scholarly journals Mathematical models for drug delivery from textile

2019 ◽  
pp. 152808371985876
Author(s):  
Meritxell Martí ◽  
Vanessa Martínez ◽  
Manel J Lis ◽  
Luisa Coderch
Keyword(s):  
Drug Delivery ◽  
Gallic Acid ◽  
Health Sector ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Solvent Evaporation Method ◽  
Physiological Serum ◽  
Finishing Process ◽  
Theoretical Amount

Gallic acid was microencapsulated in poly-ɛ-caprolactone by the solvent evaporation method and was applied onto biofunctional textile substrates, cotton, and polyamide fabrics using a finishing process. A higher content of microspheres on polyamide was obtained due to the more hydrophobic character of polyamide. Drug release in physiological serum was carried out with treated fabrics submerged into a thermostatized vessel at semi-infinite bath conditions. The kinetic study carried out allowed the determination of the drug-delivery behavior for all systems in the medium. The results showed that the hydrophobicity and affinity of textiles and gallic acid influenced the release mechanism. For cotton, a clear Fickian diffusion was obtained; for polyamide, the diffusion was anomalous. However, no differences were found in the global mass transport. The model could address the need of the medical and health sector for assessing the theoretical amount of drug released from biofunctional textile.

scholarly journals Cellulose/Exosome Nanocarrier for Improved Prolonged Release of 5-Fluorouracil: Preparation, Characterization, Drug Release Behavior and Cytotoxicity

2021 ◽  
Author(s):  
Maryam Saeidifar ◽  
Mobina Seyedahmadi ◽  
Jafar Javadpour ◽  
Hamid Reza Rezaei
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Prolonged Release ◽  
Release Behavior ◽  
Scanning Calorimetry ◽  
Human Colon Cancer

Abstract Designing of nanoparticle drug delivery systems and improving the efficacy of anticancer drugs are a great deal of effort in the recent years. In this study, a novel biocompatible nanocarrier based on bacterial cellulose (BC) in presence of exosome (Exo) was prepared to controlled release of 5-fluorouracil (5-FU), (5-FU.Exo@BC). The physicochemical properties of 5-FU.Exo@BC was characterized using field emission scanning electron microscopy (FESEM), Differential Scanning Calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and X-ray Diffraction (XRD) techniques that confirmed the successful preparation of 5-FU.Exo@BC. The release behavior of 5-FU.Exo@BC compared to 5-FU and 5-FU@BC demonstrated a significant sustained release during 162 h. The release mechanism of the above three systems followed Korsmeyer-peppas with non-Fickian diffusion for 5-FU@BC and 5-FU.Exo@BC. In addition, the viability of HT-29 cells (human colon cancer cell line), towards BC, 5-FU@BC and 5-FU.Exo@BC indicated the promising efficacy of 5-FU into 5-FU.Exo@BC. Subsequently, the prepared bio-nanocomposite could be proposed as a potential drug delivery system with effective controlled-release function.

scholarly journals FORMULATION AND EVALUATION OF ETORICOXIB MICROBEADS FOR SUSTAINED DRUG DELIVERY

2019 ◽  
Author(s):  
Gurleen Kaur ◽  
Sonia Paliwal
Keyword(s):  
Drug Delivery ◽  
Entrapment Efficiency ◽  
Oral Route ◽  
Fickian Diffusion ◽  
Polymeric Chain ◽  
Release Mechanism ◽  
Sustained Drug Delivery ◽  
Sustained Effect ◽  
Dosing Frequency ◽  
Drug Polymer Interaction

The aim of the study was to develop novel drug design of etoricoxib microbeads for sustained drug delivery by oral route which reduces the dosing frequency. Etoricoxib is a NSAIDs commonly used by patients so to reduce the dosing frequency of drug administration the etoricoxib loaded microbeads were prepared with sodium alginate and calcium chloride in different ratios by inotropic gelation technique and characterized by FTIR, drug entrapment efficiency, particle size, swelling Index and release profile. The microbeads show that 3.86±0.28% of surface entrapment, drug content87±0.35%, swelling Index was found to be 80.76 and 88.72±0.15drug entrapment of F4 formulation depending on polymer/drug ratio. The IR spectrum shows stable character of etoricoxib in the microbeads and revealed an absence of drug polymer interaction. The prepared microbeads were spherical in shape and had a size range of 125±0.02to 165±0.18µm, the release of the drug was found to be 64.092±0.24 in F4 formulation among all formulation in 240 minutes which shows that the drug released by sustained effect and shows kinetic release mechanism the formulation F1 shows fickian diffusion and F2, F3 and F4 shows the super-case Ⅱ transport which depends upon the loss of polymeric chain and the release of drug takes place.

