scholarly journals “Long covid” (postcovid syndrome). Mechanism of occurrence, diagnosis and rehabilitation

2022 ◽  
pp. 156-164
Author(s):  
En. D. Choi
Keyword(s):  
Light Scattering ◽  
Comparison Group ◽  
Integrated Approach ◽  
Laboratory Method ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Coronavirus Infection ◽  
Methods Of Treatment

Introduction. The article is devoted to the study of the mechanism of occurrence of postcovid syndrome, a new laboratory method for its diagnosis and issues of drug and non-drug rehabilitation of patients who have suffered COVID-19.The purpose of this work was to study the possibilities of using the method of monochrome analysis of nanoparticles for instrumental and laboratory diagnostics of postcovid syndrome and to substantiate the use of complex therapeutic approaches to the treatment of patients.Materials and methods. The biomaterial (saliva) of 250 patients who underwent COVID-19 in mild, moderate and severe forms, with a slight predominance of males, in the age range from 18 to 75 years, who were in the Center of Eastern and European Medicine (Moscow) on rehabilitation treatment in the period from June 2020 to September 2021, was studied by the method of monochrome analysis of nanoparticles. According to the results of the work carried out, it was found that the most typical saliva spectrum of patients diagnosed with “postcovid syndrome” was multimodal (three or more peaks) with the greatest contribution (45%) to light scattering on agglomerates of  nanoparticles with a  diameter of  more than 1000  nm, with detectable nanoparticles of the middle sub-range of the spectrum from 119 to 122 nm with a 15% contribution to light scattering and an increased contribution to light scattering up to 41% on small nanoparticles with a diameter of 22 nm.Results. Analysis of the results of the study showed a statistically significant (p < 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group). Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment. >< 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group).Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment.

scholarly journals Influence of the Plant-citrate Complex on Indicators of Systemic Inflammation in Patients with Urolithiasis

2021 ◽  
pp. 41-46
Author(s):  
Olena Karpenko ◽  
Anna Petrova
Keyword(s):  
Systemic Inflammation ◽  
Modern Medicine ◽  
Control Group ◽  
Slowing Down ◽  
Non Invasive ◽  
Citrate Complex ◽  
Group I ◽  
Therapeutic Properties ◽  
Methods Of Treatment

Treatment of urolithiasis is a complex task of modern medicine. The search for non-invasive methods of treatment, prevention of relapses and complications, slowing down the development of renal failure is an urgent issue of our time. The study demonstrated a comprehensive analysis of indicators of systemic inflammation in patients with urolithiasis and the effectiveness of using the plant-citrate complex. The objective: to conduct a clinical assessment of systemic inflammation in patients with urolithiasis, to determine the effectiveness of the use of the plant-citrate complex of the drug Uriklar on the indicators of systemic inflammation. Materials and methods. There were examined 52 (55.6 %) patients with urolithiasis, which were divided into two groups: Group I (main group) – 32 patients with urolithiasis who received the herbal citrate complex and Group II (comparison group) – 20 patients with urolithiasis. The control group included 20 almost healthy individuals. All patients underwent clinical and laboratory tests: general and biochemical blood tests to determine the parameters of iron metabolism, lipid profile, CRP, determination of the levels of cytokines in the blood, blood pressure, body mass index. Results. The results of this study demonstrate the development of systemic inflammation in patients with urolithiasis, determined by a decrease in GFR. Against the background of the treatment with Uriklar, a decrease in the levels of pro-inflammatory cytokines, CRP and ferritin is observed, which indicates the anti-inflammatory properties of the drug. Conclusion. Such properties of the plant-citrate complex are pathogenetically substantiated and can be recommended for urolithiasis, which, along with the therapeutic properties, allows to obtain the provision of metaphylaxis of urolithiasis and to slow down the rate of development of chronic kidney disease.

scholarly journals ‘Long Covid’ (post-covid syndrome): Mechanism of occurrence, diagnosis and rehabilitation

