CT features and clinical manifestations of ordinary pneumonia with COVID-19 infection: A multi-center study

Abstract Purpose: Investigate clinical and CT manifestations of ordinary coronavirus disease (COVID-19) pneumonia.Materials and methods: Patients with ordinary COVID-19 pneumonia (confirmed by RT-PCR) and performed initial chest CT were retrospectively enrolled. Fifty-eight patients were assigned to group 1 (<50 years, n=33) and group 2 (50≥years, n=25) on the basis of age. The clinical data, laboratory results, and imaging findings were evaluated. Imaging features were analyzed and compared across the two groups.Results: On chest CT imaging, 44 (75.9%) patients showed bilateral lung involvement, 14(24.1%) showed unilateral lung involvement, with predominant peripheral distribution (26/58, 44.8%) and mixed distribution (30/58, 51.7%). 445(445/634, 70.2%) lesions occurred in the lung periphery, 189 (29.8%) in the center. There were more lobes involved in group 2(median 4, IQR 3-5) than group 1(median 3, IQR 1.5-4) (P=0.024). Ground glass opacity (GGO) (451/634, 71.1%) and consolidation (157/634, 24.8%) were the main CT findings. Lesions with a maximum diameter greater than 5cm were more common in group 2 (19/25, 76%) than group 1 (12/33, 36.4%) (P=0.003). The CT score of bilateral lungs, right lung, left lung and each lobe in group 2 was significantly higher than those of group 1 (all P < 0.05), except for the middle lobe of the right lung (P=0.979). Conclusions: Ordinary COVID-19 pneumonia on chest CT generally manifested as multiple GGO and consolidation in the bilateral lung, with predominant peripheral or mixed distribution. Older age might be a risk factor for progression in ordinary COVID-19 pneumonia.

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COVID-19 discharged patients in Hunan, China: correlation between early features and prognosis

10.21203/rs.3.rs-18121/v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

yeyu cai ◽

jiayi liu ◽

Haitao Yang ◽

Taili Chen ◽

Qizhi Yu ◽

...

Keyword(s):

Chest Ct ◽

Hunan Province ◽

Impact Factors ◽

Imaging Features ◽

Persistent Symptoms ◽

Significant Difference ◽

Discharged Patients ◽

Group 2 ◽

The Impact ◽

Group 1

Abstract Purpose To describe the correlation between the clinical, laboratory and radiological findings with hospitalization days in Coronavirus Infected Disease-19 (COVID-19) discharged patients. Method In this multicenter study, we retrospectively identified 153 discharged patients with COVID-19 pneumonia from Jan 16, 2020 to Feb 26, 2020 in Hunan province. Patients were grouped based on the hospitalization days: Group 1 (hospitalization days≦12 days) and Group 2((hospitalization days> 12days). Demographic, clinical characteristics and laboratory findings on admission and the imaging features of the first Chest CT on admission were analyzed. The differences between groups were analyzed using univariate logistic regression to find the impact factors. Results The cohort included 153 discharged patients (85 males and 68 females, with the mean age of 42.32±14.03 years old). 90(58.8%) patients had hospitalization days≦12 and 63(41.2%) patients had hospitalization days>12. 44(48.9%) patients in Group1 and 28(44.4%) in Group 2 had been to Wuhan. In both Group1 and Group2, most common symptoms at onset were fever (62.2%, 60.3%) and cough (33.3%, 50.8%). Cough was occurred more common in Group 2(50.8%) than Group 1(33.3%) with a significant difference (p=0.03). 6(6.7%) patients in Group1 and 10(15.9%) in Group2 had admitting diagnosis as non-pneumonia (p=0.07), some of them occurred mild pneumonia during hospital stay. White blood cell (2.2%, 9.5%) and neutrophil (9.5%) count above normal were more common on in Group 2 (p=0.04, p=0.04). Patients in Group 2 had higher concentration of aspartate aminotransferase (P=0.04) than Group 1. Most of patients had multiple lesions (75.6%, 69.8%) with bilateral distribution (73.3%, 58.7%) in both groups. Mixed ground-glass opacity (GGO) and consolidation appearance were seen in most patients. GGO components > consolidation appearance were more common in Group 1(31.1%) than in Group 2(8.0%) with a significant difference between groups (P<0.01). Patients had cough at onset disease (OR, 0.47; 95%CI, 0.23 to 0.96, p=0.04) and CT represented as GGO components more than consolidation (OR, 4.84; 95%CI, 1.80 to 13.04, p<0.01) were associated with hospitalization days. Conclusions COVID-19 non-pneumonia patients with longer hospitalization days might have the persistent symptoms or pneumonia occurrence after admission. Chest CT could help prompt diagnosis and monitor disease progression, GGO/consolidation >1 in mixed lesions was associated with shorter hospitalization days. Special attention should be paid to the role of radiological features in monitoring disease prognosis.

