Trend research of vitamin D receptor: Bibliometric analysis

2021 ◽  
Vol 27 (4) ◽  
pp. 146045822110431
Author(s):  
Mohamed Abouzid ◽  
Anna K. Główka ◽  
Marta Karaźniewicz-Łada
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Polycystic Ovary ◽  
The United States ◽  
Single Nucleotide ◽  
Alcoholic Fatty Liver ◽  
University Of Wisconsin ◽  
The University ◽  
Nucleolar Rna

Studies on vitamin D receptor (VDR) and its association with multiple disorders are expanding. This bibliometric study aims to find and summarize VDR-related publications, and compare them across various countries, organizations, and journals to demonstrate trends in VDR research. VOSviewer and Excel 2019 were used to classify and summarize Web of Science articles from 1900 to mid-2021. Total records of 8762 articles were analyzed, and maps of co-citations bibliometric keywords co-occurrence were designed. In conclusion, relative research interest and published papers related to VDR were growing in the past 30 years. The United States of America dominates the research regarding VDR. The highest quality of VDR research was achieved by the University of California System, University of Wisconsin System, and Harvard University. J Steroid Biochem Mol Biol, PLoS One, and J Biol Chem are the leading three productive journals on VDR. Various aspects of vitamin D deficiency associated disorders and genetic studies regarding VDR, including single nucleotide polymorphism, gene variants, epigenome, long non-coding ribonucleic acid (lncRNA), and small nucleolar RNA host gene 6 are potentially the recent research hotspot in this field. Moreover, coronavirus disease, polycystic ovary syndrome, non-alcoholic fatty liver disease, gut microbiota, gestational diabetes, systemic sclerosis, and chemoresistance are the trending medical conditions associated with VDR.

scholarly journals Vitamin D receptor, vitamin D binding protein and CYP27B1 single nucleotide polymorphisms and susceptibility to viral infections in infants

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Zacharioudaki ◽  
Ippokratis Messaritakis ◽  
Emmanouil Galanakis
Keyword(s):  
Vitamin D ◽  
Single Nucleotide Polymorphisms ◽  
Viral Infection ◽  
Vitamin D Receptor ◽  
Viral Infections ◽  
Binding Protein ◽  
Genotypic Differences ◽  
Nucleotide Polymorphisms ◽  
Vitamin D Binding Protein ◽  
Single Nucleotide

AbstractThe role of vitamin D in innate and adaptive immunity is recently under investigation. In this study we explored the potential association of genetic variances in vitamin D pathway and infections in infancy. Τhis prospective case–control study included infants 0–24 months with infection and age-matched controls. The single nucleotide polymorphisms of vitamin D receptor (VDR) gene (BsmI, FokI, ApaI, TaqI), vitamin D binding protein (VDBP) (Gc gene, rs7041, rs4588) and CYP27B1 (rs10877012) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. In total 132 infants were enrolled, of whom 40 with bacterial and 52 with viral infection, and 40 healthy controls. As compared to controls, ΤaqI was more frequent in infants with viral infection compared to controls (p = 0.03, OR 1.96, 95% CI 1.1–3.58). Moreover, Gc1F was more frequent in the control group compared to infants with viral infection (p = 0.007, OR 2.7, 95% CI 1.3–5.6). No significant differences were found regarding the genetic profile for VDR and VDBP in infants with bacterial infection compared to the controls and also regarding CYP27B1 (rs10877012) between the studied groups. Genotypic differences suggest that vitamin D pathway might be associated with the host immune response against viral infections in infancy.

Water-Soluble Vitamin D in Human Milk: A Myth

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 499-499
Author(s):  
Joseph A. Little
Keyword(s):  
Vitamin D ◽  
Human Milk ◽  
Clinical Observation ◽  
Water Soluble ◽  
University Of Wisconsin ◽  
Water Soluble Vitamin ◽  
The University ◽  
Breast Fed

I was happy to read the report from Greer et al.1 This biochemically confirms the clinical observation that the majority of children who develop clinical rickets are breast-fed. During the ten years, 1970-1979, I have seen six cases of clinical rickets. All of these infants were breast-fed.2 The only exception has been the rickets of prematurity. I should like to commend, again, the report from the Department of Pediatrics and Biochemistry of the University of Wisconsin.

scholarly journals Association of low penetrance vitamin D receptor Tru9I (rs757343) gene polymorphism with risk of premenopausal breast cancer

