The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)

2006 ◽  
Vol 20 (6) ◽  
pp. 834-841 ◽  
Author(s):  
Linh M. Van ◽  
Amir Heydari ◽  
Jiansong Yang ◽  
Judith Hargreaves ◽  
Karen Rowland-Yeo ◽  
...  
Keyword(s):  
Experimental Design ◽  
The Impact

The impact of commonly used air filters in eliminating the exposure to secondhand smoke constituents

2015 ◽  
Vol 17 (3) ◽  
pp. 543-551
Author(s):  
Chris A. Pritsos ◽  
Thivanka Muthumalage
Keyword(s):  
Experimental Design ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Secondhand Smoke ◽  
Air Filters ◽  
Machine System ◽  
The Impact ◽  
Exposure To Secondhand Smoke

The use of microchip controlled TE-10 smoke machine system with 3R4F research cigarettes as a part of the experimental design in order to create an atmosphere with environmental tobacco smoke constituents.

De impact van emotionele communicatie op de gepercipieerde oprechtheid en de reputatie van organisaties in crisis

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
An-Sofie Claeys ◽  
Verolien Cauberghe
Keyword(s):  
Experimental Design ◽  
Crisis Communication ◽  
Experimental Studies ◽  
Emotional Communication ◽  
Discrete Emotions ◽  
Stealing Thunder ◽  
The Impact ◽  
A Company

The impact of emotional communication on perceived sincerity and reputation of organizations in crisis The impact of emotional communication on perceived sincerity and reputation of organizations in crisis This paper examines the impact of emotional communication of an organizational spokesperson in times of crisis on consumers’ perceptions of the spokesperson (i.e. sincerity) and the organization (i.e. reputation) by two experimental studies. The results of study one using a 2 (crisis timing strategy: thunder vs. stealing thunder) × 2 (rational vs. sad message) between-subjects experimental design illustrates that emotional crisis communication leads to less reputational damage than rational crisis communication (N = 168), but only if the organization self-discloses the incrementing information. In study two, the discrete emotions were manipulated in a self-disclosing setting to be sadness or anger (N = 60). The results of study two show that a company is perceived to take more responsibility for the crisis when the spokesperson expresses sadness instead of anger. The sincerity of the spokesperson/organization mediates these effects. Both studies stress the importance of emotional communication by spokespersons for organizations in crisis.

Optimisation of geotechnical surveys using a BIM-based geostatistical analysis

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Elham Mahmoudi ◽  
Marcel Stepien ◽  
Markus König
Keyword(s):  
Experimental Design ◽  
Data Structures ◽  
Digital Design ◽  
Ground Model ◽  
Content Type ◽  
Design Environments ◽  
Spatial Estimation ◽  
Computational Performance ◽  
Geological Models ◽  
The Impact

PurposeA principle prerequisite for designing and constructing an underground structure is to estimate the subsurface's properties and obtain a realistic picture of stratigraphy. Obtaining direct measure of these values in any location of the built environment is not affordable. Therefore, any evaluation is afflicted with uncertainty, and we need to combine all available measurements, observations and previous knowledge to achieve an informed estimate and quantify the involved uncertainties. This study aims to enhance the geotechnical surveys based on a spatial estimation of subsoil to customised data structures and integrating the ground models into digital design environments.Design/methodology/approachThe present study's objective is to enhance the geotechnical surveys based on a spatial estimation of subsoil to customised data structures and integrating the ground models into digital design environments. A ground model consisting of voxels is developed via Revit-Dynamo to represent spatial uncertainties employing the kriging interpolation method. The local arrangement of new surveys are evaluated to be optimised.FindingsThe visualisation model's computational performance is modified by using an octree structure. The results show that it adapts the structure to be modelled more efficiently. The proposed concept can identify the geological models' risky locations for further geological investigations and reveal an optimised experimental design. The modifications criteria are defined in global and local considerations.Originality/valueIt provides a transparent and repeatable approach to construct a spatial ground model for subsequent experimental or numerical analysis. In the first attempt, the ground model was discretised by a grid of voxels. In general, the required computing time primarily depends on the size of the voxels. This issue is addressed by implementing octree voxels to reduce the computational efforts. This applies especially to the cases that a higher resolution is required. The investigations using a synthetic soil model showed that the developed methodology fulfilled the kriging method's requirements. The effects of variogram parameters, such as the range and the covariance function, were investigated based on some parameter studies. Moreover, a synthetic model is used to demonstrate the optimal experimental design concept. Through the implementation, alternative locations for new boreholes are generated, and their uncertainties are quantified. The impact of the new borehole on the uncertainty measures are quantified based on local and global approaches. For further research to identify the geological models' risky spots, the development of this approach with additional criteria regarding the search neighbourhood and consideration of barriers and trends in real cases (by employing different interpolation methodologies) should be considered.