scholarly journals FORMULATION AND EVALUATION OF MASLINIC ACID LOADED TRANSDERMAL PATCHES

2021 ◽  
pp. 89-98
Author(s):  
NEHA CHOUDHORY ◽  
TARANJIT KAUR ◽  
AJEET PAL SINGH ◽  
AMAR PAL SINGH
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
Vapour Permeability ◽  
Maslinic Acid ◽  
Casting Technique ◽  
Transdermal Patches

Objective: To develop and evaluate Transdermal patch of Maslinic acid for Transdermal drug delivery. The current study is to develop Transdermal drug delivery system. Methods: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for preparation of Transdermal patch. Results: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for the preparation of the system was found satisfactory. Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation technique with the incorporation of penetration enhancer such as dimethylsulfoxide and dibutyl phthalate as plasticizer In vitro studies concluded that HPMC E5 patches has better release than that of EC patches, which may be attributed to high water vapour permeability of HPMC patches and hydrophobic nature of EC. An attempt was made to incorporate HPMC E5 and EC to the monolithic system for better release and prolong the duration of release. Formulation F7 containing an equal ratio of HPMC E5: EC (5:5) showed maximum and sustained release of 86.816±0.264 within 24 h. Kinetic models were used to confirm the release mechanism of the formulations. Maslinic acid release from the patches F1 to F7 followed non Fickian diffusion rate controlled mechanism.

scholarly journals Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization

2014 ◽  
Vol 50 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Venkata Srikanth Meka ◽  
Senthil Rajan Dharmanlingam ◽  
Venkata Ramana Murthy Kolapalli
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Release Mechanism ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physico-chemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate kinetics with non-Fickian diffusion mechanism. The optimized formulation was characterised with FTIR studies and observed no interaction between the drug and the polymers.

scholarly journals DESIGN AND DEVELOPMENT OF LOSARTAN POTASSIUM FLOATING DRUG DELIVERY SYSTEMS

2018 ◽  
Vol 10 (6) ◽  
pp. 168
Author(s):  
Prasanta Kumar Mohapatra ◽  
Ch. Prathibha ◽  
Vivek Tomer ◽  
Mandeep Kumar Gupta ◽  
Satyajit Sahoo
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Angle Of Repose ◽  
Losartan Potassium ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Release Mechanism ◽  
In Vitro Drug Release ◽  
Dissolution Studies

Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression parameters known as the angle of repose, bulk density, tapped density, Hausner’s ratio, compressibility index, and post-compression parameters are uniformity of weight, hardness, and drug content percentage, variability, in vitro buoyancy, dissolution studies, and Fourier transform infrared spectroscopy (FTIR).Results: An in vitro dissolution study was carried out by using buffer pH 1.2. From in vitro dissolution studies, it has been found that an increase in polymer concentration diminishes the drug release profile. The in vitro drug release percentage from F4-F9 formulations ranged from 60.28%-98.66% at the closing of 12 h and buoyancy found over 12 h.Conclusion: The in vitro drug release from F1-F3 and F7-F9 followed zero-order, F4 followed Higuchi order, F5 and F6 followed Hixon-Crowell release kinetics. The drug release mechanism was set up to be F1-F8 non-Fickian (anomalous behavior) and F9 having Fickian diffusion type.

scholarly journals FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS

2021 ◽  
pp. 82-88
Author(s):  
SAHIDUL ALAM ◽  
AMLAN BISHAL ◽  
BRATATI BANDYOPADHYAY
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Release ◽  
Sustained Release ◽  
Xanthan Gum ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Metformin Hydrochloride ◽  
Major Advance

