Intraocular light scatter in patients on topical intraocular pressure–lowering medication

2018 ◽  
Vol 28 (6) ◽  
pp. 652-661
Author(s):  
Francisco Pérez-Bartolomé ◽  
Jose María Martínez de la Casa ◽  
Pedro Arriola-Villalobos ◽  
Cristina Fernández-Pérez ◽  
Julián García-Feijoó
Keyword(s):  
Intraocular Pressure ◽  
Light Scattering ◽  
Treatment Duration ◽  
Control Group ◽  
Eye Drops ◽  
Light Scatter ◽  
Non Invasive ◽  
Pressure Lowering ◽  
Breakup Time ◽  
Objective Scatter Index

Purpose: To quantify ocular light scattering in patients under treatment with intraocular pressure–lowering eye-drops. Methods: In this prospective, observational, cross-sectional case series study, 160 eyes of 160 patients with primary open angle glaucoma or primary ocular hypertension were consecutively recruited from our Glaucoma Department over 7 months. In total, 46 eyes of 46 healthy volunteers matched for age and sex served as the control group. The variables recorded in a single visit were as follows: drug and number of drops per day, treatment duration, OXFORD corneal staining grade, lower tear meniscus height as measured by spectral domain optical coherence tomography, ocular redness and non-invasive tear breakup time measured with the Oculus Keratograph 5M, ocular surface disease index questionnaire score and objective scatter index through a double-pass technique (Optical Analysis System II). Results: Objective scatter index was higher in the patient group (3.1, interquartile range = 1.8–5.47) than in the control group (1.95; interquartile range = 0.7–5; p = 0.017). In a multiple linear regression model, non-invasive tear breakup time was identified as the most influential variable on light scatter (mean ratio = −1.015; p = 0.003; 95% confidence interval = −1.025 to −1.005). No correlation with objective scatter index was observed for number of daily eye-drops, preservative concentration or treatment duration. Conclusion: Participants on anti-glaucoma medication showed a significantly higher objective scatter index than control group individuals. In the treated patient group, a lower non-invasive tear breakup time was associated with a higher objective scatter index. This suggests that lubricating eye-drops to improve tear breakup time could also improve vision quality in these patients by diminishing light scattering.

scholarly journals Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Ophthalmopathy

2020 ◽  
Author(s):  
Magdalena Gumińska ◽  
Roman Goś ◽  
Janusz Śmigielski ◽  
Michał Szymon Nowak
Keyword(s):  
Intraocular Pressure ◽  
Corticosteroid Therapy ◽  
Topical Treatment ◽  
Final Visit ◽  
Control Group ◽  
Eye Drops ◽  
Systemic Corticosteroids ◽  
Subgroup Ii ◽  
Elevated Intraocular Pressure ◽  
Study Participants

Purpose: The evaluation of the efficacy of topical hypotensive treatment and/or systemic corticosteroids therapy in patients with elevated intraocular pressure and Graves’ orbitopathy (GO). Methods: 172 eyes in 86 individuals with duration of GO ≥ 3 months, intraocular pressure in either eye ≥ 25.0 mmHg and GO ranked ≥ 3 at least in one eye in modified CAS form, were included. The study subjects were divided into three treatment subgroups: subgroup I was administered latanoprost QD; subgroup II was administered a combined preparation of brimonidine and timolol BID; subgroup III was the control group, not receiving any topical hypotensive treatment. All the study participants received systemic treatment – intravenous corticosteroid therapy at the same dose, according to the EUGOGO guideline Results: On the final visit, the mean IOP value was significantly lower in all treatment subgroups comparing to the initial values. In both subgroups receiving topical treatment the IOP reduction was higher than in the control group receiving systemic corticosteroids only. However, the latanoprost eye drops decreased intraocular pressure more effectively than drops containing brimonidine and timolol. Conclusion: Topical ocular hypotensive treatment is effective in reducing intraocular pressure in GO and decreases intraocular pressure more effectively than systemic corticosteroid therapy alone.