2022 ◽  
pp. 20-26
Author(s):  
E. G. Choi
Keyword(s):  
Laboratory Method ◽  
The Body ◽  
Drug Rehabilitation ◽  
Distinctive Features ◽  
Restorative Treatment ◽  
Inflammatory Drugs ◽  
Coronavirus Infection ◽  
And Shifts ◽  
First Time ◽  
Methods Of Treatment

The article is devoted to the study of an urgent problem of modern humanity – the fight against a pandemic caused by a new coronavirus infection, namely: the study of the mechanism of development of ‘long Covid’ (post-covid syndrome), a new clinical and laboratory method of its diagnosis, issues of drug and non-drug rehabilitation of patients who have suffered COVID‑19. The paper describes the etiopathogenesis of post-covid syndrome (PS), the distinctive features of which are the defeat of the cardiovascular, respiratory, nervous, digestive, immune systems of the body, ENT organs and musculoskeletal system. For the diagnosis of post-covid syndrome, a monochrome nanoparticle analyzer (MAN) has been tested for the first time in the Russian Federation, which allows determining pathophysiological shifts in the homeostasis system. It was found that the MAN method has a sufficiently high diagnostic sensitivity (78%), and shifts in the homeostasis system in post-covid syndrome are statistically significant (p < 0.001). A fundamentally important point of this study is that an algorithm has been developed for noninvasive diagnosis of PS by saliva (oropharyngeal flushes), based on the detection of a high contribution to the scattering of laser radiation in the mid-frequency range of the spectrum on nanoparticles ranging in size from 119 to 121 nm. The article also pays special attention to medicinal and non-medicinal methods of treatment of patients with ‘long Covid’ experiencing the consequences of a new coronavirus infection. It has been established that the best effect is provided by complex treatment combining methods of the traditional European school (drug therapy with the use of cardiovascular drugs, nootropic agents, chondroprotectors, vitamins and mineral complexes, hormones, hepatoprotectors, biostimulants, sedatives and anti-inflammatory drugs and other drugs) and non-drug methods of restorative treatment practiced by Oriental medicine (acupuncture, hirudotherapy, massage, osteopathy, etc.).

Variation of COVID-19 Specific Immunoglobulin's and Some Inflammatory Factors in COVID-19 Patients in the Sabratha Isolation Center, Western Libya

2021 ◽  
Vol 2 (7) ◽  
pp. 01-09
Author(s):  
Azab Elsayed Azab ◽  
J.M. Jbireal ◽  
S. Alzahani ◽  
Rabia A. M. Yahya
Keyword(s):  
Virus Infection ◽  
Biochemical Parameters ◽  
Statistical Significance ◽  
Venous Blood ◽  
Inflammatory Factors ◽  
Control Group ◽  
Nasopharyngeal Swab ◽  
Healthy Individuals ◽  
Coronavirus Infection ◽  
D Dimer

