scholarly journals Efficacy of Traditional Chinese Medicine in Treatment and Prophylaxis of Radiation-Induced Oral Mucositis in Patients Receiving Radiotherapy: A Randomized Controlled Trial

2017 ◽  
Vol 17 (2) ◽  
pp. 444-450 ◽  
Author(s):  
Cong Wang ◽  
Peiguo Wang ◽  
Huaqiang Ouyang ◽  
Jing Wang ◽  
Lining Sun ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Body Mass ◽  
Oral Mucositis ◽  
Visual Analysis ◽  
Control Group ◽  
Oral Pain ◽  
Radiation Induced

Objective: To estimate the efficacy of traditional Chinese medicine (Chining decoction, CHIN) for radiation-induced oral mucositis in patients with head and neck cancer. Methods: From May 2014 to December 2015, 70 consecutive patients were randomly assigned to receive CHIN (treatment group) or recombinant human epidermal growth factor (rhEGF) spray (control group) at a 1:1 ratio. CHIN was administered to treatment group from the first day of radiotherapy until the completion of radiotherapy. Simultaneously, the rhEGF spray was administered to control group on the oral mucosa of irradiated area. The clinical benefit was determined by gradation of mucositis (Common Terminology Criteria for Adverse Events v4.0), oral pain, and xerostomia (visual analysis scale) for each week during radiotherapy. Body mass index was evaluated before and after radiotherapy. Results: Patients in the treatment group had prominent remission of oral pain and grade of mucositis on each observing point compared with those in control group ( P < .01). Xerostomia was decreased notably in treatment group compared with control group ( P < .01). Body mass index in the treatment group exhibited advantage over control group after radiotherapy, but there was no statistical significance (19.8 ± 3.26 vs 18.8 ± 2.5 kg/m2, P = .153, >.05). Conclusions: CHIN presented an obvious advantage in preventing radiation-induced oral mucositis compared with rhEGF spray.

scholarly journals Effect of Qingre Jiedu Huoxue Huayu Recipe on blood stasis and toxin syndrome in patients with non-ST segment elevation acute coronary syndrome, serum Lp-PLA2, TNF- α, and PIGF expression level

2022 ◽  
Vol 67 (4) ◽  
pp. 121-129
Author(s):  
Tan Zifu ◽  
Li Jiaquan ◽  
Zhang Juan
Keyword(s):  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Blood Stasis ◽  
Control Group ◽  
Comprehensive Treatment ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

The pathological basis of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is severe coronary stenosis, unstable plaque erosion, and rupture, resulting in coronary blood flow reduction and myocardial ischemia, leading to acute thrombosis cardiovascular disease events. This subject intends to study the treatment of NSTE-ACS patients with blood stasis and toxin syndrome by Qingre Jiedu Huoxue Huayu Decoction, observe its clinical efficacy, and explore the effects of serum lipoprotein phospholipase A2 (Lp-PLA2) and tumor necrosis factor- α (TNF- α), the effect of placental growth factor (PIGF) expression. In this study, 100 patients with blood stasis and toxin syndrome of NSTE-ACS treated in the cardiovascular department of Enshi National Hospital from August 2020 to August 2021 were selected as the research object. They were randomly divided into traditional Chinese medicine comprehensive treatment groups and conventional western medicine control groups, with 50 cases. The conventional western medicine control group was treated with hydroclopidogrel tablets orally, and the comprehensive treatment group of traditional Chinese medicine combined with Qingre Jiedu Huoxue Huayu formula orally. The patients in both groups were treated for four weeks. The results showed that after treatment, the practical clinical rate of the comprehensive treatment group was significantly higher than that of the conventional western medicine control group. After treatment, the TCM syndrome score, angina pectoris attack duration, and angina pectoris attack frequency, myocardial zymogram index level, serum Lp-PLA2 and TNF of the two groups were measured- α. The levels of PIGF were significantly lower than those before treatment. The decline of the above indexes in the comprehensive treatment group of traditional Chinese medicine was significantly better than that in the control group of conventional Western Medicine (P<0.05). The incidence of MACE events in the TCM Comprehensive treatment group was significantly lower than that in the conventional western medicine control group (P <0.05).

