The Use of 2.5% Natamycin, as Orally Administered Drops, in the Treatment of Fungal Infections of the Oral Cavity in Children with Chronic Blood Diseases

1989 ◽  
Vol 17 (1) ◽  
pp. 82-86 ◽  
Author(s):  
R. Rokicka-Milewska ◽  
D. Derulska ◽  
D. Lipnicki ◽  
A. Skrobowska-Woźniak ◽  
A. Moszczeńska
Keyword(s):  
Candida Albicans ◽  
Side Effects ◽  
Oral Cavity ◽  
Effective Treatment ◽  
Fungal Infections ◽  
Oral Candidiasis ◽  
Oral Lesions ◽  
Blood Diseases

A total of 34 children with oral candidiasis were treated with 2.5% natamycin in the form of orally administered drops; 6–20 drops applied to oral lesions four times daily for up to 8 weeks. A total cure was achieved in 28 (82.3%) cases. No side-effects were observed. This preparation was an effective treatment for Candida albicans infections in children with blood diseases, and was well tolerated.

scholarly journals Denture Stomatitis: Report of a Case with Rarely Used Treatment Modality and Review of Literature

2020 ◽  
Vol 4 (5) ◽  
pp. 116-119
Author(s):  
Parul Uppal Malhotra ◽  
Neera Ohri ◽  
Yagyeshwar Malhotra ◽  
Anindita Mallik
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Fungal Infections ◽  
Bacterial Colonization ◽  
Oral Candidiasis ◽  
Clinical Signs ◽  
Fungal Growth ◽  
Dimorphic Fungus ◽  
Denture Stomatitis ◽  
Microbial Invasion

Candida albicans is the most common Candida species isolated from the oral cavity both in healthy and diseased. Candida albicans is a dimorphic fungus existing both in blastopore phase (yeast phase) and the hyphal or mycelial phase. Although these organisms typically colonize mucocutaneous surfaces, the latter can be portals of entry into deeper tissues when host defences are compromised. Denture stomatitis is a common form of oral candidiasis that manifests as a diffuse inflammation of the maxillary denture bearing areas & is associated with angular cheilitis. At least 70% of individuals with clinical signs of denture stomatitis exhibit fungal growth & these conditions most likely result from yeast colonization of the oral mucosa combined with Bacterial colonization. Candida species act as an endogenous infecting agent on tissue predisposed by chronic trauma to microbial invasion. At one time, oral fungal infections were rare findings in general dentist's office. They were more commonly seen in hospitalized and severely debilitated patients. However with enhanced medical and pharmaceutical technology, increasing numbers of ambulatory immunosuppressed individuals with oral fungal infections are seeking out general dentists for diagnosis and treatment of these lesions.

Results of a Clinical Investigation of Clotrimazole (Canesten), A New Anti-Mycotic Substance, in the Therapy of Vaginal Fungal Infections

1974 ◽  
Vol 2 (5) ◽  
pp. 366-369 ◽  
Author(s):  
T Kobayashi ◽  
Y Amenomori
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Fungal Infections ◽  
Clinical Investigation ◽  
Controlled Trial ◽  
Trichomonas Vaginitis

In an open controlled trial, 100 patients with vaginitis were treated with clotrimazole vaginal tablets. Ninety-four patients were infected with Candida and six patients with trichomonas. Therapy was continued for six days in 80% of patients and for up to twelve days in 18%. Judged on clinical and mycological results at the end of therapy, 57 patients were cured and 25 patients improved (90·1% effective). No patients were made worse and side-effects were minimal. The trial showed that clotrimazole was a fast, safe and effective treatment for candida vaginitis. Insufficient patients had trichomonas vaginitis for a clear conclusion to be drawn.

scholarly journals Atypical oral candidiasis in a psoriatic patient during targeted immunotherapy with an interleukin 17 inhibitor (secukinumab)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bruna Lavinas Sayed Picciani ◽  
Arkadiusz Dziedzic ◽  
Juliana Tristão Werneck ◽  
Marcello Alves Marinho ◽  
Thaylla Núñez Amin Dick ◽  
...  
Keyword(s):  
Side Effects ◽  
Fungal Infections ◽  
Oral Candidiasis ◽  
Human Monoclonal Antibody ◽  
Health Assessment ◽  
Diagnostic Process ◽  
Interleukin 17 ◽  
Clinical Approach ◽  
Oral Corticosteroids ◽  
Assessment And Monitoring

