scholarly journals Nonmelanoma Facial Skin Cancer: A Review of Diagnostic Strategies, Surgical Treatment, and Reconstructive Techniques

2019 ◽  
Vol 12 ◽  
pp. 117955061986527 ◽  
Author(s):  
Ido Badash ◽  
Orr Shauly ◽  
Christopher G Lui ◽  
Daniel J Gould ◽  
Ketan M Patel
Keyword(s):  
Surgical Treatment ◽  
Skin Cancer ◽  
Treatment Options ◽  
The United States ◽  
Diagnostic Strategies ◽  
Skin Cancers ◽  
The Face ◽  
Nonmelanoma Skin Cancers ◽  
Frequent Exposure ◽  
Reconstructive Techniques

Nonmelanoma skin cancer is the most common form of cancer in the United States, and the face is a common area for skin cancer development due to its frequent exposure to the sun. This article focuses on the surgical management of facial nonmelanoma skin cancers, including diagnostic considerations, biopsy techniques, and staging. In addition, we discuss surgical treatment options, including indications, techniques, outcomes, and facial reconstruction following tumor excision.

scholarly journals Botanical Agents for the Treatment of Nonmelanoma Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jillian W. Millsop ◽  
Raja K. Sivamani ◽  
Nasim Fazel
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
The United States ◽  
Nonmelanoma Skin Cancer ◽  
Surgical Removal ◽  
Chemopreventive Agents ◽  
Treatment And Prevention ◽  
Skin Cancers ◽  
United States Standard ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are common neoplasms worldwide and are the most common cancers in the United States. Standard therapy for cutaneous neoplasms typically involves surgical removal. However, there is increasing interest in the use of topical alternatives for the prevention and treatment of nonmelanoma skin cancer, particularly superficial variants. Botanicals are compounds derived from herbs, spices, stems, roots, and other substances of plant origin and may be used in the form of dried or fresh plants, extracted plant material, or specific plant-derived chemicals. They possess multiple properties including antioxidant, anti-inflammatory, and immunomodulatory properties and are, therefore, believed to be possible chemopreventive agents or substances that may suppress or reverse the process of carcinogenesis. Here, we provide a review of botanical agents studied for the treatment and prevention of nonmelanoma skin cancers.

scholarly journals Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 332
Author(s):  
Luca Fania ◽  
Francesca Sampogna ◽  
Francesco Ricci ◽  
Mariafrancesca Hyeraci ◽  
Andrea Paradisi ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Sampling Procedure ◽  
Skin Cancer Prevention ◽  
Snowball Sampling ◽  
Scientific Publications ◽  
Current State ◽  
Skin Cancers ◽  
Knowledge And Attitude ◽  
Nonmelanoma Skin Cancers

Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new nonmelanoma skin cancers (NMSCs), while other oral photoprotectors failed to achieve the reduction of new melanoma or NMSC formation in humans. The aim of this study was to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments. Methods: The survey was conducted on a sample of dermatologists recruited according to a snowball sampling procedure. The questionnaire consisted of a first part asking for characteristics of the participant and a second part with 12 specific questions on their knowledge about systemic photoprotection, particularly their knowledge of astaxanthin, β-carotene, nicotinamide, and vitamin D3. Results: One hundred eight dermatologists answered the survey. Most of them (85.2%) stated that oral photoprotectors have a role in the prevention of skin cancer, and responses mainly mentioned nicotinamide. More than half of them (54.6%) had prescribed all the considered oral photoprotectors, but the majority of them had prescribed nicotinamide, mainly for 2 to 3 months during summer, almost invariably (n = 106) associated with topical photoprotectors. Most dermatologists (>80%) were aware of scientific publications demonstrating an effect of systemic photoprotectors on NMSC. Conclusions: Most Italian dermatologists have positive views on oral photoprotection in skin cancer and are aware of the demonstrated potential of nicotinamide in the prevention of NMSCs.

