Oxprenolol in Hypertension: A Report on 187 Patients in General Practice Originally Treated with Clonidine

1975 ◽  
Vol 3 (6) ◽  
pp. 395-398 ◽  
Author(s):  
W A Forrest
Keyword(s):  
Blood Pressure ◽  
General Practice ◽  
Side Effects ◽  
Receptor Antagonist ◽  
Systolic Pressure ◽  
Hypertensive Patients ◽  
Β Receptor

Substitution, in part or totally, of the β- receptor antagonist, oxprenolol, for clonidine in 187 hypertensive patients resulted in significant reduction in blood pressure levels, particularly of systolic pressure. The incidence of unwanted side-effects was markedly reduced, with an accompanying improvement in the quality of the patient's life.

Oxprenolol in Hypertension. A Report on 2,770 Patients in General Practice Originally Treated with Methyldopa

1976 ◽  
Vol 21 (1) ◽  
pp. 28-30 ◽  
Author(s):  
W. A. Forrest
Keyword(s):  
Blood Pressure ◽  
General Practice ◽  
Receptor Antagonist ◽  
Considerable Improvement ◽  
Hypertensive Patients ◽  
Β Receptor

Substitution, in part or totally, of the non-selective β-receptor antagonist oxprenolol for methyldopa in 2,770 treated hypertensive patients resulted in a significant reduction in blood pressure levels and a considerable improvement in the quality of the patient's life.

Multicentre General Practitioner Assessment of ‘Tenormin’ and Methyldopa

1979 ◽  
Vol 7 (4) ◽  
pp. 324-327
Author(s):  
J A Tweed ◽  
B Mason ◽  
R Sleigh
Keyword(s):  
Blood Pressure ◽  
General Practice ◽  
General Practitioner ◽  
Side Effects ◽  
Large Scale ◽  
Pressure Control ◽  
Hypertensive Patients ◽  
Relative Lack ◽  
Dosage Regime ◽  
Set Up

A large scale study in general practice was set up to investigate the effects, of transferring hypertensive patients from treatment with usually less than 1 g daily of methyldopa to atenolol ('Tenormin') 100 mg daily. The results demonstrate an improvement in blood pressure control with atenolol treatment and a reduction in the incidence of side-effects. The simple dosage regime, combined with proven effectiveness and a relative lack of side-effects makes atenolol a useful treatment for the hypertensive patient.

scholarly journals Pengaruh Medication Therapy Management (MTM) terhadap Outcome Klinik dan Kualitas Hidup Pasien Hipertensi di Puskesmas Kota Yogyakarta

2021 ◽  
Vol 10 (4) ◽  
Author(s):  
Tiara Dewi Salindri Pratama ◽  
Nanang Munif Yasin ◽  
Susi Ari Kristina
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Clinical Outcomes ◽  
Medication Therapy Management ◽  
Wilcoxon Test ◽  
P Value ◽  
Hypertensive Patients ◽  
Therapy Management ◽  
Medication Therapy

Medication therapy management (MTM), is a service model aimed at helping general health problems by preventing morbidity and mortality. Hypertension is a non-communicable disease which is a serious health problem which requires long-term therapy.  This study aims to see the effect of MTM on clinical Outcomes and quality of life of patients in hypertensive patients. This type of research is a quasi experimental one group with a pretest-posttest design. Analysis using paired sample t-test and Wilcoxon test with a significance used P <0,05. Respondents were 70 people, 67,1% were women. The characteristics of the majority age are 55-64 years with a percentage of 51,4%, the majority of education level is high school with 42,8%, non-civil servant jobs with a percentage of 45,7%, the length of diagnosis is dominated by 1-10 years (77,1%) and comorbidities diabetes mellitus occurred the most (10,0%). The results showed that the quality of life increased from before getting MTM 54,4 ± 8,9 and after MTM intervention 60,4 ± 6,6 (P value <0,001). Clinical outcome from systolic 159,2 ± 8,9 mmHg and diastolic 103,8 ± 8,0 mmHg before MTM to 144,1 ± 14,4 mmHg for systolic and 89,7 ± 8,8 mmHg for diastolic with p value <0,001 (p <0,05) for systolic blood pressure and p value: 0,016 (p <0,05) after receiving MTM intervention. Medication Therapy Management (MTM) has a significant influence on improving the quality of life and clinical Outcomes of hypertensive patients. The higher the quality of life of patients, blood pressure becomes more controlled.