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The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

Cell Transplantation ◽

10.1177/09636897211024942 ◽

2021 ◽

Vol 30 ◽

pp. 096368972110249

Author(s):

G Adas ◽

Z Cukurova ◽

K Kart Yasar ◽

R Yilmaz ◽

N Isiksacan ◽

...

Keyword(s):

Growth Factors ◽

Critically Ill ◽

Inflammatory Cytokines ◽

Clinical Manifestations ◽

Systematic Effect ◽

Cytokine Storm ◽

Group 3 ◽

Anti Inflammatory ◽

Group 2 ◽

Group 1

The aim of this clinical trial was to control the cytokine storm by administering mesenchymal stem cells (MSCs) to critically-ill COVID-19 patients, to evaluate the healing effect, and to systematically investigate how the treatment works. Patients with moderate and critical COVID-19 clinical manifestations were separated as Group 1 (moderate cases, n = 10, treated conventionally), Group 2 (critical cases, n = 10, treated conventionally), and Group 3 (critical cases, n = 10, treated conventionally plus MSCs transplantation therapy of three consecutive doses on treatment days 0, 3, and 6, (as 3 × 106 cells/kg, intravenously). The treatment mechanism of action was investigated with evaluation markers of the cytokine storm, via biochemical parameters, levels of proinflammatory and anti-inflammatory cytokines, analyses of tissue regeneration via the levels of growth factors, apoptosis markers, chemokines, matrix metalloproteinases, and granzyme-B, and by the assessment of the immunomodulatory effects via total oxidant/antioxidant status markers and the levels of lymphocyte subsets. In the assessment of the overall mortality rates of all the cases, six patients in Group-2 and three patients in Group-3 died, and there was no loss in Group-1. Proinflammatory cytokines IFNγ, IL-6, IL-17A, IL-2, IL-12, anti-inflammatory cytokines IL-10, IL-13, IL-1ra, and growth factors TGF-β, VEGF, KGF, and NGF levels were found to be significant in Group-3. When Group-2 and Group-3 were compared, serum ferritin, fibrinogen and CRP levels in Group-3 had significantly decreased. CD45 +, CD3 +, CD4 +, CD8 +, CD19 +, HLA-DR +, and CD16 + / CD56 + levels were evaluated. In the statistical comparison of the groups, significance was only determined in respect of neutrophils. The results demonstrated the positive systematic and cellular effects of MSCs application on critically ill COVID-19 patients in a versatile way. This effect plays an important role in curing and reducing mortality in critically ill patients.

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The role of the new coronavirus infection (COVID-19) in the progression and development of cerebrovascular diseases. A competent choice of pathogenic treatment is the key to success in treatment and prevention. An expert’s view from the ‘red zone’

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2021-1-57-66 ◽

2021 ◽

Vol 13 (1) ◽

pp. 57-66

Author(s):

V. V. Kovalchuk

Keyword(s):

