scholarly journals PERBEDAAN TINGKAT KEPARAHAN PSORIASIS PADA PASIEN PSORIASIS DENGAN DAN TANPA FOKAL INFEKSI

2018 ◽  
Vol 11 (2) ◽  
pp. 80
Author(s):  
Caroline Astrid ◽  
Ismiralda Oke Putranti ◽  
Kurniasih Dwi Purwanti

Psoriasis adalah penyakit kulit yang sering dijumpai, kronik, tidak menular, terjadi akibat kelainan kompleks pada pertumbuhan dan diferensiasi epidermal serta abnormalitas multipel dari biokimia, imunologi, dan vaskular. Salah satu faktor risiko psoriasis adalah fokal infeksi. Penelitian ini bertujuan mengetahui perbedaan tingkat keparahan psoriasis pada pasien psoriasis dengan dan tanpa disertai fokal infeksi di RSUD Prof. Dr. Margono Soekarjo, Purwokerto. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Subjek penelitian adalah 40 pasien psoriasis yang berobat di Poli Kulit dan Kelamin RSUD Prof. Dr. Margono Soekarjo pada bulan November hingga Desember 2017 yang memenuhi kriteria inklusi dan eksklusi. Tingkat keparahan psoriasis diukur menggunakan Psoriasis Area Severity Index (PASI). Analisis data menggunakan independent t-test. Rata-rata tingkat keparahan psoriasis pada pasien dengan fokal infeksi 28,63 dan tanpa fokal infeksi 17,29, dengan jenis fokal infeksi didapatkan fokal infeksi intraoral (47,5%) dan genital (2,5%). Perbedaan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi didapatkan p = 0,000 (p < 0,05). Terdapat perbedaan signifikan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi.     Psoriasis is a common, chronic, noncontagious skin disease, caused by complex abnormal epidermal growth with multiple abnormality of biochemistry, immunology, and vascular. One of psoriasis risk factors is focal infection. This study was an analytical study with cross-sectional approach, to establish the difference of Psoriasis Area Severity Index (PASI) in patients with and without focal infections in Prof. Dr. Margono Soekarjo Public Hospital, Purwokerto. Subjects of this study were psoriasis outpatients in Dermatology and Venereology Clinic in November until December 2017. Forty subjects who fulfilled the inclusion and exclusion criteria were measured using PASI. This study showed the average of the PASI on patients with focal infections was 28.63 and without focal infections was 17.29, with types of the focal infection were intraoral focal infections (47,5%) and genital focal infections (2,5%). The difference of PASI between patients with and without focal infections was significant with p = 0,000 (p < 0,05). There is a significant difference on degree of psoriasis between patients with and without focal infections.

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Marianne C. Jacobus ◽  
Max F.J Mantik ◽  
Adrian . Umboh

Abstract: Haemoglobin is the main component of red blood cells that serves as a transporter of oxygen and carbon dioxide in the blood. The normal range of haemoglobin values can be used to determine the degree of anemia according to age and gender. Geographical condition such as altitude influences the haemoglobin value. This study aimed to obtain the difference of haemoglobin levels between teenagers with good nutrition status who live at the highland and those at the seaside. This was an observational analytical study with a cross sectional design. Samples were students with good nutrition status of SMPN 3 Tomohon (living at the highland) and those of SMP Kristen Nazaret Tuminting (living at the seaside). There were 60 students who met the inclusion criteria as follows: adolescent, good nutrition status, healthy, aged 13-15 years, lived at the highland or at the seaside ≥ 6 month, and willing to be performed blood examinations, and had been approved by their parents. The Mann-Whitney test for the difference between haemoglobin levels of the two groups showed a p value < 0,001. Conclusion: There was a very significant difference between haemoglobin levels of good nutrition teenagers who lived at the highland and at the seaside. Keywords: haemoglobin levels, good nutrition, teenagers, highland, seaside  Abstrak: Hemoglobin merupakan komponen utama sel darah merah dan berfungsi sebagai transporter oksigen dan karbon dioksida dalam darah. Batas normal nilai hemoglobin dapat digunakan untuk menetapkan derajat anemia, dengan distribusi usia dan jenis kelamin spesifik didasarkan pada sampel referensi sehat. Kondisi geografis, seperti ketinggian tempat dari permukaan laut menjadi faktor pertimbangan dalam distribusi nilai normal hemoglobin. Penelitian ini bertujuan untuk mendapatkan perbedaan kadar hemoglobin antara remaja gizi baik yang tinggal di pegunungan dengan yang tinggal di tepi pantai. Jenis penelitian ini analitik-observasional dengan desain potong lintang. Sampel penelitian yaitu remaja gizi baik yang tinggal di pegunungan yaitu siswa SMPN 3 Tomohon dan yang di tepi pantai yaitu siswa SMP Kristen Nazaret Tuminting. Subjek penelitian berjumlah 60 remaja yang memenuhi kriteria inklusi yaitu gizi baik, sehat, berumur 13-15 tahun, berdomisili di pegunungan atau tepi pantai ≥6 bulan, bersedia dilakukan pemeriksaan darah, dan telah disetujui oleh orang tua. Data yang diperoleh dianalisis menggunakan uji Mann-Whitney dengan bantuan program SPSS. Hasil uji Mann-Whitney mengenai perbedaan kadar hemoglobin antara kedua kelompok menunjukkan nila p <0,001. Simpulan: Terdapat perbedaan yang sangat bermakna kadar hemoglobin remaja gizi baik yang tinggal di pegunungan dengan di tepi pantai.Kata kunci: kadar hemoglobin, remaja gizi baik, pegunungan, tepi pantai