scholarly journals Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

Lab on a Chip ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 1461-1471 ◽  
Author(s):  
Mario Rothbauer ◽  
Gregor Höll ◽  
Christoph Eilenberger ◽  
Sebastian R. A. Kratz ◽  
Bilal Farooq ◽  
...  
Keyword(s):  
Light Scattering ◽  
Inflammatory Arthritis ◽  
Three Dimensional ◽  
Lab On A Chip ◽  
Tissue Level ◽  
Stress Factors ◽  
Light Scatter ◽  
Organ Cultures ◽  
Non Invasive ◽  
Systemic Stress

We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.

scholarly journals “Long covid” (postcovid syndrome). Mechanism of occurrence, diagnosis and rehabilitation

2022 ◽  
pp. 156-164
Author(s):  
En. D. Choi
Keyword(s):  
Light Scattering ◽  
Comparison Group ◽  
Integrated Approach ◽  
Laboratory Method ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Coronavirus Infection ◽  
Methods Of Treatment

Introduction. The article is devoted to the study of the mechanism of occurrence of postcovid syndrome, a new laboratory method for its diagnosis and issues of drug and non-drug rehabilitation of patients who have suffered COVID-19.The purpose of this work was to study the possibilities of using the method of monochrome analysis of nanoparticles for instrumental and laboratory diagnostics of postcovid syndrome and to substantiate the use of complex therapeutic approaches to the treatment of patients.Materials and methods. The biomaterial (saliva) of 250 patients who underwent COVID-19 in mild, moderate and severe forms, with a slight predominance of males, in the age range from 18 to 75 years, who were in the Center of Eastern and European Medicine (Moscow) on rehabilitation treatment in the period from June 2020 to September 2021, was studied by the method of monochrome analysis of nanoparticles. According to the results of the work carried out, it was found that the most typical saliva spectrum of patients diagnosed with “postcovid syndrome” was multimodal (three or more peaks) with the greatest contribution (45%) to light scattering on agglomerates of  nanoparticles with a  diameter of  more than 1000  nm, with detectable nanoparticles of the middle sub-range of the spectrum from 119 to 122 nm with a 15% contribution to light scattering and an increased contribution to light scattering up to 41% on small nanoparticles with a diameter of 22 nm.Results. Analysis of the results of the study showed a statistically significant (p < 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group). Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment. >< 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group).Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment.

scholarly journals The Effect of Intraocular Pressure-lowering Eye Drops on Myopic RetinoschisisPatients

2020 ◽  
Vol 61 (4) ◽  
pp. 341-346
Author(s):  
Jung Hwa Lee ◽  
Kyu Hwan Jang ◽  
Suchan Lee ◽  
Mingui Kong ◽  
Joon Hong Sohn
Keyword(s):  
Intraocular Pressure ◽  
Eye Drops ◽  
Pressure Lowering

scholarly journals Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Orbitopathy

2020 ◽  
Vol 17 (24) ◽  
pp. 9331
Author(s):  
Magdalena Gumińska ◽  
Roman Goś ◽  
Janusz Śmigielski ◽  
Michał S. Nowak
Keyword(s):  
Intraocular Pressure ◽  
Corticosteroid Therapy ◽  
Topical Treatment ◽  
Final Visit ◽  
Control Group ◽  
Eye Drops ◽  
Systemic Corticosteroids ◽  
Elevated Intraocular Pressure ◽  
Graves Orbitopathy ◽  
Study Participants

Purpose: In this study, we evaluated the efficacy of topical hypotensive treatment and/or systemic corticosteroids therapy in patients with elevated intraocular pressure and Graves’ orbitopathy (GO). Methods: We included 172 eyes in 86 individuals with duration of GO ≥ 3 months, intraocular pressure in either eye ≥ 25.0 mmHg, and GO ranked ≥ 3 at least in one eye in modified CAS form. The study subjects were divided into three treatment subgroups: subgroup I was administered latanoprost once a day; subgroup II was administered a combined preparation of brimonidine and timolol BID; subgroup III was the control group, not receiving any topical hypotensive treatment. All the study participants received systemic treatment, intravenous corticosteroid therapy at the same dose, according to the European Group of Graves’ Orbitopathy (EUGOGO) guideline. Results: On the final visit, the mean IOP value was significantly lower in all treatment subgroups compared to the initial values. In both subgroups receiving topical treatment, the IOP reduction was higher than in the control group receiving systemic corticosteroids only. However, the latanoprost eye drops decreased intraocular pressure more effectively than drops containing brimonidine and timolol. Conclusion: Topical ocular hypotensive treatment is effective in reducing intraocular pressure in GO and decreases intraocular pressure more effectively than systemic corticosteroid therapy alone.

