scholarly journals Radiographic characteristics and early clinical manifestations of family clustered coronavirus disease 2019 (COVID-19)

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094589
Author(s):  
Bingyan Zhan ◽  
Shujuan Lan ◽  
Zhoucuomao La ◽  
Deting Li ◽  
Xinmei Wang ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Influenza Virus Infection ◽  
Chest Ct ◽  
The Body ◽  
Qinghai Province ◽  
Infected Case ◽  
Elderly Female ◽  
History Of ◽  
Sporadic Cases ◽  
Bilateral Lung

Object To study chest computed tomography (CT) findings in family clusters of coronavirus disease 2019 (COVID-19). Methods Twenty-one patients with confirmed COVID-19 were enrolled at the West District Qingdao Municipal Hospital, the Fifth People's Hospital of Qinghai Province and Jiaozhou Central Hospital. Eleven were family clustered cases and 10 were sporadic cases not associated with family gatherings. Results Ten patients were male and 11 were female. The time elapsed onset of fever and cough to diagnosis was 3 to 7 days. The body temperatures of patients fluctuated between 36.7 and 38.9°C. One elderly female patient had no fever. On chest CT, 14 patients with family clustered COVID-19 had bilateral lung lesions. By contrast, 7 patients with no history of familial gatherings showed single lung exudative lesions or consolidation. Seven patients with family clustered COVID-19 had bilateral multiple exudative lesions. Four patients with no history of familial gathering had unilateral lesions. Conclusion Not all patients with COVID-19 have direct epidemiological links to an infected case. They may become infected because of poor protection. In patients with family clustered COVID-19, chest CT often showed multiple exudative lesions in both lungs. In some patients, symptoms may be complicated by influenza virus infection.

scholarly journals Clinical and chest CT presentations from 27 patients with COVID-19 pneumonia in Mogadishu, Somalia: a descriptive study

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Yahye Garad Mohamed ◽  
Mohamed Farah Yusuf Mohamud ◽  
M. Sabri Medişoğlu ◽  
Ihsan Yavuz Atamaca ◽  
Ibrahim Hussein Ali
Keyword(s):  
Sore Throat ◽  
Pulmonary Nodules ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
First Case ◽  
Abnormal Chest ◽  
Lower Lung ◽  
History Of ◽  
Normal Chest ◽  
Bilateral Lung

Abstract Background Coronavirus disease 2019 (COVID-19) is an acute viral pneumonia that had recently been found in humans. The first case was discovered in Wuhan, Hubei province, China, in December 2019. In this article, we aimed to demonstrate the clinical and radiological characteristics of COVID-19 patients in Somalia from 20 March 2020 to 20 April 2020. Results Twenty-seven patients that had a positive RT-PCR test between 20 March 2020 and 20 April 2020 were retrospectively observed. This study included 19 (70.4%) males and 8 (29.6%) females, and the mean age and range were 43 years (SD ± 14.0) and 27–70 years, respectively. The majority (59.3%) of COVID-19-infected patients had no obvious history of exposure to infected patients. The participants of our study mostly presented with dry cough 24 (88.9%) patients, fever 19 (70.4%), myalgia 18 (66.6%), and sore throat 16 (59.3%). Twenty-five of 27 patients had abnormal chest CT, while 2 (7.4%) patients had normal chest CT. The most common patterns of abnormality seen on chest CT in patients with COVID-19 were ground-glass opacity (GGO) 74.1%, crazy paving pattern 18.5%, consolidation 14.8%, and mixed GCO 11.1%. Also, the most common predominant lesion distributions were bilateral lung involvement (88.9%), peripheral distribution (77.8%), and lower lung predominance (63%). Particularly, lung cavitation, discrete pulmonary nodules, pleural effusion, and underlying pulmonary fibrosis or emphysema had not been observed. Conclusion Dry cough, fever, myalgia, and sore throat were the most clinical presentations. GGO, crazy paving pattern, patchy consolidation, and mixed GCO were the typical chest CT manifestations.

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

2021 ◽  
pp. 112067212199404
Author(s):  
He Yu ◽  
Xinyu Ma ◽  
Nianting Tong ◽  
Zhanyu Zhou ◽  
Yu Zhang
Keyword(s):  
Myasthenia Gravis ◽  
Medical Center ◽  
Postoperative Radiotherapy ◽  
Clinical Manifestations ◽  
Subretinal Fluid ◽  
Metastatic Tumor ◽  
The Body ◽  
Pleural Thickening ◽  
History Of ◽  
Clinically Significant

Importance: This is the first reported case of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) in a patient with thymoma, accompanied by myasthenia gravis (MG) and polymyositis. Objective: To examine the pathogenesis of ocular disease in a patient with yolk-like fundus lesions and thymoma, MG, and polymyositis throughout the body based on clinical manifestations, diagnosis, differential diagnosis, and genetic testing to determine the appropriate treatment course. Design, setting, and participants: We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient’s medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1 year prior, she had been examined for pleural thickening due to suspected metastatic tumor. Results: On her most recent follow-up visit at 3 months after initial diagnosis, the patient was stable with no clinically significant progression in ocular or systemic conditions.

