Recent development on physical and biological properties of chitosan-based composite films with natural extracts: A review

2021 ◽  
pp. 088391152110142
Author(s):  
Lutfor Rahman ◽  
Jutika Goswami
Keyword(s):  
Molecular Weight ◽  
Biological Activities ◽  
Composite Films ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Promising Candidate ◽  
Natural Extracts ◽  
Biocomposite Films ◽  
Recent Developments ◽  
Biomedical Fields

Being credited with the most extensively studied polysaccharide polymer and promising candidate for versatile applications, chitosan has proved to be a standalone material with loads of diversified properties in various structural forms such as blends and composites. Considering the abundance of this biopolymer and its non-toxic nature, exploiting chitosan offers two-folded benefits – environment friendliness and fabrication as per the need. Alkaline deacetylation of chitin produces chitosan as a polymer that can be tuned to a great extent as per the requirement by altering the degree of deacetylation (DDA) and molecular weight (MW). This biopolymer has been widely investigated for potential application in the food and biomedical fields due to its antimicrobial and antibacterial properties. Chitosan based composite films incorporated with different natural extracts have shown significant enhancement in the physical and biological activities as reported by different studies. The current study reviews recent developments and investigations of chitosan based biocomposite films incorporated with different natural extracts emphasizing on the improvement of physical and biological properties and its applications.

scholarly journals Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Nattaphop Noothuan ◽  
Kantamas Apitanyasai ◽  
Somsak Panha ◽  
Anchalee Tassanakajon
Keyword(s):  
Biological Activities ◽  
Protein Pattern ◽  
Protein Profile ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Specific Protein ◽  
Land Snails ◽  
Snail Species ◽  
Significant Difference ◽  
Different Types

Abstract Objective Snails secrete different types of mucus that serve several functions, and are increasingly being exploited for medical and cosmetic applications. In this study, we explored the protein pattern and compared the biological properties of the mucus secreted from the mantle collar and foot of two snail species, Lissachatina fulica and Hemiplecta distincta. Result Protein profile showed a different pattern between the two species and between the two secretory parts. The mantle-specific protein bands were further characterized and among them was an antibacterial protein, achacin. Accordingly, the mucus from the mantle exhibited the higher antibacterial activity than that from the foot in both snail species. The mucus from H. distincta, first reported here, also showed antibacterial properties, but with a lower activity compared to that for L. fulica. Snail mucus also exhibited anti-tyrosinase activity and antioxidant activity but with no significant difference between the foot and mantle mucus. These results indicate some different protein compositions and biological activities of snail slime from the mantle and foot, which might be associated with their specific functions in the animal and are useful for medical applications.

Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones

2021 ◽  
Vol 18 ◽  
Author(s):  
Vitor F. Ferreira ◽  
Alcione S. de Carvalho ◽  
David R. da Rocha
Keyword(s):  
Molecular Weight ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Biological Properties ◽  
Low Molecular Weight ◽  
Biological Targets ◽  
Sulfur Heterocycles

: The subclass of compounds that have the nucleus 1,4-naphthoquinone is the most diverse of the class of quinones, which have a large number of substances and several that have useful applications ranging from medicinal chemistry to application in materials with special properties. The introduction of one or two substituents with the sulfur heteroatom in the naphthoquinone nucleus generates products containing alkyl and aryl groups that amplify certain biological properties against bacteria, viruses and fungi. There are several methods of preparing these compounds, mainly from low molecular weight naphthoquinones with two electrophilic sites capable of reacting with sulfides generating diversity and new classes of compounds, including new sulfur heterocycles and sulfur heterocycles fused with naphthoquinones. These compounds have been shown to be bioactive against several biological targets. This review will describe the methods of their synthesis and, when applicable, their biological activities.

scholarly journals The Effects of Silver Nanoparticles Compositions on the Mechanical, Physiochemical, Antibacterial, and Morphology Properties of Sugar Palm Starch Biocomposites for Antibacterial Coating

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2605 ◽  
Author(s):  
A. Rozilah ◽  
C. N. Aiza Jaafar ◽  
S. M. Sapuan ◽  
I. Zainol ◽  
R. A. Ilyas
Keyword(s):  
Silver Nanoparticles ◽  
Composite Films ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Microscopic Analysis ◽  
Decomposition Temperature ◽  
Gravimetric Analysis ◽  
Ftir Analysis ◽  
Antibacterial Coatings ◽  
Biocomposite Films

