Mixed chorangioma and leiomyoma of the placenta, with a brief review of nontrophoblastic placental lesions

2021 ◽  
pp. 109352662110477
Author(s):  
Stacy D. Webb ◽  
Maria Paola Bonasoni ◽  
Andrea Palicelli ◽  
Giuseppina Comitini ◽  
Debra S. Heller
Keyword(s):  
Smooth Muscle ◽  
Intrauterine Growth Restriction ◽  
Immunohistochemical Staining ◽  
Unusual Case ◽  
Common Type ◽  
Maternal Origin ◽  
Maternal Complications ◽  
Intrauterine Growth ◽  
Vascular Proliferation ◽  
Characteristic Features

Chorangioma is the most common type of primary non-trophoblastic tumor of the placenta, usually identified incidentally on ultrasound or at delivery. Leiomyomas within the placenta have been described, though they are rare and usually of maternal origin. We present an unusual case of a placental tumor with combined histopathologic and immunohistochemical features of both chorangioma and leiomyoma. A 39-year-old woman was found to have an echogenic placental mass at 33 weeks of gestation on ultrasound, that was thought to be a chorangioma. They followed up weekly, and performed a cesarean section at 39 weeks, due to concern for intrauterine growth restriction. No fetal or maternal complications occurred. Grossly, a 9-cm, red-brown mass with a broad-based stalk was identified on the fetal surface of the placenta near the periphery. Microscopically, the lesion was found to display characteristic features of chorangioma, with vascular proliferation, which stained positive for CD34 and CD31. SMA and caldesmon immunohistochemical staining was also positive, highlighting the proliferation of smooth muscle throughout the neoplasm. Literature review revealed a single additional case with similar characteristics.

scholarly journals UTERINE ARTERY DOPPLER INDICES AS PREDICTIVE MEASURES FOR THE PRE-ECLAMPSIA AND INTRAUTERINE GROWTH RESTRICTION

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
MN Rashid ◽  
M Kari ◽  
R Rashid ◽  
MA Rana ◽  
A Amjad ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Uterine Artery ◽  
Growth Restriction ◽  
Cross Sectional Survey ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Uterine Artery Doppler ◽  
Intrauterine Growth ◽  
Pregnant Females ◽  
Doppler Indices

Preeclampsia and Intrauterine growth restriction (IUGR) remains as the important causes for the neonatal and maternal complications leading to even death in some cases. Uterine artery Doppler USG can be done transvaginally or trans abdominal and performed in the 1st or 2nd trimester of the pregnancy to detect these complications Doppler waveform suggested the high vascular resistance to blood flow. In our present study, we conclude uterine artery Doppler indices as prognostic procedure for the preeclampsia and intrauterine growth restriction. A cross-sectional survey design with convenient sampling technique was used. Mixture of standardized and self-modified structured questionnaire was undertaken to determine the indices of pre eclampsia and IUGR by uterine artery. The data was collected from Bahria International Hospital, Lahore during the period of 9 months. This study was included 162 pregnant females with identification of the main uterine artery on a longitudinal scan lateral to the uterus.  Initial diastolic notch of right and left side of the uterine artery waveforms was recorded. At every antenatal checkup, urine was tested for protein and blood pressure readings were taken to identify preeclampsia. Further analysis was done dividing patients as normotensive and those patients developing hypertension after 30 weeks of gestation. After delivery neonates observed for IUGR by head circumference and body weight. The study was concluded that from the total sample size of 162 pregnant females who undergoes uterine artery Doppler, 34% females shows diastolic notch and almost all of these later diagnosed with preeclampsia and 19.8% deliver babies with IUGR. So, based on the study, we have concluded that uterine artery Doppler is helpful to provide diagnosis of preeclampsia and IUGR in early pregnancy.

scholarly journals Fetal Toxicity of Immunosuppressive Drugs in Pregnancy

2018 ◽  
Vol 7 (12) ◽  
pp. 552 ◽  
Author(s):  
Claudio Ponticelli ◽  
Gabriella Moroni
Keyword(s):  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Immunosuppressive Treatment ◽  
Immunosuppressive Drugs ◽  
Biologic Agents ◽  
Maternal Complications ◽  
Careful Planning ◽  
Intrauterine Growth ◽  
Fetal Toxicity ◽  
In Pregnancy