Abstract Background Secukinumab is a human monoclonal antibody immunoglobulin that neutralises interleukin (IL)-17A, and as such, is effective in the treatment of psoriasis. However, as IL-17A is essential in protection against fungal infections, patients treated with this drug may develop candidiasis. This report presents a case of atypical oral candidiasis occurring during targeted drug immunotherapy with an interleukin 17 (IL-17) inhibitor (secukinumab), with the aim of emphasisinge the necessity of periodical oral health assessment and monitoring. It provides a rational clinical approach to therapeutic protocol in the treatment of side effects associated with novel medications for autoimmune diseases. Case presentation Symptomatic tongue lesions were observed in a 50-year-old female patient on a monthly systemic treatment of 300 mg of secukinumab, which appeared after 60 days of using the medication. Two inconclusive biopsies and an unsuccessful application of oral corticosteroids made the diagnostic process challenging. Papillae on the back of the tongue were atrophied, forming a well-defined erythema and white non-detachable plaques on the lateral border of the tongue. Cytopathological and histopathological exam results were compatible with a diagnosis of oral candidiasis. Topical antifungal medication led to subsequent regression of the tongue lesions. During asymptomatic period and follow up for 7 months, a reduced monthly dose 150 mg of secukinumab was administered. Conclusions Patients undergoing treatment with IL-17 blockers, such as secukinumab, should be carefully monitored in order to avoid oral side effects resulting from the use of this medication.

scholarly journals Effect of Cannabis Smoke Condensate on C. albicans Growth and Biofilm Formation

2021 ◽  
Vol 9 (11) ◽  
pp. 2348
Author(s):  
Neftaha Tazi ◽  
Xavier Pigeon ◽  
Jérôme Mulamba Mbuyi-Boisvert ◽  
Simon Giret ◽  
François Béland ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Oral Cavity ◽  
Biofilm Formation ◽  
Culture Medium ◽  
Oral Candidiasis ◽  
Hyphal Length ◽  
Clinical Observations

The most common use of cannabis is smoking. The oral ecosystem, among other constituents, can be deregulated by the presence of cannabis smoke in the oral cavity. We evaluated the effect of cannabis smoke condensate (CSC) on the behavior of Candida albicans, a common yeast found in the oral cavity. The yeast was first cultured with different concentrations of CSC, and its growth was evaluated. The transition from the blastospore to the hyphal form and the hyphae size were assessed after 3 and 6 h, along with biofilm formation after 72 h of contact with CSC. The response of C. albicans to oxidative (H2O2) stress was also examined. Our results show that CSC contained high amounts of THC (about 1055 ppm), CBN (63 ppm), and CBG (about 47 ppm). The presence of various concentrations of CSC in the culture medium increased C. albicans growth. CSC also contributed to increases in both the hyphal length and biofilm mass. Following oxidative stress (H2O2 at either 100 or 500 μM), CSC prevented the damaging effect of H2O2 on both C. albicans shape and growth. These findings support clinical observations demonstrating that cannabis may promote C. albicans growth and oral candidiasis.

scholarly journals Chronic vulvovaginitis caused by Candida dubliniensis in an immunologically competent adult female

2018 ◽  
Vol 30 (1) ◽  
pp. 90-93
Author(s):  
Ketan Kolekar ◽  
Swagata Tambe ◽  
Rashmi Aderao ◽  
Chitra Nayak
Keyword(s):  
Candida Albicans ◽  
Adult Female ◽  
Candida Species ◽  
Genital Tract ◽  
Fungal Infections ◽  
Oral Candidiasis ◽  
Infectious Agent ◽  
Candida Dubliniensis ◽  
Dimorphic Fungus ◽  
Life Threatening

Candida, a commensal dimorphic fungus, is the most common microorganism that causes opportunistic fungal infections worldwide. It can cause diseases ranging from superficial mucosal infections to disseminated, systemic life-threatening infections. Among Candida species, Candida albicans is the most common infectious agent. Nowadays, non- albicans Candida species are also emerging as significant pathogens. Candida dubliniensis has been implicated as a causative agent of oral candidiasis in HIV-infected individuals but has also been recovered from HIV non-infected individuals with oral candidiasis and rarely from the genital tract of women with vaginitis. Such cases have been under-reported due to phenotypic resemblance to C. albicans. The majority of C. dubliniensis clinical isolates tested to date have been susceptible to fluconazole, but they tend to develop resistance rapidly. Here, we report a case of chronic vulvovaginitis due to C. dubliniensis not responding to standard doses of fluconazole.

