homozygotes, as compared with noncarriers. These HDL increases theoretically predicted hazard ratios for ICD of 0.87 [95% confidence interval (CI) 0.84–0.90], 0.96 (95% CI 0.95–0.97), and 0.91 (95% CI 0.89–0.94), respectively; this calculation assumes that genetically elevated HDL levels confer decreased risk similar to common HDL elevations. In contrast, when all cases and controls were combined, the observed odds ratios for ICD for these three genetic variants vs. noncarriers were 1.19 (0.76–1.88), 1.04 (0.96–1.13), and 1.08 (0.89–1.30), respectively. Hazard/odds ratios for ICD in carriers vs. noncarriers of the four remaining hepatic lipase genetic variants did not differ consistently from 1.0. Conclusion: Hepatic lipase genetic variants with elevated levels of HDL cholesterol did not associate with risk of ICD.

scholarly journals Pengaruh suplementasi serat Psyllium husk dan diet rendah kalori seimbang terhadap berat badan, kadar kolesterol high-density lipoprotein, dan trigliserida serum pada obes I

2014 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Irnawaty Rasyid ◽  
Rachmad Soegih ◽  
Dante Saksono Harbuwono
Keyword(s):  
Body Weight ◽  
High Density Lipoprotein ◽  
Dietary Fiber ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Cholesterol Concentration ◽  
Soluble Fiber ◽  
Psyllium Husk ◽  
Insignificant Difference

Background: The increased prevalence of obesity will bring a great impact in the health sector, due to the effect of the influence of organ in the body such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Reduced energy diet and exercise are effective for management weight loss. During the restriction diet, an obese person should increase the amount of dietary fiber up to 20−35 g/day, specifically of soluble fiber, to more effective fat loss and improve serum high-density lipoprotein (HDL) and triglyceride (TG) cholesterol concentration. Psyllium husk (PH) is a source of natural soluble fiber obtained from Plantago ovate Forssk seed.Objective: The aim of the study have investigated the change of body weight, serum HDL cholesterol, and TG concentration in obese I after supplemented PH 8.4 g/day and balanced deficit calories diet (BDCD) for 4 weeks.Method: The survey used double-blind randomized clinical trial with parallel design. Subjects were randomly divided into two groups; treatment (T) group and placebo (P) group. The T subjects received psyllium husk (PH) 8.4 g/day and BDCD 1200 kcal/day and the P subjects received placebo and BDCD 1200 kcal/day. The analyzed used independent t-test and Mann-Whitney.Results: A total 28 subjects (14 subjects in each group) had completed the intervention. There were no serious adverse effects reported during the intervention. Intake of dietary fiber in T group was 17.2 ± 2.8 g/day had significantly higher than P group 8.6 (5.2−15.2) g/day, although supplemented with PH didn’t meet the recommendation of fiber intake (20-35 g/day). Decrease of body weight was -1,8 ± 0,8 kg and triglyceride level was -1,5 (-416−77) in T group that statistically insignificant difference (p=0,39 and p=0,84) with P group -1,6 ± 0,9 kg and -10,0 ± 31,3. Soluble supplementation (P group) increased serum HDL cholesterol concentration was 0,0 ± 4,3 mg/dL that statistically insignificant difference (p=0,86) with T group -0,4 ± 5,9.Conclusion: PH supplementation 8.4 g/day and BDCD 1200 kcal/day in obese I can not reduce body weight, serum high-density lipoprotein cholesterol, and triglyceride concentration level in 4 weeks.

scholarly journals GAMBARAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH PADA MAHASISWA ANGKATAN 2011 FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI DENGAN INDEKS MASSA TUBUH ≥23,0 kg/m2

2013 ◽  
Vol 1 (3) ◽  
Author(s):  
Yessica Octavia Sinaga ◽  
Murniati Tiho ◽  
Yanti M. Mewo
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Body Fat ◽  
Density Lipoprotein ◽  
Sampling Technique ◽  
Hdl Cholesterol ◽  
High Density ◽  
Epidemic Disease ◽  
Microsoft Excel

