Renal Protective Effects of a Diet and Exercise Intervention in Type 2 Diabetic Rats

2015 ◽  
Vol 18 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Hua Liang
Keyword(s):  
Blood Glucose ◽  
Exercise Intervention ◽  
Microvascular Complications ◽  
Kidney Tissue ◽  
Protective Effects ◽  
Lipid Levels ◽  
Diet And Exercise ◽  
Diet And Exercise Intervention ◽  
Group D

Purpose: Diabetic nephropathy (DN) is one of the most common diabetic microvascular complications. Inflammatory factors participate in each stage of DN, and nuclear factor (NF)-κB and monocyte chemoattractant protein-1(MCP-1) play important mediation roles. The purpose of this study was to investigate the renal protective effects of a diet and exercise intervention in a rat model of Type 2 diabetes mellitus (T2DM). Method: Control rats (Group A, n = 10) were fed a normal diet, while 30 rats were fed a high-glucose, high-fat diet and given an intraperitoneal injection of streptozocin to establish the T2DM model. Model rats ( n = 8 per group) were randomized into Groups B, C, and D. Groups C and D were treated with glibenclamide, and Group D received an 8-week diet and exercise intervention. Blood, 12-hr urine, and kidney tissue samples were collected postintervention for detecting blood glucose and lipid levels, expression of MCP-1 and NF-κB, and renal function indices. Results: Postintervention, blood glucose, and lipid levels in Groups C and D were lower than those in Group B, with decreases in Group D significantly greater than in Group C. Every index of renal protection showed greater improvement in Group D than in Group C ( p < .05). The expression of NF-κB and MCP-1 was lower in Group D than in Group C ( p < .05). Conclusions: The diet and exercise intervention reduced the inflammatory reaction and delayed T2DM and DN progression by inhibiting the activation of NF-κB and downregulating the expression of MCP-1.

scholarly journals PO-038 Effect of diet and exercise intervention on the treatment of diabetic patients

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Zunhua Xu ◽  
Bin Huang
Keyword(s):  
Blood Glucose ◽  
Exercise Intervention ◽  
Glycosylated Hemoglobin ◽  
Intervention Group ◽  
Nutrition Intervention ◽  
Control Group ◽  
Diabetic Patients ◽  
Group Exercise ◽  
Diet And Exercise ◽  
Diet And Exercise Intervention

Objective To investigate the effect of nutrition and exercise intervention on lowering blood glucose level in type 2 diabetes patients. Methods In Wuhou district of Chengdu and Tianfu New Area, select TongZi Community health service centers and Er Jiang community health service center in patients with type 2 diabetes health management team, the latest Glycosylated Hemoglobin (HbAlc) ≧ 7.4% of the patients as the research object, 592, randomized methods for nutrition intervention group + exercise intervention group, exercise intervention group and control group, each group of about 200 people. Adopt the self-designed questionnaire to collect the general information of patients, including gender, age, culture level, course of the disease and the complications, etc., using the standard method of measurement, the measurement of the patient's body, including blood pressure, heart rate, biochemical tests Glycosylated Hemoglobin (HbAlc) and so on. Patients were followed for one year. At 3, 6 and 12 months, patients were followed up with questionnaires, physical measurements and HbAlc tests Results The patients with 3, 6 and 12 months the total response rate was 98.2%, 99.2% and 98.6%, compared with the baseline, the two intervention groups Glycosylated Hemoglobin (HbAlc) in different periods of follow-up is falling, 6 months is more noticeable, nutrition intervention group + exercise intervention group decreased by 0.44%, movement intervention group decreased by 0.23%, while the control group increased by 0.08%. It can be seen that proper exercise can increase the sensitivity of body tissues to insulin, thus increasing the use of glucose angiosperms and other tissues in blood and lowering blood glucose. Even for individual patients, exercise combined with diet therapy can even stabilize blood glucose at normal levels. Effective exercise and nutrition intervention is an important measure to treat diabetes. Conclusions   The long-term diet and exercise intervention for diabetic patients is not only beneficial to the health of diabetes, but also can significantly improve the quality of life of patients. Effective exercise and nutrition intervention are important measures to treat diabetes.

