scholarly journals Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults

2016 ◽  
Vol 37 (11) ◽  
pp. 3568-3579 ◽  
Author(s):  
Chang-Woo Ryu ◽  
Jean-Philippe Coutu ◽  
Anna Greka ◽  
H Diana Rosas ◽  
Geon-Ho Jahng ◽  
...  
Keyword(s):  
White Matter ◽  
High Density Lipoprotein ◽  
Kidney Function ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Cross Sectional ◽  
Systemic Health

Age-associated cerebrovascular disease impacts brain tissue integrity, but other factors, including normal variation in blood markers of systemic health, may also influence the structural integrity of the brain. This cross-sectional study included 139 individuals between 40 to 86 years old who were physically healthy and cognitively intact. Eleven markers (total-cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride, insulin, fasting glucose, glycated hemoglobin, creatinine, blood urea nitrogen, albumin, total protein) and five derived indicators (estimated glomerular filtration rate, creatinine clearance rate, insulin-resistance, average glucose, and cholesterol/high-density lipoprotein ratio) were obtained from blood sampling. Diffusion tensor imaging was used to evaluate white matter tissue health. Blood markers were clustered into five factors. The first factor (defined as insulin/high-density lipoprotein factor) was associated with markers of integrity in the deep white matter and projection fiber systems, while the third factor (defined as kidney function factor) was associated with different markers of integrity in the periventricular and watershed white matter regions. Differential segregated associations for insulin and high-density lipoprotein levels and serum markers of kidney function may provide information about distinct mechanisms of brain changes across the lifespan. These results emphasize the need to determine whether therapeutic modulation of systemic health and organ function may prevent decline in brain structural integrity.

scholarly journals Hubungan paparan bising dan profil lipid dengan gangguan pendengaran pada pekerja pabrik minyak goreng

2016 ◽  
Vol 46 (1) ◽  
pp. 1
Author(s):  
Adlin Adnan ◽  
Renold Yurensa
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Noise Exposure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Study Data ◽  
High Density ◽  
Average Intensity ◽  
Cross Sectional

Latar belakang: Gangguan pendengaran akibat bising (GPAB) adalah komplikasi yang palingumum disebabkan oleh paparan terhadap bising, meskipun ada beberapa komplikasi lain yang bisadisebabkan oleh paparan bising. Komplikasi metabolik dari paparan terhadap bising telah dievaluasi olehberbagai penelitian.Tujuan: Meneliti hubungan antara GPAB dengan kadar profil lipid pada pekerja yangterpapar bising di lingkungan kerja.Metode: Penelitian ini bersifat deskriptif analitik dengan desain crosssectional study. Data diperoleh melalui proses wawancara, pemeriksaan audiometri, dan pemeriksaankadar profil lipid.Hasil: Rerata intensitas kebisingan bagian proses 98 dB, dan non-proses berkisar 46-98 dB. Berdasarkan hasil pemeriksaan audiometri terhadap 50 pekerja yang memenuhi kriteria inklusidan eksklusi, didapatkan 26 orang (52%) dengan GPAB tuli sensorineural dan 24 orang (48%) tidakmengalami GPAB. Kami menemukan hubungan signifikan antara paparan bising pada pekerja denganpeningkatan kadar trigliserida (TG), total kolesterol (TC), low-density lipoprotein (LDL), dan penurunankadar high-density lipoprotein (HDL) (p<0,05). Terdapat hubungan antara kadar TG yang tinggi terhadapterjadinya GPAB pada pekerja yang terpapar bising dengan intensitas >85 dB (p<0,05) dan tidak dijumpaihubungan peningkatan kadar TC, LDL, dan penurunan kadar HDL terhadap terjadinya GPAB (p>0,05).Kesimpulan: Pada penelitian ini, ada hubungan antara hiperlipidemia dengan GPAB. Pekerja denganhipertrigliseridemia yang tepapar bising >85 dB berisiko lebih besar menderita GPAB. Kata kunci: Kebisingan, GPAB, profil lipid ABSTRACTBackground: Noise induced hearing loss (NIHL) is the most common complication that causedby noise exposure, although there are other complications as a result of noise exposure. Metaboliccomplications from noise exposure have been evaluated in various studies. Purpose: To examine therelationship between NIHL with lipid profile in workers who are exposed to noise in workplace. Methods:The study design was analytic descriptive with cross-sectional study. Data collection was done throughinterviews, audiometry screening, and lipid profile examinations. Results: The average intensity in processsection was 98 dB, and in non-process section ranged between 46-98 dB. The results of audiometricexamination of the 50 workers who met the inclusion criteria, were 26 persons (52%) with sensorineuralNIHL and 24 persons (48%) did not experience NIHL. We found a significant association between noiseexposure among workers with elevated levels of triglyceride (TG), total cholesterol (TC), low-densitylipoprotein (LDL), and decreased high-density lipoprotein (HDL) levels (p<0,05). There was highcorrelation beween TG levels with the NIHL among workers who are exposed to noise >85 dB (p<0,05),and no correlation between elevated levels of TC, LDL and decreased HDL levels with NIHL (p>0,05).Conclusion: We found a significant relationship between hyperlipidemia and NIHL. Workers withhypertriglyceridemia had greater risk of suffering NIHL when exposed to noise >85 dB in the workplace. Keywords: Noise, NIHL, lipid profile