Abstract: Obesity or overweight has become a epidemic disease that threatening the world and is a secondary factor of coronary heart disease. Women with more than 30% of body fat and men with more than 25% of body fat are considered obese. Low levels of High Density Lipoprotein (HDL) are one of risk factors for atherosclerosis. The objective of this research is to obtain a picture of High Density Lipoprotein cholesterol in student of class 2011 of Faculty of Medicine, Sam Ratulangi University with Body Mass Index of > 23,0 kg/m2. This is a descriptive study with data collection using a purposive sampling technique, that is, taking samples from respondents know to have fulfilled the inclusive and exclusive criteria. The data were obtained from the examination of blood samples of every respondent and presented in the form of frequency distribution using Microsoft Excel 2007. The results of research conducted on 26 respondents show the picture of HDL cholesterol levels is that is 58% normal and 42% high.Keywords: Description of High Density Lipoprotein, Body Mass Index > 23,0 kg/m2.Abstrak: Obesitas atau kegemukan telah menjadi penyakit epidemik yang mengancam dunia dan merupakan faktor sekunder timbulnya penyakit jantung koroner (PJK). Wanita dengan lemak tubuh lebih dari 30% dan pria dengan lemak tubuh lebih dari 25% dianggap mengalami obesitas. Rendahnya kadar High Density Lipoprotein merupakan salah satu faktor resiko terjadinya aterosklerosis. Penelitian ini bertujuan untuk memperoleh gambaran kadar kolesterol High Density Lipoprotein darah pada mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi dengan indeks massa tubuh > 23,0 kg/m2.Penelitian yang dilakukan bersifat deskriptif dengan teknik pengambilan data menggunakan teknik purposive, yaitu dengan mengambil sampel pada responden yang telah diketahui memenuhi kriteria inklusi dan eksklusi. Data diperoleh dari hasil pemeriksaan sampel darah setiap responden dan disajikan dalam bentuk distribusi frekuensi dengan menggunakan Microsoft Excel 2007. Hasil penelitian yang dilakukan pada 26 responden didapatkan gambaran High Density Lipoprotein adalah normal sebanyak 58% dan tinggi berjumlah 42%.Kata kunci: Gambaran Kadar Kolesterol High Density Lipoprotein, Indeks Massa Tubuh > 23,0 kg/m2.

scholarly journals A Comparison of Three Methods of Measuring Serum High Density Lipoprotein Cholesterol in Diabetics and Non-Diabetics

1980 ◽  
Vol 17 (4) ◽  
pp. 199-204 ◽  
Author(s):  
Paul N Durrington
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Cholesterol Concentration ◽  
Diabetic Patients ◽  
Small Magnitude ◽  
Men And Women ◽  
Serum High Density Lipoprotein ◽  
Cholesterol Levels

Serum high density lipoprotein (HDL) cholesterol was measured in non-diabetic and diabetic men and women by ultracentrifugation, heparin-manganese chloride precipitation (heparin/Mn++), and sodium phosphotungstate-magnesium chloride precipitation (PT/Mg++). Results of the three methods were closely correlated in both diabetics and non-diabetics. Concentrations were, however, generally lowest by PT/Mg++, intermediate by ultracentrifugation, and highest by heparin/Mn++. These differences were of small magnitude except in the case of diabetic patients treated with insulin. In these patients, serum HDL cholesterol levels were significantly greater than those of non-diabetic patients when measured by heparin/Mn++ and ultracentrifugation, but not by PT/Mg++ This was explained by the finding that the discrepancy between PT/Mg++ and ultracentrifugation increased with increasing HDL cholesterol concentration

Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis

2003 ◽  
Vol 105 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Nassr M. AL-DAGHRI ◽  
Omer AL-ATTAS ◽  
Ashok PATEL ◽  
Nikolai D. BELYAEV ◽  
William A. BARTLETT ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Cholesteryl Ester ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Concentration ◽  
Cholesterol Levels ◽  
Significant Difference

Plasma concentrations of HDL (high-density lipoprotein) cholesterol are low in the Saudi Arabian population. A B polymorphism at the CETP (cholesteryl ester protein transfer) locus that is detectable with the restriction enzyme TaqI is a genetic determinant of the plasma HDL cholesterol concentration. We assessed the relationship between the TaqI B CETP polymorphism and lipid and apolipoprotein concentrations in a study sample of 335 Saudi residents. The TaqI B1 and B2 allele frequencies were 0.54 and 0.46 respectively, similar to those in other populations. HDL cholesterol levels in B2B2 homozygotes were significantly higher than in B1B1 homozygotes [1.01 (0.3) compared with 0.92 (0.2) mmol/l; mean (S.D.); P=0.03]. There was also a significant difference between the B2B2 and B1B1 homozygotes with regard to apolipoprotein AI concentration [123.6 (16.4) compared with 113.7 (13.9) mg/dl; P=0.04]. This genetic variation was independent of metabolic risk factors known to influence HDL cholesterol levels. The allele frequency of the TaqI B CETP polymorphism and its relatively modest impact on HDL cholesterol concentrations argue against an important role for this allele, or for strongly linked loci, in determining the low levels of HDL cholesterol seen in the Saudi population.

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