scholarly journals The Effect of the Transtheoretical Model Approach Towards the Body Mass Index of Overweight and Obese Children in Makassar

2014 ◽  
Vol 6 (1) ◽  
pp. 51
Author(s):  
Kadek Ayu Erika
Keyword(s):  
Body Mass Index ◽  
Treatment Group ◽  
Body Mass ◽  
Transtheoretical Model ◽  
Health Risk Behaviors ◽  
Overweight And Obesity ◽  
The Body ◽  
Control Group ◽  
Research Subjects ◽  
Obese Children

BACKGROUND: Overweight and obesity is now ranked fifth as a global risk for the cause of death. Urban lifestyle is fueled by excessive food intake and lack of activity in overweight and obese children. The assessment of the children’s Body Mass Index (BMI) is one of the indicators to assess the nutritional status of children. One strategy that can be used is the transtheoretical model (TTM) approach which is behavior change that helps children and parents in making more effective decisions to reduce health-risk behaviors among children so that the children’s BMI can decrease. This study aims to identify the differences between children's BMI before and after the TTM approach.METHODS: This research was conducted in the district area of Tamalanrea and Biringkanaya, Makassar. The design used is the Quasy Experiment namely pre- and post-test with control group design. Research subjects were overweight or obese children in the 4th, 5th, and 6th grade of elementary school. The samples in the treatment group consisted of 31 participants, while the control group consisted of 33 participants which were selected using purposive sampling. Intervention research was conducted during a six month period by providing guide books on healthy lifestyle, visiting the families every month using questionnaires, and measurements of children’s height, weight and BMI using WHO’s AntrhoPlus software year 2007.RESULTS: Post-pretest results showed the average value of the treatment group’s BMI was -1.48 and the control group was 1.35. This means that the treatment group experienced a decrease in BMI after the application of TTM. The Mann Whitney test results indicate that there is a difference in the BMI pre-post intervention with the value of p=0.00 (>0.05).CONCLUSION: The overweight and obese children’s BMI was influenced by TTM approach.KEYWORDS: transtheoretical model, children’s BMI, overweight, obesity

scholarly journals Clinical Study of Radiofrequency Ozone and Injection of Anti-inflammatory Analgesic Solution into the Internal Orifice of Nerve Root Combined with Traditional Chinese Medicine Hook Operation in the Treatment of Lumbar Disc Herniation

2021 ◽  
Author(s):  
WanHai Zhang ◽  
ZhiGang Wang ◽  
JianWei Yin ◽  
YuanYuan Bai ◽  
FengChao Qiu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Nerve Root ◽  
Lumbar Disc ◽  
Control Group ◽  
Lumbar Intervertebral Disc ◽  
Anti Inflammatory

Abstract Background: This study aims to explore the clinical efficacy of radiofrequency ozone and injection of anti-inflammatory analgesic solution into the internal orifice of nerve root combined with traditional Chinese medicine hook operation in the treatment of lumbar disc herniation. Methods: The patients with lumbar disc herniation in our hospital from December 20, 2017 to June 19, 2019 were selected as the main research subjects, and the patients were numbered according to the order of their first visits, and the included patients were divided into treatment group and control group using random number table method. Patients in the treatment group were treated with radiofrequency ozone and injection of anti-inflammatory analgesic solution into the internal orifice of nerve root combined with traditional Chinese medicine hook operation. Patients in the control group were treated with traditional lumbar intervertebral disc radiofrequency treatment. The clinical treatment effects of the two groups were observed. Results: A total of 113 patients were included in this study, of which 73 were in the treatment group and 40 were in the control group. The results of the study showed that the NRS scores of patients in the treatment group before treatment were 5±1.68 points, and the NRS scores were 2±0.78 points, 1±0.54 points, and 1±0.77 points 1 month, 3 months, and 1 year after treatment, respectively. The NRS scores of patients in the control group were 3±0.48 points, 2±0.63 points, and 2±0.85 points 1 month, 3 months, and 1 year after treatment. Compared with before treatment and the control group, there were significant differences (P<0.01). Conclusion: Compared with single lumbar intervertebral disc radiofrequency treatment, radiofrequency ozone and injection of anti-inflammatory analgesic solution into the internal orifice of nerve root combined with hook operation can obtain good short-term and medium-term effects in the treatment of lumbar disc herniation. It is a safe and effective minimally invasive treatment method.

