New Medicines: Potency, Selectivity and the Pill

1977 ◽  
Vol 5 (6) ◽  
pp. 141-143
Author(s):  
Michael A Bodin
Keyword(s):  
Oral Contraceptives ◽  
Biologically Active ◽  
Metabolic Effects ◽  
Intrinsic Activity ◽  
Per Se ◽  
Low Incidence ◽  
Synthetic Progestogen

The development of a selective, synthetic progestogen ought to dispel any notion that high intrinsic activity ( potency) per se is disadvantageous. Provided there is excellent cycle control with a low incidence of additional actions, the patient can only benefit long-term from the ingestion of biologically active steroids in lower quantities than were formerly available in oral contraceptives. When intrinsic activities for androgenic, oestrogenic or metabolic effects are diminished, it is difficult to conceive the disadvantages for the patient.

Fluoride therapy in osteoporosis: Acute effects on parathyroid and mineral homoeostasis

1988 ◽  
Vol 75 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Trevor C. B. Stamp ◽  
Michael V. Jenkins ◽  
Nigel Loveridge ◽  
Peter W. Saphier ◽  
Monica Katakity ◽  
...  
Keyword(s):  
Sodium Fluoride ◽  
Serum Levels ◽  
Biologically Active ◽  
Metabolic Effects ◽  
Calcium Balance ◽  
Acute Effects ◽  
Phosphorus Absorption ◽  
Therapeutic Results ◽  
Calcium And Phosphorus

1. Acute metabolic effects of sodium fluoride therapy were analysed among 41 osteoporotic patients already receiving large calcium supplements, 33 of whom underwent simultaneous metabolic balance studies. 2. Mean serum calcium fell transiently within 24–48 h by 0.03 ±0.07 (sd) mmol/l (P < 0.01) and phosphorus by 0.06±0.08 (sd) mmol/l (P < 0.001). In a subgroup, ionized calcium fell and biologically active parathyroid hormone (bio-PTH) rose more than fivefold (P < 0.01). Urine calcium rose after an insignificant fall. 3. Pretreatment calcium and phosphorus balances were significantly positive and did not change overall during the first 8 days of treatment. However, on analysing balances in two groups relative to serum changes, in patients whose serum levels changed least sodium fluoride increased faecal calcium (P < 0.025) and phosphorus (P < 0.01) and reduced calcium balance (P < 0.01), giving a mean balance difference between the two groups of 2.1 mmol daily (P < 0.001). 4. Very small changes in serum levels therefore indicate well-marked metabolic responses: sodium fluoride acutely stimulates bio-PTH activity and must also enhance mineral uptake from circulation into tissue(s). By separate and opposing action(s) it inhibits intestinal calcium and phosphorus absorption, predominantly in those whose serum levels remain stable. All these effects may be relevant to long-term therapeutic results.

The prognostic blood biomarker proadrenomedullin for outcome prediction in patients with chronic obstructive pulmonary disease (COPD): a qualitative clinical review

2015 ◽  
Vol 53 (4) ◽  
Author(s):  
Philipp Schuetz ◽  
Robert J. Marlowe ◽  
Beat Mueller
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cardiopulmonary Exercise Testing ◽  
The Body ◽  
Biologically Active ◽  
Metabolic Effects ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Blood Biomarker

AbstractPlasma proadrenomedullin (ProADM) is a blood biomarker that may aid in multidimensional risk assessment of patients with chronic obstructive pulmonary disease (COPD). Co-secreted 1:1 with adrenomedullin (ADM), ProADM is a less biologically active, more chemically stable surrogate for this pluripotent regulatory peptide, which due to biological and ex vivo physical characteristics is difficult to reliably directly quantify. Upregulated by hypoxia, inflammatory cytokines, bacterial products, and shear stress and expressed widely in pulmonary cells and ubiquitously throughout the body, ADM exerts or mediates vasodilatory, natriuretic, diuretic, antioxidative, anti-inflammatory, antimicrobial, and metabolic effects. Observational data from four separate studies totaling 1366 patients suggest that as a single factor, ProADM is a significant independent, and accurate, long-term all-cause mortality predictor in COPD. This body of work also suggests that combined with different groups of demographic/clinical variables, ProADM provides significant incremental long-term mortality prediction power relative to the groups of variables alone. Additionally, the literature contains indications that ProADM may be a global cardiopulmonary stress marker, potentially supplying prognostic information when cardiopulmonary exercise testing results such as 6-min walk distance are unavailable due to time or other resource constraints or to a patient’s advanced disease. Prospective, randomized, controlled interventional studies are needed to demonstrate whether ProADM use in risk-based guidance of site-of-care, monitoring, and treatment decisions improves clinical, quality-of-life, or pharmacoeconomic outcomes in patients with COPD.

