Trends in incidence and mortality of squamous cell carcinoma of the skin: An observational analysis of the Global Burden of Disease database from 1990 to 2017.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10569-10569
Author(s):  
Dorothy Yang ◽  
Chinmay Jani ◽  
Conor Crowley ◽  
Richard Goodall ◽  
Joseph Shalhoub ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Burden Of Disease ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Global Burden ◽  
Incidence And Mortality ◽  
The Usa ◽  
Observation Period

10569 Background: Epidemiological data relating to non-melanoma skin cancer (NMSC), including squamous cell carcinoma (SCC), is highly under-reported and under-studied due to its lower metastatic potential. In recent years, incidence and prevalence of SCC has increased in many countries due to earlier detection, increased ultraviolet light exposure, as well as increasing life expectancy. This investigation compared trends in SCC incidence, mortality and disability-adjusted life years (DALYs) in 33 countries. Methods: We utilized the Global Burden of Disease (GBD) database for 33 countries, including the European Union nations as well as other selected high-income countries including the UK and USA. We extracted data including age-standardized incidence rates (ASIRs), age-standardized mortality rates (ASMRs) and DALYs for SCC of the skin from 1990 to 2017. Joinpoint regression analysis was used to describe the trends. Results: For both sexes, the highest ASIRs were seen in the USA and Australia: ASIRs were 362.8/100,000 and 283.7/100,000 respectively for males, and 171.2/100,000 and 152.4/100,000 respectively for females. Males had higher ASIRs than females at the end of the observation period in all countries. In contrast, the highest ASMRs for males were observed in Australia (2.77/100,000) and Latvia (2.44/100,000), while the highest ASMRs for females were observed in Romania (0.95/100,000) and Croatia (0.90/100,000). The highest DALYs for both sexes were seen in Australia and Romania: DALYs were 58.4/100,000 and 43.8/100,000 respectively for males, and 16.9/100,000 and 14.9/100,000 respectively for females. Over the observation period, there were more countries demonstrating decreasing trends in mortality than in incidence. There was also a disparity between which countries had comparatively high mortality rates and which had high incidence rates – for instance, the USA, which had by far the highest SCC incidence rates, had among the lower mortality rates. Overall reductions in DALYs were observed in 24 of 33 countries for males, and 25 countries for females. Conclusions: Over the past 27 years, although trends in SCC incidence have risen in most countries, there is evidence that mortality rates have been decreasing, especially towards the end of the observation period. Overall, burden of disease as assessed using DALYs has decreased in the majority of countries. Future work will explore potential explanatory factors for the observed disparity in trends in SCC incidence and mortality.

Penile Invasive Squamous Cell Carcinoma: Analysis of Incidence, Mortality Trends, and Geographic Distribution in Canada

2019 ◽  
Vol 24 (2) ◽  
pp. 124-128 ◽  
Author(s):  
François Lagacé ◽  
Feras M. Ghazawi ◽  
Michelle Le ◽  
Evgeny Savin ◽  
Andrei Zubarev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Invasive Squamous Cell Carcinoma ◽  
Crude Incidence ◽  
Incidence And Mortality ◽  
Adjusted Incidence

Background Penile invasive squamous cell carcinoma (SCC) is a rare disease with several known risk factors. However, few studies have assessed its incidence, mortality, and temporal trends. Objective Our objectives are to analyze the epidemiology of penile SCC in Canada and to examine patient distribution with this cancer across Canada in order to elucidate population risk factors. Methods Three independent cancer registries were used to retrospectively analyze demographic data from Canadian men diagnosed with penile invasive SCC between 1992 and 2010. The Canadian Census of Population was used to calculate incidence and mortality rates at the province and Forward Sortation Area levels. Results The overall age-adjusted incidence rate was 6.08 cases per million males. Four provinces with statistically significantly higher incidence rates were identified. The national crude incidence rates increased linearly between 1992 and 2010, whereas the age-adjusted incidence rates showed no significant increase during this time period. The overall age-adjusted mortality rate was 1.88 deaths per million males per year. The province of Saskatchewan had significantly higher mortality rates. There was no increase in crude or age-adjusted mortality rates between 1992 and 2010. There was a significant positive correlation between incidence rates and obesity, Caucasian ethnicity, and lower socioeconomic status. Conclusion This study was able to establish geographic variation for this malignancy at the provincial level. Although there are many established risk factors for penile SCC, our results suggest that the increase in crude incidence rates observed is largely due to the aging population.