2017 ◽  
Vol 30 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Ester Del Duca ◽  
Francesca Farnetani ◽  
Nathalie De Carvalho ◽  
Ugo Bottoni ◽  
Giovanni Pellacani ◽  
...  

Psoriasis is a chronic inflammatory skin disease affecting 2%–3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks. This study was conducted as a randomized, controlled, single-blind, intra-patient left- to right-side trial comparing the efficacy and safety of vitamin B12-containing ointment (M-treatment) with a glycerol-petrolatum-based emollient cream (C-treatment). The Psoriasis Area Severity Index (PASI) was determined at baseline (T0), at time points T2 (14 days), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks) and 4 weeks after the end of the wash-out period (F1). In total, 24 patients with plaque psoriasis were randomized to receive left- or right-side treatment with B12 ointment. From time point T2 to time point F1, there was a statistically significant difference in PASI reduction between M-treatment side and C-treatment side. At time point T 12, the difference between the mean reductions from baseline PASI scores by 5.92 ± 2.49 (87, 6%) in the M-treatment side versus 1.08 ± 1.02 (23, 1%) C-treatment side was statistically highly significant ( PWex < 0.001). On the contemporary panorama in the treatment of psoriasis, we conclude that vitamin B12 ointment will represent a new concrete therapy option and should be considered in the update of therapeutic algorithm for the treatment of psoriasis


Author(s):  
Sianny Herawati ◽  
J Nugraha

Tuberculosis is an infectious disease which is the second cause of death in the world. Indonesia belongs to the third ranks as themost prevalent tuberculosis country. However the eradication is programmed only to focus on finding the case and treatment of theactive tuberculosis patients. Health care workers are at risk to tuberculosis infection, but there is no examination yet for early detectionactivity of tuberculosis. In order to know the activity of tuberculosis, other examinations are needed such as IL-18 examination. Today, no research about IL-18 is performed yet in Indonesia; therefore this study is performed in order to know the difference of IL-18level in active tuberculosis patients and nurses at risk. This study is to know the difference between IL-18 plasma of active tuberculosispatients and nurses at risk by analysis. A cross sectional, observational analytical study of 8 nurses at risk of tuberculosis and 8 activetuberculosis patients, has been conducted from February up to April 2007, at the Dr. Soetomo General Hospital and Karang TembokHospital in Surabaya. The diagnosis of active tuberculosis patients was based on positive sputum bacteriological examination, positiveradiology examination and who never had received anti-tuberculosis drugs. Nurses at risk of tuberculosis consisted of those who had beenworking more than 2 years, and was examined by negative bacteriological and radiology examination, TB-dot and positive tuberculinskin test with a diameter – 10 mm. IL-18 examination was done by double antibody sandwich ELISA method (MBL/Medical & BiologicalLaboratories Co.Ltd). IL-18 level in active tuberculosis patients was 491.4–1215.3 pg/ml (mean 794.6 pg/ml, SD 222.6), in nursesat risk of tuberculosis was 88.9–429.0 pg/ml (mean 256.2 pg/ml, SD 137.6). There was a significant difference of IL-18 level amongactive tuberculosis patients and nurses at risk of tuberculosis (p < 0.001); the IL-18 level in active tuberculosis patients was significantlyhigher than in nurses at risk of tuberculosis.


