Improved Healing of Rabbit Patellar Tendon Defects After an Atelocollagen Injection

2021 ◽  
pp. 036354652110305
Author(s):  
Duck Kyu Kim ◽  
Jiyong Ahn ◽  
Seon Ae Kim ◽  
Eun Jeong Go ◽  
Dong Hwan Lee ◽  
...  
Keyword(s):  
Patellar Tendon ◽  
Statistical Significance ◽  
Biomechanical Testing ◽  
Patellar Tendinopathy ◽  
Control Group ◽  
Daily Life Activities ◽  
Tendon Defect ◽  
Significant Difference ◽  
Load To Failure ◽  
Experimental Group

Background: Patellar tendinopathy is a common cause of limitations in daily life activities in young and/or active people. The patellar tendon consists of a complex of collagen fibers; therefore, collagen could be used as a scaffold in the treatment of patellar tendinopathy. Purpose: To evaluate the healing capacity of injected atelocollagen as a treatment scaffold for patellar tendon defect and, hence, its potential for the treatment of patellar tendinopathy. Study Design: Controlled laboratory study. Methods: After receiving a full-thickness patellar tendon defect, 24 New Zealand White rabbits were divided into a control group (without treatment) and an experimental group that received an atelocollagen injection into the defect. Six rabbits from each group were subsequently used for either histologic scoring or biomechanical testing. The Mann-Whitney U test was used to compare histologic evaluation scores and load to failure between the 2 groups. Statistical significance was set at P < .05. Results: The experimental group showed excellent repair of the damaged patellar tendon and good remodeling of the defective area. In contrast, the control group showed defective healing with loose, irregular matrix fibers and adipose tissue formation. A statistically significant difference was found between the 2 groups in both histologic scores and biomechanical tests at postoperative week 12. Conclusion: Injection of atelocollagen significantly improved the regeneration of damaged patellar tendons. Clinical Relevance: Atelocollagen gel injections could be used to treat patellar tendinopathy in outpatient clinic settings.

scholarly journals THE STATE OF THE OPTICAL DENSITY OF THE ALVEOLAR PROCESS OF THE JAWS OF RATS IN SUPRAOCCLUSIVE RELATIONSHIPS OF INDIVIDUAL TEETH IN THE AGE ASPECT

2021 ◽  
Vol 74 (8) ◽  
pp. 1800-1803
Author(s):  
Yurii V. Lakhtin ◽  
Serhii M. Zviahin ◽  
Lidia M. Karpez
Keyword(s):  
Optical Density ◽  
Statistical Significance ◽  
Statistical Processing ◽  
The State ◽  
Wilcoxon Test ◽  
Control Group ◽  
Alveolar Process ◽  
Mineral Density ◽  
Significant Difference ◽  
Experimental Group

The aim of the study was to conduct a comparative assessment of the optical density of bone tissue of the alveolar process of the jaws of rats in supraocclusive relationships of individual teeth in the age aspect. Materials and methods: The study was performed on 60 white laboratory rats. Rats were divided into control (30 individuals) and experimental (30 individuals) groups. According to the age of rats each group was divided into 3 subgroups (10 animals): young, mature and senile. In the experimental group, the state of supraocclusion was modeled by increasing the height of the lower right second molars placing a seal 1 mm high. Experimental animals were removed from the experiment on the 15th day through decapitation. The lower jaws were skeletonized, jaw blocks were sawn in the molar area. Bone mineral density was determined using optical densitometry. The statistical processing defined the average (M) and its error (m). The statistical significance of the difference in two independent groups was performed according to nonparametric criteria (Mann-Whitney U-test and W-Wilcoxon test). Statistical processing was conducted with the help of integrated package of statistical program AtteStat 12.0.5 for MS Excel. Differences at p≤ 0.05 were considered statistically significant. Results: Statistical discrepancy is present in rats of mature and senile age, as well as between the indicators of all rats of the control and experimental groups (≤0.05). No significant difference was observed in young rats, but the indicators of the experimental group were 3.82% worse than in the control group. In senile rats, the density of the alveolar process decreased by 26.6%, in adult rats by 17.5%. Conclusions: The presence of supraocclusive relationships of individual teeth causes a decrease in bone density of the alveolar process of the jaws in rats. The greatest loss of density among age groups in elderly rats.

