Penile Invasive Squamous Cell Carcinoma: Analysis of Incidence, Mortality Trends, and Geographic Distribution in Canada

2019 ◽  
Vol 24 (2) ◽  
pp. 124-128 ◽  
Author(s):  
François Lagacé ◽  
Feras M. Ghazawi ◽  
Michelle Le ◽  
Evgeny Savin ◽  
Andrei Zubarev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Invasive Squamous Cell Carcinoma ◽  
Crude Incidence ◽  
Incidence And Mortality ◽  
Adjusted Incidence

Background Penile invasive squamous cell carcinoma (SCC) is a rare disease with several known risk factors. However, few studies have assessed its incidence, mortality, and temporal trends. Objective Our objectives are to analyze the epidemiology of penile SCC in Canada and to examine patient distribution with this cancer across Canada in order to elucidate population risk factors. Methods Three independent cancer registries were used to retrospectively analyze demographic data from Canadian men diagnosed with penile invasive SCC between 1992 and 2010. The Canadian Census of Population was used to calculate incidence and mortality rates at the province and Forward Sortation Area levels. Results The overall age-adjusted incidence rate was 6.08 cases per million males. Four provinces with statistically significantly higher incidence rates were identified. The national crude incidence rates increased linearly between 1992 and 2010, whereas the age-adjusted incidence rates showed no significant increase during this time period. The overall age-adjusted mortality rate was 1.88 deaths per million males per year. The province of Saskatchewan had significantly higher mortality rates. There was no increase in crude or age-adjusted mortality rates between 1992 and 2010. There was a significant positive correlation between incidence rates and obesity, Caucasian ethnicity, and lower socioeconomic status. Conclusion This study was able to establish geographic variation for this malignancy at the provincial level. Although there are many established risk factors for penile SCC, our results suggest that the increase in crude incidence rates observed is largely due to the aging population.

Trends in incidence and mortality of squamous cell carcinoma of the skin: An observational analysis of the Global Burden of Disease database from 1990 to 2017.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10569-10569
Author(s):  
Dorothy Yang ◽  
Chinmay Jani ◽  
Conor Crowley ◽  
Richard Goodall ◽  
Joseph Shalhoub ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Burden Of Disease ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Global Burden ◽  
Incidence And Mortality ◽  
The Usa ◽  
Observation Period

10569 Background: Epidemiological data relating to non-melanoma skin cancer (NMSC), including squamous cell carcinoma (SCC), is highly under-reported and under-studied due to its lower metastatic potential. In recent years, incidence and prevalence of SCC has increased in many countries due to earlier detection, increased ultraviolet light exposure, as well as increasing life expectancy. This investigation compared trends in SCC incidence, mortality and disability-adjusted life years (DALYs) in 33 countries. Methods: We utilized the Global Burden of Disease (GBD) database for 33 countries, including the European Union nations as well as other selected high-income countries including the UK and USA. We extracted data including age-standardized incidence rates (ASIRs), age-standardized mortality rates (ASMRs) and DALYs for SCC of the skin from 1990 to 2017. Joinpoint regression analysis was used to describe the trends. Results: For both sexes, the highest ASIRs were seen in the USA and Australia: ASIRs were 362.8/100,000 and 283.7/100,000 respectively for males, and 171.2/100,000 and 152.4/100,000 respectively for females. Males had higher ASIRs than females at the end of the observation period in all countries. In contrast, the highest ASMRs for males were observed in Australia (2.77/100,000) and Latvia (2.44/100,000), while the highest ASMRs for females were observed in Romania (0.95/100,000) and Croatia (0.90/100,000). The highest DALYs for both sexes were seen in Australia and Romania: DALYs were 58.4/100,000 and 43.8/100,000 respectively for males, and 16.9/100,000 and 14.9/100,000 respectively for females. Over the observation period, there were more countries demonstrating decreasing trends in mortality than in incidence. There was also a disparity between which countries had comparatively high mortality rates and which had high incidence rates – for instance, the USA, which had by far the highest SCC incidence rates, had among the lower mortality rates. Overall reductions in DALYs were observed in 24 of 33 countries for males, and 25 countries for females. Conclusions: Over the past 27 years, although trends in SCC incidence have risen in most countries, there is evidence that mortality rates have been decreasing, especially towards the end of the observation period. Overall, burden of disease as assessed using DALYs has decreased in the majority of countries. Future work will explore potential explanatory factors for the observed disparity in trends in SCC incidence and mortality.

scholarly journals Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada

2020 ◽  
Vol 27 (3) ◽  
Author(s):  
L. Cattelan ◽  
F. M. Ghazawi ◽  
M. Le ◽  
E. Savin ◽  
A. Zubarev ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Anal Cancer ◽  
Squamous Cell ◽  
Demographic Data ◽  
Cancer Registries ◽  
The United States ◽  
Incidence Rates ◽  
Anal Squamous Cell Carcinoma ◽  
Incidence And Mortality