scholarly journals Potential Pathogenicity of Candida Species Isolated from Oral Cavity of Patients with Diabetes Mellitus

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hasti Nouraei ◽  
Mehdi Ghaderian Jahromi ◽  
Leila Razeghian Jahromi ◽  
Kamiar Zomorodian ◽  
Keyvan Pakshir
Keyword(s):  
Diabetes Mellitus ◽  
Candida Albicans ◽  
Oral Cavity ◽  
Hemolytic Activity ◽  
Candida Species ◽  
Extracellular Enzymes ◽  
Oral Candidiasis ◽  
Agar Plate ◽  
Blood Agar Plate ◽  
Diabetic Patients

Introduction. In the recent decade, the increased immunocompromised population such as diabetic patients makes a high incidence of invasive Candida infections. Diabetes mellitus is the most common endocrine metabolic disorder, and diabetic patients are more susceptible to oral candidiasis infection. Candidiasis is an opportunistic fungal infection caused by many species of Candida. Secretion of exoenzymes plays an important role in the virulence and pathogenesis of Candida species. The aim of this study was to evaluate the potential role of phospholipase, esterase, and hemolytic activity of Candida species isolated from oral cavity lesions of diabetic patients. Methods. A total of 108 Candida species including 75 Candida albicans and 33 non-Candida albicans species were recovered from the oral cavity of diabetic patients included in our study. Egg yolk agar, Tween 80 opacity medium, and blood agar plate assays were used for determining phospholipase, esterase, and hemolytic activities, respectively. Results. Candida albicans species had the most exoenzyme activity in comparison to non-albicans isolates. Candida albicans isolates showed 97.3%, 100%, and 77.3% phospholipase, hemolysin, and esterase activities, respectively. The difference between Candida albicans and non-Candida albicans was significant in phospholipase ( P < 0.001 ) and hemolytic activity ( P = 0.027 ), but not significant in esterase activity ( P = 0.076 ). Conclusion. This study showed that most of the isolates had different enzymatic patterns, and Candida albicans isolates had the most exoenzyme activity. So due to the potential effects of these enzymes in pathogenesis and virulence effects of Candida species, we can conclude that the severity of extracellular enzymes may play a role in the severity of signs and symptoms of Candida oral cavity infections in diabetic patients.

scholarly journals Candida albicans rvs161Δ and rvs167Δ Endocytosis Mutants Are Defective in Invasion into the Oral Cavity

mBio ◽  
2019 ◽  
Vol 10 (6) ◽  
Author(s):  
Shamoon Naseem ◽  
Lois M. Douglas ◽  
James B. Konopka
Keyword(s):  
Candida Albicans ◽  
Environmental Factors ◽  
Oral Cavity ◽  
Fungal Infections ◽  
Hyphal Growth ◽  
Antifungal Drugs ◽  
Invasive Growth ◽  
Oropharyngeal Candidiasis ◽  
Content Type ◽  
Therapeutic Value

ABSTRACT Invasive growth in tissues by the human fungal pathogen Candida albicans is promoted by a switch from budding to hyphal morphogenesis that is stimulated by multiple environmental factors that can vary at different sites of infection. To identify genes that promote invasive growth in the oral cavity to cause oropharyngeal candidiasis (OPC), we first identified C. albicans mutants that failed to invade agar medium. Analysis of nine severely defective mutants in a mouse model of OPC revealed that the strongest defects were seen for the rvs161Δ and rvs167Δ mutants, which lack amphiphysin proteins needed for endocytosis. The rvsΔ mutants initially adhered to the tongue but failed to invade efficiently and were lost from the oral cavity. Previous studies indicated that rvsΔ mutants formed filamentous hyphae in the kidney albeit with morphological abnormalities, suggesting that the rvsΔ mutants were influenced by factors that vary at different sites of infection. Consistent with this, increasing concentrations of CO2, an inducer of hyphal growth that is more abundant in internal organs than air, partially rescued the invasive-growth defects of the rvsΔ mutants in vitro. Interestingly, preinduction of the rvsΔ mutants to form hyphae prior to introduction into the oral cavity restored their ability to cause OPC, identifying a key role for endocytosis in initiating invasive hyphal growth. These results highlight the influence of distinct environmental factors in promoting invasive hyphal growth in the oral cavity and indicate that blocking endocytosis could have therapeutic value in preventing the initiation of OPC. IMPORTANCE Oropharyngeal candidiasis (OPC) is a common fungal infection that is associated with severe morbidity. Another concern is that patients at risk for developing OPC often take long courses of antifungal drugs, which can lead to the emergence of drug-resistant C. albicans strains. We therefore identified nine mutants with defects in undergoing invasive hyphal growth in the oral cavity, increasing the number of genes known to be involved in OPC by more than 30%. The two strongest mutants, rvs161Δ and rvs167Δ, have defects in endocytosis. The rvsΔ mutants appear to have a specific defect in initiating invasive growth, as preinducing the cells to form hyphae prior to infection restored their ability to cause OPC. These results indicate that blocking endocytosis could have therapeutic value in preventing the initiation of OPC without leading to development of resistance against drugs currently used to treat fungal infections.