scholarly journals Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes

Diabetes ◽  
2009 ◽  
Vol 59 (3) ◽  
pp. 627-633 ◽  
Author(s):  
J. B. Albu ◽  
L. K. Heilbronn ◽  
D. E. Kelley ◽  
S. R. Smith ◽  
K. Azuma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Exercise Intervention ◽  
Metabolic Changes ◽  
Diet And Exercise ◽  
Diet And Exercise Intervention

scholarly journals Triphala improves glucose homeostasis by alleviating atherogenic lipids and oxidative stress in human Type 2 diabetes mellitus

2015 ◽  
Vol 6 (3) ◽  
Author(s):  
Nita Singh ◽  
Sunil Mahajan ◽  
Senthil K Subramani ◽  
Dhananjay Yadav ◽  
Lokendra Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Protective Effect ◽  
Tail Length ◽  
Protective Effects ◽  
Lipid Levels

Aims: ‘Triphala’ constituting equal parts of three medicinal dried plant fruits Emblica Officinalis Gaertn., Terminalia chebula Retz. and Terminalia bellerica Gaertn. is an antioxidant rich Ayurvedic formulation. The present study assessed therapeutic as well as protective effects of Triphala on human subjects with Type 2 diabetes mellitus (T2DM) and Impaired glucose tolerance (IGT). Materials and methods: Triphala at a dose of 5 gms BD was administered to two cohorts viz., IGT, N= 20 and T2DM, N=30 consecutively for a period of 12 months. The therapeutic efficacy was assessed quarterly by monitoring blood glucose and lipid levels; the protective effect by monitoring antioxidants level quarterly and DNA damage annually. Toxicity if any, to liver and kidney due to long term administration was assessed quarterly in both cohorts.Results: Continuous ‘Triphala’ therapy for 12 months significantly reduced blood glucose (p≤0.001) and lipid levels (p≤0.05) in both the cohorts. Triphala resisted oxidative stress generated during the course of hyperglycemia by significantly increasing the activity of super oxide dismutase and Catalase (p≤0.001) and the level of reduced glutathione (p≤0.001). Protective effect on DNA was accessed through significant reduction in the comet tail length (p≤0.001).Conclusions: ‘Triphala’ ameliorated not only the oxidative stress but also normalized glucose and lipid homeostasis in subjects with impaired glucose and T2DM. 

scholarly journals Challenges encountered in the Implementation of A Diet and Exercise Intervention for Low-Income Hispanic Older Adults with Diabetes

2020 ◽  
Author(s):  
Joan Vaccaro ◽  
Trudy Gaillard ◽  
Stephanie Caceres ◽  
Monica Hollifield ◽  
Fatma Huffman
Keyword(s):  
Type 2 Diabetes ◽  
Health Beliefs ◽  
Low Income ◽  
Exercise Intervention ◽  
Health Belief ◽  
Grocery Stores ◽  
Diet And Exercise ◽  
Hispanic Adults ◽  
Diet And Exercise Intervention

The purpose of this study was to present the challenges faced when implementing a diet and exercise intervention for low-income older Hispanics with type 2 diabetes with an observational study of recruitment, attendance, and characteristics of Hispanic adults with type 2 diabetes in a community congregate meal site pre and post administration of a diet and exercise intervention. This report evaluates retentions and diabetes self-management beliefs Hispanic adults &ge;60 years with type 2 diabetes (n=17) at baseline, and completion of the six-month intervention in terms of the Health Belief Model. There was limited interest in controlling diabetes with diet and exercise. Major barriers included lack of perceived vulnerability to diabetes complications and a belief that medication alone is sufficient to stabilize blood glucose. Environmental barriers included lack of transportation, access to exercise groups, access grocery stores, and limited ability to pay for healthy foods. A lesson learned from this intervention was that the diet and exercise intervention given was insufficient as a cue to action for this population interventions to engage low-income, older Hispanics with diabetes in diet and exercise need to consider strategies to overcome barriers such as health beliefs, transportation issues, lack of access to nutritious food and group exercise classes.

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