Background Anal cancer is a rare disease, constituting 0.5% of new cancer cases in the United States. The most common subtype is squamous cell carcinoma (scc). Studies in several developed nations have reported on an increasing incidence of anal cancer in recent decades, and various risk factors pertaining to the pathogenesis of the disease have been identified, including infection with the human papillomavirus, tobacco use, and immunosuppression. The epidemiology and distribution of anal scc throughout Canada remain poorly understood, however. Methods Using 3 population-based cancer registries, a retrospective analysis of demographic data across Canada for 1992–2010 was performed. The incidence and mortality for anal scc was examined at the levels of provinces, cities, and the forward  sortation area (FSA) component (first 3 characters) of postal codes. Results During 1992–2010, 3720 individuals were diagnosed with anal scc in Canada; 64% were women. The overall national incidence rate was 6.3 cases per million population per year, with an average age at diagnosis of 60.4 years. The incidence increased over time, with significantly higher incidence rates documented in British Columbia and Nova Scotia (9.3 cases per million population each). Closer examination revealed clustering of cases in various urban centres and self-identified lgbtq communities in Toronto, Montreal, and Vancouver. Discussion This study provides, for the first time, a comprehensive analysis of the burden of anal scc in Canada, identifying susceptible populations and shedding light onto novel avenues of research to lower the incidence of anal cancer throughout the country.

scholarly journals Tongue Squamous Cell Carcinoma in a Young Patient Free of Risk Factors:

2014 ◽  
Vol 4 (1) ◽  
pp. 43-47
Author(s):  
Abdulrhman A. Abulaban ◽  
Lujain A. Khoja ◽  
Sara S. Baghlaf ◽  
Moataz M. Aldahlawi ◽  
Mahmoud S. Al-Ahwal
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Recognition ◽  
Tongue Squamous Cell Carcinoma ◽  
Invasive Squamous Cell Carcinoma ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Supraomohyoid Neck Dissection

Tongue squamous cell carcinoma progresses from an oral premalignant lesion to invasive squamous cell carcinoma. The incidence of tongue carcinoma has been increasing markedly even in patients free of risk factors as the reporting case of a 22-years-old female complaining of small tender whitish discoloration over the left side of the tongue. First, there was a dilemma in the diagnosis taking in consideration that she is young and free of risk factor, but the magnetic resonance imaging of the head and neck showed a heterogenous mass in the tongue with deep muscular invasion. After the result of positron emission tomography-computed tomography, the patient underwent left hemiglossectomy with left supraomohyoid neck dissection and histopathology report showed invasive squamous cell carcinoma. Thus, she was referred for adjuvant radiotherapy. At this point, it emphasized that early recognition is essential; as an extensive history should be obtained from the patient that includes the symptoms emerged and risk factors.

Pancreatic squamous cell carcinoma: Epidemiology, clinicopathologic characteristics, and outcomes.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 220-220
Author(s):  
Oxana V. Makarova-Rusher ◽  
Susanna Varkey Ulahannan ◽  
Tim F. Greten ◽  
Austin G. Duffy
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Metaplasia ◽  
Relative Survival ◽  
Incidence Rates ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Poorly Differentiated ◽  
Adjusted Incidence

220 Background: Although squamous metaplasia is commonly detected in pancreatic parenchyma, primary pancreatic squamous cell carcinoma (SCC) is a rare malignancy with unknown incidence and unclear prognosis. Methods: Using SEER-18 database primary code C25 in conjunction with histology codes for SCC (8052-8053, 8070-8078, 8083-8084) and for adenocarcinoma (AC) (8052-8053, 807-8078, 8083-8084), we identified cases diagnosed from 2000 to 2012. Age-adjusted incidence rates and trends over time were calculated. Patients with SCC were compared with AC by clinical features (TNM categories and histological differentiation), and 1-year and 2-year relative survival (RS) outcomes. Chi-square tests for categorical variables and t-tests for continuous variables were conducted. Kaplan-Meier method was used to estimate RS and Z-test was used to compare RS rates. SEERStat and GraphPad were used for analysis. Results: We identified 214 patients with microscopically confirmed SCC and 72,860 patients with AC. SCC constituted less than 1% of all cases of primary pancreatic cancer; however, age-adjusted incidence rates for this subtype tripled between 2000 and 2012. The annual percent increase of SCC incidence rate was 5.5%. Significant differences were observed by age, gender and race: older age groups, blacks and males had higher SCC incidence rates. Compared to AC, a greater proportion of patients with SCC had poorly differentiated histology (15.8% vs. 30.4%, p < 0.01). Similar to AC, the majority of patients with SCC had stage IV disease at diagnosis, 54.3% for AC vs. 56.4% SCC. The 1-year and 2-year relative survival rates were significantly lower in patients with SCC than AC. The 1-year relative survival rate was 15.8% (95%CI = 10.4-22.3) for SCC, compared with 24.7% (95%CI = 24.3-25.1) for AC, p < 0.001. Conclusions: Although primary squamous pancreatic carcinoma is a rare neoplasm, incidence rates for this subtype are markedly rising. Relative to adenocarcinoma, pancreatic squamous cell carcinoma is characterized by poorly differentiated histology and worse survival.