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

Redefining the Neck: A Retrospective Review Utilizing Hyoid Suspension

2018 ◽  
Vol 35 (4) ◽  
pp. 198-204
Author(s):  
Sami A. Nizam ◽  
Rhys Branman
Keyword(s):  
Standard Deviation ◽  
Statistical Significance ◽  
Biomechanical Testing ◽  
Retrospective Chart Review ◽  
Mean Difference ◽  
Control Group ◽  
P Value ◽  
Hyoid Suspension ◽  
The Mean ◽  
Experimental Group

Neck contouring is one of the most frequent reasons patients seek cervicofacial rhytidectomy. But what makes for aesthetically pleasing youthful neck? Ellenbogen and Karlin described 5 criteria in their 1980 landmark publication, including having a cervicomental angle between 105° and 120° and a visible subhyoid depression. Recent advances in neck anatomy have revealed the existence of ligamentous like structures attaching the skin and platysma to the hyoid. These have been termed the hyoplatysmal ligament (HPL) and cervicomental suspensory angle ligament by different authors. This study was undertaken to determine whether surgically reestablishing the above structures utilizing a hyoid suspension technique resulted in statistically significant changes in cervicomental contour. A retrospective chart review was performed from January 2014 to present. After December 2016, the second author began utilizing a hyoid suspension technique where the inter- and subplatysmal fat was resected and the HPL was reestablished surgically (hyoid suspension). Cases before this date served as controls if a similar neck manipulation was performed without reestablishing the HPL. In total, 104 charts were queried, of which, 21 charts fit inclusion criteria to serve as controls and 20 as the experimental group. Before and after profile pictures were then compared for differences in cervicomental angle utilizing commercially available imaging software (Canfield Mirror, Parsippany, New Jersey). An unpaired Student t test was then performed to determine whether this 2 groups differed significantly utilizing a P value of .05 to denote statistical significance. The mean difference between pre- and postoperative cervicomental angle for the control group was 17.38° with a standard deviation of 8.05°. The mean difference between pre and postoperative cervicomental angle for the experimental group was 28.75° with a standard deviation of 15.52°. The resulting 11.37° difference in cervicomental angle between the 2 groups was found to be statistically significant with a P value of .0051. Our cosmetic surgical and anatomical knowledge continues to progress. Brant first described a ligamentous structure that attaches the platysma to the hyoid. Through biomechanical testing, he noted this ligament to be one of the weakest in the face and neck. Thereafter, in 2016 Yousif et al and Le Lourn separately described similar procedures to attach the platysma to the hyoid, in effect reestablishing this ligament. Utilizing one simple surgical maneuver, the hyoid suspension reestablishes the HPL. This surgically creates an acute cervicomental angle, resulting in less platysmal displacement postoperatively, with virtually no addition to surgical time or morbidity.

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

scholarly journals Effect of using a proposed method in teaching physics at the skill of the experiment the fourth-grade science students their application Physical principles

2018 ◽  
Vol 226 (3) ◽  
pp. 163-184
Author(s):  
Dr. Waheed Ghaffouri . Al- Saadi
Keyword(s):  
Statistical Significance ◽  
Fourth Grade ◽  
Sample Survey ◽  
Control Group ◽  
Science Students ◽  
Significant Difference ◽  
The Stability ◽  
Teaching Physics ◽  
Experimental Group ◽  
Physical Principles