scholarly journals PO-186 Effects of Shaolin Ba Duan Jin on Hypertensive Patients

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Xianfeng Hua
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Heart Rate ◽  
Martial Arts ◽  
Hypertensive Patients ◽  
Quality Of Life Scale ◽  
Before And After ◽  
Life Scale ◽  
Blood Pressures

Objective To investigate the effects of Shaolin Ba Duan Jin on patients with hypertension. Methods In the hypertensive patients detected in the national physical fitness test of public officials in Guiyang City, 40 patients with hypertension were selected. The experiment was started after Shaolin Ba Duan Jin has been practiced for seven days and the subjects had learned it. Experimental method: Frequency of subjects practicing Ba Duan Jin is 7 days a week, subjects practice once a day, practicing time is 6:00-7:30 am or 18:00 -19:30 pm, practicing lasts 1.5 hours each time (practicing has 3 groups, 14 minutes in each group；subjects rest 2 minutes between groups,；preparing part is 8 minutes；ending part is 5 minutes), record the blood pressure of the subjects before and after each experiment, and fill in the quality of life scale (WHOQOL-BREF scale) regularly for a period of 12 weeks. Questionnaire method: Fill in the quality of life scale every three weeks and measure heart rate and blood pressure before and after each exercise. Mathematical statistics: The paired sample t test was used to analyze the changes in blood pressure before and after the 12-week experiment. Results 1) The systolic and diastolic blood pressures of the subjects were significantly lower than before the experiment (P <0.01). 2) The WHOQOL-BREF scale after 12 weeks has improved significantly in all areas than before the experiment. Conclusions 1) Martial arts Ba Duan Jin has a good influence on the circulatory system of hypertensive patients. The performance is that the heart rate is slow and the systolic and diastolic blood pressures have a downward trend. 2) Martial arts Ba Duan Jin has significant improvement in the physiology, psychology, social relations, environment and other fields .

The Addition of Oxprenolol to Hypertensive Patients Treated with Methyldopa – A General Practice Study

1974 ◽  
Vol 2 (1) ◽  
pp. 1-6 ◽  
Author(s):  
J E Murphy ◽  
Susan M Standen ◽  
W A Forrest
Keyword(s):  
Blood Pressure ◽  
General Practice ◽  
Subsequent Reduction ◽  
Hypertensive Patients ◽  
Practice Study

In eighty-seven hypertensive patients in general practice, treated with either methyldopa or the combination of methyldopa and a diuretic, oxprenolol 80 mg was added to the regime with subsequent reduction in methyldopa dosage. In the two groups of patients studied, those whose blood pressure was ‘well controlled’ and another group with a higher blood pressure, the control of blood pressure levels was improved and the incidence of reported tiredness decreased.

scholarly journals EVALUATION OF THE EFFECT OF YOGIC PRACTICES ON RAKTAGATA VATA (ESSENTIAL HYPERTENSION)

2018 ◽  
Vol 11 (9) ◽  
pp. 425
Author(s):  
Pradeep Kumar Pal ◽  
Neera Saini ◽  
Mishra Vn ◽  
Awasthi Hh
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Nervous System ◽  
Essential Hypertension ◽  
System Control ◽  
Energy Channel ◽  
Hypertensive Patients ◽  
First Order ◽  
Positive Effects

Objective: Essential hypertension is the most frequent kind of hypertension and also known as primary hypertension or idiopathic, affecting 95% of hypertensive patients. This study was conducted to see the effect of Yogic practices as Nadi Shodhana Pranayama (NSP = cleaning of subtle energy channel along with regulation of rhythm of breathing) and Dhyana (meditation) on the symptoms of Raktagata Vata (essential hypertension), blood pressure, and Hamilton’s anxiety rating scale.Methods: This clinical study was conducted on 50 cases of Raktagata Vata, and these were randomly divided into two subgroups: (1) Control and (2) intervention consisting of 25 cases in each subgroup. Yogic practices were done regularly for 3 months by the registered cases in both subgroups. Light medication of first order initially was also prescribed to intervention subgroup.Result: In both subgroups, significant results (p<0.001) were observed and most of the symptoms of Raktagata Vata improved better in the intervention than control subgroup. Significant results (p<0.001) were also observed in blood pressure along with Hamilton’s anxiety scale scoring.Conclusion: Yogic practices impact positive effects on Agya Chakra (hypothalamus-cerebral system), control autonomic nervous system and improve the quality of life of Raktagata Vata patients by improving symptoms and regulating the blood pressure.

Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction

2001 ◽  
Vol 100 (6) ◽  
pp. 601-607 ◽  
Author(s):  
Roger TAYLOR ◽  
Daniel FATOVICH ◽  
Thomas HITCHCOCK ◽  
Catherine MORRISON ◽  
Lloyd CURTIS
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Acute Myocardial Infarction ◽  
Receptor Antagonist ◽  
Platelet Activating Factor ◽  
Systolic Pressure ◽  
Induced Hypotension ◽  
Paf Receptor ◽  
Double Blinded ◽  
Paf Receptor Antagonist

Continuing efforts are being made to improve thrombolytic therapy for acute myocardial infarction (AMI). The rate of streptokinase (SK) infusion is commonly limited by the hypotension that is induced. If this could be avoided, an accelerated regimen of SK could be given, analagous to that used for other thrombolytic agents such as alteplase. The mechanism of the SK-induced hypotension is unknown, but there is some evidence that platelet-activating factor (PAF) plays a role. The potent PAF receptor antagonist lexipafant (10 mg) (n = 35), or matching placebo (n = 36), was administered intravenously over 5 min, in a randomized double-blinded protocol, to consecutive patients about to receive SK for AMI; all but three had inferior MI, because of the preference for strategies other than SK therapy in patients with anterior MI. The rate of infusion of SK was set to give 1.5×106 units over 30 min, anticipating significant hypotension. Blood pressure fell sharply over the first 10 min of SK administration. The maximum fall in systolic blood pressure occurred between 8 and 12 min, and averaged 43±28 mmHg (mean±S.D.) and 40±26 mmHg in patients given placebo and lexipafant respectively. Systolic pressure having fallen to < 90 mmHg, according to protocol the SK administration rate was reduced in 21 of 36 (58%) of patients given placebo and in 19 of 35 (54%) of patients given lexipafant. The total SK dose was given to all subjects over 40.3±17.5 and 40.2±13.4 min for the placebo and lexipafant groups respectively. Peak and time integrals of creatine kinase were not different in the two groups. There were no adverse effects attributable to lexipafant. It is concluded that the PAF receptor antagonist lexipafant has no significant effect on SK-induced hypotension and does not facilitate an accelerated regimen of administration.

scholarly journals Health-Related Quality of Life, Blood Pressure, and Biochemical and Anthropometric Profile in Vegetarians and Nonvegetarians

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jacksaint Saintila ◽  
Tabita E. Lozano López ◽  
Percy G. Ruiz Mamani ◽  
Michael White ◽  
Salomón Huancahuire-Vega
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Lipid Profile ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Anthropometric Profile

Several studies have been carried out which mainly focus on the analysis of the lipid profile in vegetarians and nonvegetarians. However, few studies have been undertaken in this population oriented to quality of life and health. This study aimed to compare health-related quality of life, blood pressure, and biochemical and anthropometric profile in vegetarians and nonvegetarians. The study included 149 participants out of an initial sample of 162: 62 vegetarians and 87 nonvegetarians. Health-related quality of life was assessed with the SF-12 Health Questionnaire version 2 and was related with the lipid profile, glucose, blood pressure, anthropometric measures, and sociodemographic characteristics. Vegetarians presented better Body Mass Index (BMI) and waist circumference (WC), as well as higher LDL levels. No significant differences in HDL and TG concentrations were found. Serum glucose concentrations were significantly lower among vegetarians. Nonvegetarian males had higher diastolic pressure levels. Vegetarian women had significantly higher levels of systolic pressure. As for the physical health and mental health components of quality of life, no significant differences were found in vegetarian and nonvegetarian women and men. In conclusion, vegetarians presented a better anthropometric profile, lower glycaemia, and higher LDL levels but no significant differences in health-related quality of life compared with nonvegetarians.

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