scholarly journals A Dockers Storage Performance Evaluation: Impact of Backing File Systems

2021 ◽  
pp. 8-17
Author(s):  
Amer Ramadan ◽  
Keyword(s):  
Performance Evaluation ◽  
Experimental Design ◽  
File Systems ◽  
Experimental Results ◽  
File Server ◽  
Storage Performance ◽  
File Access ◽  
Mail Server ◽  
The Impact ◽  
E Mail

This paper reports on an in-depth examination of the impact of the backing filesystems to Docker performance in the context of Linux container-based virtualization. The experimental design was a 3x3x4 arrangement, i.e., we considered three different numbers of Docker containers, three filesystems (Ext4, XFS and Btrfs), and four application workloads related to Web server I/O activity, e-mail server I/O activity, file server I/O activity and random file access I/O activity, respectively. The experimental results indicate that Ext4 is the most optimal filesystem, among the considered filesystems, for the considered experimental settings. In addition, the XFS filesystem is not suitable for workloads that are dominated by synchronous random write components (e.g., characteristical for mail workload), while the Btrfs filesystem is not suitable for workloads dominated by random write and sequential write components (e.g., file server workload).

scholarly journals The Impact of The Strategy Analog Thinking in acquiring Social Content Material Concepts of Fourth Primary Class Pupils

2019 ◽  
pp. 375-396
Author(s):  
Manal Taha Yaseen Al-Taʼie
Keyword(s):  
Experimental Design ◽  
Primary Schools ◽  
Control Group ◽  
Partial Control ◽  
Control Group Design ◽  
Social Content ◽  
Group Design ◽  
The Impact ◽  
Academic Year ◽  
Experimental Group

The present study aims the experimental design adopted in the present study is the partial control experimental design of a pre-post control group design. The present study has been limited to the fifth primary class pupils included with in the state primary schools in Baghdad during the academic year (2017-2018), The sample consists of 63 male and female 4th primary class pupils , distributed into 31 ones as an experimental group from Al-Mutanbi Primary school and 32 students as a control group Equalization. The instrument is constructing test measuring concepts acquisition consisted of (8) concepts which consists of (24) items. Experimental group pupils, who have been exposed to Strategy Analog Thinking, have been superior to those at the control group in social content material acquisition.

scholarly journals The Impact of Performance Goals on Cheating Depends on How Performance is Evaluated

2019 ◽  
Author(s):  
Martin Daumiller ◽  
Stefan Janke
Keyword(s):  
Experimental Design ◽  
High Stakes Testing ◽  
Performance Goals ◽  
Performance Tests ◽  
High Stakes ◽  
Academic Cheating ◽  
Evaluation Standards ◽  
Evaluation Standard ◽  
New Knowledge ◽  
The Impact

We investigated how evaluation standards employed in performance tests affect the impact of performance goals (here: focused on appearance) on academic cheating. Thereby, we assumed that appearance goals would only lead to increased cheating if students’ performance was presumably evaluated based on results rather than on strategies applied to solve the questions. 169 university students (68.6% female) participated in an experimental design with 2 (induced appearance goals versus no goal induction) x 2 (process-based versus result-based evaluation standards) between-subject conditions. We assessed cheating using a confederate student observing participants’ behaviors and by measuring whether participants reported that they solved unsolvable questions. Confirming our hypotheses, we found that students were only more likely to cheat when appearance goals were induced and the evaluation standard focused on the results. This new knowledge helps to explain mixed findings regarding how performance goals affect cheating and provides opportunities to reduce cheating in high-stakes testing situations.

scholarly journals Impactul managementului disfagiei asupra calității vieții persoanelor cu accident vascular cerebral

2021 ◽  
Vol 7 (1) ◽  
pp. 17-28
Author(s):  
Raluca-Mariana Popa
Keyword(s):  
Quality Of Life ◽  
Experimental Design ◽  
Clinical Evaluation ◽  
Management Of Dysphagia ◽  
The Impact ◽  
Neurological Pathology ◽  
Attack Type

The objective of the following research is the investigation of the impact that management of dysphagia has upon quality of life in persons with neurological pathology of vascular cerebreal attack type. The group of participants in this study has 6 members with ages between 34 and 69, all suffering from a neurological pathology of VCA type or cranio-cerebreal trauma with direct implications on the swallowing process. This paper used case study methode as experimental design, the goal being to detect the impact that speach therapy has on the dysphagia, in the context of safety and quality of life. A series of instruments regarding clinical evaluation of dysphagia and quality of life in the context of VCA and dysphagia where been translated and adapted in the fallowing research.