Antibacterial sugar palm starch biopolymer composite films were developed and derived from renewable sources and inorganic silver nanoparticles (AgNPs) as main ingredients for antibacterial coatings. The composite films were produced by solution casting method and the mechanical and physicochemical properties were determined by tensile test, Fourier Transform Infrared (FTIR) analysis, thermal gravimetric analysis (TGA), antibacterial screening test and field emission scanning electron microscopy (FESEM) images. It was found that mechanical and antibacterial properties of biocomposite films were improved after the addition of AgNPs compared with the film without active metals. The weakness of neat biocomposite films was improved by incorporating inorganic AgNPs as a nanofiller in the films’ matrix to avoid bacterial growth. The results showed that the tensile strength ranged between 8 kPa and 408 kPa and the elasticity modulus was between 5.72 kPa and 9.86 kPa. The addition of AgNPs in FTIR analysis decreased the transmittance value, caused small changes in the chemical structure, caused small differences in the intensity peaks, and produced longer wavelengths. These active films increased the degradation weight and decomposition temperature due to the more heat-stable AgNPs. Meanwhile, the average inhibited areas measured were between 7.66 and 7.83 mm (Escherichia coli), 7.5 and 8.0 mm (Salmonella cholerasuis), and 0.1 and 0.5 mm for Staphylococcus aureus. From the microscopic analysis, it was observed that the average size of all microbes for 1 wt% and 4 wt% AgNPs ranged from 0.57 to 2.90 mm. Overall, 3 wt% AgNP nanofiller was found to be the best composition that fulfilled all the mechanical properties and had better antimicrobial properties. Thus, the development of an organic-inorganic hybrid of antibacterial biopolymer composite films is suitable for antibacterial coatings.

scholarly journals Snail Mucus From the Mantle and Foot of Two Land Snails, Lissachatina Fulica and Hemiplecta Distincta, Exhibits Different Protein Profile and Biological Activity

2021 ◽  
Author(s):  
Nattaphop Noothuan ◽  
Kantamas Apitanyasai ◽  
Somsak Panha ◽  
Anchalee Tassanakajon
Keyword(s):  
Biological Activities ◽  
Protein Pattern ◽  
Protein Profile ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Specific Protein ◽  
Land Snails ◽  
Snail Species ◽  
Significant Difference ◽  
Different Types

Abstract Objective: Snails secrete different types of mucus that serve several functions, and are increasingly being exploited for medical and cosmetic applications. In this study, we explored the protein pattern and compared the biological properties of the mucus secreted from the mantle collar and foot of two snail species, Lissachatina fulica and Hemiplecta distincta.Result: Protein profile showed a different pattern between the two species and between the two secretory parts. The mantle-specific protein bands were further characterized and among them was an antibacterial protein, achacin. Accordingly, the mucus from the mantle exhibited the higher antibacterial activity than that from the foot in both snail species. The mucus from H. distincta, first reported here, also showed antibacterial properties, but with a lower activity compared to that for L. fulica. Snail mucus also exhibited anti-tyrosinase activity and antioxidant activity but with no significant difference between the foot and mantle mucus. These results indicate some different protein compositions and biological activities of snail slime from the mantle and foot, which might be associated with their specific functions in the animal and are useful for medical applications.

Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives

2019 ◽  
Vol 16 (1) ◽  
pp. 17-37 ◽  
Author(s):  
Jaskirat Kaur ◽  
Divya Utreja ◽  
Ekta ◽  
Nisha Jain ◽  
Shivali Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Microbial Activity ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Indole Derivatives ◽  
Antimicrobial Drugs ◽  
Wide Range ◽  
Recent Developments

Background:Heterocyclic compounds containing nitrogen have been known to possess a very important role in the field of medicinal chemistry. Indole and its derivatives displayed a wide range of biological properties such as anti-inflammatory, analgesic, anti-microbial, anti-convulsant, antidepressant, anti-diabetic, antihelmintic and anti-allergic activities etc. The diverse biological activities exhibited by compounds containing indole moiety has provided the impetus to explore its anti-microbial activity in order to save the valuable life of patients. </P><P> Objective: The review focuses on the advances in the synthesis of indole derivatives and antimicrobial properties exhibited by them.Conclusion:A great deal of work has been done in order to synthesize indole derivatives and to evaluate antimicrobial potential, as indicated by the review. The information provided in this article may be helpful for the researchers for the development of efficient antimicrobial drugs.

Comparison the Physical and Antimicrobial Properties of Poly(Lactic Acid) Film and its Composites with ZnO Nanoparticles

2018 ◽  
Vol 772 ◽  
pp. 100-104
Author(s):  
Tongsai Jamnongkan ◽  
Nareerat Kamlong ◽  
Nicha Thiangtrong ◽  
Rattanaphol Mongkholrattanasit
Keyword(s):  
Composite Films ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Poly Lactic Acid ◽  
Solvent Casting ◽  
Bacterial Strains ◽  
Zno Nps ◽  
Casting Technique ◽  
Good Antibacterial Activity ◽  
Biocomposite Films