scholarly journals Risk factors for invasive squamous cell carcinoma of the vulva and vagina—Population-based case–control study in Denmark

2008 ◽  
Vol 122 (12) ◽  
pp. 2827-2834 ◽  
Author(s):  
Birgitte S. Madsen ◽  
Helle L. Jensen ◽  
Adriaan J.C. van den Brule ◽  
Jan Wohlfahrt ◽  
Morten Frisch
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Invasive Squamous Cell Carcinoma ◽  
Control Study

scholarly journals Tongue Squamous Cell Carcinoma in a Young Patient Free of Risk Factors:

2014 ◽  
Vol 4 (1) ◽  
pp. 43-47
Author(s):  
Abdulrhman A. Abulaban ◽  
Lujain A. Khoja ◽  
Sara S. Baghlaf ◽  
Moataz M. Aldahlawi ◽  
Mahmoud S. Al-Ahwal
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Recognition ◽  
Tongue Squamous Cell Carcinoma ◽  
Invasive Squamous Cell Carcinoma ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Supraomohyoid Neck Dissection

Tongue squamous cell carcinoma progresses from an oral premalignant lesion to invasive squamous cell carcinoma. The incidence of tongue carcinoma has been increasing markedly even in patients free of risk factors as the reporting case of a 22-years-old female complaining of small tender whitish discoloration over the left side of the tongue. First, there was a dilemma in the diagnosis taking in consideration that she is young and free of risk factor, but the magnetic resonance imaging of the head and neck showed a heterogenous mass in the tongue with deep muscular invasion. After the result of positron emission tomography-computed tomography, the patient underwent left hemiglossectomy with left supraomohyoid neck dissection and histopathology report showed invasive squamous cell carcinoma. Thus, she was referred for adjuvant radiotherapy. At this point, it emphasized that early recognition is essential; as an extensive history should be obtained from the patient that includes the symptoms emerged and risk factors.

scholarly journals Clinico-pathological study of oesophageal cancer: a 3 years retrospective and 1½ year’s prospective analysis

2021 ◽  
Vol 9 (10) ◽  
pp. 3000
Author(s):  
Shrikant S. Suryawanshi ◽  
Saia Chenkula ◽  
John Zohmingthanga ◽  
Zothansanga Ralte
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Oesophageal Cancer ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Incidence Rates ◽  
Common Symptom ◽  
Civil Hospital ◽  
History Of ◽  
Adjusted Incidence

Background: In India, oesophageal cancer is second most common cancer among males and fourth most common among females and is associated with certain diets and lifestyle. In India, the age-adjusted incidence rates for oesophageal cancer are the highest in men (25.5) and women (5.5) in Mizoram. Aim of the study was to find the clinical and histopathological findings of oesophageal cancer patients at Civil Hospital, Aizawl.Methods: A descriptive study (3 years retrospective and 1½ years prospective) was conducted at Civil Hospital, Aizawl, Mizoram from July 2013 to December 2014 (1½ years) amongst 104 patients reporting to Civil Hospital, Aizawl for oesophageal cancer.Results: History of progressive dysphagia to solids was most common symptom and observed in 91.3% patients. Histopathological examination of resected esophageal specimen showed 95.7% patients were detected with squamous cell carcinoma, 4.3% patients were detected with no proper malignancy/residual tumor.Conclusion: Squamous-cell carcinoma was the most common type of esophageal cancer occurring in the middle third of the oesophagus with as observed on upper gastrointestinal (GI) endoscopy. More men were affected than female. 

Esophageal Cancer

2018 ◽  
Author(s):  
Christian C. Abnet ◽  
Olof Nyrén ◽  
Hans-Olov Adami
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Incidence Rates ◽  
Alcoholic Beverages ◽  
Nutritional Deficiencies ◽  
Middle Income ◽  
Western Countries

Esophageal cancer shows distinct geographic distributions, changing incidence rates, and primary risk factors when examined separately as squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma remains the dominant histologic type in many low- and middle-income countries and occurs frequently, while adenocarcinoma is classified as rare but predominates in Western countries. Tobacco and alcohol are the dominant risk factors for squamous cell carcinoma in Western countries, but not in high-incidence Asian populations, where hot beverages and specific nutritional deficiencies may be important. For adenocarcinoma, tobacco use is causal while alcoholic beverages are not. Rather, obesity and gastroesophageal reflux disease are the other dominant identified risk factors. Genetic predisposing factors and somatic mutations are also cell type specific. The differences in esophageal cancer incidence within and between countries, by sex and race, and in known risk factors suggest major strides in understanding the etiology of esophageal cancer is within reach.

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