scholarly journals Clinical Effect Observation of Jieyu Decoction in the Treatment of Generalized Anxiety Disorder

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Hanmei Xue ◽  
Xiaofang Ren
Keyword(s):  
Anxiety Disorder ◽  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Generalized Anxiety Disorder ◽  
Control Group ◽  
Generalized Anxiety ◽  
Chinese Medicine Syndrome ◽  
Traditional Chinese Medicine Syndrome ◽  
Significant Difference

Objective: To observe the clinical effect of Jieyu decoction in treating generalized anxiety disorder with stagnation-heat in liver meridian type. Methods: There were 72 cases of generalized anxiety disorders outpatient and inpatient patients, and 36 in the control and treatment group. The control group was given oral Deanxit; the treatment group was given Jieyu decoction granules, and necessary psychological counseling was given to patients in both groups. Changes in traditional Chinese medicine syndrome scoring scale, Hamilton scale (HAMA), dynamic electrocardiogram heart rate variability and other indicators were recorded and compared between the two groups. Results: The total effective rate of the control group was 76.5%, and the total effective rate of the treatment group was 80.0%. The curative effect of the treatment group and the control group was significantly higher than that before treatment (P < 0.05), and there was no significant difference in the overall curative effect between the two groups (P > 0.05). The HAMA scale score of the two groups was significantly lower than that before treatment (P < 0.05), and there was no significant difference in the reduction rate of HAMA score between the two groups (P > 0.05). The traditional Chinese medicine syndrome scores of the two groups were significantly decreased compared with that before treatment (P < 0.05). The traditional Chinese medicine syndrome scores of the treatment group were significantly different from that of the control group after 8 weeks of treatment (P < 0.05). Two groups of heart rate variability in 24 h period of standard deviation between the average normal R - R (SDNN), 24 h per 5 min normal R - R period between the standard deviation (SDANN), root mean square of phase difference between adjacent R - R (RMSSD) and the number of cardiac 50 ms accounted for the percentage of the total number of cardiac (PNN50) than before treatment significantly increased (P < 0.05), 8 weeks after treatment the SDNN, SDANN than the control group no significant difference (P > 0.05), RMSSD,PNN50 significantly difference compared with control group (P < 0.05). Conclusion: Jieyu decoction has good efficacy and high safety in the treatment of generalized anxiety disorder of the type of liver meridian and heat stagnation, which is suitable for clinical promotion and application.

Efficacy of WC03 in treating radiotherapy-induced oral mucositis (RIOM): A multicenter nonrandomized controlled clinical trial.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24127-e24127
Author(s):  
Dongmei Chen ◽  
Tian Gu ◽  
Liqun Jia
Keyword(s):  
Head And Neck Cancer ◽  
Treatment Group ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Effective Rate ◽  
Secondary Outcome ◽  
Control Group ◽  
Oral Pain

