Changes in Lipid Profile by Vegetable Oil Blends Rich in Polyunsaturated Fatty Acids in Rats with Hypercholesterolemia

2009 ◽  
Vol 15 (2) ◽  
pp. 119-130 ◽  
Author(s):  
M.F. Ramadan ◽  
M.M. Afify Amer ◽  
S.S. El-Saadany ◽  
R. Abd El-Fatah El-Masry ◽  
A. El-Said Awad
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Lipid Profile ◽  
Vegetable Oils ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Oil Blends

The objective of this study was to investigate the effect of different blended vegetable oils having different levels and profiles of polyunsaturated fatty acids (PUFA) on hypercholesterolemia by analyzing the changes in lipid profile in high-cholesterol diet fed rats. Three vegetable oils (soy oil, sunflower oil, and the nonconventional flaxseed oil) were blended to obtain blends rich in PUFA. Thirty albino rats were used over the 2-month period. The animals were divided into five groups, wherein group 5 represents negative control, where rats were fed basal diet, while rats in group 4 received high cholesterol diet and served as positive controls. The other three groups were fed hypercholesterolemic diet (1% cholesterol + 0.25% colic acid) supplemented with blended oils. Generally, rats fed blended oils showed significantly lower levels of total cholesterol (TC), triacylglycerol (TG), and low-density lipoprotein (LDL) cholesterol as well as higher levels of high-density lipoprotein (HDL) cholesterol, in comparison with animals fed high-cholesterol diet and cholesterol-free diet. Thus, oil blends under study may be useful formulations for the treatment of hypercholesterolemia. In addition to improving the lipid profile by lowering TC, total TG, and total LDL and increasing HDL, blending of vegetable oils can result in an economic advantage of lower prices.

scholarly journals Antioxidant and Hypolipidemic Effects of Ipomoea batatas L and Pandanus conoideus Lam Combination on Rats Fed with High Cholesterol Diet

2021 ◽  
Vol 9 (A) ◽  
pp. 473-476
Author(s):  
A. A. Ngurah Subawa ◽  
I Wayan Putu Sutirta Yasa ◽  
I Made Jawi ◽  
Agung Nova Mahendra
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Ipomoea Batatas ◽  
Single Agent ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

BACKGROUND: Chronic hypercholesterolemia is an important predisposing factor of cardiovascular diseases. The underlying process is commonly associated with oxidative stress. AIM: This study aimed to evaluate the effects of Ipomoea batatas (IB) L tablet and Pandanus conoideus (PC) Lam extract against oxidative stress and lipid profile in rats. METHODS: This study used a pre- and post-test control group design. Wistar male rats were randomized into four groups consisting of seven rats each. The groups were control group, PC Lam extract 0.4 cc/rat/day (PC group), IB L tablet 200 mg/rat/day (IB group), and PC 0.2 cc+IB 200 mg/rat/day (PC+IB group). All groups were received high cholesterol diet for 4 weeks. The blood samples at baseline and the end of this study were used for the lipid profile, superoxide dismutase (SOD), and malondialdehyde (MDA) examination. The result was then analyzed with an Analysis of Variance test. RESULTS: There were significant differences in changes of total cholesterol, Low-density lipoprotein, triglycerides, high-density lipoprotein, MDA, and SOD in the treatment group (PC, IB, PC+IB) compared to the control (p < 0.001). The decrease of MDA and increase of SOD were mainly found in the PC+IB group compared to the PC group and IB group (p < 0.05). The changes in lipid profiles were mainly found in the PC+IB group and PC group compared to the IB group (p < 0.05). CONCLUSION: Administration of PC and IB combination is an effective hypolipidemic agent. This combination has superior antioxidant activity compared to the single-agent (PC or IB) and control.