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic causing significant mortality and morbidity and implementation of strict isolation measures. Serological testing can diagnose illness by detecting antibodies (IgM and IgG). Testing antibodies against SARS-CoV-2 is rapid and sensitive for the auxiliary diagnosis of COVID-19. The serum levels of CRP, D-dimers, and ferritin, which may be used in risk stratification to predict severe and fatal COVID-19 in hospitalized patients. Objectives The present study aimed to investigate the variations in COVID-19 Specific Immunoglobulin's and Some Inflammatory factors in COVID-19 Patients in Sabratha isolation center, Western Libya. Subjects and Methods: Sixty Confirmed COVID-19 patients hospitalized in the Isolation Centre located in Sabratha city, Libya from the 2nd October 2020 to the 2nd June 2021, were enrolled in this prospective study. Covid-19 patients were defined as positive cases after the detection of SARS-CoV-2 RNA in oro-nasopharyngeal swab samples. Data collected included demographic, clinical, and biological factors. Also, 30 healthy individuals without any chronic disease or respiratory symptoms were recruited for the control group. Blood samples were collected by vein puncture 5 ml of venous blood was withdrawn from each participant in the study by using disposable syringes under the aseptic technique; they were then transferred to a sterile tube for estimating biochemical parameters. Biochemical parameters were determined using automated COBAS E411 and INTEGRA 400 machines in the Sabratha Isolation Centre laboratory. The statistical significance of differences between groups was evaluated with the Kruskal-Wallis H test. Results: The results showed that patients with COVID-19 had a significant (P<0.0001) increase in IgM levels at 0 day, 14 days, and 21 days, respectively compared with the healthy individuals. Also, IgG levels were showed a gradual significantly (P<0.0001) increase during COVID-19 Virus Infection among COVID-19 patients at 0 day, 14 days, and 21 days compared with the controls. In addition, coronavirus infection caused a significant (P<0.0001) increase in D-dimer, CRP, and Ferritin levels compared with the healthy control individuals. Conclusion: It can be concluded that coronavirus infection caused a significant increase in IgM, IgG, D-dimer, CRP, and Ferritin levels at different periods compared to the controls. Further studies are needed to confirm these results. COVID-19 Specific Immunoglobulin's and Some Inflammatory factors in COVID-19 Patients These changes in IgM, IgG, D-dimer, CRP, and Ferritin levels during COVID-19 Virus Infection among COVID-19 patients may help the clinicians to better understand the COVID-19 and provide more clinical treatment options.

Intraocular light scatter in patients on topical intraocular pressure–lowering medication

2018 ◽  
Vol 28 (6) ◽  
pp. 652-661
Author(s):  
Francisco Pérez-Bartolomé ◽  
Jose María Martínez de la Casa ◽  
Pedro Arriola-Villalobos ◽  
Cristina Fernández-Pérez ◽  
Julián García-Feijoó
Keyword(s):  
Intraocular Pressure ◽  
Light Scattering ◽  
Treatment Duration ◽  
Control Group ◽  
Eye Drops ◽  
Light Scatter ◽  
Non Invasive ◽  
Pressure Lowering ◽  
Breakup Time ◽  
Objective Scatter Index

Purpose: To quantify ocular light scattering in patients under treatment with intraocular pressure–lowering eye-drops. Methods: In this prospective, observational, cross-sectional case series study, 160 eyes of 160 patients with primary open angle glaucoma or primary ocular hypertension were consecutively recruited from our Glaucoma Department over 7 months. In total, 46 eyes of 46 healthy volunteers matched for age and sex served as the control group. The variables recorded in a single visit were as follows: drug and number of drops per day, treatment duration, OXFORD corneal staining grade, lower tear meniscus height as measured by spectral domain optical coherence tomography, ocular redness and non-invasive tear breakup time measured with the Oculus Keratograph 5M, ocular surface disease index questionnaire score and objective scatter index through a double-pass technique (Optical Analysis System II). Results: Objective scatter index was higher in the patient group (3.1, interquartile range = 1.8–5.47) than in the control group (1.95; interquartile range = 0.7–5; p = 0.017). In a multiple linear regression model, non-invasive tear breakup time was identified as the most influential variable on light scatter (mean ratio = −1.015; p = 0.003; 95% confidence interval = −1.025 to −1.005). No correlation with objective scatter index was observed for number of daily eye-drops, preservative concentration or treatment duration. Conclusion: Participants on anti-glaucoma medication showed a significantly higher objective scatter index than control group individuals. In the treated patient group, a lower non-invasive tear breakup time was associated with a higher objective scatter index. This suggests that lubricating eye-drops to improve tear breakup time could also improve vision quality in these patients by diminishing light scattering.

scholarly journals Lymphocyte-platelet adhesion and aggregation of platelets in patients with erysipelas