scholarly journals Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada

2020 ◽  
Vol 27 (3) ◽  
Author(s):  
L. Cattelan ◽  
F. M. Ghazawi ◽  
M. Le ◽  
E. Savin ◽  
A. Zubarev ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Anal Cancer ◽  
Squamous Cell ◽  
Demographic Data ◽  
Cancer Registries ◽  
The United States ◽  
Incidence Rates ◽  
Anal Squamous Cell Carcinoma ◽  
Incidence And Mortality

Background Anal cancer is a rare disease, constituting 0.5% of new cancer cases in the United States. The most common subtype is squamous cell carcinoma (scc). Studies in several developed nations have reported on an increasing incidence of anal cancer in recent decades, and various risk factors pertaining to the pathogenesis of the disease have been identified, including infection with the human papillomavirus, tobacco use, and immunosuppression. The epidemiology and distribution of anal scc throughout Canada remain poorly understood, however. Methods Using 3 population-based cancer registries, a retrospective analysis of demographic data across Canada for 1992–2010 was performed. The incidence and mortality for anal scc was examined at the levels of provinces, cities, and the forward  sortation area (FSA) component (first 3 characters) of postal codes. Results During 1992–2010, 3720 individuals were diagnosed with anal scc in Canada; 64% were women. The overall national incidence rate was 6.3 cases per million population per year, with an average age at diagnosis of 60.4 years. The incidence increased over time, with significantly higher incidence rates documented in British Columbia and Nova Scotia (9.3 cases per million population each). Closer examination revealed clustering of cases in various urban centres and self-identified lgbtq communities in Toronto, Montreal, and Vancouver. Discussion This study provides, for the first time, a comprehensive analysis of the burden of anal scc in Canada, identifying susceptible populations and shedding light onto novel avenues of research to lower the incidence of anal cancer throughout the country.

scholarly journals Increasing Incidence Rates of Squamous Cell Carcinoma of the Skin in Sweden

2001 ◽  
Vol 81 (4) ◽  
pp. 268-272 ◽  
Author(s):  
Cecilia Wassberg ◽  
Magnus Thörn ◽  
Anna-Maria Johansson ◽  
Reinhold Bergström ◽  
Ulrik Ringborg ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Incidence Rates

scholarly journals Increasing Incidence rates of Oropharyngeal Squamous Cell Carcinoma in Germany and Significance of Disease Burden Attributed to Human Papillomavirus

2019 ◽  
Vol 12 (6) ◽  
pp. 375-382 ◽  
Author(s):  
Claus Wittekindt ◽  
Steffen Wagner ◽  
Ayman Bushnak ◽  
Elena-Sophie Prigge ◽  
Magnus von Knebel Doeberitz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Disease Burden ◽  
Incidence Rates ◽  
Oropharyngeal Squamous Cell Carcinoma

scholarly journals Esophageal Cancer in Canada: Trends according to Morphology and Anatomical Location

2012 ◽  
Vol 26 (10) ◽  
pp. 723-727 ◽  
Author(s):  
Michael C Otterstatter ◽  
James D Brierley ◽  
Prithwish De ◽  
Larry F Ellison ◽  
Maureen MacIntyre ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Esophageal Adenocarcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Relative Survival ◽  
Incidence Rates ◽  
Anatomical Location ◽  
Males And Females