e24127 Background: RIOM is a common side effect of radiotherapy for head and neck cancer patients, however, no standard and effective treatment existed so far. WC03 is an oily Traditional Chinese Herbal Medicine recipe for external-use in mouth, which had been utilized to treat RIOM in China-Japan Friendship Hospital for more than ten years. This trial aimed to investigate the safety and efficacy of WC03 in treating RIOM. Methods: Between May 2017 and June 2018, we conducted a multicenter, non-randomized controlled trial within 7 hospitals in China. Inclusion criteria included head and neck cancer patients who developed RIOM (≥ grade II) undergoing radiotherapy or after radiotherapy (within 6 months). They were assigned to different groups based on their willingness. Patients in treatment group were treated by WC03, which was daily applied to the oral mucosa for 30 min twice a day. Patients in control group were treated with Kangfuxin (Periplaneta americana) Lotion combined with conventional treatment such as vitamin B12 and rhGM-CSF. The interventions lasted for 2 weeks. The primary outcome was overall effective rate, which was calculated through changes of radio-induced oral mucositis grade before and after interventions (according to National Cancer Institute Common Toxicity Criteria). Secondary outcome was oral pain which was measured by Numeric Pain Rating Scale. Results: 48 eligible participants were enrolled, 24 in treatment group and 24 in control group, respectively. 2 patients in treatment group were withdrawn from the study in the first week because of developing secondary infection and treatment got changed. Thus, 22 were included at the terminal of the study. All the 24 participants in control group were included. After the intervention, the overall effective rate was 95.45%(21/22) in the treatment group, which was significantly higher than that of 70.83% (17/24) in the control group (p = 0.049). Similarly, 86.36%(19/22) of the participants in treatment group got cured, which was significantly higher than that of 45.83%(11/24) in the control group(p = 0.007). There is a trend that oral pain relief rate in the treatment group was higher than that of the control group, but not statistically significant (100.00% vs. 87.50%, p = 0.210). Patients in treatment group used less time to get relieved from RIOM than control group (5 vs. 8 days, p < 0.001). No adverse event had been observed in both two groups. Conclusions: WC03 is safe and effective in treating radiotherapy-induced oral mucositis. RCT is necessary in future studies.

Acupuncture to Boost Breast Milk in Postpartum Hypogalactia: Randomized Controlled Trial

2021 ◽  
Vol 104 (12) ◽  
pp. 1930-1936
Keyword(s):  
Chinese Medicine ◽  
Treatment Group ◽  
Breast Milk ◽  
Traditional Chinese Medicine ◽  
Conventional Treatment ◽  
Controlled Trial ◽  
Control Group ◽  
Breast Milk Production ◽  
Early Postpartum ◽  
Breastfeeding Rate

Background: Breast milk is appropriate and useful but the exclusive breastfeeding rate in Thailand was quite low at only 23.1%. Hypogalactia is one of the important barriers of breastfeeding. Studies in Asia and the west have shown that acupuncture could boost breast milk. However, some articles had controversial result. There has been no study to assess efficiency of acupuncture in early postpartum hypogalactia. Objective: To compare the efficacy of acupuncture and conventional treatment for stimulating breast milk in early postpartum hypogalactia at 48 hours. Materials and Methods: A randomized, prospective, clinical trial was used for the present study. Sixty postpartum hypogalactic women of term gestation in postpartum ward in Charoenkrung Pracharak Hospital between March 1, 2020 and February 28, 2021 were enrolled. They were randomized into acupuncture and control groups. In the study group, mothers received once a day acupuncture at 13 acupoints without electrode for three consecutive days by qualified Traditional Chinese Medicine practitioner other than conventional treatment. Breast milk quantity were measured at day 1, day 7, and day 14 after the intervention. Results: Mean age of all participants was 29.72±5.96 year, mostly primigravida, delivered by vaginal route. Mean milk volume in the treatment group were significantly higher than the control group (p<0.05) with day 1 at 19.00±22.25 versus 5.97±6.08 mL, day 7 at 78.10±60.38 versus 40.17±28.82 mL, and day 14 at 128.33±64.86 versus 75.00±57.96 mL. The amount of breast milk in the treatment group were 3-fold, 2-fold, and 1.7-fold times more than the control group at day 1, day 7, and day 14, in respective order (p<0.05). Conclusion: Accurate acupuncture intervention could boost breast milk production in early postpartum hypogalactia at 48 hours. Keywords: Postpartum hypogalactia; Acupuncture; Traditional Chinese Medicine (TCM)

scholarly journals Research Progress of Non-drug Therapy of Traditional Chinese Medicine in the Treatment of Obese Polycystic Ovary Syndrome