scholarly journals Adherence Improvement in Glaucoma Patients: Effects of Educational Intervention Using an Eye Drop Chart

2021 ◽  
Vol 62 (12) ◽  
pp. 1617-1625
Author(s):  
Woo Seok Choi ◽  
Jong Heon Kim ◽  
Chang Hoon Lee ◽  
Chong Eun Lee ◽  
Sam Seo
Keyword(s):  
Intraocular Pressure ◽  
Educational Intervention ◽  
Pressure Control ◽  
Demographic Characteristics ◽  
Control Group ◽  
Eye Drops ◽  
Supplementary Education ◽  
Adherence Score ◽  
Education Group ◽  
Multicenter Prospective Study

Purpose: To evaluate the effects of an educational intervention using an eye drop chart and supplementary education on glaucoma patients’ adherence.Methods: In this multicenter prospective study, medically treated glaucoma patients were educated on the administration of eye drops using an eye drop chart. At the time of recruitment, all of the patients completed a questionnaire on demographic characteristics and adherence. Three months after the initial educational intervention, the patients were randomly divided into two groups: an education group and a control group. The education group received supplementary education. Immediately thereafter and at 6 months, all of the patients completed the questionnaire on adherence again. Changes in instillation behavior, the relationship between the adherence score and demographic characteristics, and factors contributing to an improvement in adherence and intraocular pressure were then analyzed.Results: The adherence scores were significantly higher in patients with fewer medications, a higher annual income and higher educational level, and an urban residence (p = 0.038, p = 0.033, p = 0.041 and p = 0.047, respectively). Education on the administration of eye drops and use of the eye drop chart improved adherence scores from 23.05 ± 3.52 to 21.30 ± 3.95 (p = 0.021) and significantly reduced the average intraocular pressure from 14.3 ± 2.9 to 12.4 ± 3.1 mmHg (p < 0.001). Working indoors (odds ratio [OR] = 5.47, p = 0.032) and supplementary education at 3 months (OR = 4.53, p = 0.030) were also correlated with improved adherence.Conclusions: An eye drop chart is an effective tool for improving adherence and intraocular pressure control in glaucoma patients. Improvement in adherence was especially notable in patients whose work predominantly involved indoor activity. The effectiveness of the eye drop chart was improved by supplementary education.

scholarly journals The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Naoto Tokuda ◽  
Yasushi Kitaoka ◽  
Akiko Matsuzawa ◽  
Junsuke Miyamoto ◽  
Shinsuke Sakae ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ocular Surface ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Control Group ◽  
Eye Drops ◽  
Drug Induced ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial ◽  
Significant Difference

Purpose. To examine the efficacy of ophthalmic rebamipide suspensions on ocular surface disorders induced by antiglaucoma eye drops.Patients and Methods. Forty eyes of 40 patients receiving latanoprost (0.005%) and timolol (0.5%) were included in this randomized prospective study. The patients were randomly divided into two groups (n= 20): the rebamipide-treated group and control group. Changes in intraocular pressure, tear film break-up time (TBUT), and corneal epithelial barrier function were evaluated at baseline, 4 weeks, and 8 weeks after rebamipide administration. Furthermore, superficial punctate keratopathy severity was evaluated by scoring the lesion area and density.Results. There was no significant difference in intraocular pressure before and after rebamipide treatment. However, corneal epithelial barrier function improved significantly 4 and 8 weeks after rebamipide treatment. TBUT was partially, but significantly, increased (P= 0.02) 8 weeks after rebamipide treatment, whereas no significant change was observed at 4 weeks. Additionally, a significant decrease in area and density of keratopathy was observed 8 weeks after rebamipide treatment but not at 4 weeks. The control group showed no significant difference compared to baseline.Conclusions. Our data suggests that rebamipide treatment may reduce the occurrence of drug-induced ocular surface disorder.

scholarly journals Fixed combination bimatoprost-timolol in prevention of ocular hypertension after phacoemulsification of uncomplicated cataract

