Value agenda for heart failure in Ontario: Application of the Porter model

2017 ◽  
Vol 30 (6) ◽  
pp. 278-282 ◽  
Author(s):  
Rakesh Calton ◽  
Kim de Haan ◽  
Kerrie Dewachter ◽  
Susan Komhyr Smith

Value in healthcare is a challenge that is faced all over the world; costs continue to rise despite efforts to increase quality and efficient healthcare delivery. Heart failure is a progressive chronic condition that has been demonstrated to benefit from close monitoring with positive effects on mortality and morbidity when well managed. This article will review the Porter model for value in healthcare by comparing the current state of heart failure management in Ontario, Canada, with the six key concepts of the value agenda. The Ontario quality-based procedure model has been implemented for heart failure management and will be applied against the Porter model to provide an increased understanding of how managers can think differently about patient outcomes. An examination as to how the quality and value of the treatment of this condition can be improved will be conducted using the principles of the value agenda.

Author(s):  
V. Pan'kov

In a long historical perspective, the globalization of the economy is, no doubt, the future of the mankind. However, we should not overlook the contradiction that has dramatically intensified as a result of the 2008-2009 recession. This is the contradiction between globalization as an objective process with mostly positive effects and its model that is being implemented today (namely, the policy of globalization). Furthermore, we can propose a number of important arguments in favor of a statement that at the current state of affairs the globalization has exhausted itself. Nobody can exclude a short-term braking down of the globalization progress nor even a U-turn, albeit temporary, to a de-globalization. Under unfavorable circumstances such a reverse movement can cover the entire period up to 2020. The author states that transnational corporations are the main subject of the world economy which will the most actively oppose such a development.


2020 ◽  
pp. 107815522096353
Author(s):  
Hira Shaikh ◽  
Amir Kamran ◽  
Dulabh K Monga

While gastroesophageal (GE) cancers are one of the most common cancers worldwide, unfortunately, the mortality remains high. Commonly used treatment options include surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy, which improve survival only minimally; thus, affirming the dire need for exploring alternative strategies to improve patient outcomes. Immunotherapy, which has revolutionized the world of oncology, has somewhat lagged behind in GE malignancies. Tumor-associated microenvironment and regulatory T cells, alongside cell cycle checkpoints, have been proposed by various studies as the mediators of carcinogenesis in GE cancers. Thus, inhibition of each of these could serve as a possible target of treatment. While the approval of pembrolizumab has provided some hope, it is not enough to override the dismal prognosis that this disease confers. Herein, we discuss the prospects of immunotherapy in this variety of cancer.


2021 ◽  
Vol 4 (12) ◽  
pp. 01-05
Author(s):  
Rodolfo Llamas

Influenza is a common, but serious illness, which has a burden of disease all over the world. It is estimated that there are about 3 to 5 million severe case of the disease that may require hospital admission, and around 290,000 to 650,000 deaths in each seasonal outbreak. The whole population is at risk of becoming ill due to influenza. However, children and patients with chronic illnesses, such as those with cardiovascular diseases or multiple disorders, have a higher risk of developing complications. The prevention of infection due to influenza through vaccination is well known in the childhood population, but also has an important role in the maintenance of health and prevention of mortality and morbidity in patients with cardiovas- cular disease. This is due to known cardioprotective mechanisms, mainly in the prevention of acute myocardial infarction or heart failure. Nowadays, immunization must be included in the comprehensive secondary prevention in these patients


2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
M. Demede ◽  
A. Pandey ◽  
L. Innasimuthu ◽  
G. Jean-Louis ◽  
S. I. McFarlane ◽  
...  

Hypertension (HTN) is the most common co-morbidity in the world, and its sequelae, heart failure (HF) is one of most common causes of mortality and morbidity in the world. Current understanding of pathophysiology and management of HTN in HF is mainly based on studies, which have mainly included whites. Among racial groups, African-American adults have the highest rates (44%) of hypertension in the world and are more resistant to treatment. There is an emerging consensus on the significance of racial disparities in the pathophysiology and treatment options of hypertension and heart failure. However, African Americans had been underrepresented in all the trials until the initiation of the A-HEFT trial. Since the recognition of obstructive sleep apnea (OSA) as an important medical condition, large clinical trials have shown benefits of OSA treatment among patients with HTN and HF. This paper focuses on the pathophysiology, causes of secondary hypertension, and treatment of hypertension among African-American patients with heart failure. There is increasing need for randomized clinical trials testing innovative treatment options for African-American patients.


2021 ◽  
Author(s):  
Fatima Zahra Merzouk ◽  
Sara Oualim ◽  
Mohammed Sabry

Peripartum cardiomyopathy (PPCM) is the most common cardiomyopathy in pregnancy. It is potentially life-threatening. It is, diagnosed in women without a history of heart disease 1 month before delivery or within 5 months. It is marked by heart failure and left ventricular dyshfunction. The evolution is favorable. LV function improves within 6 months in the majority of patients, but long-lasting mortality and morbidity are not infrequent. Recent work suggests the critical toxic role for late-gestational hormones on the maternal vasculature and the genetic underpinnings of PPCM. Complications include different types of supraventricular and ventricular arrhythmias, heart failure and ischemic stroke. The brain natriuretic peptide (BNP) can be used to risk stratify women for adverse events. Management of peripartum cardiomyopathy is based on treatment of heart failure. The addition of bromocriptine seemed to improve LVEF. Close monitoring of pregnant women with cardiomyopathy by multidisciplinary team is recommended.


2021 ◽  
Vol 23 (Supplement_E) ◽  
pp. E19-E24
Author(s):  
Antonio L Bartorelli ◽  
Cristina Ferrari ◽  
Paolo Olivares ◽  
Giovanni Monizzi ◽  
Luca Grancini

Abstract Tricuspid regurgitation (TR) is common in patients with left-sided valvular heart disease and is independently associated with increased mortality and morbidity because it leads to right-sided heart failure and recurrent hospitalization. The prognostic benefit of isolated TR surgical repair or replacement is unclear and medical treatment of decompensated right heart failure alone does not prevent the progression of the disease. Recently, minimal invasive catheter-based techniques have emerged as a feasible and effective option for TR treatment in selected high-risk patients who would clinically benefit from tricuspid valve repair. We provide an overview of the current state of transcatheter TR treatment using the edge-to-edge technique.


2016 ◽  
Vol 2016 (3) ◽  
Author(s):  
Leslie W Miller

Cardiovascular disease (CVD) remains the leading cause of death as well as morbidity in the world. While there has been continued progress in reducing the mortality of most forms of CVD, the prevalence, as well as mortality and morbidity from heart failure, continues to increase, making it a major health care problem world wide. This increase in prevalence is in part due to the correlation of increasing CVD with advancing age, but also to improved diagnostics and earlier detection as well as improved interventions for acute MI and medical management. Despite these advances, an increasing number of patients become unresponsive to therapy and progress to the advanced stage, which has a mortality as high as 70–80% at one year. 


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