scholarly journals Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis

2017 ◽  
Vol 30 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Ester Del Duca ◽  
Francesca Farnetani ◽  
Nathalie De Carvalho ◽  
Ugo Bottoni ◽  
Giovanni Pellacani ◽  
...  
Keyword(s):  
Plaque Psoriasis ◽  
Severity Index ◽  
Vitamin B ◽  
Psoriasis Area Severity Index ◽  
Wide Range ◽  
Significant Difference ◽  
Therapy Option ◽  
The Difference ◽  
Time Point ◽  
Emollient Cream

Psoriasis is a chronic inflammatory skin disease affecting 2%–3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks. This study was conducted as a randomized, controlled, single-blind, intra-patient left- to right-side trial comparing the efficacy and safety of vitamin B12-containing ointment (M-treatment) with a glycerol-petrolatum-based emollient cream (C-treatment). The Psoriasis Area Severity Index (PASI) was determined at baseline (T0), at time points T2 (14 days), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks) and 4 weeks after the end of the wash-out period (F1). In total, 24 patients with plaque psoriasis were randomized to receive left- or right-side treatment with B12 ointment. From time point T2 to time point F1, there was a statistically significant difference in PASI reduction between M-treatment side and C-treatment side. At time point T 12, the difference between the mean reductions from baseline PASI scores by 5.92 ± 2.49 (87, 6%) in the M-treatment side versus 1.08 ± 1.02 (23, 1%) C-treatment side was statistically highly significant ( PWex < 0.001). On the contemporary panorama in the treatment of psoriasis, we conclude that vitamin B12 ointment will represent a new concrete therapy option and should be considered in the update of therapeutic algorithm for the treatment of psoriasis

scholarly journals PERBEDAAN TINGKAT KEPARAHAN PSORIASIS PADA PASIEN PSORIASIS DENGAN DAN TANPA FOKAL INFEKSI

2018 ◽  
Vol 11 (2) ◽  
pp. 80
Author(s):  
Caroline Astrid ◽  
Ismiralda Oke Putranti ◽  
Kurniasih Dwi Purwanti
Keyword(s):  
Public Hospital ◽  
Analytical Study ◽  
Severity Index ◽  
Exclusion Criteria ◽  
Psoriasis Area Severity Index ◽  
Cross Sectional ◽  
Focal Infection ◽  
Significant Difference ◽  
Epidermal Growth ◽  
The Difference

Psoriasis adalah penyakit kulit yang sering dijumpai, kronik, tidak menular, terjadi akibat kelainan kompleks pada pertumbuhan dan diferensiasi epidermal serta abnormalitas multipel dari biokimia, imunologi, dan vaskular. Salah satu faktor risiko psoriasis adalah fokal infeksi. Penelitian ini bertujuan mengetahui perbedaan tingkat keparahan psoriasis pada pasien psoriasis dengan dan tanpa disertai fokal infeksi di RSUD Prof. Dr. Margono Soekarjo, Purwokerto. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Subjek penelitian adalah 40 pasien psoriasis yang berobat di Poli Kulit dan Kelamin RSUD Prof. Dr. Margono Soekarjo pada bulan November hingga Desember 2017 yang memenuhi kriteria inklusi dan eksklusi. Tingkat keparahan psoriasis diukur menggunakan Psoriasis Area Severity Index (PASI). Analisis data menggunakan independent t-test. Rata-rata tingkat keparahan psoriasis pada pasien dengan fokal infeksi 28,63 dan tanpa fokal infeksi 17,29, dengan jenis fokal infeksi didapatkan fokal infeksi intraoral (47,5%) dan genital (2,5%). Perbedaan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi didapatkan p = 0,000 (p < 0,05). Terdapat perbedaan signifikan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi.     Psoriasis is a common, chronic, noncontagious skin disease, caused by complex abnormal epidermal growth with multiple abnormality of biochemistry, immunology, and vascular. One of psoriasis risk factors is focal infection. This study was an analytical study with cross-sectional approach, to establish the difference of Psoriasis Area Severity Index (PASI) in patients with and without focal infections in Prof. Dr. Margono Soekarjo Public Hospital, Purwokerto. Subjects of this study were psoriasis outpatients in Dermatology and Venereology Clinic in November until December 2017. Forty subjects who fulfilled the inclusion and exclusion criteria were measured using PASI. This study showed the average of the PASI on patients with focal infections was 28.63 and without focal infections was 17.29, with types of the focal infection were intraoral focal infections (47,5%) and genital focal infections (2,5%). The difference of PASI between patients with and without focal infections was significant with p = 0,000 (p < 0,05). There is a significant difference on degree of psoriasis between patients with and without focal infections.