scholarly journals Oral cavity manifestations by COVID-19 infections: a review

2021 ◽  
Vol 7 (8) ◽  
pp. 1391
Author(s):  
Santosh Kumar Swain ◽  
Priyanka Debta ◽  
Ansuman Sahu ◽  
Smarita Lenka
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Oral Candidiasis ◽  
Review Article ◽  
Primary Site ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Immunocompromised Patients ◽  
Elderly Age ◽  
Oral Ulcers

<p class="abstract">Coronavirus disease 2019 (COVID-19) is a threat to the global health caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lungs are the primary site of infection in COVID-19 patient and the symptoms ranges from mild flu like manifestations to fulminant pneumonia and respiratory failure. COVID-19 infection also significantly affects the oral cavity and salivary glands with oral mucosal manifestations. Other than airway manifestations, COVID-19 patients are presenting with oral cavity lesions such as aphthous like ulcers, glossitis, oral mucositis or stomatitis, oral candidiasis and herpetic recurrences. These oral lesions are often associated with immunocompromised patients and elderly age. Direct involvement of the SARS-CoV-2 virus for development of oral ulcers remains uncertain. The salivary gland related symptoms and taste disturbances are highly common in COVID-19 patients. In COVID-19 patient, certain presentations like ulcers or blisters or diffuse reddish lesions affect both keratinized and non-keratinized tissues of the oral cavity. These lesions are found in palate, lip mucosa, buccal mucosa and tongue. The ulceration and blisters of the oral cavity are more often seen. There is still a gap of knowledge related to the oral manifestations of the COVID-19 infections and its impact on the oral cavity. This review article discussed the details of the oral cavity lesions in COVID-19 patients.</p>

scholarly journals Candida sp in the oral cavity with and without lesions: maximal inhibitory dilution of Propolis and Periogard

1999 ◽  
Vol 30 (4) ◽  
pp. 335-341 ◽  
Author(s):  
Rosa Vitória Palamin Azevedo ◽  
Marilena Chinalli Komesu ◽  
Regina Celia Candido ◽  
Cristiane Salvetti ◽  
Fausto Hanaoka Caetano Rezende
Keyword(s):  
Oral Cavity ◽  
Oral Candidiasis ◽  
Mean Value ◽  
Control Group ◽  
Oral Lesions ◽  
Commercial Products ◽  
Candida Sp ◽  
Prevention And Treatment

Fifty individuals of both sexes aged on average 45.2 years were evaluated at the Semiology Clinic of FORP-USP in order to isolate and identify yeasts from the oral cavity, with and without lesions, and to determine the maximal inhibitory dilution (MID) of the commercial products Propolis (Apis-Flora) and Periogard (Colgate) against the strains isolated. Yeasts of the genus Candida were detected in the saliva of 9/19 (47.4%) individuals with a clinically healthy mouth, 18/22 (81.8%) of individuals with oral lesions, and in 4/9 (44.4%) of patients with deviation from normality, and were detected in 19/22 (86.4%) of the lesions. In the group with oral candidiasis, we isolated in tongue and lesion, respectively for each specie: C.tropicalis (8% and 10.7%), C.glabrata (4% and 3.6%) and C.parapsilosis (2% and 3.6%), in addition to C.albicans (71.4% and 67.8%) as the only species and the prevalent. The total cfu counts/ml saliva showed a higher mean value in the group with oral candidiasis (171.5% x 10(3)) than in the control group (72.6 x 10(3)) or the group with abnormalities (8.3 x 10(3)). Most of the test strains 67/70 (95.71%) were sensitive to the antiseptics, with Propolis presenting a MID of 1:20 for 54/70/77.1%), and Periogard a MID of 1:160 for 42/70 (60%) strains from healthy sites, results similar to those obtained with strains from oral lesions. Different results were mainly observed among different species. The results indicate the possibility of using the antiseptics Propolis and Periogard (chlorhexidine) for the prevention and treatment of oral candidiasis.

