Low Testosterone Levels Are Associated With Poor Peripheral Bone Mineral Density and Quantitative Bone Ultrasound at Phalanges and Calcaneus in Healthy Elderly Men

2014 ◽  
Vol 17 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Jose M. Moran ◽  
Raul Roncero Martin ◽  
Maria Pedrera-Canal ◽  
Javier Alonso-Terron ◽  
Francisco J. Rodriguez-Velasco ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Normal Serum ◽  
Total Serum ◽  
Mineral Density ◽  
Os Calcis ◽  
Healthy Elderly ◽  
The Relationship ◽  
Peripheral Bone

Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men. We examined 162 men aged 65–88 years and assessed total serum T concentrations. Total serum T < 300 ng/dL was used as the threshold for biochemical T deficiency. The sample was divided into low ( n = 66) or normal ( n = 96) T levels; both groups were matched for age, weight, height, and body mass index ( p > .05 for all the comparisons). All measured bone parameters were higher in the normal serum T group ( p < .05). Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and phalangeal pBMD. Our data indicate that T is an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.

scholarly journals The Relationship between Nutrient Patterns and Bone Mineral Density in Postmenopausal Women

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1262 ◽  
Author(s):  
Bolaji Lilian Ilesanmi-Oyelere ◽  
Louise Brough ◽  
Jane Coad ◽  
Nicole Roy ◽  
Marlena Cathorina Kruger
Keyword(s):  
Bone Mineral Density ◽  
Fatty Acids ◽  
Vitamin E ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Health ◽  
Mineral Density ◽  
Omega 6 ◽  
Nutrient Patterns ◽  
The Relationship

In women, the menopausal transition is characterized by acid-base imbalance, estrogen deficiency and rapid bone loss. Research into nutritional factors that influence bone health is therefore necessary. In this study, the relationship between nutrient patterns and nutrients important for bone health with bone mineral density (BMD) was explored. In this cross-sectional analysis, 101 participants aged between 54 and 81 years were eligible. Body composition and BMD analyses were performed using dual-energy X-ray absorptiometry (DXA). Nutrient data were extracted from a 3-day diet diary (3-DDD) using Foodworks 9 and metabolic equivalent (MET-minutes) was calculated from a self-reported New Zealand physical activity questionnaire (NZPAQ). Significant positive correlations were found between intakes of calcium (p = 0.003, r = 0.294), protein (p = 0.013, r = 0.246), riboflavin (p = 0.020, r = 0.232), niacin equivalent (p = 0.010, r = 0.256) and spine BMD. A nutrient pattern high in riboflavin, phosphorus and calcium was significantly positively correlated with spine (p < 0.05, r = 0.197) and femoral neck BMD (p < 0.05, r = 0.213), while the nutrient pattern high in vitamin E, α-tocopherol, β-carotene and omega 6 fatty acids was negatively correlated with hip (p < 0.05, r = −0.215) and trochanter BMD (p < 0.05, r = −0.251). These findings support the hypothesis that a nutrient pattern high in the intake of vitamin E, α-tocopherol and omega 6 fatty acids appears to be detrimental for bone health in postmenopausal women.

scholarly journals Exploring the Relationships Among the Inflammatory Potential of the Diet, Bone Mineral Density, and Injury Incidence in Collegiate Athletes (P23-006-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Kiley Field ◽  
John Gieng ◽  
Giselle Pignotti ◽  
Sofia Apsey
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Collegiate Athletes ◽  
Whole Body ◽  
Research Centre ◽  
Injury Incidence ◽  
Mineral Density ◽  
The Relationship ◽  
Prior Injury