386 An Exploratory Study of Bedtime Procrastination and Emotional Regulation Strategies in Insomnia compared to healthy individuals

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A153-A153
Author(s):  
Goeun Kim ◽  
Hyojin Nam ◽  
Huisu Jeon ◽  
Sooyeon Suh
Keyword(s):  
Emotional Regulation ◽  
Severity Index ◽  
Ministry Of Education ◽  
Chi Square ◽  
Healthy Group ◽  
Significant Difference ◽  
Regulation Strategies ◽  
The Difference ◽  
The Republic ◽  
Bedtime Procrastination

Abstract Introduction Bedtime Procrastination (BP) is defined as the behavior of voluntarily delaying going to bed, without having external reasons for doing so. Recent research on procrastination behavior suggests that when negative emotions are elevated, procrastination behaviors can be triggered in order to find pleasure to avoid and alleviate them. Procrastination can also occur when there is difficulty regulating emotions. In addition, the reason for bedtime procrastination may be different depending on whether the individuals present with insomnia. According to previous studies, patients with insomnia may exhibit more pronounced negative avoidance of bedtime due to prolonged sleeplessness. Therefore, this study compared the difference between of the bedtime procrastination and the emotional regulation strategies between the insomnia group and the healthy group. Methods This study was conducted in 582 adults (mean age 23.06 ±2.16 years), 81.6% females. Individuals scoring higher than 15 on the Insomnia Severity Index (ISI) were classified into the insomnia group (n=375), and those less than 15 were classified into the healthy group (n=207). Participants completed the Bedtime Procrastination Scale (BPS), Emotional Regulation Strategies Checklist. Data was analyzed using descriptive statistics, chi square test, and independent t tests. Results The insomnia group had significantly higher bedtime procrastination scores than the healthy group (t=-6.241, p&lt;.001), and also the avoidant/distractive regulation style score was significantly higher (t=-1.969, p&lt;.05). In addition, the score of active regulation style was significantly lower in the insomnia group than in the healthy group (t=3.050, p&lt;.01). There was no significant difference between the two groups in the support-seeking regulation style. Conclusion Based on these results, it was confirmed that there was a difference in the bedtime procrastination and the emotional regulation strategies between the insomnia group and the healthy group. Support (if any) This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea(NRF-2018S1A5A8026807)

The Research on the Mechanical Property of CBF/PP Composite Board

2010 ◽  
Vol 150-151 ◽  
pp. 1063-1067
Author(s):  
Fei Fei Zhu ◽  
Zhi Li Zhong ◽  
Zong Fu Guo
Keyword(s):  
Mechanical Property ◽  
Polypropylene Fiber ◽  
Basalt Fiber ◽  
Variance Analysis ◽  
Forming Process ◽  
Composite Board ◽  
Actual Application ◽  
Wide Range ◽  
Significant Difference ◽  
The Difference

The three composite boards which were made of continuous basalt fiber (CBF) and polypropylene fiber (PP) in different fiber ratios were researched on this paper. The manufacturing forming process included blending, carding, web formation, laminating and compression molding orderly. The tension and bending properties were investigated experimentally, and then dual variance analysis was used to show the significant difference of the mechanical property in the transverse and longitudinal orientation as well the appreciable impact of different fiber ratios to the mechanical property. The results show that the difference of the tension and blending strength in the same direction, among composite boards in different fiber proportions, is about 1~10Mpa; the difference in the same fiber proportion, between transverse and longitudinal, vary within a wide range from 10Mpa to 30Mpa. The results of variance analysis have also proved the conclusion, the difference between transverse and longitudinal is more significant than the difference among different fiber proportions. In the similar study, the significance hadn’t been seen sufficiently, so this paper provides reference to the actual application of the composite board.