2012 ◽  
Vol 93 (2) ◽  
pp. 216-220
Author(s):  
A N Emel’yanova ◽  
Yu A Vitkovskiy
Keyword(s):  
Platelet Adhesion ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Absolute Number ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Platelet Hyperaggregation ◽  
Aggregation Of Platelets ◽  
Primary Form

Aim. To study the lymphocyte-platelet adhesion in patients with various forms of erysipelas in the dynamics of treatment. Methods. 90 patients with erysipelas participated in the study: 20 with the erythematous-bullous form and 20 with the erythematous form. According to the recurrence of the disease the patients were divided into two groups: the main group (40 patients with the primary form of erysipelas) and the comparison group (50 people with recurrent erysipelas). The control group, which was comparable by sex and age, was comprised of 55 healthy people. The index of lymphocyte-platelet adhesion and hemostasis were studied in all patients. Results. The index of lymphocyte-platelet adhesion sharply declined already during the onset of the disease, despite the fact that no significant changes in the content of the absolute number of lymphocytes compared to healthy individuals during this period were identified. Severe course (erythematous-bullous form) was accompanied by significant shifts in the parameters of lymphocyte-platelet adhesion, and their dynamics made it possible to evaluate the effectiveness of treatment. Conclusion. The ability of lymphocytes to adhere to the surface of platelets is reduced during erysipelas; platelet hyperaggregation develops during the first days of onset of clinical manifestations, the nature and duration of which depends on the form of the disease.

scholarly journals Novel methodological approaches in the system of early diagnosis of mastopathy with the use of computer dermography

2019 ◽  
Vol 100 (1) ◽  
pp. 117-124
Author(s):  
G A Merkulova ◽  
E V Pegova
Keyword(s):  
Prognostic Model ◽  
Comparison Group ◽  
Methodological Approach ◽  
Risk Groups ◽  
Control Group ◽  
Study Group ◽  
Health State ◽  
Non Invasive ◽  
Basic Functions ◽  
Diagnostic Complex

Aim. Optimization of the early detection of mastopathy on screening examinations due to the inclusion of data received with the use of computer dermography into the algorithm of complex diagnosis. Methods. Integral evaluation of the health state was performed with the use of computer dermography as part of the diagnostic complex DgKTD-01. Fertile females (n=107) were divided into three groups. The study group (n=36) included the female patients with differentiated mastopathy. The control group (n=51) united the females complaining of discomfort in breasts, engorgement and tenderness. Parameters of the baseline level in the study group and the control group were studied; a prognostic model of mastopathy was developed. Comparative analysis of identified characteristics was performed in the comparison group. Results. Females from the study group are in the group of adaptation risk with formation of premorbid states and diseases. The prognostic model of mastopathy was consistent disorder of the tonic activity of basic functions F2' and F3', functions F5-1', F5-2', F5-3' with the extremum in segments Th4-6 in regimen 2 which allowed determining females with the risk of the development of this pathology in comparison group. Conclusion. Method of computer dermography serves as a methodological approach to revealing pre-nosological states which alllows using it as an additional non-invasive diagnostic screening test to determine mastopathy risk groups; the obtained results give ground to continue the further studies and improvement of the diagnosis on a large clinical material and to development of computed system for interpretation of the obtained data.

Morphological and haemodynamic abnormalities in the jugular veins of patients with multiple sclerosis

2011 ◽  
Vol 27 (4) ◽  
pp. 168-172 ◽  
Author(s):  
D Radak ◽  
J Kolar ◽  
S Tanaskovic ◽  
D Sagic ◽  
Z Antonic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Venous Insufficiency ◽  
Morphological Changes ◽  
Cost Effective ◽  
Control Group ◽  
Healthy Individuals ◽  
Venous Flow ◽  
Jugular Veins ◽  
Non Invasive ◽  
Different Levels