Abstract Objectives The relationship between the inflammatory potential of the diet, estimated by the Dietary Inflammatory Index (DII) score, and bone health has been studied in older populations and suggests that the diet can influence bone mineral density (BMD) and fracture risk. These relationships have yet to be explored in other potentially vulnerable populations, such as athletes, where risk of injuries may be more common due to high physical stresses and over-use. The aims of this study were 1) to examine the correlation between DII scores, and BMD in collegiate athletes, and 2) to assess the relationship between DII score and self-reported prior injury incidence. Methods Healthy collegiate athletes (n = 43) were recruited for this study: football, n = 12; men's soccer, n = 2; women's soccer, n = 13; women's swimming, n = 12; and women's basketball, n = 4. For each athlete, three 24-hour dietary intakes were collected using a standardized multiple-pass interview methodology (Nutrition Data System for Research) and this data was used to calculate individual DII scores. Body composition, including whole-body sub-total BMD, was measured using dual-energy X-ray absorptiometry. A modified overuse injury questionnaire (Oslo Sports Trauma Research Centre) was used to assess incidence of injuries in the prior 12 months. Results The participants (n = 14 male, n = 29 female) had a mean age of 19.4 ± 1.1 yrs and BMI of 25.8 ± 4.1 kg/m2. Mean DII score was −0.43 ± 0.17 points (range: −3.94 to 4.34). Mean BMD was 1.251 ± 0.169 g/cm2. Overall, DII score and BMD was not correlated (P = 0.47). Furthermore, DII scores of athletes that reported no prior injury did not differ from those who reported 1 or more injuries. Conclusions Unlike research in postmenopausal women, it appears that bone health of young healthy athletes is less vulnerable to the influence of diets with higher inflammatory potential. Moreover, the lack of difference in DII score among athletes reporting various levels of prior injury suggests that the inflammatory potential of the diet is a poor predictor of injury risk in collegiate athletes. Funding Sources N/A.

Bone health and multiple sclerosis

2012 ◽  
Vol 18 (11) ◽  
pp. 1522-1528 ◽  
Author(s):  
Ruth Dobson ◽  
Sreeram Ramagopalan ◽  
Gavin Giovannoni
Keyword(s):  
Multiple Sclerosis ◽  
Bone Mineral Density ◽  
Clinical Practice ◽  
General Population ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Bone Health ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
The Relationship

People with multiple sclerosis (MS) have many reasons to have low bone mineral density and an increased fracture risk. Osteoporosis is a major cause of morbidity and mortality, and is more common in people with MS than the general population. A number of studies have examined the relationship between multiple sclerosis and reduced bone mineral density. In this topical review we seek to address the risk of low bone mineral density, osteoporosis and fractures associated with MS, and make practical suggestions as to how this pertinent issue may be approached in clinical practice.

scholarly journals SAT0485 PERCENTAGE BODY FAT HAS A STRONGER ASSOCIATION WITH BONE MINERAL DENSITY AT THE HIP AND SPINE COMPARED TO BODY MASS INDEX

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1198.1-1199
Author(s):  
C. Thurston ◽  
R. Tribbick ◽  
J. Kerns ◽  
F. Dondelinger ◽  
M. Bukhari
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Body Mass Index ◽  
Confidence Intervals ◽  
Bone Mineral ◽  
Effect Size ◽  
Bone Health ◽  
P Value ◽  
Mineral Density ◽  
The Relationship