LEPROSY WITH PSORIASIS A RARE ISOTOPIC PHENOMENON

2017 ◽  
Vol 2 (01) ◽  
Author(s):  
Ishita Raka ◽  
Pratik Gahalaut ◽  
Nitin Mishra ◽  
Madhur K. Rastogi
Keyword(s):  
Psoriasis Patient ◽  
The Body ◽  
Number Of Factors ◽  
Chief Complaints ◽  
History Of ◽  
Sporadic Cases ◽  
Previously Treated ◽  
Oral Hypoglycemic Drugs ◽  
Relationship Of ◽  
Peculiar Phenomenon

Introduction: Isotopic phenomenon refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar phenomenon but none has been proven conclusively. We report a case where leprosy developed at the site of psoriatic lesion previously treated with medical therapy. Case Report: A 50 years old male presented with chief complaints of erythematous, mildly itchy scaly lesions all over the body with a history of relapses and remissions for last 20 years. After confirming the diagnosis of psoriasis with leprosy, patient was managed as an inpatient with oral hypoglycemic drugs along with multibacillary multi drug therapy. For psoriasis, patient was prescribed topical corticosteroids along with emollients over thick scaly lesions. Conclusion: This case has been reported due to the rarity of Wolf’s isotopic phenomenon and the coexistence of psoriasis with leprosy. The existing sporadic cases in literature which question the mutually exclusive relationship of leprosy and psoriasis needs further evaluation.

REPORT OF SUBCOMMITTEE ON ACCIDENTAL POISONING

PEDIATRICS ◽  
1961 ◽  
Vol 27 (4) ◽  
pp. 676-680
Author(s):  
Keyword(s):  
Public Health ◽  
Urban Areas ◽  
Health Surveys ◽  
Clinical Manifestations ◽  
The Body ◽  
Lead Intoxication ◽  
Accidental Poisoning ◽  
History Of ◽  
Ready Access ◽  
Age Range

LEAD INTOXICATION occurs most frequently in children between 1 and 3 years of age. (In the various series of cases reported in the literature approximately 85% of the cases were first diagnosed in the children in this age range.) For reasons not completely understood approximately 80% of symptomatic cases occur during the summer months. With rare exceptions children exhibiting clinical lead intoxication reside in the older sections of urban areas where they may have ready access to crumbling, peeling or easily chipped paint. Lead pigment paints were widely used for indoor painting until approximately 25 years ago. Lead pigments are still found in exterior paints, particularly those specified as mildew suppressants. Since the absorption of lead from the intestine proceeds slowly a child must nibble upon these flakes for several months before a quantity of lead sufficient to produce toxic manifestations is absorbed into the body. The child need ingest only a few chips each week; but if he continues this practice for longer than 3 to 6 months the clinical manifestations of lead intoxication to be described may occur thereafter, especially during the summer months. Although a history of pica may be a valuable question to ask in public health surveys, one must not overlook the possibility of pica even when it is denied. It is important for the clinician to realize that mothers may or may not observe their children eating a paint chip now and then. Even when they do see it they may not attribute much importance to the ingestion of the paint. If the clinician strongly suspects the possibility of lead poisoning he should proceed with the necessary laboratory diagnostic steps.

scholarly journals CT features and clinical manifestations of ordinary pneumonia with COVID-19 infection: A multi-center study

2020 ◽  
Author(s):  
Kun-ming Yi ◽  
Liu Yu ◽  
Hai-peng Tong ◽  
Yun Tian ◽  
Xiao-hui Li ◽  
...  
Keyword(s):  
Left Lung ◽  
Clinical Manifestations ◽  
Chest Ct ◽  
Maximum Diameter ◽  
Imaging Features ◽  
Lung Involvement ◽  
Mixed Distribution ◽  
Group 2 ◽  
Bilateral Lung ◽  
Group 1