BACKGROUND: Esophageal adenocarcinoma has one of the fastest rising incidence rates and one of the lowest survival rates of any cancer type in the Western world. However, in many countries, trends in esophageal cancer differ according to tumour morphology and anatomical location. In Canada, incidence and survival trends for esophageal cancer subtypes are poorly known.METHODS: Cancer incidence and mortality rates were obtained from the Canadian Cancer Registry, the National Cancer Incidence Reporting System and the Canadian Vital Statistics Death databases for the period from 1986 to 2006. Observed trends (annual per cent change) and five-year relative survival ratios were estimated separately for esophageal adenocarcinoma and squamous cell carcinoma, and according to location (upper, middle, or lower one-third of the esophagus). Incidence rates were projected up to the year 2026.RESULTS: Annual age-standardized incidence rates for esophageal cancer in 2004 to 2006 were 6.1 and 1.7 per 100,000 for males and females, respectively. Esophageal adenocarcinoma incidence rose by 3.9% (males) and 3.6% (females) per year for the period 1986 to 2006, with the steepest increase in the lower one-third of the esophagus (4.8% and 5.0% per year among males and females, respectively). In contrast, squamous cell carcinoma incidence declined by 3.3% (males) and 3.2% (females) per year since the early 1990s. The five-year relative survival ratio for esophageal cancer was 13% between 2004 and 2006, approximately a 3% increase since the period from 1992 to 1994. Projected incidence rates showed increases of 40% to 50% for esophageal adenocarcinoma and decreases of 30% for squamous cell carcinoma by 2026.DISCUSSION: Although esophageal cancer is rare in Canada, the incidence of esophageal adenocarcinoma has doubled in the past 20 years, which may reflect the increasing prevalence of obesity and gastroesophageal reflux disease. Declines in squamous cell carcinoma may be the result of the decreases in the prevalence of smoking in Canada. Given the low survival rates and the potential for further increases in incidence, esophageal adenocarcinoma warrants close attention.

scholarly journals Carcinoma espinocelular em assoalho bucal: relato de caso

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Dannilo Wiklymber Roldao Mendonça ◽  
Helinaldo Corrêa da Conceicao ◽  
Gleicy Gomes de Lima ◽  
Maria de Fátima Araújo ◽  
Lioney Nobre Cabral ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rio De Janeiro ◽  
Matched Pair ◽  
Incidence And Mortality ◽  
Head Neck ◽  
Carcinoma Of The Tongue