Objectives Multiple areas of stenosis and different levels of obstruction of internal jugular and azygous veins (a condition known as cronic cerebrospinal venous insufficiency) recently emerged as an additional theory to the well-known autoimmune concept, explaining etiology of multiple sclerosis (MS). The aim of our study was to evaluate internal jugular vein (IJV) morphology and haemodynamic characteristics in patients with MS and compare it with well-matched healthy individuals and to evaluate the prevalence of venous flow abnormalities in both groups. Methods Sixty-four patients with clinically proven MS and 37 healthy individuals were included in our study. In all patients, IJV morphology and haemodynamic characteristics were evaluated by colour Doppler sonography as well as venous flow disorder. The patients were classified into four groups according to MS clinical form presentation. The prevalence of morphological and haemodynamic abnormalities in the IJV were assessed. Results The presence of stenosing lesion, mostly intraluminal defects like abnormal IJV valves, were observed in 28 patients (43%) in the MS group, and in 17 patients (45.9%) in the control group ( P = NS). By adding haemodynamic Doppler information in the IJV venous outflow was significantly different in 42% of MS patients showing flow abnormalities (27/64), as compared with 8.1% of the controls (3/37), P < 0.001. Conclusion In our group of patients, patients suffering from MS had significantly more IJV morphological changes and haemodynamic abnormalities when compared with healthy individuals not suffering from MS. These findings can be well demonstrated by non-invasive and cost-effective Doppler ultrasound.

scholarly journals Biomarkers of bone remodeling in ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs: results of an ETHICS research program

2017 ◽  
Vol 89 (12-2) ◽  
pp. 185-189
Author(s):  
I Z Gaydukova ◽  
A V Aparkina ◽  
E V Khondkaryan ◽  
A P Rebrov
Keyword(s):  
Ankylosing Spondylitis ◽  
Bone Resorption ◽  
Comparison Group ◽  
Control Group ◽  
Type I ◽  
Healthy Individuals ◽  
On Demand ◽  
Ethics Research ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. To evaluate changes in the concentration of biomarkers for osteoproliferation and bone resorption in ankylosing spondylitis (AS) patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in different regimens. Subjects and methods. Forty patients with AS (according to the modified New York criteria), who had BASDAI ≥ 4.0 at baseline and at 52 weeks of on-demand NSAID treatment were examined and randomized into 2 groups: 1) 30 patients who used continuously oral tenoxicam 20 mg daily (a study group); 2) 10 patients who continued previous therapy (a comparison group). BASDAI and ASDAS were calculated; the serum levels of C-reactive protein, C-terminal type I procollagen propeptide (PICP), and C-terminal telopeptide of type I collagen (CTX-I) were measured at baseline and at 52 and 56 weeks of treatment. A control group consisted of 19 healthy volunteers. Results. The continuous use of NSAIDs (tenoxicam) decreased higher baseline BASDAI and ASDAS scores. There were no changes in the indicators of AS activity in the patients who took on-demand NSAIDs. Baseline CTX-I levels did not differ between the patients with AS and the healthy individuals; those declined during continuous intake of tenoxicam and remained unchanged during on-demand administration. In the patients with AS, baseline PICP levels exceeded those in the healthy individuals. In the tenoxicam-treated patients, the concentrations of PICP at baseline and at 52 and 56 weeks were 17.1±9.0, 16.8±9.9, and 13.29±6.7 ng/ml, respectively (p=0.0001 for differences between the baseline and week 56 levels); in the comparison group, PICP levels did not change statistically significantly (p≥0.05 for all intergroup comparisons). Conclusion. Changing the inefficient long-term on-demand use of NSAIDs to their continuous intake is associated with a rapid decrease in clinical AS activity (within 4 weeks) with a reduction in the higher baseline concentration of the marker for osteoproliferation and in the normal level of the marker for bone resorption.

scholarly journals Immunodepressant and oxidant potential of standard leukaemia drug regimen