scholarly journals Detailed head localization and incidence of skin cancers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marta Fijałkowska ◽  
Mateusz Koziej ◽  
Bogusław Antoszewski
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Vertical Dimension ◽  
Surgical Department ◽  
Surface Areas ◽  
Common Cancer ◽  
Skin Cancers ◽  
Sex Type ◽  
Cancer Subtype ◽  
The Face

AbstractSkin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. These items were selected: sex, age, type of skin cancer, subtype of basal cell carcinoma (BCC), grading of squamous cell carcinoma (SCC), localization and dimensions of the tumor. The study sample consisted of 387 cases. BCC was the most common cancer and its nodular type was the most frequent. In older patients, the vertical dimension of excised carcinoma was significantly larger. Moreover, this connection was detected only in women compared to men. There were statistically significant differences between dimensions of the skin cancer and sex. In men group, skin cancers had statistically higher vertical dimensions and larger surface areas. On the face and head, BCC more often localizes in the nasal area, while SCC on the auricle. It has been demonstrated that the older the patient, the larger the vertical dimension of the tumor. As such, tumor size is larger in men than in women, as women usually see their physicians sooner than men: cosmetic concerns are more important to them.

scholarly journals A clinical review of reconstructive techniques for patients with multiple skin cancers on the face

2018 ◽  
Vol 19 (3) ◽  
pp. 194-199 ◽  
Author(s):  
Geon Woo Kim ◽  
Yong Chan Bae ◽  
Sung Hwan Bae ◽  
Su Bong Nam ◽  
Dong Min Lee
Keyword(s):  
Clinical Review ◽  
Skin Cancers ◽  
The Face ◽  
Reconstructive Techniques

Surgical Management of Melanoma and Other Skin Cancers

2015 ◽  
Author(s):  
Jennifer A. Wargo ◽  
Kenneth Tenabe
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Stage Iii ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Stage Iv Melanoma ◽  
Melanoma Skin

The prevalence of malignant skin cancers has increased significantly over the past several years. Approximately 1.2 million cases of non-melanoma skin cancer are diagnosed per year. More alarming, up to 80,000 cases of melanoma are diagnosed per year, an incidence that has been steadily increasing, with a lifetime risk of 1 in 50 for the development of melanoma. The disturbing increase in the incidence of both non-melanoma skin cancer and melanoma can largely be attributed to the social attitude toward sun exposure. The clinical assessment and management of skin lesions can be challenging. This review describes the assessment process, including thorough history and examination; the need for possible biopsy; and excision criteria. Specific types of skin cancer are distinguished and include basal cell carcinoma; squamous cell carcinoma; and melanoma; and for each type the incidence; epidemiology; histologic subtypes; diagnosis; and both surgical and non-surgical treatments are provided. Stages I-IV of melanoma are detailed, with prognostic factors described. Surgical treatment for stages I and II include description of the margins of excision and sentinel lymph node biopsy. The surgical treatment of Stage III melanoma further includes therapeutic lymph node dissection and isolated limb perfusion. Adjuvant therapies are also presented and include radiotherapy and chemotherapy. The additional treatment of metastasectomy for Stage IV melanoma is described. For both Stage III and IV melanoma, the study of vaccines to host immune cells is reported. For Stage IV melanoma, the text also describes immunotherapy treatment. Operative procedures specific to superficial and deep groin dissections are outlined. This review contains 9 figures, 3 tables, and 96 references.

Dermatology

2016 ◽  
pp. 297-314
Author(s):  
Carilyn N. Wieland
Keyword(s):  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
The United States ◽  
Non Hodgkin Lymphoma ◽  
Exposed Skin ◽  
Skin Cancers ◽  
Clinical Presentations ◽  
History Of ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers (basal cell carcinoma, squamous cell carcinoma) are the most common malignancies in the United States. Both basal cell and squamous cell carcinomas commonly occur on sun-exposed skin areas. The strongest risk factors for melanoma are a family history of melanoma, multiple benign or atypical nevi, and a previous melanoma. Cutaneous T-cell lymphoma is a non-Hodgkin lymphoma characterized by expansion of malignant T cells within the skin. The most common clinical presentations are mycosis fungoides and Sézary syndrome.