2016 ◽  
Vol 9 (2) ◽  
pp. 69-73
Author(s):  
Igor’ B Alekseev ◽  
Bella N Khatsukova ◽  
Marija M Soshina ◽  
Nadezhda I Samokhina ◽  
Julija A Nam ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Ocular Hypertension ◽  
Postoperative Period ◽  
Fixed Combination ◽  
Corneal Edema ◽  
Main Group ◽  
Control Group ◽  
Surgical Trauma ◽  
Eye Drops

To date, cataract surgery development aims at minimizing surgical trauma in order to achieve a quicker rehabilitation. However, one of the severe complications of cataract surgery is increased intraocular pressure due to the inflammatory response, the so-called reactive syndrome that occurs in the early postoperative period. Aim of the study was to evaluate the efficacy of a fixed combination of bimatoprost and timolol (Ganfort) eye drops in prevention of ocular hypertension and corneal edema after ultrasonic phacoemulsification. Materials and methods. The study included 60 patients (60 eyes) with uncomplicated cataracts of varying maturity degree. All patients were divided into 2 groups. Patients in the main group (30 patients, 30 eyes, 20 female and 10 male) underwent pneumotonometry before surgery and received a single instillation of Ganfort, and pneumotonometry was performed again 30 minutes after instillation (before surgery), and then again after surgery. Patients in the control group (30 patients, 30 eyes, 19 female and 11 male) underwent pnemotonometry before and after surgery. Results. The postoperative period was similar in both groups. On the first day after surgery, mean intraocular pressure in patients of the main group was 12.9 mmHg while in the control group the mean intraocular pressure was 20.1 mmHg. In patients of the main group, intraocular pressure decreased by 1/3 with Ganfort therapy on the first day after surgery, and biomicroscopic corneal findings were less pronounced in the main group compared to the control group. Conclusion. The results of our study show that even uncomplicated cataract phacoemulsification with IOL implantation leads to a reactive postoperative increase of intraocular pressure from 17.5 to 20.1 mmHg. In our study, the use of Ganfort did not cause side effects or intolerability. Ganfort use may be considered as an effective prophylactics of ocular hypertension and corneal edema after ultrasonic phacoemulsification.

scholarly journals Long-term Follow-up of Patients receiving Intraocular Pressure-lowering Medications as Cataract Surgery Candidates: A Case—control Study

2017 ◽  
Vol 11 (3) ◽  
pp. 107-112 ◽  
Author(s):  
Georgios Bontzos ◽  
Michail Agiorgiotakis ◽  
Efstathios T Detorakis
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Case Control Study ◽  
Cataract Extraction ◽  
Control Group ◽  
Pressure Lowering ◽  
Long Term Follow Up ◽  
Control Study

ABSTRACT Aim In this study, we reviewed demographics and biometric characteristics among patients receiving chronic β-blockers and prostaglandins (PGs) for primary open-angle glaucoma. We compared the age at the time of cataract surgery in different patient groups and in a control group which was not under any medication. Materials and methods Retrospective chart review of glaucomatous patients who underwent cataract extraction at the Department of Ophthalmology of the University Hospital of Heraklion, Crete, Greece, between January 1998 and December 2016 was done. Age at cataract surgery, axial length (AL), and preoperative and postoperative best-corrected visual acuities (BCVAs) were recorded. A cohort of patients without glaucoma who were operated for cataract extraction was also evaluated. Results In all, 320 patients were reviewed. There were significant results in mean age difference between the beta-antagonist and the PG group [3.05 years, 95% confidence interval (CI) 1.54-4.57] and between the beta-antagonist group with the patients receiving a combined therapy (3.02 years, 95% CI 1.14-4.91). No significant difference was found between the PG and the combination group. All the three treated groups had a significant lower mean age than the control group at the time of cataract surgery. Conclusion Based on our study, we concluded that there might be a possible association between chronic treatment with beta-antagonist agents and earlier cataract surgical time in the treated eye. Clinical significance Intraocular pressure control is often usually achieved using ophthalmic agents. Their topical and systemic effects should be monitored precisely. Earlier cataract formation might be an important side effect which the physician has to keep in mind before choosing the suitable medication. How to cite this article Bontzos G, Agiorgiotakis M, Detorakis ET. Long-term Follow-up of Patients receiving Intraocular Pressure-lowering Medications as Cataract Surgery Candidates: A Case—control Study. J Curr Glaucoma Pract 2017;11(3):107-112.

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