O câncer de boca representa um problema de saúde pública em todo o mundo, das neoplasias malignas que podem afetar a cavidade oral, o carcinoma espinocelular (CEC), destaca-se por cerca de 90% de todas as lesões malignas diagnosticadas na boca. Descrever o diagnóstico de um caso de (CEC) em região de assoalho bucal em um paciente tabagista. Paciente com 43 anos de idade, sexo masculino, melanoderma, garimpeiro, cor parda, compareceu ao atendimento na Policlínica Odontológica da Universidade do Estado do Amazonas (UEA) para exame estomatológico de rotina. Durante a anamnese o paciente relatou ser tabagista e etilista há mais de 30 anos e fazia uso de cigarros de maconha frequentemente. Ainda através da anamnese, soube-se que o paciente foi exposto por muito tempo à luz solar quando o mesmo trabalhava como garimpeiro. Mencionou também sentir bastante dor e ardência na região da lesão. Diante das informações clínicas colhidas, chegou-se à hipótese diagnóstica de (CEC). O diagnóstico foi confirmado por meio de biopsia incisional e exame histopatológico, com posterior encaminhamento para tratamento médico junto ao centro de controle de oncologia de Manaus (AM). Compete ao cirurgião-dentista diagnosticar e tratar em conjunto com outras especialidades, já que o diagnóstico precoce desta neoplasia torna-se essencial.Descritores: Neoplasias Bucais; Carcinoma de Células Escamosas; Soalho Bucal.ReferênciasFerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al. Cancer incidence and mortality wordwide: sources, methods and major patterns in Globocan 2012. Int J Cancer. 2015;136(5):E359-386.Instituto Nacional de Câncer Jose Alencar Gomes da Silva. Estimativa 2018: incidência de câncer no Brasil / Coordenação de Prevenção e Vigilância. – Rio de Janeiro: INCA, 2017.Dib LL, Sabba LMB, Marques LA, Araújo NS. Fatores prognósticos em carcinoma de bordas de língua: análise clínica e histopatológica. Acta Oncol Bras. 1994;14(2):88-93.Regezi JA, Sciubba JJ, Jordan RCK. Patologia oral: correlações clinicopatológicas. 5. Ed. Rio de Janeiro: Elsevier; 2008.Neville BW, Damm DD, Alen CM, Bouquot JE.  Patologia oral e maxilofacial. Rio de Janeiro: Elsevier; 2009.Abreu MAMM, Pimentel DRN, Silva OMP, Blachman IT, Michalany NS, Hirata CH et al. Squamous cell carcinoma of the lip: assessment of prognostic factors. Rev Bras Otorrinolaringol. 2004;70(6):765-70.Oliveira LR, Ribeiro Silva A, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira. J Bras Patol Med Lab. 2006;42(5):385-92.Figuero Ruiz E, Carretero Peláez MA, Cerero Lapiedra R, Esparza Gómez G, Moreno López LA. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Med Oral. 2004;9(1):14-23.Fardin M, Freitas SM, Dedivitis RA, Rapoport A, Denardin OVP, A-Sobrinho J. Fatores de risco no prognóstico do câncer da boca: estudo de 1440 casos. Rev Bras Cirurgia Cabeça Pescoço. 2004;33(1):27-33.Silva PSL, Leão VML, Scarpel RD. Caracterização da população portadora de câncer de boca e orofaringe atendida no setor de cabeça e pescoço em hospital de referência na cidade de Salvador – BA. Rev CEFAC. 2009;11(3):441-47.Souza LRB, Ferraz KD, Pereira NS, Martins MV. Conhecimento acerca do câncer bucal e atitudes frente à sua etiologia e prevenção em um grupo de horticultores de Teresina (PI). Rev Bras Cancerol. 2012;58(1):31-9.Syrjänen S, Lodi G, von Bultzingslowen I, Aliko A, Arduino P, Campisi G et al. Human papilloma viruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17(Suppl 1):58-72.Vidal AKL, Caldas Júnior AF, Mello RJV, Brandão VRA, Rocha GI, Taromaru E. J Bras Patol Med Lab. 2004;40(1):21-6.Sina M, Pedram M, Ghojazadeh M, Kochaki A, Aghbali A. P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran. Med Oral Patol Oral Cir Bucal. 2014;19(6):e550-55.Marchioni DML, Fisberg RM, Gois Filho JF, Kowalski LP, Carvalho MB, Abrahão M et al. Fatores dietéticos e câncer oral: estudo caso-controle na região metropolitana de São Paulo, Brasil. Cad Saúde Pública. 2007;23(3):553-64.Paiva M, Pileggi C, Nobile CGA, Angelillo IF. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83(5):1126-34.Brown LM, Moradi T, Gridley G, Plato N, Dosemeci M, Fraumeni Jr JF. Exposures in the paiting trades and paint manufacturing industry and risck among men and women in Sweden. J Occup Environ Med. 2002;44(3):258-64.Silva MFA. Avaliação da condição de saúde bucal e da qualidade de vida em pacientes com câncer de cabeça e pescoço após radioterapia [monografia]. Campina Grande: UEPB; 2012.Coaracy AEV, Lopes FF, Cruz MCFN, Bastos EG. Correlação entre os dados clínicos e histopatológicos dos casos de carcinoma espinocelular oral do Instituto Maranhense de Oncologia Aldenora Bello, em São Luís, MA. J Bras Patol Med Lab. 2008;44(1): 31-5.Iamarron A, Pattanaporn K, Pongsiriwet S, Wanachantararak S, Prapayasatok S,Jittidecharaks S et al. Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofac Surg. 2004;33(1):84-8.Sassi LM, Oliveira BV, Pedruzzi PAG, Ramo GHA, Stramandinoli RT, Gugelmin G et al. Carcinoma espinocelular de boca em paciente jovem: relato de caso e avaliação dos fatores de risco. RSBO. 2010;7(1):105-9.Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP. Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis. Head Neck. 1998;20(5):363-68.Gomes LC, Macena FCS, Ferreira VS, Barreto VR. Revisão de Literatura: câncer de boca - diagnóstico e fatores de riscos associados. Rev Interdisciplinar em saúde. 2018;5(4):655-70.Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg. 2000;122(1):44-51.Souza DP. Carcinoma espinocelular relacionado ao hábito de mascar tabaco: relato de caso clínico [monografia]. Manaus: Universidade do Estado do Amazonas – UEA; 2017.