Recognising skin cancers in the dental patient

2012 ◽  
Vol 3 (3) ◽  
pp. 158-165 ◽  
Author(s):  
Carrie Newlands
Keyword(s):  
At Risk ◽  
Skin Cancer ◽  
Skin Lesions ◽  
Facial Skin ◽  
Older Population ◽  
Skin Cancers ◽  
Dental Patient ◽  
The Face ◽  
Fair Skin

Skin cancer is increasing in incidence and the face is the commonest site for skin cancers to occur. Patients who are at risk from skin cancers include those who have fair skin and who have had long-term exposure to sunshine.1 While facial skin cancers are more common in the older population, greater numbers of younger people are developing these cancers.2-4 Facial skin lesions are common. This article aims to help members of the dental team recognise the features of those lesions which may indicate malignancy or pre-malignancy.

scholarly journals Regulation of Apoptosis during Environmental Skin Tumor Initiation

2021 ◽  
Author(s):  
Bilal Bin Hafeez ◽  
Eunmi Park ◽  
Kyung-Soo Chun ◽  
Yong-Yeon Cho ◽  
Dae Joon Kim
Keyword(s):  
Skin Cancer ◽  
Signaling Pathways ◽  
The United States ◽  
Common Type ◽  
Skin Tumor ◽  
Tumor Initiation ◽  
Environmental Carcinogens ◽  
Skin Cells ◽  
Skin Cancers ◽  
The Impact

Skin cancer is more prevalent than any other cancer in the United States. Non-melanoma skin cancers are the more common forms of skin cancer that affect individuals. The development of squamous cell carcinoma, the second most common type of skin cancer, can be stimulated by exposure of environmental carcinogens, such as chemical toxicants or UVB. It is developed by three distinct stages: initiation, promotion, and progression. During the initiation, the fate of DNA-damaged skin cells is determined by the homeostatic regulation of pro-apoptotic and anti-apoptotic signaling pathways. The imbalance or disruption of either signaling will lead to the survival of initiated cells, resulting in the development of skin cancer. In this chapter, we will discuss signaling pathways that regulate apoptosis and the impact of their dysfunction during skin tumor initiation.

scholarly journals Nonmelanoma skin cancer in the population of the city of Belgrade in the period 1999-2011

2015 ◽  
Vol 143 (5-6) ◽  
pp. 290-295 ◽  
Author(s):  
Goran Videnovic ◽  
Dragan Miljus ◽  
Danijela Ilic ◽  
Dragan Krasic ◽  
Snezana Zivkovic
Keyword(s):  
Skin Cancer ◽  
Incidence Rate ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Skin Carcinoma ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers ◽  
The City ◽  
Squamous Cell Skin Carcinoma

Introduction. Nonmelanoma skin cancers in the literature are mainly related to basal cell and squamous cell skin carcinoma. Objective. The aim of the study was to determine the trend in the incidence of histological types of nonmelanoma skin cancers in the population of the city of Belgrade from 1999 to 2011. Methods. From the Serbian National Cancer Registry we extracted all recorded cases of skin cancer in Belgrade from January 1st 1999 to December 31st 2011. Incidence rates were standardized by the method of direct standardization with the world population as the standard population. Trends and annual percentage change (APC) of incidence rate were calculated by performing joinpoint regression analyses. Results. Incidence rate of nonmelanoma skin cancer showed significantly increasing trend between 1999 and 2006 with APC of 8.6% (95% CI: 5.6-11.7), basal cell carcinoma increased with APC of 8.4% (95% CI: 5.2-11.6) and squamous cell skin carcinoma with APC of 9.33% (95% CI: 5.7-13.1). The incidence increased with age for both men and women, especially after the age of 60. Conclusion. Our results showed a continuously increasing incidence trend of both basal cell and squamous cell skin carcinomas in the population of the city of Belgrade between 1999 and 2011. Adequate primary and secondary prevention would certainly be successful in reducing this type of cancer in the future.

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