Background:A decreased body mass index (BMI) is associated with poorer bone health, a decreased bone mineral density (BMD), and an increased fracture risk. Cardiovascular (CVS) data has shown that the waist:hip ratio is a more robust measurement for CVS outcomes than BMI (1). Waist:hip ratio has never been evaluated as an outcome measure for bone health. Dual-energy x-ray absorptiometry (DEXA) has the capacity to measure average percentage fat in the L1-L4 region and at the hip, and directly relates to the measurement of waist:hip ratio.Objectives:To evaluate the relationship between BMD and average percent fat in a cohort referred for DEXA scanning.Methods:We analysed data routinely collected from patients referred for DEXA between 2004 and 2010 at the Royal Lancaster Infirmary in the North of England. Data collected for these patients included DEXA scans of BMD at the left and right hip, and at the lumbar spine, as well as average percent far and other risk factors for osteoporosis, including the FRAX risk factors. We used only the measures collected at baseline (time of first scan). We modelled the T scores of the BMD measurements using a linear regression model including percentage fat and BMI as explanatory variables, and adjusting for gender, age at scan, and other known risk factors for osteoporosis, including the FRAX risk factors. BMI and average percent fat were standardised.Results:The number of patients included was 33037, (82% female). Results of both regression models are shown in table 1 below. We show the standardised effect size estimates for average percent fat and BMI.Anatomical locationEffect size estimate for average percent fat (95% confidence intervals)P valueEffect size estimate for BMI (95% confidence intervals)P valueLeft neck-0.156 (-0.171, -0.141)<0.001-0.0255 (-0.0441, -0.00701)0.00692Left total-0.225 (-0.241, -0.208)<0.001-0.0680 (-0.0882, -0.0477)<0.001Left Ward’s-0.181 (-0.196, -0.166)<0.001-0.0268 (-0.0456, -0.00813)0.00493Left trochanter-0.263 (-0.281, -0.246)<0.001-0.0667 (-0.0882, -0.0451)<0.001Right neck-0.139 (-0.154, -0.124)<0.001-0.0131 (-0.0317, 0.00549)0.167Right total-0.221 (-0.237, -0.204)<0.001-0.0611 (-0.0811, -0.0411)<0.001Right Ward’s-0.180 (-0.196, -0.165)<0.001-0.0193 (-0.0381, -0.000586)0.0433Right trochanter-0.261 (-0.278, -0.243)<0.001-0.0598 (-0.0810, -0.0386)<0.001Spine (averaged L1-L4)0.219 (0.195, 0.242)<0.001-0.00846 (-0.0379, 0.0206)0.563Conclusion:The analysis shows that average percent fat is a statistically significant predictor for BMD at different anatomical locations, and a larger predictor in comparison to BMI when evaluated in the same model. In the right hip neck and the spine, BMI was not predictive of changes in BMD. Higher average percent fat increases the BMD in the spine, compared to a decline at the hip. Further research is needed to characterise the relationship more precisely and identify whether there is a causal link.References:[1]Obes Rev. 2012 Mar;13(3):275-86. doi: 10.1111/j.1467-789X.2011.00952.xDisclosure of Interests:None declared

scholarly journals Association of total testosterone status with bone mineral density in adults aged 40–60 years

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Nan Wang ◽  
Lixiang Wang ◽  
Chengcheng Huang
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Population Sample ◽  
Negative Association ◽  
Total Testosterone ◽  
Mineral Density ◽  
Testosterone Levels ◽  
Total Bone Mineral Density ◽  
The Relationship

Abstract Objective Evidence linking total testosterone and bone mineral density (BMD) in adults is very limited. According to our review of the literature, only a few reports have focused on the relationship between total testosterone and bone mineral density in adults. Therefore, the purpose of this study was to determine the relationship between total testosterone and total bone mineral density in adults aged 40–60 years. Methods We used a cross-sectional study of a non-institutionalized U.S. population sample from the National Health and Nutrition Examination Survey. A weighted multivariate linear regression model was used to evaluate the relationship between total testosterone and total bone mineral density. Subgroup analyses were further performed. Results In multiple regression models adjusted for potential confounders, total testosterone levels were inversely associated with total bone mineral density. However, in the sex-stratified subgroup analysis, the association between total testosterone levels and total bone mineral density was not significant in female adolescents. There was no negative association between total testosterone and total BMD among men, adults 40 to 60 years of age, and other racial/ethnic groups. There is a negative association between total testosterone and total bone mineral density when total testosterone concentration is greater than 500 ng/dL among Non-Hispanic black. Conclusion Our statistical results show that the association between total testosterone levels and total bone mineral density varies by gender and race. Elevated total testosterone levels below 500 ng/dL have adverse effects on bone health. Total testosterone concentrations below 500 ng/dL may have no effect on bone health.

scholarly journals The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Magnetic Resonance Images ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
The Relationship

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

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