scholarly journals A double-blind randomized controlled trial of topical Curcuma xanthorrhiza Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

2018 ◽  
Vol 27 (3) ◽  
pp. 178-84 ◽  
Author(s):  
Githa Rahmayunita ◽  
Tjut N.A. Jacoeb ◽  
Endi Novianto ◽  
Wresti Indriatmi ◽  
Rahadi Rihatmadja ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Clinical Manifestations ◽  
Effective Treatment Option ◽  
Psoriasis Area Severity Index ◽  
Double Blind ◽  
Old Patients ◽  
Mean Values ◽  
Significant Difference ◽  
Curcuma Xanthorrhiza ◽  
The Difference

Background: Curcuma xanthorrhiza Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of C. xanthorrhiza in psoriasis.Methods: From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% C. xanthorrhiza ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).Results: The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% C. xanthorrhiza ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% C. xanthorrhiza ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with C. xanthorrhiza and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% C. xanthorrhiza ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).Conclusion: Based on the results, 1% C. xanthorrhiza ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. C. xanthorrhiza ointment is safe for topical administration as there were no side effects reported in this study.

scholarly journals The difference of lipid profiles between psoriasis with arthritis and psoriasis without arthritis and sex-specific downregulation of methotrexate on the apolipoprotein B/apolipoprotein A-1 ratio

2022 ◽  
Vol 24 (1) ◽  
Author(s):  
Bing Wang ◽  
Hui Deng ◽  
Yao Hu ◽  
Ling Han ◽  
Qiong Huang ◽  
...  
Keyword(s):  
Inflammatory Marker ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Severity Index ◽  
Lipid Profiles ◽  
Apolipoprotein A1 ◽  
Concomitant Disease ◽  
Psoriasis Area Severity Index ◽  
Male Patients ◽  
The Difference

Abstract Background Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear. Objective To investigate the effect of MTX on lipid profiles and the difference between psoriasis without arthritis (PsO) and psoriatic arthritis (PsA). Methods In this prospective study, we recruited 288 psoriatic patients (136 PsA and 152 PsO) who completed 12 weeks of MTX treatment. Total cholesterol (TC), triglycerides (TG), lipoprotein A [LP(a)], high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and ApoB were measured. Results Compared with sex- and age-matched healthy controls, psoriatic patients had significantly (p < 0.0001) higher levels of proatherogenic lipids and lower levels of anti-atherogenic lipids. PsA patients had a higher ApoB/ApoA1 ratio than PsO patients (p < 0.05). Stepwise regression analysis found a positive correlation between the inflammatory marker hCRP and the Psoriasis Area Severity Index (PASI), ApoB/ApoA1 ratio, BMI, and smoking. ApoB was positively associated with concomitant arthritis, diabetes, and hypertension. MTX decreased the levels of pro-atherogenic and anti-atherogenic lipids. However, a significant reduction of the ApoB/ApoA1 ratio by MTX was only observed in male patients. Conclusion PsA patients had a significantly higher percentage of concomitant disease than PsO. The decrease of MTX on CVD might be related with sex. Trial registration ChiCTR2000036192

scholarly journals Running Performance and Hormonal, Maturity and Physical Variables in Starting and Non-Starting Elite U14 Soccer Players During a Congested Match Schedule

2021 ◽  
Vol 80 (1) ◽  
pp. 287-295
Author(s):  
Vinicius Zanetti ◽  
Marcelo Saldanha Aoki ◽  
Paul Bradley ◽  
Christopher Carling ◽  
Thomas Kisil Marino ◽  
...  
Keyword(s):  
High Speed ◽  
Soccer Players ◽  
Running Performance ◽  
Salivary Testosterone ◽  
Youth Soccer ◽  
Wide Range ◽  
Significant Difference ◽  
The Difference ◽  
Biological Maturity ◽  
Test Level