The mediating effects of program loyalty in loyalty rewards programs: an experimental design in coffee shops

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Pınar Başgöze ◽  
Yaprak Atay ◽  
Selin Metin Camgöz ◽  
Lydia Hanks
Keyword(s):  
Experimental Design ◽  
Customer Loyalty ◽  
Perceived Value ◽  
Deep Understanding ◽  
Loyalty Program ◽  
Content Type ◽  
Value Perception ◽  
Study Results ◽  
The Impact ◽  
The Relationship

PurposeThe purpose of this study is to evaluate the impact of reward structure on the customer's value perception of the program, loyalty to the program and loyalty to the firm.Design/methodology/approachA 2 (type of reward) x 2 (timing of redemption) between subjects experimental design was conducted. In addition, the indirect effect of the customer's value perception of the program on loyalty to the firm via loyalty to the program is tested with Hayes and Preacher's mediation procedure.FindingsStudy results indicated that type of reward has a positive impact on the perceived value of a loyalty program. Program loyalty mediates the relationship between the perceived value of the loyalty program and customer loyalty, as well as the relationship between type of reward and customer loyalty.Originality/valueThe findings of this study demonstrate the importance of the type and timing of loyalty program rewards on customer perceptions of the value of the loyalty program. In addition, this study is a step forward in providing a deep understanding of the impact of such perceptions on loyalty. These findings fill a number of research gaps and provide tangible guidance for practitioners.

The Effect of Using Class PC and Interactive Boards on Students' Academic Achievement and Creative Thinking

2017 ◽  
Vol 7 (2) ◽  
pp. 1-23
Author(s):  
Mohamad M. Hileh ◽  
Abdel-Aziz Ahmad Sharabati ◽  
Tamara Yacoub Nasereddin ◽  
Suheir Mustafa Hussein
Keyword(s):  
Academic Achievement ◽  
Experimental Design ◽  
Primary Schools ◽  
Creative Thinking ◽  
Teaching And Learning ◽  
Traditional Learning ◽  
Traditional Teaching ◽  
Post Test ◽  
Quasi Experimental ◽  
The Impact

The purpose of the article is to investigate the impact of teaching and learning methods on Jordanian students' performance in primary schools. This study is of quasi-experimental design. Three tools are used in this study: an interactive board, a class PC and traditional tools. The data was collected by questionnaires, and then regressions were used to test the hypothesis. The results indicate that for creativity thinking, the highest difference between pre and post-test is related to class PC followed by traditional learning and finally interactive boards. Moreover, results indicate that the three tools affect fluency, flexibility and originality, while they have no significant effect on elaboration. The results also indicate that for the academic achievement class the PC reported the highest mean, followed by interactive boards and finally by traditional tools. Furthermore, results show that using class the PC and interactive boards affect students' creative thinking as compared to traditional teaching.

scholarly journals Impact of Carding Parameters and Draw Frame Doubling on the Properties of Ring Spun Yarn

2013 ◽  
Vol 8 (2) ◽  
pp. 155892501300800 ◽  
Author(s):  
Abdul Jabbar ◽  
Tanveer Hussain ◽  
Abdul Moqeet
Keyword(s):  
Experimental Design ◽  
Production Rate ◽  
Quality Parameters ◽  
Cotton Yarn ◽  
Yarn Quality ◽  
Spun Yarn ◽  
Ring Spun Yarn ◽  
Yarn Tenacity ◽  
The Impact

The impact of card cylinder speed, card production rate and draw frame doubling on cotton yarn quality parameters was investigated by using the Box-Behnken experimental design. It was found that yarn tenacity, elongation and hairiness increase by increasing the number of draw frame doubling up to a certain level and then decrease by further increase in doubling. Yarn unevenness increased by increasing card production rate and total yarn imperfections increased by decreasing card cylinder speed and increasing card production rate.

Sign in / Sign up

Export Citation Format

Share Document