Abstract Purpose: Investigate clinical and CT manifestations of ordinary coronavirus disease (COVID-19) pneumonia.Materials and methods: Patients with ordinary COVID-19 pneumonia (confirmed by RT-PCR) and performed initial chest CT were retrospectively enrolled. Fifty-eight patients were assigned to group 1 (<50 years, n=33) and group 2 (50≥years, n=25) on the basis of age. The clinical data, laboratory results, and imaging findings were evaluated. Imaging features were analyzed and compared across the two groups.Results: On chest CT imaging, 44 (75.9%) patients showed bilateral lung involvement, 14(24.1%) showed unilateral lung involvement, with predominant peripheral distribution (26/58, 44.8%) and mixed distribution (30/58, 51.7%). 445(445/634, 70.2%) lesions occurred in the lung periphery, 189 (29.8%) in the center. There were more lobes involved in group 2(median 4, IQR 3-5) than group 1(median 3, IQR 1.5-4) (P=0.024). Ground glass opacity (GGO) (451/634, 71.1%) and consolidation (157/634, 24.8%) were the main CT findings. Lesions with a maximum diameter greater than 5cm were more common in group 2 (19/25, 76%) than group 1 (12/33, 36.4%) (P=0.003). The CT score of bilateral lungs, right lung, left lung and each lobe in group 2 was significantly higher than those of group 1 (all P < 0.05), except for the middle lobe of the right lung (P=0.979). Conclusions: Ordinary COVID-19 pneumonia on chest CT generally manifested as multiple GGO and consolidation in the bilateral lung, with predominant peripheral or mixed distribution. Older age might be a risk factor for progression in ordinary COVID-19 pneumonia.

scholarly journals THE HEREDITARY MECHANISM OF GAUCHER’S DISEASE

Blood ◽  
1948 ◽  
Vol 3 (11) ◽  
pp. 1238-1249 ◽  
Author(s):  
J. GROEN
Keyword(s):  
Clinical Manifestations ◽  
Early Death ◽  
The Body ◽  
Fetal Life ◽  
Gaucher's Disease ◽  
Gaucher’S Disease ◽  
Sporadic Cases ◽  
Practical Conclusion ◽  
Severity Of The Disease ◽  
Almost All

Abstract The author reviews the literature of the familial incidence of Gaucher’s disease. Almost all the familial cases which have been described occurred in the members of one generation (siblings or cousins) only. To these cases reported in the literature the author adds 25, of which 4 were "sporadic" cases. The other 21 cases occurred in 6 families. The pedigrees of these families are presented. After an analysis of the available data the author presents the following hypothesis for the hereditary mechanism in these families: Gaucher’s disease is a mutation which, once established, is transmitted as a simple dominant hereditary trait. In the affected individuals this trait gives rise to a disturbance of lipid metabolism which results in the accumulation of kerasin in the reticulum cells throughout the body. The severity of the disease may vary considerably. It can be present in such a slight degree that the amount of kerasin accumulated during life is too small to give rise to clinical manifestations. In other cases the progression may be so slow that the disease becomes manifest only in old age, provided the affected individual lives long enough. In these "subclinical cases," a diagnosis of Gaucher’s disease can sometimes be made by the detection of "early Gaucher cells" in the sternal marrow. Individuals thus affected suffer from Gaucher’s trait rather than from the actual disease. However, they can transmit the disease to 50 per cent of their offspring, and thus function as (almost) normal "carriers." In the family trees presented, it appeared that the disease tended to become more severe in every succeeding generation until after two or three generations it became clinically manifest in the affected individuals early in life. In the next generation it would then establish itself during fetal life so as to give rise to abortion, stillbirth or early death of the affected infant. In this way the mutation extinguishes itself, by permitting only the unaffected offspring of the affected individuals to persist. As a practical conclusion it is urged that a sternal marrow examination be included in every genetic investigation of Gaucher’s disease as the best method available at present for the detection of subclinical cases or "carriers."

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 88-103 ◽  
Author(s):  
Kalindi Vora
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The Body ◽  
Body Parts ◽  
Colonial History ◽  
Women's Bodies ◽  
Commercial Surrogacy ◽  
Art Practices ◽  
History Of ◽  
Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

Receptions of the Past: Commemoration, Racism, Desire

Somatechnics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 288-303
Author(s):  
Michael Connors Jackman
Keyword(s):  
Critical Point ◽  
Social Relations ◽  
White Privilege ◽  
Body Politic ◽  
The Body ◽  
Race And Racism ◽  
Lesbian And Gay ◽  
The Past ◽  
History Of

This article investigates the ways in which the work of The Body Politic (TBP), the first major lesbian and gay newspaper in Canada, comes to be commemorated in queer publics and how it figures in the memories of those who were involved in producing the paper. In revisiting a critical point in the history of TBP from 1985 when controversy erupted over race and racism within the editorial collective, this discussion considers the role of memory in the reproduction of whiteness and in the rupture of standard narratives about the past. As the controversy continues to haunt contemporary queer activism in Canada, the productive work of memory must be considered an essential aspect of how, when and for what reasons the work of TBP comes to be commemorated. By revisiting the events of 1985 and by sifting through interviews with individuals who contributed to the work of TBP, this article complicates the narrative of TBP as a bluntly racist endeavour whilst questioning the white privilege and racially-charged demands that undergird its commemoration. The work of producing and preserving queer history is a vital means of challenging the intentional and strategic erasure of queer existence, but those who engage in such efforts must remain attentive to the unequal terrain of social relations within which remembering forms its objects.

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

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