Abstract This study examined changes in match running performance (MRP) in Under-14 soccer players (13.5 ± 0.7 yrs) during a congested match schedule (CMS) (4 matches played within a 5-day period). It also examined the difference in salivary testosterone (sT) concentration, somatic maturation, jumping tests, and Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo IR1) between the players selected to play (SLG; group who participated in all matches) and players non-selected to play (NSG). A significant difference was observed for the frequency of decelerations (DEC) across matches (match 4 vs. matches 1, 2 and 3; p = 0.05; partial ƞ2 = 0.20). No difference between matches was observed for total running distance (TRD), high-speed running distance (HSRD), and frequency of accelerations (ACC) (p > 0.05). A wide range for within-player coefficient of variation (CV) values was observed for all MRP variables (range: 10.5 = TRD to 30.6 = HSRD). No difference between SLG and NSG for any of the assessed variables was observed (p > 0.05). The findings suggest that DEC was the most pertinent variable for monitoring changes in MRP during the CMS. In addition, at an elite youth soccer level, the biological maturity and fitness might not influence selection to play.

scholarly journals Perbedaan kadar caffeic acid phenethyl ester pada propolis ekstrak etanol dan propolis ekstrak air

2013 ◽  
Vol 11 (2) ◽  
pp. 43-47
Author(s):  
RIANI DWI HASTUTI ◽  
DIDING PRASETYO ◽  
SRI HARTATI HADINOTO
Keyword(s):  
Caffeic Acid ◽  
Water Extract ◽  
Ethanol Extract ◽  
Caffeic Acid Phenethyl Ester ◽  
Rat Aorta ◽  
Raw Material ◽  
Wide Range ◽  
Significant Difference ◽  
Post Test ◽  
The Difference

Hastuti RD, Prasetyo D, Hadinoto SH. 2013. The difference of caffeic acid phenethyl ester level in ethanol extract propolis and water extract propolis. Biofarmasi 11: 43-47. Propolis is a natural product derived from plant resin collected by honeybeen and its composition has wide range of biological activity. CAPE is the ester of caffeic acid, a derivative of phenolic acid, a flavonoid-like compound, one of the major components of propolis. CAPE is reported can protect nephrotoxicity due to cisplatin induction, inhibiting the growth of various types of abnormal cells, having an anti-inflammation activity, antioxidant activity, cyclooxygenase activity, vasodilatation activity in rat aorta, potential inhibitor of nitric oxidant, inhibitor oxidative process, and effectively suppress the growth of cataract in rat. Propolis can not be used as raw material, and it must be purified by extraction with solvent. Different solvents may extract different compounds, influencing its activity. The purpose of this research was to determine the difference levels of CAPE in ethanol extract propolis and water extract propolis. This research was a pure experimental research using the post-test only design. The sample of this research was raw propolis taken from bees farming in Gejen RT. 03 RW. 02, Kerjo, Karanganyar. Sampling was performed by a purposive sampling. Sample was extracted with a maserasion method with the solvents of ethanol and water. In each extract propolis was made five samples. The determination of the level of CAPE on propolis was performed by using UV-Vis spectrophotometry with Prussian Blue method. The data of the level of CAPE was analyzed by the statistical test of independent t-test. The results showed that the average of CAPE level in ethanol extract propolis was 12.268±0.658 μg/mL and the average of CAPE level in water extract propolis was 5.564±0.332 μg/mL, with p=0.125 (p>0.05). There was no significant difference between extract ethanol propolis and water extract propolis.

scholarly journals P012 α4β7 Receptor occupancy by vedolizumab at trough time-point occurs at the membranal level and is not associated with endoscopic healing in inflammatory bowel disease patients

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S135-S136
Author(s):  
B Ungar ◽  
Z Ben-Shatach ◽  
O Haj-Natour ◽  
M Yavzori ◽  
E Fudim ◽  
...  
Keyword(s):  
T Cells ◽  
Receptor Occupancy ◽  
Effector Memory ◽  
Median Percentage ◽  
Drug Levels ◽  
Wide Range ◽  
Significant Difference ◽  
Membrane Bound ◽  
Time Point ◽  
Receptor Saturation