2021 ◽  
Vol 5 (4) ◽  
pp. 106-109
Author(s):  
Chanchan Li ◽  
Nan Li
Keyword(s):  
Body Mass Index ◽  
Drug Therapy ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Relevant Literature ◽  
Research Progress ◽  
Glucose And Lipid Metabolism ◽  
The Impact

Polycystic ovarian syndrome (PCOS) as a relatively common clinical reproductive endocrine disease, the incidence is increasing year by year and the treatment is difficult, among which obese PCOS accounts for nearly 50% of the total. In recent years, non-drug therapy of traditional Chinese medicine (TCM) has been effective in the treatment of PCOS. This article summarizes the relevant literature in the past ten years from acupuncture, acupoint embedding, moxibustion, and auricular points, and observes the effects of TCM non-drug therapy on endocrine and glucose and lipid metabolism in obese PCOS patients. The impact of various indicators such as body mass index, body mass index, etc., and discuss the problems in such treatments, as well as put forward suggestions to achieve the purpose of better guiding the clinical treatment of obese PCOS.

scholarly journals Sharing the ‘weight’ of obesity management in primary care: integration of registered dietitian nutritionists to provide intensive behavioural therapy for obesity for Medicare patients

2020 ◽  
Author(s):  
Molly Jacobs ◽  
Jordan Harris ◽  
Kay Craven ◽  
Lauren Sastre
Keyword(s):  
Primary Care ◽  
Body Mass Index ◽  
Treatment Group ◽  
Clinical Outcomes ◽  
Body Mass ◽  
Fixed Effects ◽  
Care Setting ◽  
Primary Care Setting ◽  
Control Group ◽  
Registered Dietitian

Abstract Background Clinical provision of intensive behavioral therapy for obesity (IBTO) has been a reimbursable treatment for obesity since 2012. However, gaps remain in the literature regarding its impact on patient outcomes. Objectives The primary objective of this study was to examine the integration of registered dietitian nutritionist provided IBTO into a primary care setting and evaluate clinic outcomes for Medicare Part B beneficiaries. A secondary objective was to examine intensity of IBTO (quantity of IBTO visits) versus clinical outcomes and influence of socioeconomic factors. Methods A case–control retrospective chart review was conducted at a rural, Academic Family Medicine Clinic in Eastern North Carolina for patients seen between 1 January 2016 and 1 January 2019. In order to be included in the treatment group, patients had to be female, white or black race, have Medicare insurance and a body mass index ≥ 30 kg/m2. Results Mixed model analysis showed statistically significant improvements in clinical outcomes from IBTO treatment. Weight decreased by nearly 3 pounds, while body mass index was half a point lower. A1C was 0.1 units lower for IBTO patients, and they took prescription medication and average of 6 days less than the control group. Minorities and older respondents experienced smaller, all else constant, and annual fixed effects suggest that differentials widen over time. Conclusions Registered dietitian nutritionist (RDN) provision of IBTO has demonstrated benefit in improving clinical outcomes including weight, A1C, and reduced medication duration (use) as demonstrated by the IBTO treatment group versus control. IBTO intensity was not predictive of success, and its impact was reduced with older and African American patients. IBTO is beneficial and can be delivered within the primary care setting by a RDN.

scholarly journals Shengmai Yin formula modulates the gut microbiota of spleen-deficiency rats

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Yu You ◽  
Lin Luo ◽  
Yanyan You ◽  
Yanjun Lin ◽  
Huiling Hu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Vasoactive Intestinal Peptide ◽  
Body Mass ◽  
Relative Abundance ◽  
The Body ◽  
Control Group ◽  
Spleen Deficiency ◽  
Model Control