Emodin alleviated hyperlipidemia and hepatic lipid metabolism in zebrafish larvae fed a high-cholesterol diet via AMPK/SREBP-2/PCSK9/LDLR signaling pathway

2021 ◽  
Author(s):  
Linfeng He ◽  
Cheng Wang ◽  
Yafang Zhang ◽  
Chaocheng Guo ◽  
Yan Wan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Cholesterol Diet ◽  
Low Density ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Accumulation ◽  
Hepatic Lipid ◽  
Zebrafish Larvae

Abstract BackgroundEmodin (EM) is one of bioactive components extracted from Rheum palmatum L. (Dahuang), which possesses numerous pharmacological activities including hypolipidemic effect. However, the potential action of EM on hyperlipidemia (HLP) remains unclear. Here, the theraputic effect of EM against HLP were investigated.MethodsIn this study, the hypolipidemic properties of EM were evaluated using high-cholesterol diet (HCD)-stimulated zebrafish larvae model. The body weight, body length and body mass index (BMI) was measured. The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) as well as the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected by corresponding assay kits. Tg (flil: eGFP) zebrafish were utilized to observe vascular cholesterol accumulation and Tg (mpx: eGFP) zebrafish to visualize and quantify neutrophil inflammation. The hepatic lipid deposition and hepatic histopathology were analyzed by Oil red O staining and H&E staining, respectively. Finally, the underlying mechanism of EM were investigated using real-time quantitative PCR (RT-qPCR) analysis to assess the gene levels of adenosine monophosphate-activated protein kinase alpha (AMPKα), sterol regulatory element binding protein 2 (SREBP-2), proprotein convertase subtilisin kexin 9 (PCSK9), low-density lipoprotein receptor (LDLR), 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), adenosine triphosphate binding cassette transporter A1 (ABCA1) and adenosine triphosphate binding cassette transporter G1 (ABCG1).ResultsOur data indicated that EM reduced obesity of zebrafish as evidenced by the decrease in body weight, body length and BMI. EM significantly reduced TC, TG, and LDL-C, and increased HDL-C contents. Moreover, it displayed a prominent inhibitory effect on blood cholesterol accumulation, hepatic lipid accumulation, and neutrophil inflammation in vascular site. Additionally, EM improved the liver function through decreasing ALT and AST levels of zebrafish with HCD-induced hepatosteatosis. Further investigation showed that EM treatment attenuated lipid accumulation via upregulating the expression of AMPKα, LDLR, ABCA1 and ABCG1, and downregulating the expression of SREBP-2, PCSK9 and HMGCR.ConclusionTo conclude, EM alleviated lipid metabolism disorder symptoms caused by HCD via modulating AMPK/SREBP-2/PCSK9/LDLR pathway in larvae, suggesting that EM may be developed into hypolipidmic agent for treating lipid metabolism related diseases.

scholarly journals Anti-hyperlipidemic effect of crude methanolic extracts of Glycine max (soy bean) on high cholesterol diet-fed albino rats

2017 ◽  
pp. 1 ◽  
Author(s):  
Uchendu Kingsley ◽  
Onwukwe Steven ◽  
Chidozie Agu ◽  
Oliver Orji ◽  
Blessing Chekwube ◽  
...  
Keyword(s):  
Glycine Max ◽  
Albino Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Methanolic Extracts

scholarly journals Evaluation of the Hypocholesterolemic Effect and Phytochemical Screening of the Hydroethanolic Extract of Crataegus Aronia from Jordan

2012 ◽  
Vol 7 (1) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Entisar K. Al-Hallaq ◽  
Fatma U. Afifi ◽  
Shtaywy S. Abdalla
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Cholesterol Diet ◽  
Hypocholesterolemic Effect ◽  
Cholesterol Diet ◽  
Phytochemical Screening ◽  
High Cholesterol ◽  
Chemical Screening ◽  
Hydroethanolic Extract ◽  
First Time

Chemical screening of the leaves and flowers of Crataegus aronia resulted in the isolation of hyperoside, quercetin, rutin and β-sitosterol for the first time from this plant. The effects of the hydroethanolic extract of C. aronia (CAHE) on hypercholesterolemic rats were investigated. The rats, treated orally for four weeks with 400 mg/kg/day CAHE, exhibited significant decreases in serum total cholesterol (TC) and low-density lipoprotein (LDL). The results were compared with those obtained after oral administration of atorvastatin (10 mg/kg/day). Furthermore, 10-week daily co-administration of a high cholesterol diet and CAHE (200 mg/kg/day) prevented the increase in TC and LDL. These observations indicate that CAHE has a hypocholesterolemic effect.