2018 ◽  
Vol 46 (5) ◽  
pp. 1801-1814 ◽  
Author(s):  
Mehir un Nisa Iqbal ◽  
Syed Amir Maqbool ◽  
Taseer Ahmed Khan
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Nucleotide Polymorphism ◽  
Vdr Gene ◽  
Premenopausal Breast Cancer ◽  
Single Nucleotide ◽  
Polymerase Chain ◽  
Age Range ◽  
Control Study

Objective The aim of this study was to determine whether a novel polymorphism ( Tru9I) in the low penetrance vitamin D receptor (VDR) gene is associated with risk of premenopausal breast cancer (BC). Methods This case-control study included 228 patients with BC and 503 healthy women living in Pakistan who were analyzed for the VDR Tru9I (rs757343) single nucleotide polymorphism. BC cases were histopathologically confirmed, and all healthy controls were age-matched with patients (age range, 20–45 years). DNA was extracted, and the polymerase chain reaction and restriction fragment length polymorphism assays were performed. Results The VDR Tru9I polymorphism was not significantly associated with premenopausal BC. However, the risk of BC was associated with the ‘uu’ genotype (odds ratio [OR], 1.141; 95% confidence interval [95% CI], 0.206–6.317). Further, mutant Tru9I was significantly associated with Grade IV carcinoma (OR, 5.36; 95% CI, 1.181–24.338). Conclusion The VDR Tru9I ‘uu’ genotype may increase the risk of premenopausal BC.

Weaving Innovative Threads Together

2018 ◽  
pp. 22-35
Author(s):  
Judee Richardson
Keyword(s):  
Higher Education ◽  
United States ◽  
The United States ◽  
Skill Levels ◽  
Competency Based Education ◽  
University Of Wisconsin ◽  
Societal Needs ◽  
Specific Performance ◽  
Competency Based ◽  
The University

In the United States, institutions of higher education have been under mounting pressure to improve. In part, this is due to increasingly high-priced academies producing graduates who possess skill levels that are out of sync with employer and societal needs. Added to this is the fact that the United States spends more than other countries to educate its citizens but continues to perform more poorly on comparative measures of literacy, math, reading, and science. To stay globally competitive, changes need to be made. Competency-based education has re-emerged and taken root as one way in which to educate students more effectively. By focusing on demonstrable learning outcomes and discipline-specific performance, competency-based education is changing the fabric of higher education. Based upon experiences garnered from the University of Wisconsin Flexible Option, this chapter presents some of the challenges encountered when developing this type of program within a longstanding traditional educational system.

scholarly journals Patient-Computer Dialogue: A Review,

2000 ◽  
Vol 09 (01) ◽  
pp. 71-78 ◽  
Author(s):  
W.V. Slack
Keyword(s):  
United States ◽  
The United States ◽  
University Of Wisconsin ◽  
The Future ◽  
History Of ◽  
The University

AbstractSince the first study of communication between patient and computer was performed at the University of Wisconsin in 1965, programs for patient-computer dialogue have been developed, implemented, and studied in numerous settings in the United States and abroad, and the results have been encouraging. This review presents a brief history of patient-computer dialogue together with suggested guidelines for programs in the future.

Book Reviews

2012 ◽  
Vol 50 (3) ◽  
pp. 809-818
Keyword(s):  
Economic Development ◽  
Los Angeles ◽  
The United States ◽  
Factor Endowments ◽  
University Of Wisconsin ◽  
European Colonization ◽  
The University ◽  
Relative Differences

Jeffrey G. Williamson of Harvard University and University of Wisconsin reviews “Economic Development in the Americas since 1500: Endowments and Institutions” by Stanley L. Engerman and Kenneth L. Sokoloff. The EconLit abstract of the reviewed work begins: Eleven papers explore differences in the rates of economic growth in Latin America and mainland North America, specifically the United States and Canada, and consider how relative differences in growth over time are related to differences in the institutions that developed in different economies. Papers discuss paths of development -- an overview; factor endowments and institutions; the role of institutions in shaping factor endowments; the evolution of suffrage institutions; the evolution of schooling – 1800–1925; inequality and the evolution of taxation; land and immigration policies; politics and banking systems; five hundred years of European colonization; institutional and noninstitutional explanations of economic development; and institutions in political and economic development. Engerman is John H. Munro Professor of Economics and Professor of History at the University of Rochester. The late Sokoloff was Professor in the Department of Economics at the University of California, Los Angeles. Bibliography; index.

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