METABOLIC EFFECTS OF LONG-TERM GLUCAGON INFUSION

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S198
Author(s):  
Harald Frey ◽  
D. Falch ◽  
K. Forfang ◽  
N. Norman ◽  
D. Fremstad
Keyword(s):  
Metabolic Effects

Seeds as Economical Production Platform for Recombinant Proteins

2020 ◽  
Vol 27 (2) ◽  
pp. 89-104 ◽  
Author(s):  
Muhammad Sarwar Khan ◽  
Faiz Ahmad Joyia ◽  
Ghulam Mustafa
Keyword(s):  
Oral Delivery ◽  
High Protein ◽  
Biologically Active ◽  
Cold Chain ◽  
Protein Accumulation ◽  
Long Term Storage ◽  
Production Platform ◽  
Vaccine Antigens ◽  
Term Storage

: The cost-effective production of high-quality and biologically active recombinant molecules especially proteins is extremely desirable. Seed-based recombinant protein production platforms are considered as superior choice owing to lack of human/animal pathogenic organisms, lack of cold chain requirements for transportation and long-term storage, easy scalability and development of edible biopharmaceuticals in plants with objective to be used in purified or partially processed form is desirable. This review article summarizes the exceptional features of seed-based biopharming and highlights the needs of exploiting it for commercial purposes. Plant seeds offer a perfect production platform for high-value molecules of industrial as well as therapeutic nature owing to lower water contents, high protein storage capacity, weak protease activity and long-term storage ability at ambient temperature. Exploiting extraordinarily high protein accumulation potential, vaccine antigens, antibodies and other therapeutic proteins can be stored without effecting their stability and functionality up to years in seeds. Moreover, ability of direct oral consumption and post-harvest stabilizing effect of seeds offer unique feature of oral delivery of pharmaceutical proteins and vaccine antigens for immunization and disease treatment through mucosal as well as oral route.

Placental Therapy as Panacea: An Insight to Its Therapeutic Potential

2020 ◽  
Vol 06 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Madhu Gupta ◽  
Ramesh K. Goyal
Keyword(s):  
Tissue Regeneration ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Bioactive Components ◽  
Biochemical Mechanisms ◽  
Clinically Significant ◽  
Available Information ◽  
Clinical Potential ◽  
Placental Extract

Abstract:: The placenta that maintains and regulates the growth of fetus, consists of various biological treasures nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Their therapeutic usefulness can well define in the terms of biochemical mechanisms of various components present in it. Biomedical waste derived extract is also a panacea for treatment of various diseases. Placental therapy has been reported specifically to have potent action on recovery of diseases and tissue regeneration. Placental bioactive components and their multi targeting identity prompted us to compile the précised information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with clinically significant statistical conclusions. In the light of available information and the usefulness of the placental extract, it is necessary for the development of various formulations for various unmet meet for the treatment as well as access their adverse effects as well as contradictions and precisely evaluated in the short and in the long-term periods.

scholarly journals Natural Antioxidants in Anemia Treatment

2021 ◽  
Vol 22 (4) ◽  
pp. 1883
Author(s):  
Coralia Cotoraci ◽  
Alina Ciceu ◽  
Alciona Sasu ◽  
Anca Hermenean
Keyword(s):  
Plant Extracts ◽  
Iron Homeostasis ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
Natural Antioxidants ◽  
Peptide Hormone ◽  
Biologically Active ◽  
Major Public Health Problem ◽  
Stomach Pain

Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

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