In vitro and in vivo cholesterol lowering ability of Lactobacillus pentosus KF923750

2017 ◽  
Vol 8 (2) ◽  
pp. 271-280 ◽  
Author(s):  
F. Bendali ◽  
K. Kerdouche ◽  
S. Hamma-Faradji ◽  
D. Drider
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lactobacillus Pentosus ◽  
Survival Percentage

Lactobacillus pentosus KF923750 was characterised for probiotic related properties and then characterised for cholesterol uptake in vitro as well as in vivo using rabbits fed a high-cholesterol diet. The survival percentage of L. pentosus KF923750 was 100% at pH 3, 52.18% at pH 2 and 36.21% at pH 2 plus pepsin. Similarly, this strain appeared resistant to bile (0.1% [98.42%], 0.3% [88.52%], 0.5% [75.60%] and 1% [71.15%]), after 4 h exposure. Moreover, L. pentosus KF923750 controlled growth of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 through the production of a bacteriocin-like inhibitory substance and anti-adhesive capabilities. L. pentosus KF923750 was non-cytotoxic to eukaryotic cells but sensitive to some antibiotics. Compared with rabbits fed a high-cholesterol diet but without L. pentosus KF923750 supplementation, the plasma total cholesterol, low-density lipoprotein cholesterol and triglycerides levels were significantly decreased in L. pentosus KF923750-fed rabbits by 11.54, 16.00 and 18.00%, respectively, with no significant change in high-density lipoprotein cholesterol levels. The histological sections of livers revealed lesions in all the rabbits that were fed a high-cholesterol diet, but these were less pronounced in rabbits ingesting L. pentosus KF923750. This study highlights the potential of lactobacilli, such as L. pentosus KF923750, in the treatment or prevention of hypercholesterolemia.

scholarly journals Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet

2020 ◽  
Vol 10 (1-s) ◽  
pp. 178-181
Author(s):  
Ikenna Kingsley Uchendu ◽  
Ifeoma Blessing Ekeigwe ◽  
Ebuka Bitrus Nnedu
Keyword(s):  
Biochemical Markers ◽  
Curcuma Longa ◽  
Density Lipoprotein ◽  
Negative Control ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Muscle Fibres ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cardioprotective Effects

Objective: The aim of this study is to evaluate the antidyslipidaemic and cardioprotective effects of aqueous extract of Curcuma longa (AECL) in rats fed a high cholesterol diet (HCD). Methods: Twenty (20) rats were randomly grouped into four groups: A-D of five animals per group. Groups A-C received HCD (2000mg/kg, oral) and carbimazole (60mg/kg, oral) daily for eight weeks. Group A served as negative control. Group B (positive control) was treated with atorvastatin (20mg/kg), while group C served as treatment group and received AECL (400mg/kg) daily for eight weeks. Group D served as normal control and received no treatment. After the administration, biochemical markers of Lipid profiles (total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C)) were assayed using standard methods. The hearts of the rats were harvested for histopathological studies. Results: AECL significantly induced hypolipidaemia and stabilized lipid biochemical markers (p<0.05 or p<0.01); and protected the cardiac muscle fibres from injuries. Conclusion: Tumeric (Curcuma longa) has antidyslipidaemic and cardioprotective effects. Keywords: antidyslipidaemia, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemia, Medicinal foods, cardiomyopathy

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