Emotional Disorders ◽

Clinical Manifestations ◽

Cerebrovascular Diseases ◽

Recent Experience ◽

Treatment And Prevention ◽

State Recovery ◽

Group 2 ◽

State Examination ◽

Group 1

COVID-19 worsens the course of cerebrovascular diseases (CVD), including chronic cerebral ischaemia (CCI). The Actovegin drug, which has long been widely used in CCI treatment, has an antioxidant and endothelium protective effect. It makes sense to study the effect of Actovegin therapy on the clinical manifestations of CCI in patients with a recent experience of COVID-19.Objective: to evaluate Actovegin efficacy in the treatment of CCI in patients with a recent experience of COVID-19.Patients and methods. The study included 440 patients (234 female; 206 male) with a recent experience of COVID-19, suffering from CCI, their average age being 67.8 years (from 54 to 85 years). All patients were broken down into two groups of 220 people (the patients in Group 1 were administrated Actovegin, the ones in Group 2 – were not). All patients were followed up for 90 days; their condition was assessed by the severity of clinical manifestations of CCI, using special scales and questionnaires.Results and discussion. After 90 days of follow-up, the frequency of complaints of cognitive impairment, sleep disorder, dizziness, fatigue, emotional disorders, and headache in Group 1 was significantly lower than in Group 2 (p<0.05). According to Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), Multidimensional Fatigue Inventory (MFI-20), and Spiegel Sleep Questionnaire (SSQ), the average indicators improved significantly more in Group 1 than in Group 2 (p<0.05). The absence of quality of life impairment and their minimal severity were observed in Group 1 in 77.9%; in Group 2 – in 33.7% (p<0.001). Statistically significant differences between the groups of patients were also observed in relation to emotional state recovery according to the Wakefield Questionnaire and the Spielberger State Trait Anxiety inventory.Conclusion. The observational study demonstrated the efficacy of Actovegin in the treatment of main clinical manifestations of CCI in patients with recent COVID-19 experience.

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Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors

BioMed Research International ◽

10.1155/2015/613831 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

Li-Xia Zhao ◽

Hui Liu ◽

Qing Wei ◽

Guang Xu ◽

Jian Wu ◽

...

Keyword(s):

Prognostic Factors ◽

Maximum Diameter ◽

Breast Cancers ◽

Enhancement Pattern ◽

Ki 67 ◽

Small Breast ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Group 2 ◽

Group 1

This study was to investigate the correlation between contrast-enhanced ultrasonography (CEUS) characteristics with prognostic factors in breast cancers with different sizes. A retrospective analysis of CEUS characteristics of 104 pathologically proven malignant lesions from 104 women was conducted. Lesions were divided into two groups according to their size measured by US (Group 1: maximum diameter ≤20 mm; Group 2: maximum diameter >20 mm). Features including enhancement degree, order and pattern, enlargement of the enhancement area, and penetrating vessels on CEUS were evaluated. Pathologic prognostic factors, including estrogen and progesterone receptor status, and the expression of c-erb-B2, p53, Ki-67, and VEGF were assessed. Comparison of enhancement pattern parameters between Group 1 and Group 2 showed statistically significant differences (P<0.0001). A significant correlation was found between enlargement of the enhancement area and ER positivity in Group 1 (P=0.032). In Group 2 the absence of penetrating vessels was significantly associated with VEGF negativity (P=0.022) and ER negativity (P=0.022). Centripetal enhancement reflected VEGF negativity (P=0.033) in lesions with diameter >20 mm. Thus, breast cancers with different sizes show different CEUS features; small breast cancers show homogeneous enhancement pattern while cancers with diameter >20 mm show homogeneous enhancement pattern. Some CEUS characteristics of differently sized breast cancers could be correlated with prognostic factors, which may be useful in prognosis assessment.

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Rare Metachronous Multiple Carcinoma of Ear, Nose and Throat: A Case Report: Metachronous Multiple Carcinoma of Bilateral Maxillary Sinus and Lung

10.21203/rs.3.rs-1078777/v1 ◽

2021 ◽

Author(s):

Yue Liu ◽

Yan Liu ◽

Qiu Jin Li ◽

Xian Hai Guo ◽

Xue Zhao ◽

...

Keyword(s):

Lung Cancer ◽

Maxillary Sinus ◽

Postoperative Radiotherapy ◽

Left Lung ◽

Clinical Manifestations ◽

Multiple Primary Cancer ◽

Imaging Features ◽

Multiple Carcinoma ◽

Maxillary Sinus Cancer ◽

Left Maxillary Sinus

Abstract BackegroundTo report a rare case of metachronous multiple carcinoma of bilateral maxillary sinus and lung.MethodsThe clinical manifestations, pathological results, endoscopic findings and imaging features of the patient were collected and summarized.ResultsThe patient, male, 58 years old, came to our department in 2010 for "left exophthalmos and blood in snot". Combined with relevant examinations, it was diagnosed as malignant tumor of the left maxillary sinus. Postoperative radiotherapy and chemotherapy were performed. Ten years later, the patient developed right maxillary sinus cancer and left lung cancer. The postoperative pathological return of lung was lung adenocarcinoma,excluding the possibility of metastasis.ConclusionsFor otorhinolaryngology,this case of isochronous multiple lung cancer in bilateral maxillary sinuses is very rare, which also suggests that we should closely follow up tumor patients in clinical treatment.In addition to the primary site, we should also strengthen the monitoring of radiotherapy operation area and easily metastatic organs (such as lung, bone, liver, etc.), strengthening the popularization of relevant knowledge and improve patients' awareness of disease prevention, changing the bad lifestyle, further reducing the incidence of multiple primary cancer or early detection of cancer and improving the quality of life of patients.