    The current research aims to identify (the effect of using a proposed method in teaching physics at the skill of the experiment at the fourth-grade science students and their application of physical principles. The researcher adopted the experimental design of the two groups. The number of students in the research sample reached (59) students of the fourth grade of the secondary school of Ibn al-Fadr under the General Directorate for the education of Diyala / Khalis for the academic year 2016-2017 divided between two divisions, (B) and (B) to represent the experimental group studied in the proposed method. The researcher also constructed the skill test level for the physics subject of (10) paragraphs , And verified the authenticity of its content, presented to a group of specialists , And was applied to a sample to ascertain the veracity of the vertebrae, and was confirmed by the stability of the equation Koderrichardson 20, and was a coefficient of stability (0.72), and was confirmed the strength of discriminatory paragraphs, and the coefficient of difficulty, and the effectiveness of alternatives.  The researcher constructed the test applied to the physical principles of physics consisting of (30) objective paragraphs of the type of multiple choice, and verified the validity of its content, presented to a group of specialists, and then applied to a sample survey to ensure the clarity of paragraphs, The coefficient of stability was 0.77, and the discriminant force of its vertebrates, the coefficient of difficulty, and the effectiveness of its substitutions were determined. Using the t-test, with the ends of two independent samples, the null hypothesis was tested. - There is a statistically significant difference between the grades of the experimental group students who studied in the proposed method and the students of the control group who studied in the usual way and for the benefit of the experimental group in the measure of application of the physical principles. - There is a difference of statistical significance between the grades of students of the experimental group who studied in the proposed method and students of the control group who studied in the usual way and for the benefit of the experimental group in the scale of the skill of conducting the experiment. 1- Adopting the proposed method in teaching the physics subject and inserting it into curriculum syllabus and teaching methods in the faculties of education. 2 - Conduct similar studies in several materials and stages to identify their impact in other variables.

Extracorporeal Shockwave for Chronic Patellar Tendinopathy

2007 ◽  
Vol 35 (6) ◽  
pp. 972-978 ◽  
Author(s):  
Ching-Jen Wang ◽  
Jih-Yang Ko ◽  
Yi-Sheng Chan ◽  
Lin-Hsiu Weng ◽  
Shan-Lin Hsu
Keyword(s):  
Patellar Tendon ◽  
Group Versus ◽  
Patellar Tendinopathy ◽  
Control Group ◽  
Study Group ◽  
Extracorporeal Shockwave Therapy ◽  
Ultrasonographic Examination ◽  
Extracorporeal Shockwave ◽  
Shockwave Therapy ◽  
Significant Difference

Background Chronic patellar tendinopathy is an overuse syndrome with pathologic changes similar to tendinopathies of the shoulder, elbow, and heel. Extracorporeal shockwave was shown effective in many tendinopathies. Hypothesis Extracorporeal shockwave therapy may be more effective than conservative treatment for chronic patellar tendinopathy. Study Design Randomized controlled clinical trial; Level of evidence, 2. Methods This study consisted of 27 patients (30 knees) in the study group and 23 patients (24 knees) in the control group. In the study group, patients were treated with 1500 impulses of extracorporeal shockwave at 14 KV (equivalent to 0.18 mJ/mm 2 energy flux density) to the affected knee at a single session. Patients in the control group were treated with conservative treatments including nonsteroidal anti-inflammatory drugs, physiotherapy, exercise program, and the use of a knee strap. The evaluation parameters included pain score, Victorian Institute of Sports Assessment score, and ultrasonographic examination at 1, 3, 6, and 12 months and then once a year. Results At the 2- to 3-year follow-up, the overall results for the study group were 43% excellent, 47% good, 10% fair, and none poor. For the control group, the results were none excellent, 50% good, 25% fair, and 25% poor. The mean Victorian Institute of Sports Assessment scores were 42.57 ± 10.22 and 39.25 ± 10.85, respectively, before treatment (P = .129) and 92.0 ± 10.17 and 41.04 ± 10.96, respectively, after treatment (P < .001). Satisfactory results were observed in 90% of the study group versus 50% of the control group (P < .001). Recurrence of symptoms occurred in 13% of the study group and 50% of the control group (P = .014). Ultrasonographic examination showed a significant increase in the vascularity of the patellar tendon and a trend of reduction in the patellar tendon thickness after shockwave treatment compared with conservative treatments. However, no significant difference in the appearance, arrangement, and homogeneity of tendon fibers was noted between the 2 groups. There were no systemic or local complications or device-related problems. Conclusion Extracorporeal shockwave therapy appeared to be more effective and safer than traditional conservative treatments in the management of patients with chronic patellar tendinopathy.