scholarly journals Desain Senyawa Turunan Kuersetin sebagai Inhibitor Pertumbuhan Candida Albicans Menggunakan Analisis QSAR

2018 ◽  
Vol 1 (3) ◽  
pp. 056-060
Author(s):  
Esti Mumpuni ◽  
Agus Purwanggana ◽  
Esti Mulatsari ◽  
Yafi Lakstian
Keyword(s):  
Candida Albicans ◽  
Chemical Structure ◽  
Fungal Infections ◽  
Oral Candidiasis ◽  
Growth Inhibitor ◽  
Equation Model ◽  
Log P ◽  
Qsar Analysis ◽  
Inhibitory Compounds ◽  
Mic Value

Candida albicans adalah sejenis jamur oportunistik yang patogen bagi manusia dan terlibat dalam proses Oral Candidiasis (OC). Candida albicans merupakan spesies yang paling umum diisolasi dalam kasus klinis infeksi jamur invasif. Candida albicans hidup secara komensal di usus, faringeal oral, saluran kemih dan kulit. Senyawa alam seperti flavonoid, telah banyak dikembangkan untuk menghambat pertumbuhan Candida albicans salah satu diantaranya adalah kuersetin yang memiliki nilai MIC 197 µg/mL dalam menghambat pertumbuhan Candida albicans. Upaya peningkatan daya penghambatan kuersetin dalam proses inhibisi pertumbuhan Candida albicans dapat dilakukan dengan memodifikasi struktur kimia senyawa kuersetin secara komputasi. Penentuan MIC senyawa inhibitor candida albicans dari turunan kuersetin secara komputasi dilakukan menggunakan analisis QSAR dengan penentuan deskriptor menggunakan hyperchem dengan metode semi empiric Austin Model 1 dan analisis regresi multilinier (MLR) untuk menentukan model persamaan QSAR. Dari 24 persamaan QSAR yang dihasilkan, ditentukan persamaan QSAR terbaik untuk menentukan nilai MIC prediksi senyawa turunan kuersetin, yaitu : MIC = 970.428 + (0.025 Energi Ikat) + (110.503 Energi HOMO) + (-100.354 Energi LUMO) + (-37.142 log P).Dari 91 senyawa turunan kuersetin yang diuji, diperoleh 74 senyawa yang memiliki nilai MIC lebih kecil dari kuersetin dan senyawa 2,6-diisopropil kuersetin merupakan senyawa dengan MIC terkecil yaitu 27.28 µg/mL. Modifikasi struktur kimia senyawa kuersetin dapat meningkatkan aktivitas kuersetin sebagai inhibitor pertumbuhan candida albicans.   Candida albicans is a type of opportunistic fungus that is pathogenic to humans and involved in the pathogenesis of Oral Candidiasis (OC). Candida albicans is the most commonly isolated species in clinical cases of invasive fungal infections. Candida albicans lives commensally in the intestine, oral pharyngeal, urinary tract and skin.  Natural compounds such as flavonoids, have been developed to inhibit the growth of Candida albicans. one of them was quercetin which had a MIC value of 197 µg / mL in inhibiting the growth of Candida albicans.In Effort to increase the inhibitory activity of quercetin in inhibiting the growth of Candida albicans can be done by modifying the chemical structure of quercetin by computational method.The MIC determination of inhibitory compounds of albicans candida from derivatives quercetin was carried out computationally using QSAR analysis by determining descriptors using hyperchem with Austin Model 1 semi empiric method and multilateral regression analysis (MLR) to determine the QSAR equation model. Of all the 24 QSAR equations, the best QSAR equation was evaluated to determine the predicted MIC value of quercetin derivative compounds,  MIC = 970,428 + (0.025 Bond Energy) + (110,503 Energy HOMO) + (-100,354 LUMO Energy) + (-37,142 log P ). Of all the 91 quercetin derivative compounds tested, there were 74 compounds that had MIC values ​​smaller than quercetin,  2,6-diisopropyl quercetin showed the smallest MIC value of 27.28 µg / mL. Modification of quercetin chemical structure can increase the activity of quercetin as a growth inhibitor of albicans candida

Sign in / Sign up

Export Citation Format

Share Document