Abstract Background Previous studies have shown inconclusive associations between vedolizumab trough levels and therapy outcomes. A near-complete occupancy of blood and intestinal α4β7 was exerted by vedolizumab through a wide-range of drug levels, regardless of clinical outcomes. However, these observations were not conducted specifically at the time of trough drug levels, did not include α4β7 highly expressing eosinophils and did not establish whether occupancy is in fact due to fully internalised VDZ- α4β7 complex in the target T-cell. Methods Peripheral blood (PB) and intestinal lamina propria (LP) were collected from IBD patients undergoing lower endoscopies on the day of vedolizumab infusion (trough time-point). Clinical and endoscopic scores were prospectively recorded. FACS analysis was performed using fluorescent conjugated-vedolizumab to investigate α4β7 occupancy on effector-memory T cells (CD3+CD45RO+ cells) and on eosinophils (CD49d+CD294+) in PB. Using a newly-developed dissociation assay, we also assessed the degree of membrane-bound VDZ-mediated blocked- α4β7. Results Forty-five IBD patients (16, 35% Crohn’s patients, 18, 40% in endoscopic remission) underwent clinical and endoscopic assessment just before their scheduled vedolizumab infusions. The median percentage of free α4β7 receptors at trough was 1.3% (IQR 0.5–3.7%) for PB T cells and 7.2% (IQR 3.6–23.4%) for LP T cells. No statistically significant difference was detected in α4β7 receptor saturation between patients with and without mucosal healing, both for PB (free α4β7 receptors: median 0.5%, 1.46%, IQR 0.3–1.4%, 0.9–3.5% respectively, p = 0.15) and for LP (free α4β7 receptors, median: 11.5%, 7%, IQR 3.5–24.2%, 5.8–20.9%, p = 0.88). Similarly, almost complete α4β7 receptor saturation at trough was detected among PB eosinophils (1.5% free α4β7 receptors, IQR 0.9–2.6%). Upon dissociation assay, a significant number of membrane-bound α4β7 receptors became detectable both on PB and LP T cells, with medians of 31% (IQR 24–41%), 22.2% (IQR 15–31%) respectively, and also for eosinophils, with a median of 83% (IQR 67–89%). When compared with values before dissociation, the proportion of unbound receptors was considerably lower (p &lt; 0.001 for all analyses, respectively). Conclusion Even at trough, almost complete α4β7 receptor saturation is reached, both for PB and LP T cells, as well as for PB eosinophils, regardless of endoscopic activity status. This receptor occupancy is unrelated to receptor-internalisation and reflects a complete and continuous antigen-binding at the membranal level.

Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis

2015 ◽  
Vol 20 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Ankit Mittal ◽  
Sunil Dogra ◽  
Tarun Narang ◽  
Aman Sharma
Keyword(s):  
Pilot Study ◽  
Plaque Psoriasis ◽  
Severity Index ◽  
Term Treatment ◽  
Adult Patients ◽  
Efficacy And Safety ◽  
Open Label ◽  
Short Term Treatment ◽  
Psoriasis Area Severity Index ◽  
Severe Plaque Psoriasis

Background: Tacrolimus, a congener of cyclosporine, has replaced cyclosporine as a first-line treatment for most transplant patients due to its superior efficacy and safety. Tacrolimus has not been extensively studied for the treatment of psoriasis. Objectives: To study the efficacy and safety of oral tacrolimus in adult patients with severe refractory plaque psoriasis. Methods: This was an open-label pilot study. Patients with severe plaque type psoriasis who were unresponsive to at least 1 systemic treatment were treated with oral tacrolimus. Results: Thirty patients were treated. After 12 weeks, improvement in mean Psoriasis Area Severity Index (PASI) score was 80.37% ( P < .001), PASI 75 was observed in 19 of 26 (73.1%) patients, and PASI 90 was observed in 11 of 26 (42.3%) patients. No severe side effects were noted. Conclusion: Oral tacrolimus is an effective and safe option for the short-term treatment of severe plaque psoriasis.

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