Objective: Now a days as very few antidiabetic drugs are coming out of research and development and some existing drugs are showing several side effects when administered orally, multiple times in a day, hence change in the operation is a suitable and optimized way to make some drug more effective by slight alteration in the drug delivery. Matrix type drug delivery systems of an antidiabetic drug like Metformin Hydrochloride, is an interesting and promising option when developing an oral sustained release system Methods: An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning the targeting of a drug to a specific organ or tissue and controlling the rate of drug delivery to the target sites. This research work is made in designing of sustained release dosage form of Metformin Hydrochloride by wet granulation method employing both Xanthan Gum and Hydroxy Propyl Methyl Cellulose (HPMC K4M) as a rate controlling polymer. Results: The development of oral sustained release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. From all the formulation trial batches, formulation F7 shows the best results. It has been observed that HPMC K4M alone cannot give satisfactory drug release profile but the blend of HPMC K4M and Xanthan gum together give the best drug release kinetics. Conclusion: The drug release mechanism from the matrix tablets follows Fickian diffusion with first order kinetics. Thus, sustained release matrix tablets of metformin hydrochloride can be expected to reduce the frequency of administration and decrease the dose dependent side effects

scholarly journals Factorial design approach to fabricate and optimize floating tablets based on combination of natural polymer and rice bran wax

2022 ◽  
Vol 11 (1) ◽  
Author(s):  
Vidya P. Sabale ◽  
Gunjan G. Gadge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Factorial Design ◽  
Rice Bran ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Natural Polymer ◽  
Rice Bran Wax ◽  
The Stability

Abstract Background The aim of the present research work was to fabricate a novel gastroretentive drug delivery system in the form of tablets using a combination of natural polymer and rice bran wax with an intention to control drug delivery and to enhance the gastric residence time of the model drug Famotidine in the gastrointestinal tract. Results The results of the preliminary trial batches prepared by using the hot melt granulation technique resulting in six different formulations showed good physicochemical characteristics and tablets conformed to the Pharmacopoeial specifications. Gastroretentive tablets containing natural polymer showed prolonged drug release comparable to Methocel. The optimized formulation (C3) using 32 factorial design showed FLT 27 ± 2.47 s, SI 92.68 ± 1.36% and % CDR 98.89 ± 0.39% at 12 h. The stability studies indicated the stability of the formulation during storage. Conclusions It was concluded that the release profile fitted best to zero-order equation with non-Fickian diffusion mechanism of drug release which demonstrates swelling-controlled drug release mechanism. Thus, the formulated tablets have the potential for improved release and gastroretentive properties. Graphical Abstract

Quantitative Determination of Gallic acid and Cyanidin-3-O-Glucoside within Sumac Extracts by HPLC-MS/MS

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Koşar ◽  
F Göger ◽  
N Kırımer ◽  
KHC Başer
Keyword(s):  
Quantitative Determination ◽  
Gallic Acid

Human Prothrombin Activation: Determination of Plasma and Serum Levels of Prothrombin Fragment 3 by Radioimmunoassay

1979 ◽  
Author(s):  
Daniel Walz ◽  
Thomas Brown
Keyword(s):  
Blood Clotting ◽  
Factor Xa ◽  
Heart Association ◽  
Serum Levels ◽  
Cross Reactivity ◽  
Assay Procedure ◽  
A Chain ◽  
Prothrombin Activation ◽  
Theoretical Amount

Human prothrombin activation is unique in that, in addition to the release of fragment 1.2 (FI.2) from the NH-terminus of prothrombin by factor Xa during the generation of thrombin, an additional 13 residue polypeptide, fragment 3 (F3), is autocatalytically removed from the amino-terminus of the thrombin A chain. We have developed a rapid radioimmunoassay for human F3 which incorporates short incubation times and the use of a preprecipitated second antibody; the assay can be performed in three hours. Specificity studies in buffer systems show prothrombin and prethrombin 1 cross-reacting at a level of 0.001; purified thrombin does not cross-react. In the presence of 5% BSA, prothrombin displays considerably less cross-reactivity. No immunoreactive material to F3 antibodies could be detected in 400 μL of plasma. Serum, obtained from whole blood clotting, contained measurable quantities of F3 (40-100 ng/mL). This amount in serum represents only 5-10% of the theoretical amount available should all of the fragment be hydrolytically cleaved during the conversion of prothrombin to thrombin. This assay procedure is currently being utilized to monitor the activation of purified human prothrombin in the absence and presence of selected plasma inhibitors. (Supported in part by NIH 05384-17 and the Michigan Heart Association).

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