scholarly journals The Effect of Marriage Counseling Program on Improving Marital Satisfaction Among a Sample of Wives Frequently Visiting the Counseling Clinics In Zarqa Governorate, Jordan: برنامج إرشادي زواجي في تحسين الرّضا الزّواجيّ لدى عينة من النّساء المتردّدات على العيادات الإرشادية في محافظة الزّرقاء بالأردن

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Amany Waheed Shaher Tarawneh
Keyword(s):  
Marital Satisfaction ◽  
Statistical Significance ◽  
Arithmetic Mean ◽  
Marriage Counseling ◽  
Control Group ◽  
Counseling Program ◽  
Satisfaction Scale ◽  
Significant Difference ◽  
The Impact ◽  
Experimental Group

The present study aimed at identifying the level of marital satisfaction in a sample of married women who visited the family education and counseling center in Zarqa Governorate. The study also aimed to reveal the impact of a counseling program based on the Guttman model in improving marital satisfaction. The study sample consisted of 24 women, randomly divided into two groups: 12 in the experimental group and 12 in the control group. The marital satisfaction scale was developed, and a marriage counseling program was used. The results of the study indicated that there was a significant difference in the arithmetic mean of the marital satisfaction scale. The results also indicated a statistical significance between the arithmetic mean in both groups (experimental and control) on the scale of marital satisfaction, where the difference came in favour of the experimental group that received the program. Based on the results achieved, the study came out with a set of recommendations, the most important of which are: To conduct further studies to examine the effectiveness of the counseling programs based on the Gottman model in marital and family counseling, because there are lack studies about this model, and to examine its effect on other variables.

scholarly journals Effect of cryotherapy in preventing mucositis associated with the use of 5-fluorouracil

2020 ◽  
Vol 28 ◽  
Author(s):  
Andrea Bezerra Rodrigues ◽  
Maria Isis Freire De Aguiar ◽  
Patrícia Peres De Oliveira ◽  
Naiana Pacifico Alves ◽  
Renan Alves Silva ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Antineoplastic Agent ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Physiological Serum ◽  
Significant Difference ◽  
Oral Cryotherapy ◽  
And Control ◽  
Experimental Group

Objective: to evaluate the effect of oral cryotherapy compared to physiological serum on the development of oral mucositis in outpatient cancer patients using the 5-fluorouracil antineoplastic agent. Method: this is a controlled, randomized, double-blind, and multi-center clinical trial, conducted with 60 patients undergoing chemotherapy. The experimental group (n=30) used oral cryotherapy during the infusion of the 5-FU antineoplastic agent, while the control group (n=30) performed mouthwash with physiological serum at their homes. The oral cavity of the participants was assessed at three times: before randomization, and on the 7th and 14th days after using 5-FU. For data analysis, descriptive analyses and the ANOVA, paired t, and McNemar tests were used. Results: there was no statistically significant difference between the experimental and control groups in the assessments regarding the grade of mucositis. However, cryotherapy presented the chance to reduce the presence of intragroup mucositis, between the first and second assessments (p=0.000126). Conclusion: cryotherapy did not obtain statistical significance in relation to oral hygiene with serum, but it proved to be effective intragroup. Record number: RBR-4k7zh3

scholarly journals Eficácia da técnica de relaxamento com imagem guiada em pacientes oncológicos submetidos a tratamento quimioterápico