Abstract 10041: Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Masato Kajikawa ◽  
Yukihito Higashi ◽  
Tatsuya Maruhashi ◽  
Yumiko Iwamoto ◽  
Akimichi Iwamoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional

Objective: In contrast to low-density lipoprotein cholesterol, and high density lipoprotein cholesterol, which are well-established independent risk factors for cardiovascular disease, the importance of triglycerides remains controversial. In this study, we evaluated the associations between triglycerides and endothelial function in the general population. Methods and Results: We enrolled 4,908 subjects (3842 men and 1066 women; mean age, 48±12 years) who were enrolled in FMD-Japan registry. And, we investigated cross-sectional associations between triglycerides and endothelial function by measurement of flow-mediated vasodilation (FMD). The triglycerides levels were negatively associated with FMD (r=-0.10, P<0.001). Subjects were divided into six groups on the basis of the triglycerides level. FMD was significantly decreased with an increase in the triglycerides level (≤63 mg/dL, 7.0±3.5%; 64 to 83 mg/dL, 6.3±3.5%; 84 to 105 mg/dL, 6.0±3.1%; 106 to 131 mg/dL, 5.8±3.2%; 132 to 179 mg/dL, 5.7±3.1%; ≥180 mg/dL, 5.5±3.0%; P for trend<0.001). After adjustment for age, sex, cardiovascular risk factors including high density lipoprotein cholesterol, high triglycerides level groups independently remained associated with low quartile of FMD using the triglycerides ≤63 mg/dL group as the reference (Table). Conclusions: These findings supported an independent association between triglycerides and cardiovascular disease.

Cholesterol and cognitive performance among community volunteers from the Czech Republic

2015 ◽  
Vol 27 (12) ◽  
pp. 2087-2095 ◽  
Author(s):  
Marianne Chanti-Ketterl ◽  
Ross Andel ◽  
Ondrej Lerch ◽  
Jan Laczo ◽  
Jakub Hort
Keyword(s):  
Cognitive Function ◽  
High Density Lipoprotein ◽  
Cognitive Performance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ordinary Least Squares ◽  
Cross Sectional Study ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional

ABSTRACTBackground:Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS).Methods:In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores ≥ 24 (mean age = 69 years, 47% female, mean education = 14.4 years) attending a neuropsychological evaluation. Ordinary least squares regressions were adjusted for age, gender, education, and depressive symptoms in Model 1 and also for apolipoprotein E4 (APOE4) status in Model 2.Results:High-density lipoprotein cholesterol (HDL-C) was associated with better CCS (β = 0.24; p = 0.014). This association was significant among women (β = 0.30; p = 0.026) and not among men (β = 0.20; p = 0.124). HDL-C was also related to attention/working memory (β = 0.24; p = 0.021), again only among women (β = 0.37; p = 0.012) and not men (β = 0.15; p = 0.271). Adjusting for APOE4 yielded significance for high HDL-C and CCS (β = 0.24; p = 0.022).Conclusions:HDL-C was the main lipoprotein affecting cognitive function, with results somewhat more pronounced among women. Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.

scholarly journals HUBUNGAN ANTARA KEPRIBADIAN TIPE D DAN FAKTOR FISIOLOGI DENGAN VITAL EXHAUSTION PADA PASIEN INFARK MIOKARD

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Dian Novita
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Cross Sectional ◽  
Vital Exhaustion