Abstract Background Spleen-deficiency syndrome, an important pathological change in traditional Chinese medicine, has been proven to attribute to intestinal dysbacteriosis. Shengmai Yin (SMY), a classic formula for replenishing qi and restoring pulse, is a common medicine for critical emergencies in traditional Chinese Medicine. Interestingly, our previous study established a spleen-deficiency rat model and verified the potency of SMY formula in curing spleen-deficiency rats. Our goal herein was to explore whether SMY can modulate the composition of intestinal flora and alleviate spleen-deficiency in rats. Methods This experiment was randomly divided into three groups, namely the normal control group (NC), model control group (MC), and the Shengmai Yin group (SMY). After the treatment, the weight and symptom indexes of the rats were recorded, histological changes in the colon were observed, levels of serum D-xylose, gastrin (GAS), and vasoactive intestinal peptide (VIP) were measured, and gut microbiota profiling was conducted by 16S rRNA sequencing. Results The body mass of the spleen-deficiency model rats significantly decreased compared with that of the NC group, and SMY treatment significantly increased body mass compared with the MC group (P < 0.01). Colon histopathology revealed that SMY treatment alleviated colonic mucosal damage in spleen-deficiency rats. The serum levels of D-xylose and gastrin (GAS) were significant increased by SMY (P < 0.05, P < 0.01), and vasoactive intestinal peptide (VIP) was reduced by SMY (P < 0.01) compared with MC. Furthermore, alpha diversity was significantly decreased in the model rats compared to the normal rats (P < 0.05) and increased with SMY treatment (P < 0.01). The most abundant phyla were Firmicutes and Bacteroidetes, followed by Proteobacteria, Verrucomicrobia, and Actinobacteria. At the genus level, there was a lower relative abundance of Lactobacillus, Bacteroides, Akkermasia, and Allobaculum, and a higher relative abundance of Lachnospiraceae NK4A 136 group, Ruminococcaceae UCG-014, and Sphingomonas in the MC group. The relative abundance of Actinobacteria, Alistipes, Bifidobacterium, Bifidobacterium, Bifidobacteriaceae, Lachnospiraceae NK4A136group, Lactobacillus, Lactobacillaceae, Bacilli, Verrucomicrobiae, and Akkermansia were significantly abundant in the treatment groups, and thus may be singled out as potential biomarkers for SMY in the treatment of spleen deficiency. In addition, analysis on the correlation between species and physicochemical indexes showed that the abundance of Parasutterella was negatively correlated with the change in GAS, and positively correlated with the change in VIP (P < 0.01). Conclusion Our findings have provided preliminary evidence that modulating the gut microbiota may play a role in the treatment of spleen deficiency with SMY. However, further studies are needed to clarify the mechanism by which SMY regulation of related gut microbiota occurs.

Impact of Acute Physical Activity on Children's Divergent and Convergent Thinking: The Mediating Role of a Low Body Mass Index

2019 ◽  
Vol 126 (4) ◽  
pp. 603-622 ◽  
Author(s):  
Ashish Bollimbala ◽  
P. S. James ◽  
Shirshendu Ganguli
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Treatment Group ◽  
Body Mass ◽  
Control Group ◽  
Convergent Thinking ◽  
Creative Potential ◽  
Divergent And Convergent Thinking ◽  
Low Body Mass Index ◽  
The Impact

While prior studies have examined the positive influence of physical activity (PA) programs on children's creative potential, they have not explored the mediating roles of psychological and physiological variables. In this study, we investigated the impact of a single dance session as a form of PA on two indicators of creative potential—divergent and convergent thinking, each of which adopts a different cognitive pathway. We also investigated the influence of a physiological condition, low body mass index (BMI), on the relation between PA and creative potential. This was a randomized controlled experiment involving 34 school children randomly assigned to either the dance intervention or a sedentary group based on their BMI profile. We measured the children's divergent and convergent thinking at pre- and post-intervention time points. Following this single PA session, we found a significant difference between divergent and convergent thinking abilities in treatment group participants with normal BMI levels and participants in the control group, but there was no difference between low BMI level treatment group participants and those in the control group. This study supported hypothesized boundary conditions for executive function improvements from PA and suggests a need for a holistic approach (involving both proper nourishment and PA) in order to facilitate improved creativity in children.

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