Author(s):  
Naivah Harharah

Objective: To compare serum Anti Müllerian Hormone (AMH) levels in infertile women with and without endometriosis, and to determine the mean levels of serum AMH in every stage of endometriosis. Method: We performed a cross-sectional study. Sixty-eight subjects who have undergone laparoscopy and fulfilled both inclusion and exclusion criteria are recruited consecutively. They are divided into two groups, namely group with endometriosis and without endometriosis. Blood samples are taken from each subject before laparoscopy, where serum AMH levels are then measured. The difference in mean levels of each group are tested with Mann-Whitney test. Result: The mean levels of serum AMH were significantly lower in the endometriosis group than those in the group without endometriosis (2.30 1.8 ng/ml vs 3.75 2.13 ng/ml; p=0.005). Using Kruskal-Wallis test, it was found that there was a statistically significant difference among endometriosis groups based on the severity of endometriosis. There was no significant difference in the mean serum AMH levels between the minimal-mild endometriosis group and without endometriosis group (p=0.34), but the mean levels of serum AMH were significantly lower in the moderate-severe endometriosis compare to the group without endometriosis (p


Author(s):  
Fahdiansyah Fahdiansyah ◽  
Ruswana Anwar ◽  
Setyorini Irianti

Objectives: To analyse the difference of serum adiponectin level between patients with endometriotic cyst and those with non-endometriotic cyst, and its difference between endometriosis stages. Methods: This is a cross-sectional comparative analytical study involving 25 women with endometriotic cyst and 25 women with nonendometriotic cyst, which had undergone laparoscopy or laparotomy surgery. Blood samples were withdrawn and checked for serum adiponectin level in PRODIA laboratory in Jakarta. Serum adiponectin level of both groups were then measured and compared. The study was conducted in Dr. Hasan Sadikin Hospital in September- December 2012. Results: Shows no significant difference in subjects’ characteristic which are age (p = 0.994) and BMI (p = 0.267). There is a significant difference (p < 0.0001) between serum adiponectin level in endometriosis group (mean = 3.91 ± 1.976) with level of which in nonendometriosis group (mean = 8.59 ± 1.977). There is no significant difference (p = 0.384) of serum adiponectin level between stage III endometriosis (mean = 4.24 ± 1.8168) and stage IV endometriosis (mean = 3.54 ± 2.1531). Conclusion: Serum adiponectin level in patients with endometriotic cyst is significantly lower compared to level of which in patients with non-endometriotic cyst. There is no significant difference of serum adiponectin level between endometriosis stages. [Indones J Obstet Gynecol 2013; 1-3: 119-23] Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage


2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Magdalena I. Simanullang ◽  
George N. Tanudjaja ◽  
Djon Wongkar ◽  
Taufiq F. Pasiak