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COVID-19 pneumonia: The first two chest CTs in the Bamrasnaradura Infectious Disease Institute

The ASEAN Journal of Radiology ◽

10.46475/aseanjr.2020.10 ◽

2020 ◽

pp. 69-81

Author(s):

Panyaros Kongpanya ◽

Parichut Vongthawatchai ◽

Priyanut Atiburanakul ◽

Nayot Panitanum ◽

Patama Suttha

Keyword(s):

Infectious Disease ◽

Ground Glass Opacity ◽

Chest Ct ◽

Lung Involvement ◽

Chest Computed Tomography ◽

Ct Findings ◽

Infectious Disease Institute ◽

The World ◽

Bilateral Lung ◽

Interlobular Septal Thickening

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly around the world. We reported the first two cases of COVID-19 pneumonia who had the chest computed tomography (CT) performed at the Bamrasnaradura Infectious Disease Institute (BIDI). The chest CT findings in the two patients with COVID-19 pneumonia showed bilateral lung involvement, multifocal involvement, peripheral distribution, ground glass opacity (GGO), consolidation and GGO with interlobular septal thickening (“crazy-paving” pattern). The chest CT findings in these patients are nonspecific and overlapped with other diseases.

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Correlations of CT scan with high-sensitivity C-reactive protein and D-dimer in patients with coronavirus disease 2019

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.6.2961 ◽

2020 ◽

Vol 36 (6) ◽

Author(s):

Jin Zhu ◽

Cheng Chen ◽

Rongshu Shi ◽

Bangguo Li

Keyword(s):

Ct Scan ◽

High Sensitivity ◽

Chest Ct ◽

Ground Glass ◽

C Reactive Protein ◽

Reactive Protein ◽

Group 2 ◽

Chest Ct Scan ◽

D Dimer ◽

Group 1

Objectives: To study the correlations of CT scan with high-sensitivity C-reactive protein (hs-CRP) and D-dimer in patients with coronavirus disease 2019 (COVID-2019). Methods: From January to March 2020, COVID-19 patients were divided into two groups according to the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (trial version 7), with mild and ordinary cases as Group-1 and critical and severe cases as Group-2. The chest CT scan results, hs-CRP, D-dimmer levels of the two groups from admission to discharge were compared by the c2 test or Fisher’s exact test. The quantitative data were represented as mean ± standard deviation (±s). Intergroup comparisons were performed by the independent samples t test, and the ineligible data were subjected to the nonparametric rank sum test. Binary logistic regression model was used for multivariate correlation analysis, using independent variables that were significant in univariate analysis. The correlations between the above indices were analyzed. Results: In Group-1, there were two cases of normal chest CT scan results, one case of fibrosis, and 25 cases of abnormalities during the first diagnosis, mainly manifested as single or scattered ground-glass shadows. After treatment, the CT scan results became normal. The chest CT scan of Group-2 showed abnormalities, including 21 cases of multiple ground-glass shadows, and six cases of multiple consolidations accompanied by ground-glass shadows, who were critically ill and died. In addition, there were 16 cases of multiple ground glass shadows with partial consolidation, and the CRP and D-dimer levels of Group-2 were significantly higher than those of Group-1. Chest CT scan results were significantly positively correlated with CRP and D-dimer levels (P<0.05). Conclusion: The chest CT scan results of COVID-19 patients are characteristic, being correlated with CRP and D-dimer levels. D-dimer and CRP levels significantly increase in most severe and critical patients, which are closely related to their prognosis. The indices may play predictive roles in clinical treatment and prognosis evaluation. doi: https://doi.org/10.12669/pjms.36.6.2961 How to cite this:Zhu J, Chen C, Shi R, Li B. Correlations of CT scan with high-sensitivity C-reactive protein and D-dimer in patients with coronavirus disease 2019. Pak J Med Sci. 2020;36(6):1397-1401. doi: https://doi.org/10.12669/pjms.36.6.2961 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Epicardial obesity as a significant preclinical predictor of atherosclerosis of brachiocephalic arteries