scholarly journals Screening and identification of significant genes in esophageal squamous cell carcinoma by bioinformatical analysis

2020 ◽  
Author(s):  
Weirui Ren ◽  
Chuang Zhang ◽  
Lei Pan ◽  
Weijing Wang ◽  
Wenjuan Zhao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Disease Free Survival ◽  
Hub Genes ◽  
Incidence And Mortality ◽  
Bioinformatical Analysis

Abstract Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with notably high incidence and mortality rates. However, the molecular mechanism underlying ESCC pathogenesis and prognosis is very complicated. The main objective of our investigation has been to obtain some knowledge of significant genes with poor outcome and their underlying mechanisms.Methods: Gene expression profiles of GSE26886, GSE23400, GSE20347 and GSE17351 were available from GEO database. The differentially expressed genes (DEGs) were identified, and function enrichment analyses were performed. The protein-protein interaction network (PPI) was constructed and the module analysis was performed using STRING and Cytoscape software.Results: A total of 105 DEGs were identified between normal esophagus and ESCC bioinformatical analysis samples. Functional annotations of the common DEGs indicate that extracellular matrix (ECM) remodeling plays a key role in tumor formation and progression.18 hub genes were identified and disease free survival analysis showed that CDKN3, RAD51AP1, KIF4A may be involved in poor prognosis in ESCC patients.Conclusions: DEGs and hub genes identified in the present study help us understand the molecular mechanisms underlying the carcinogenesis and progression of ESCC, and provide candidate targets for diagnosis and treatment of ESCC.

Demographics and incidence of anal squamous cell carcinoma in people living in high HIV prevalence geographical areas

2021 ◽  
pp. sextrans-2021-055271
Author(s):  
Danielle Rebecca Louise Brogden ◽  
Christos Kontovounisios ◽  
Sundhiya Mandalia ◽  
Paris Tekkis ◽  
Sarah Catherine Mills
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Incidence Rates ◽  
Hiv Prevalence ◽  
People Living With Hiv ◽  
Early Stage Disease ◽  
Anal Squamous Cell Carcinoma ◽  
Stage Disease

ObjectivesAnal squamous cell carcinoma (ASCC) is an uncommon cancer that is rapidly increasing in incidence. HIV is a risk factor in the development of ASCC, and it is thought that the rapidly increasing incidence in men is related to increasing numbers of people living with HIV (PLWH). We undertook a population-based study comparing the demographics and incidence of ASCC in patients residing high HIV prevalence areas in England to patients living in average HIV prevalence areas in England.MethodsThis is a cross-sectional study following the ‘Strengthening the Reporting of Observational Studies in Epidemiology’ statement. Demographic data and incidence rates of ASCC within Clinical Commissioning Groups (CCGs) between 2013 and 2018 were extracted from the Cancer Outcomes and Services Dataset. CCGs were then stratified by HIV prevalence from data given by Public Health England, and high HIV prevalence geographical areas were compared with average HIV geographical areas.ResultsPatients in high HIV areas were more likely to be young and male with higher levels of social deprivation. Incidence rates in men between 2013 and 2017 were higher in high HIV areas than average HIV areas with a rapidly increasing incidence rates in early-stage disease and a 79.1% reduction in incidence of metastatic stage 4 disease.Whereas women in high HIV areas had lower ASCC incidence than the national average and a low incidence of early-stage disease; however, metastatic disease in women had quintupled in incidence in high HIV areas since 2013.ConclusionsPatients presenting with ASCC in high HIV geographical areas have different demographics to patients presenting in average HIV geographical areas. This may be related to screening programmes for PLWH in high HIV areas.

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