Women affected by autoimmune diseases, organ transplantation, or neoplasia need to continue immunosuppressive treatment during pregnancy. In this setting, not only a careful planning of pregnancy, but also the choice of drugs is critical to preventing maternal complications and minimizing the fetal risks. Some immunosuppressive drugs are teratogenic and should be replaced even before the pregnancy, while other drugs need to be managed with caution to prevent fetal risks, including miscarriage, intrauterine growth restriction, prematurity, and low birth weight. In particular, the increasing use of biologic agents raises the question of their compatibility with reproduction. In this review we present data on the indication and safety in pregnancy of the most frequently used immunosuppressive drugs.

Effect of Aspirin Dose on Preeclampsia Prevention and Fetal-maternal Complications: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Chamani ◽  
Saeid Shahrabi ◽  
Ali Malmir ◽  
Fereshteh Hassanzadeh
Keyword(s):  
Clinical Trial ◽  
Intrauterine Growth Restriction ◽  
Developmental Disorders ◽  
Treatment Process ◽  
Fetal Death ◽  
The Other ◽  
Intrauterine Fetal Death ◽  
P Value ◽  
Maternal Complications ◽  
Intrauterine Growth

Background: Preeclampsia (PE) is a disease characterized by abnormalities in the placenta and endothelial cells. The pathogenesis is not fully understood; however, aspirin prescription can be effective to treat the disease and prevent fetal developmental disorders. Methods: This study was performed as a clinical trial in Shahid Akbrabadi Hospital in Tehran city. Eighty patients participated in two groups (n = 40). The first group of patients received the dose of 80 mg, and the second group received the dose of 160 mg aspirin. Then, the fetal-maternal and treatment process complications were examined in the patients. Results: The results showed that the incidence of fetal-maternal complications, including intrauterine growth restriction (IUGR) and intrauterine fetal death (IUFD) was lower in patients treated with 160 mg aspirin than in the other group, but this difference was not statistically significant (P-value > 0.05). Aspirin complications such as bleeding were more in the second group than in the first one (P-value < 0.05). Conclusions: Although the increasing dose of aspirin reduces fetal-maternal complications in PE patients, the problems such as aspirin-induced bleeding should be considered.

Cardiac Disease complicating Pregnancy: A Tertiary Care Center Experience

2017 ◽  
Vol 3 (2) ◽  
pp. 41-44
Author(s):  
R Nagarathnamma ◽  
C Sarojamma ◽  
P Sneha
Keyword(s):  
Cardiac Disease ◽  
Intrauterine Growth Restriction ◽  
Neonatal Outcome ◽  
Care Center ◽  
Tertiary Care ◽  
Fetal Outcome ◽  
Adverse Outcomes ◽  
Tertiary Care Center ◽  
Maternal Complications ◽  
Intrauterine Growth

ABSTRACT Introduction Cardiac disease in pregnancy is a major problem worldwide, particularly in developing countries. It often poses a difficult clinical scenario with the responsibility of the treating obstetrician also extending to the unborn fetus. In the present study, we aim to know the maternal and fetal outcomes in pregnancies complicated by cardiac disease. Materials and methods All pregnant patients with cardiac disease who delivered at our institution during 2014 to 2016 were evaluated to look for the final pregnancy outcomes. Results Out of 36 study cases, 44.44% had no maternal complications, while 88.89% had good fetal/neonatal outcome. The commonest maternal cardiac complication was sustained tachyarrhythmia/bradycardia followed by pulmonary edema, while intrauterine growth restriction was encountered in fetal outcome. Conclusion Multidisciplinary team management of cardiac disease, led by an experienced obstetrician and cardiologist, reduces the adverse outcomes in pregnancies complicated by cardiac diseases. How to cite this article Sneha P, Sarojamma C, Nagarathnamma R. Cardiac Disease complicating Pregnancy: A Tertiary Care Center Experience. J Med Sci 2017;3(2):41-44.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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