European Heart Journal ◽

10.1093/ehjci/ehaa946.3026 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

A Ott ◽

G.A Chumakova

Keyword(s):

Cardiometabolic Risk ◽

Subclinical Atherosclerosis ◽

Prognostic Significance ◽

Clinical Manifestations ◽

Area Under The Curve ◽

Visceral Obesity ◽

Threshold Value ◽

Group 2 ◽

Brachiocephalic Arteries ◽

Group 1

Abstract Obesity is one of the significant factors of cardiovascular risk. Nowadays it is understood that it is visceral obesity (VO), which has metabolic activity due to the synthesis of adipokines, that determines cardiometabolic risk. The effect of epicardial obesity (EO), as a variant of VO on the formation of cardiometabolic risk (in particular coronary atherosclerosis) is being actively studied. The role of EO in the development of atherosclerosis of other localizations has been little studied. Objective To study the predictor value of EO as well as traditional criteria for obesity: body mass index (BMI) and waist circumference (WC) for the formation of atherosclerosis of brachiocephalic arteries (BCA). Materials and methods The study included 140 men 45.2±4.3 years old with arterial hypertension (AH) of the 1–3 degree and the absence of clinical manifestations and anamnesis of atherosclerosis of any localizations with a BMI of 20–35 kg /m2 and abdominal obesity according to WC ≥94 cm. Patients were divided into two groups depending on the thickness of the epicardial adipose tissue (EAT) measured behind the free wall of the right ventricle by echocardiography. Group 1 consisted of 60 patients with epicardial obesity (EAT ≥7 mm), group 2 included patients without epicardial obesity (EAT <7 mm). Subclinical atherosclerosis of BCA was evaluated in all subjects using duplex brachiocephalic arteries (BCA). Results When assessing the thickness of the intima-media of the carotid arteries (TIM), a subclinical marker of BCA atherosclerosis, higher average TIM values in group 1 (EAT ≥7 mm) were revealed (1.09±0.34 mm versus 0.74±0, 05 mm in group 2 (EAT <7 mm) (p=0.0001). Prevalence of subclinical BCA atherosclerosis from (20–45%) in group 1 patients was found in 57%, in group 2 only 4% (p=0.01). In the first group, hemodynamically significant asymptomatic BCA stenosis (50–65%) was found in 8% of patients. No hemodynamically significant BCA stenosis was detected in the second group. Using ROC analysis, the threshold value of EAT (9.25 mm) was obtained as a risk factor for hemodynamically significant stenoses of BCA (50% or more) with high prognostic significance (the area under the curve was 0.92). Using multivariate analysis of variance, the effect of various criteria of obesity on the formation of BCA atherosclerosis was studied. As a result of the analysis it was revealed that only EAT (p=0.02) influenced the development of BCA atherosclerosis (TIM more than 1.3 mm). WC and BMI did not affect the development of BCA subclinical atherosclerosis (p=0.21; p=0.24, respectively). Conclusions EO (EAT ≥7 mm) is an early marker of BCA subclinical atherosclerosis in contrast to the traditional criteria for obesity (BMI, WC). Patients with EAT of 9.25 mm or more need additional examinations and the appointment of pharmacotherapy aimed at the prevention of secondary complications. Funding Acknowledgement Type of funding source: None

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Phenotypic Spectrum of Myopathies with Recessive Anoctamin-5 Mutations

Journal of Neuromuscular Diseases ◽

10.3233/jnd-200515 ◽

2020 ◽

Vol 7 (4) ◽

pp. 443-451

Author(s):

José Vázquez ◽

Claire Lefeuvre ◽

Rosa Elena Escobar ◽

Alexandra Berenice Luna Angulo ◽

Antonio Miranda Duarte ◽

...