2020 ◽  
Vol 11 (4) ◽  
pp. 5608-5614
Author(s):  
Marwan M. Merkhan ◽  
Ibrahim M. Faisal ◽  
Dema Z. Alsaleem ◽  
Omer M. Shindala ◽  
Hani M. Almukhtar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serum Levels ◽  
Drug Regimen ◽  
Significant Rise ◽  
Laboratory Method ◽  
Cytotoxic Drugs ◽  
Control Group ◽  
Healthy Individuals ◽  
Leukaemia Therapy ◽  
Immunoglobulin Levels

Chemotherapy improves cancer status but also could carry a risk of harmful side effects. In leukaemia patients, oxidative status and immune system are crucial parameters for patient improvement. The present study is aimed to assess the oxidative stress and the levels of immunoglobulin, including; IgG, IgA, and IgM in acute myelocytic leukaemias (AML) patients. A total of twenty-one patients with AML were enrolled in this study, alongside 24 healthy individuals as a control group. Initially, in both groups, the serum MDA, IgA, IgG, and IgM levels were measured. Then after a month of treatment with standard leukaemia therapy; the measurement of levels of these parameters were repeated for both the patients’ group and the control group for measuring immunoglobulin levels while analysis of MDA was done by the laboratory method. A highly significant rise in the serum MDA level was detected (P&lt;0.001) in patients with AML after treatment with specific cytotoxic drugs was observed in comparison with the control. Moreover, there was a significant modulation in the serum concentration of Ig after starting cytotoxic drugs in comparison with the controls. The study revealed that AML was associated with elevated oxidative stress parameters following treatment with cytotoxic drugs as reflected by the rise in the serum levels of MDA. The decreased serum Ig levels indicate a reduction in immune response in patients with AML due to cytotoxic drugs.

scholarly journals Application of noninvasive neuromodulation in patients with asthenic neurosis

2021 ◽  
Vol 18 (4) ◽  
pp. 237-241
Author(s):  
Alexey A. Voropaev ◽  
Marina Yu. Gerasimenko
Keyword(s):  
Drug Therapy ◽  
Pulse Generator ◽  
Physical Factor ◽  
Control Group ◽  
Non Invasive ◽  
Neurotic Disorders ◽  
Economic Significance ◽  
High Prevalence ◽  
Noninvasive Neuromodulation ◽  
Methods Of Treatment

The relevance of the work is associated with the high prevalence and socio-economic significance of neurotic disorders associated with stress. Standards of medical care for patients with neurotic disorders associated with stress do not provide for the use of any physiotherapy or hardware effects. Drug therapy is mainly used, but its use is not always effective and is limited by the risk of developing allergies, drug addiction, toxic manifestations, side effects, etc. Therefore, more and more attention has been paid to non-drug treatment methods recently. Non-invasive neuromodulation is a therapeutic exogenous effect on various parts of the nervous system using an electromagnetic physical factor in the conditions of drug therapy. Purpose. Study the effectiveness of noninvasive neuromodulation in patients with asthenic neurosis. Material and methods. A total of 79 patients with the diagnosis of F48.0 Neurasthenia were studied (59 women and 20 men). The median age was 44 4.5 years. The main group 49 patients, 30 patients made up the control group. The course of non-invasive neuromodulation was performed against the background of medical treatment in accordance with the MES with the use of a pulse generator "TETOS" with feedback in the form of electroencephalography (registration certificate no.FRS2011/11198). Results. Immediately after the end of the course of treatment, 80% of patients manage to achieve a significant improvement in their subjective state. As a result of the proposed method, not only significant, but also persistent improvement in the condition of patients is achieved. Conclusions. The basis of this method is the interaction of two methods of treatment: physiotherapy and medication. As a result of the application of the proposed method, the main cause of the disease (psychotraumatic factor, life circumstances, etc.) is gradually identified, and the patient himself becomes aware of it, with subsequent correction of the condition. As a result, not only significant, but also persistent improvement in the condition of patients is achieved. According to the results of observations of the authors of the application, the disease does not resume for 1.52 years.

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