Abstract: Anthropometry is a measurement of certain parts of human body including height. This study was aimed to obtain the difference in height between after waking up in the morning and before going to bed at night among Minahasan sub-ethnic people at Senduk village. This was an analytical study with a cross-sectional design. Sampels were obtained by using purposive sampling method. There were 65 people as subjects. The results showed that the heights after waking up in the morning were longer than the heights before going to bed at night with an average of 1-2 cm for both sexes. The Wilcoxon test showed a significant difference between the heights after waking up in the morning and the heights before going to bed at night (p=0.002 for males and p=0.000 for females). Conclusion: There was a significant difference between the heights after waking up in the morning and the heights before going to bed at night. The heights after waking up in the morning were longer than the heights before going to bed at night.Keywords: height, after waking up in the morning, before going to bed at night Abstrak: Antropometri merupakan sebuah alat ukur yang digunakan untuk mengukur bagian-bagian tubuh manusia termasuk tinggi badan. Penelitian ini bertujuan untuk mendapatkan perbedaan tinggi badan sebelum tidur dan setelah bangun pagi pada sub-etnis Minahasa di Desa Senduk. Jenis penelitian ialah analitik dengan desain potong lintang. Sampel diambil secara purposive sampling sebanyak 65 orang. Hasil penelitian mendapatkan bahwa tinggi badan setelah bangun pagi lebih panjang dibandingkan sebelum tidur malam hari dengan rerata perbedaan 1-2 cm untuk kedua jenis kelamin. Hasil uji Wilcoxon mendapatkan perbedaan bermakna antara tinggi badan setelah bangun pagi dan sebelum tidur (p=0,002 untuk laki-laki dan p=0,000 untuk perempuan). Simpulan: Terdapat perbedaan bermakna antara tinggi badan setelah bangun pagi dan sebelum tidur malam hari. Tinggi badan setelah bangun pagi lebih pendek dibandingkan sebelum tidur malam hari. Kata kunci: tinggi badan, sebelum tidur malam hari, setelah bangun pagi


2021 ◽  
Vol 5 (1) ◽  
pp. 82-89
Author(s):  
David Perdana ◽  
Defrin Defrin ◽  
Firdawati Firdawati

The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α


2019 ◽  
Vol 2 (1) ◽  
pp. 16-20
Author(s):  
Gunawan Efri ◽  
Dovy Djanas

Objective: To determine the difference in mean ratio of sodium content between pregnancy with severe preeclampsia and eclampsia.Method: This is an analytical study using a cross sectional study design. The study was conducted inMaternity room of Dr. M. Djamil Padang from January 15th, 2016 to December 31st, 2017, there were 60 patients as subjects, the sample was divided into 2 groups: severe preeclampsia and eclampsia. Furthermore, history and physical examination to obtain data and clinical diagnosis. Data is recorded in a research form that has been provided, then performed blood electrolytes of Sodium and Potassium. Statistical analysis to assess significance using T-test.Results: In the severe preeclampsia and eclampsia, multiparous parity had the highest respondent. This is consistent with the literature in which the incidence of preeclampsia is more common in late pregnancy.Conclusions: There was no significant difference in the mean sodium ratio between normal severe preeclampsia pregnancy and normal pregnancy.Keywords: pregnancy condition, severe preeclampsia, eclampsia, and sodium.


2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.


SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A153-A153
Author(s):  
Goeun Kim ◽  
Hyojin Nam ◽  
Huisu Jeon ◽  
Sooyeon Suh

Abstract Introduction Bedtime Procrastination (BP) is defined as the behavior of voluntarily delaying going to bed, without having external reasons for doing so. Recent research on procrastination behavior suggests that when negative emotions are elevated, procrastination behaviors can be triggered in order to find pleasure to avoid and alleviate them. Procrastination can also occur when there is difficulty regulating emotions. In addition, the reason for bedtime procrastination may be different depending on whether the individuals present with insomnia. According to previous studies, patients with insomnia may exhibit more pronounced negative avoidance of bedtime due to prolonged sleeplessness. Therefore, this study compared the difference between of the bedtime procrastination and the emotional regulation strategies between the insomnia group and the healthy group. Methods This study was conducted in 582 adults (mean age 23.06 ±2.16 years), 81.6% females. Individuals scoring higher than 15 on the Insomnia Severity Index (ISI) were classified into the insomnia group (n=375), and those less than 15 were classified into the healthy group (n=207). Participants completed the Bedtime Procrastination Scale (BPS), Emotional Regulation Strategies Checklist. Data was analyzed using descriptive statistics, chi square test, and independent t tests. Results The insomnia group had significantly higher bedtime procrastination scores than the healthy group (t=-6.241, p&lt;.001), and also the avoidant/distractive regulation style score was significantly higher (t=-1.969, p&lt;.05). In addition, the score of active regulation style was significantly lower in the insomnia group than in the healthy group (t=3.050, p&lt;.01). There was no significant difference between the two groups in the support-seeking regulation style. Conclusion Based on these results, it was confirmed that there was a difference in the bedtime procrastination and the emotional regulation strategies between the insomnia group and the healthy group. Support (if any) This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea(NRF-2018S1A5A8026807)


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