Keyword(s):

Muscle Strength ◽

Pulmonary Function Tests ◽

Lower Limbs ◽

Manual Muscle Testing ◽

Compound Heterozygous ◽

Imaging Features ◽

Muscular Weakness ◽

Muscle Testing ◽

Group 2 ◽

Group 1

Background: Biallelic variants in Anoctamin 5 (ANO5) gene are causative of limb-girdle muscular dystrophy (LGMD) R12 anoctamin5-related, non-dysferlin Miyoshi-like distal myopathy (MMD3), and asymptomatic hyperCKemia. Objective: To describe clinic, histologic, genetic and imaging features, of ANO5 mutated patients. Methods: Five patients, four from France (P1, P2, P3 and P4) and one from Mexico (P5), from four families were included. P1 and P2, belonging to group 1, had normal muscle strength; Group 2, P3, P4 and P5, presented with muscular weakness. Muscle strength was measured by manual muscle testing, Medical Research Council (MRC) grades 1/5 to 5/5. Laboratory exams included serum CK levels, nerve conduction studies (NCS)/needle electromyography (EMG), pulmonary function tests, EKG and cardiac ultrasound. ANO5 molecular screening was performed with different approaches. Results: Group 1 patients showed myalgias with hyperCKemia or isolated hyperCKemia. Group 2 patients presented with limb-girdle or proximo-distal muscular weakness. Serum CK levels ranged from 897 to 5000 UI/L. Muscle biopsy analysis in P4 and P5 showed subsarcolemmal mitochondrial aggregates. Electron microscopy confirmed mitochondrial proliferation and revealed discontinuity of the sarcolemmal membrane. Muscle MRI showed asymmetrical fibro-fatty substitution predominant in the lower limbs. P1 and P2 were compound heterozygous for c.191dupA (p.Asn64Lysfs*15) and c.1898 + G>A; P3 was homozygous for the c.692G>T. (p.Gly231Val); P4 harbored a novel biallelic homozygous exons 1–7 ANO5 gene deletion, and P5 was homozygous for a c.172 C > T (p.(Arg 58 Trp)) ANO5 pathogenic variant. Conclusions: Our cohort confirms the wide clinical variability and enlarge the genetic spectrum of ANO5-related myopathies.

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Laboratory indicators of pathological changes in patients with chronic heart failure with metabolic syndrome

Russian Clinical Laboratory Diagnostics ◽

10.51620/0869-2084-2021-66-2-75-79 ◽

2021 ◽

Vol 66 (2) ◽

pp. 75-79

Author(s):

A. P. Roytman ◽

N. A. Sedova ◽

M. A. Godkov

Keyword(s):

Heart Failure ◽

Metabolic Syndrome ◽

Chronic Heart Failure ◽

Clinical Manifestations ◽

Laboratory Markers ◽

Number Of Patients ◽

General Rank ◽

Group 2 ◽

Ntprobnp Level ◽

Group 1

The presence of metabolic syndrome (MS) significantly increases the risk of developing cardiovascular diseases that lead to chronic heart failure (CHF). The values of NT-proBNP, ST-2, and CRP markers and their mutual correlations were studied in 37 patients with chronic heart failure (CHF) without metabolic syndrome (MS) (group 1) and 37 patients with CHF with MS (group 2). The aim of the study was to determine the features of their changes in patients with CHF complicated by MS, and to rank patients by assigning a rank value to the values of NTproBNP, ST2, and CRP concentrations. The average ST2 level was 51±24 ng/ml in group 1 and 62±27 ng/ml in group 2. The average values of CRP in group 1 were 23.1±5.3 mg/l, in group 2-33.0±4.4 mg/l (p<0.05). The NTproBNP level was 2413±1586 PG/ml and 2721±1635 PG/ml in groups 1 and 2, respectively. Correlations between the values of NTproBNP and ST2, NTproBNP and CRP were demonstrated. In the group of CHF with MS, compared with the group of CHF, there were significantly more patients with the most pronounced pathological levels of damage markers: the number of patients with a General rank of 6-9 in the group of CHF with MS was 59%, in the group of CHF without MS-38% (p<0.05). Of the 18 patients who died, 17 were among those who had an overall rank of 6 to 9, only 1 patient who died after hospitalization had an overall rank of 5. At the same time, among 22 patients who had improved CHF in the outcome of hospitalization, 18 patients had a total rank from 0 to 5, and in 4 patients of this category, the clinical manifestations of CHF remained virtually unchanged. The results of ranking the level of the studied laboratory markers indicate that they can be used as a predictor of various outcomes of CHF.

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