2017 ◽  
Vol 27 (1) ◽  
pp. 25701 ◽  
Author(s):  
Claudia Adriana Facco Lufiego ◽  
Rodolfo Herberto Schneider ◽  
Ângelo José Gonçalves Bós
Keyword(s):  
Cancer Patients ◽  
Guided Imagery ◽  
Statistical Significance ◽  
University Hospital ◽  
Relaxation Technique ◽  
Control Group ◽  
Depression And Anxiety ◽  
Significant Difference ◽  
Anxiety Levels ◽  
Experimental Group

Aims: To evaluate the efficacy of guided imagery relaxation in decreasing depression and anxiety levels in cancer patients submitted to chemotherapy.Methods: A nonrandomized clinical trial was performed in male and female patients aged 30 years or older submitted to chemotherapy at a university hospital in Porto Alegre, southern Brazil. The patients were divided into an Experimental Group, which received the intervention (relaxation technique), and into a Control Group, which did not receive it. Twelve-minute guided imagery relaxation sessions were performed for 14 weeks, always during the chemotherapy procedure. In order to evaluate depression and anxiety levels, the Beck Depression Inventory and Beck Anxiety Inventory were applied at baseline and at the end of the study period. The data were analyzed by the EpiInfo7.0 statistical software using Student’s t, Wilcoxon-Mann-Whitney, and Pearson’s chi-square tests. Statistical significance was obtained when p <0.05.Results: A total of 113 participants with a mean age of 51.3 years, among whom 62.8% were female and 72.6% were married, were included in the study. Breast, lung, and intestinal cancers were the most prevalent types of neoplasms. Fifty-seven patients were assigned to the Experimental Group and 56 to the Control Group. There was a decrease in depression and anxiety levels in the Experimental Group, in which depression scores ranged from 17.3±9.04 to 14.5±7.47 (p <0.0001) and anxiety scores ranged from 15.1±8.84 to 12.9±7.58 (p <0.0001). No significant difference was observed in the Control Group between the baseline and final evaluations.Conclusions: The guided imagery relaxation technique was efficacious in reducing depression and anxiety levels in this sample of chemotherapy-treated cancer patients.

scholarly journals The Effect of Dutasteride in Peri-Operative Blood Loss During Transurethral Resection of Prostate (Turp)

2020 ◽  
Vol 22 (2) ◽  
pp. 177-181
Author(s):  
Md Mostafizur Rahaman ◽  
Md Habibur Rahman ◽  
Muhammad Hossain ◽  
Md Saiful Islam ◽  
Mohammad Shafiqur Rahman
Keyword(s):  
Blood Loss ◽  
Transurethral Resection ◽  
Statistical Significance ◽  
Control Group ◽  
Transurethral Resection Of Prostate ◽  
Double Blind ◽  
Significant Difference ◽  
Group B ◽  
Group Control Group ◽  
Experimental Group

This prospective double blind comparative study was designed to compare the effect of Dutasteride on the perioperative blood loss in Transurethral Resection of Prostate (TURP).Sixty patients with BPH underwent TURP were divided into 2 groups. Patients belong to the group B (Control) and group A (Experimental). Experimental group patients were given Cap. A (dutasteride 0.5 mg) before two weeks of TURP and group B (control) were given Cap. B (placebo). Postoperative comparison between two groups showed that there were no significant difference between the weight of resected prostatic tissue (control =22.41±6.83 gm, and experimental = 25.38±7.22 gm; p=0.107). Postoperative hemoglobin level of both group (Control group = 10.78±0.64 gm/dL and experimental group = 10.83±.51 gm/dL) revealed no significant difference (p=0.774). The mean hemoglobin loss per gram of prostate tissue in both groups (control = 1.81±0.81 gm/gm and experimental = 1.79±0.88 gm/gm) did not show any statistical difference (p=0.938). In this the study it was found that if the BPH patients are subjected with dutasteride 0.5mg before 2 weeks of TURP, bleeding decrease slightly (Control group = 20.35±7.99 ml/gm and Experimental groups = 17.41±7.70 ml/gm). However, these data of bleeding loss did not show any statistical significance. Bangladesh Journal of Urology, Vol. 22, No. 2, July 2019 p.177-181

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