Polylactic acid (PLA) is a bioplastic, which is produced from natural materials. It is well known that the PLA can be degraded in the environment which is alternatively rendered to replace the plastic from a petroleum base. In this paper, we study the physical properties of composite films prepared from PLA composited with zinc oxide nanoparticles (ZnO NPs) by using solvent casting technique. It was found that the ZnO NPs have affected to the morphological, water absorbency, mechanical and antibacterial properties of biocomposite films. In addition, we also found that the particles of ZnO NPs can disperse within the PLA matrices, which enhanced the stress and Young’s modulus of biocomposite films. Additionally, the result shown that the PLA/ZnO NPs films exhibit good antibacterial activity both in Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains.

scholarly journals Changes in Physicochemical and Biological Properties of Polyphenolic-Protein-Polysaccharide Ternary Complexes from Hovenia dulcis after In Vitro Simulated Saliva-Gastrointestinal Digestion

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2322
Author(s):  
Ding-Tao Wu ◽  
Yuan He ◽  
Meng-Xi Fu ◽  
Ren-You Gan ◽  
Yi-Chen Hu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Biological Activities ◽  
In Vitro Digestion ◽  
Biological Properties ◽  
Inhibitory Effects ◽  
Gastrointestinal Digestion ◽  
Sugar Release ◽  
Physicochemical And Biological Properties ◽  
Hovenia Dulcis

The present study aimed to explore the impacts of in vitro simulated saliva-gastrointestinal digestion on physicochemical and biological properties of the polyphenolic-protein-polysaccharide ternary complex (PPP) extracted from Hovenia dulcis. The results revealed that the in vitro digestion did remarkably affect physicochemical properties of PPP, such as content of reducing sugar release, content of bound polyphenolics, and molecular weight distribution, as well as ratios of compositional monosaccharides and amino acids. In particular, the content of bound polyphenolics notably decreased from 281.93 ± 2.36 to 54.89 ± 0.42 mg GAE/g, which might be the major reason for the reduction of bioactivities of PPP after in vitro digestion. Molecular weight of PPP also remarkably reduced, which might be attributed to the destruction of glycosidic linkages and the disruption of aggregates. Moreover, although biological activities of PPP obviously decreased after in vitro digestion, the digested PPP (PPP-I) also exhibited remarkable in vitro antioxidant and antiglycation activities, as well as in vitro inhibitory effects against α-glucosidase. These findings can help to well understand the digestive behavior of PPP extracted from H. dulcis, and provide valuable and scientific supports for the development of PPP in the industrial fields of functional food and medicine.

A Review: The Anti-inflammatory, Anticancer and Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice

2020 ◽  
Vol 27 (12) ◽  
pp. 1997-2011 ◽  
Author(s):  
Ze-Feng Wang ◽  
Jia Liu ◽  
Yong-An Yang ◽  
Hai-Liang Zhu
Keyword(s):  
Organic Chemistry ◽  
Mechanism Of Action ◽  
Biological Activities ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Licorice Root ◽  
Chemical Components ◽  
Pharmacological Activities ◽  
Active Compounds ◽  
Anti Inflammatory

: Plants have always been an important source of medicines for humans, and licorice is a very significant herb in the development of humans. As a traditional herb, it is widely cultivated in China, Japan, Russia, Spain and India. With the development of organic chemistry and biochemistry, various chemical ingredients extracted from licorice have been studied and identified. Among them, many chemical components were considered to have strong pharmacological activities, such as anti-inflammatory, anti-ulcer, antibacterial, anticancer and so on. Based on those reports, licorice has attracted the attention of many researchers in recent years, and they are devoted to discovering the active ingredients and mechanism of action of active compounds. Licorice flavonoids are one of the main extracts of licorice root and stem and have many potential biological properties. This paper aims to summarize the four kinds of licorice flavonoids, including liquiritigenin, isoliquiritigenin, licochalcone (including licochalcone A and licochalcone B) and glabridin, about their biological activities of anti-inflammatory, anticancer, antibacterial.

Circulating Activities During Constant Infusion of Heparin or a Low Molecular Weight Derivative (Enoxaparine): Failure to Demonstrate any Circadian Variations

1987 ◽  
Vol 58 (04) ◽  
pp. 1068-1072 ◽  
Author(s):  
P Toulon ◽  
J F Vitoux ◽  
C Leroy ◽  
T Lecomte ◽  
M Roncato ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Circadian Rhythm ◽  
Biological Activities ◽  
Constant Infusion ◽  
Low Molecular Weight ◽  
Circadian Variations ◽  
Heparin Cofactor Ii ◽  
Heparin Infusion ◽  
Chromogenic Assay ◽  
Heparin Affinity

SummaryWe compared in six patients successively treated with an unfractionated heparin (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa activity, measured in a chromogenic assay, during a 36 h constant infusion. The values varied in a wider range during UHF infusion, but remained in the therapeutic range except once in one patient. No circadian rhythm could be demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa circulating activities. In both cases, there were no significant modifications of three proteins with high heparin affinity (antithrombin III, heparin cofactor II, histidine-rich glycoprotein).Our results suggest that the circadian rhythm of the biological activities previously observed in patients treated with constant heparin infusion using clotting method is due to other factors than heparin itself.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

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