! exhaustion (VE) merupakan prediktor utama terjadinya infark miokard (IM), diduga kepribadian D mempunyai hubungan independen dengan VE. Hubungan kepribadian tipe-D, faktor fisiologi: sterol total, indeks masa tubuh (IMT), high density lipoprotein (HDL), low density lipoprotein (LDL), tekanan darah diastolik (TDD), serta faktor gaya hidup dengan VE, telah diungkapkan oleh beberapa namun belum jelas. Penelitian ini bertujuan untuk mengindentifikasi hubungan antara kepribadian D dan faktor fisiologi berbungan dengan terjadinya VE pada pasien IM penelitian ini menggunakan da cross sectional designs. Dengan jumlah sampel sebanyak 68 yang dipilih menggunakan teknik ecutive sampling pada subjek yang datang dirawat di ICCU RSUPN Cipto Mangunkusumo dan ung Perawatan lantai 3,4, dan 5 RSJPD Harapan Kita Jakarta, mulai tanggal 1 Mei sampai dengan 15 2009. VE diukur dengan 21 pertanyan dari Maastric Questionnaire, kepribadian tipe-D terdiri dari ciri afekif negatif (AN) 7 dan hambatan sosial (HS) 7 pertanyaan, faktor fisiologi: IMT, kolesterol , HDL, LDL, dan TDD data sekunder yang didapat pada catatan medis pasien. Karakteristik subjek Ipakan perancu. Hasil penelitian membuktikan kepribadian tipe D, kolesterol total dan TDD ubungan signifikan dengan VE dan faktor yang paling berhubungan dengan VE adalah kepribadian D. p=0,01a:0,05, OR 6,83 (CI:1,58-29,48). Simpulan penelitian ini yaitu pasien IM yang epribadian tipe-D mempunyai peluang 6,8 kali mengalami VE dibanding pasien IM bukan tipe-D ah dikontrol oleh kolesterol total, TDD dan peminum minuman keras, dan pasien dengan kolesterol berisiko berpeluang 5,9 kali mengalami VE dibanding dengan kolesterol total tidak berisiko setelah ntrol oleh tipe-D, TDD, dan peminum minuman keras, serta pasien dengan TDD berisiko berpeluang kali mengalami VE setelah dikontrol TDD tidak berisiko, kolesterol total dan tipe-D. Rekomendasi elitian adalah memasukkan kepribadian tipe-D dan VE, dalam format pengkajian asuhan keperawatan Etiap seting pelayanan pasien jantung.

scholarly journals GAMBARAN PROFIL LIPID DAN RASIO LIPID PADA PASIEN STROKE ISKEMIK BERULANG DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA

2020 ◽  
Vol 7 (2) ◽  
pp. 1
Author(s):  
Muhammad Fadlan Adam ◽  
Yetty Octavia Hutahaean ◽  
Loly Rotua Dharmanita Siagian
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Cross Sectional ◽  
Purposive Sampling

Stroke iskemik merupakan tipe stroke yang paling sering terjadi pada serangan berulang. Subtipe yang paling sering terjadi adalah aterosklerosis arteri besar yang menyebabkan oklusi arteri pada otak. Abnormalitas lipid plasma merupakan penyebab utama terjadinya aterosklerosis. Rasio lipid dapat menginformasikan risiko aterosklerosis yang sulit diukur dengan pemeriksaan rutin dan peningkatan rasio lipid menggambarkan ketidakseimbangan antara fraksi lipid aterogenik dan antiaterogenik. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid dan rasio lipid pada pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda. Penelitian ini bersifat deskriptif dengan desain studi cross sectional. Pengambilan sampel secara purposive sampling pada pasien stroke iskemik yang mempunyai riwayat stroke iskemik sebelumnya sebanyak 71 sampel. Pengambilan data profil lipid menggunakan data sekunder dari rekam medik dan rasio lipid didasarkan pada perbandingan kolesterol total (K-Total)/kolesterol high density lipoprotein (K-HDL), kolesterol low density lipoprotein (K-LDL)/K-HDL, dan trigliserida (TG)/K-HDL. Pada penelitian ini didapatkan hasil pasien stroke iskemik berulang paling banyak dengan K-Total yang optimal sebesar 49,3%, K-LDL mendekati optimal 42,2%, K-HDL rendah 71,8%, TG optimal 62,0%, rasio K-Total/K-HDL di atas nilai risiko 76,1%, rasio K-LDL/K-HDL di atas nilai risiko 63,4%, dan rasio TG/K-HDL di atas nilai risiko 52,1%. Berdasarkan hasil ini dapat disimpulkan bahwa profil lipid pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda paling banyak ditemukan dengan kadar K-Total dan TG yang optimal, K-LDL yang mendekati optimal, dan kadar K-HDL yang rendah. Rasio lipid yang terdiri dari rasio K-Total/K-HDL, rasio K-LDL/K-HDL dan rasio TG/K-HDL masing-masing ditemukan paling banyak dengan rasio di atas nilai risiko.

scholarly journals Lipid Profile in Postmenopausal Diabetic Female.

2021 ◽  
Vol 18 (1) ◽  
pp. 45-48
Author(s):  
Rabindra Simkhada ◽  
Sanjay Singh KC ◽  
Dharma Nath Yadav ◽  
Ravi Sahi
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Cross Sectional ◽  
Increased Risk

Background and Aims: Postmenopausal diabetic female are at increased risk of cardiovascular disease. The objective of this study was to study their lipid profile and prevalence of dyslipidemia and assess relation of control of lipid components with various risk factors. Methods: A cross sectional prospective study conducted at Shahid Gangalal National Heart Centre from 15th July 2020 to 14th October 2020 including 109 postmenopausal diabetic female. Detailed history along with clinical examination were conducted. Fasting lipid profile and other relevant investigations were obtained. Results: Mean age of participants was 63.48±9.26 years. Mean age of menopause was 48.59±1.88 years. A total of 37 (33.9%) were hypertensive, 17 (15.6%) were smoker, 67 (61.5%) were physically inactive. A total of 91 (83.5%) were non-vegetarian. Thirty eight (34.9%) had their blood sugar controlled with hemoglobin A1c of <7%. The mean total cholesterol and high density lipoprotein were 5.21±0.97 mmol/l and 1.02±0.13 mmol/l. Similarly mean triglyceride and low density lipoprotein were 2.24±0.75 mmol/l and 3.04±0.12 mmol/l. Dyslipidemia was present in 82.6%. Significant correlation of control of blood sugar with total cholesterol control status (R=0.28, P=0.01), low density lipoprotein control status (R=0.38, P=0.01), high density lipoprotein control status (R=0.36, P=0.04) and triglyceride control status (R=0.30, P=0.04) were seen. Conclusion: Dyslipidemia was common in post menopausal diabetic female. Blood sugar control status showed significant correlation with lipid profile parameters. A good sugar control and evaluation for lipid abnormalities is recommended in postmenopausal diabetic female.

scholarly journals Hubungan Konsumsi Alkohol dengan Kadar High Density Lipoprotein

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Aditya N. Batara ◽  
Erwin Pangkahila ◽  
Hedison Polii
Keyword(s):  
Alcohol Consumption ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Cross Sectional ◽  
Political Sciences ◽  
Cross Sectional Design ◽  
Spearman Test

Abstract: Alcohol consumption has some effect on myocardial infarction (heart attack), and could decrease low density lipoprotein (LDL) level as well as increase high density lipoprotein (HDL) level. This study was aimed to determine the relationship between alcohol consumption and HDL level. This was an analytical study with a cross sectional design. Subjects were students of Faculty of Social and Political Sciences at Sam Ratulangi University. Data were analyzed by using the Spearman correlation test (significancy <0.05). The results showed that 31 students were involved in this study. There were 26 students (83.87%) with normal HDL levels and 5 students (16.13%) with abnormal HDL levels. The Spearman test of the correlation between alcohol consumption (frequency, duration, and the amount of alcohol consumption) and HDL level showed the P values, as follows: P=0.256, P=0.410, and P=0.459. Conclusion: There was no correlation between alcohol consumption and HDL level.Keywords: alcohol, HDL levels Abstrak: Konsumsi alkohol diketahui memiliki efek terhadap infark miokard, penurunan kadar low density lipoprotein (LDL), dan peningkatan kadar high density lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan konsumsi alkohol dengan kadar HDL. Jenis penelitian ialah analitik dengan desain potong lintang. Subyek penelitian ialah mahasiswa Fakultas Ilmu Sosial dan Politik di Universitas Sam Ratulangi. Analisis data menggunakan uji korelasi Spearman dengan nilai signifikansi P<0,05. Hasil penelitian mendapatkan 31 mahasiswa laki-laki sebagai subyek penelitian. Subyek yang memiliki kadar HDL normal sebanyak 26 orang (83,87%) dan yang tidak normal sebanyak 5 orang (16,13%). Uji korelasi Spearman terhadap hubungan antara konsumsi alkohol (frekuensi konsumsi, lama konsumsi, jumlah konsumsi alkohol) dengan kadar HDL memiliki nilai P berturut-turut ialah P=0,256, P=0,410, dan P=0,459. Simpulan: Tidak terdapat hubungan bermakna antara konsumsi alkohol dengan kadar HDL.Kata kunci: alkohol, kadar HDL

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