scholarly journals 5 Reasons Why Scoliosis X-Rays Are Not Harmful

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582095779 ◽  
Author(s):  
Paul A. Oakley ◽  
Niousha Navid Ehsani ◽  
Deed E. Harrison

Radiographic imaging for scoliosis screening, diagnosis, treatment, and management is the gold standard assessment tool. Scoliosis patients receive many repeat radiographs, typically 10-25 and as many as 40-50, equating to a maximum 50 mGy of cumulative exposure. It is argued this amount of radiation exposure is not carcinogenic to scoliosis patients for 5 main reasons: 1. Estimated theoretical cumulative effective doses remain below the carcinogenic dose threshold; 2. Scoliosis patient x-rays are delivered in serial exposures and therefore, mitigate any potential cumulative effect; 3. Linear no-threshold cancer risk estimates from scoliosis patient cohorts are flawed due to faulty science; 4. Standardized incidence/mortality ratios demonstrating increased cancers from aged scoliosis cohorts are confounded by the effects of the disease entity itself making it impossible to claim cause and effect resulting from low-dose radiation exposures from spinal imaging; 5. Children are not more susceptible to radiation damage than adults. Radiophobia concerns from patients, parents, and doctors over repeat imaging for scoliosis treatment and management is not justified; it adds unnecessary anxiety to the patient (and their parents) and interferes with optimal medical management. X-rays taken in the evidence-based management of scoliosis should be taken without hesitation or concern about negligible radiation exposures.

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e017548 ◽  
Author(s):  
Rebecca Ward ◽  
William D Carroll ◽  
Paula Cunningham ◽  
Sheng-Ang Ho ◽  
Mary Jones ◽  
...  

ObjectivesCumulative radiation exposure is associated with increased risk of malignancy. This is important in cystic fibrosis (CF) as frequent imaging is required to monitor disease progression and diagnose complications. Previous estimates of cumulative radiation are outdated as the imaging was performed on older equipment likely to deliver higher radiation. Our objectives were to determine the radiation dose delivered to children during common radiological investigations using modern equipment and to identify the number of such investigations performed in a cohort of children with CF to calculate their cumulative radiation exposure.Design, setting and participantsData including age at investigation and radiation exposure measured as estimated effective dose (EED) were collected on 2827 radiological studies performed on children at one UK paediatric centre. These were combined with the details of all radiological investigations performed on 65 children with CF attending the same centre to enable calculation of each child’s cumulative radiation exposure.ResultsThe mean EED for the common radiological investigations varied according to age. The range was 0.01–0.02 mSv for chest X-rays, 0.03–0.11 mSv for abdominal X-rays, 0.57–1.69 mSv for CT chest, 2.9–3.9 mSv for abdominal and pelvic CT, 0.20–0.21 mSv for sinus CT and 0.15–0.52 mSv for fluoroscopy-guided procedures. The mean EED was three to five times higher for helical compared with axial chest CT scans. The mean annual cumulative EED for our cohort of children with CF was 0.15 mSv/year with an estimated cumulative paediatric lifetime EED (0–18 years) of 3.5 mSv.ConclusionsThis study provides up-to-date estimations of the radiation exposure when using common radiological investigations. These doses and the estimates of cumulative radiation exposure in children with CF are lower than previously reported. This reflects the reduced EED associated with modern equipment and the use of age-specific scanning protocols.


2017 ◽  
Vol 10 (01) ◽  
pp. 31
Author(s):  
Kerry K Assil ◽  
V Nicholas Batra ◽  
◽  

Comprehensive evaluation of retinal health prior to and following cataract surgery is critical to supporting optimal outcomes. In addition to the importance of identifying retinal pathology that may prevent or delay cataract surgery, continuous advances in refractive intraocular lens technology and cataract surgical technique, coupled with increasingly high expectations regarding visual outcomes among younger patients, make the consideration of long-term quality of vision paramount in the cataract assessment. Optos® ultrawidefield retinal imaging supports this clinical objective by providing imaging standardization in a streamlined, patient-friendly exam process, supporting robust documentation that facilitates mapping of disease progression, and offering potential economic advantages in a resourceconstrained environment.


Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Lamia Ait-Ali ◽  
Nicoletta Botto ◽  
Maria Grazia Andreassi ◽  
Pierluigi Festa ◽  
Eugenio Picano

Background: The “Biological effects of Ionizing Radiation” (BEIR VII,2005) underlines “the need of studies of infants who are exposed to diagnostic radiation”. Aim: to assess the individual cumulative lifetime radiological dose in grown up congenital heart disease (GUCH) patients. Methods: In 41 consecutive operated GUCH patient (24 males, age= 27 ± 9 years old), followed in our outpatient clinic, a cumulative radiological history was collected with a structured questionnaire and access to lifetime hospital records. All patient underwent at least one surgical intervention during the infancy for Tetralogy of Fallot (n=18), aortic coarctation (n=10), anatomical/functional univentricular heart (n=8), other congenital heart disease (n=5) The cumulative exposure was expressed in milliSievert (mSv) and derived from average effective dose estimates of individual examinations proposed by the European Commission Medical Imaging Guidelines (2001). The attributable cancer risk was estimated from BEIR VII, 2005 document. Results: On average, cumulative dose estimate was 22.3 ± 12.4 (mean ± SD) mSv per patient, equivalent to about 1115 ± 620 chest x-rays. Diagnostic and interventional catheterization accounted for the most important sources of exposure (see figure ). The median cumulative dose gave an average extra-risk of cancer of about 1 out of 200 patients (range, 1 in 448 to 1 out of 58). Conclusion: the average contemporary GUCH patient is exposed to a significant cumulative radiological effective dose. Every effort should be done to justify the indications and to optimise dose delivery during ionizing testing.


Author(s):  
Kaye Shelton ◽  
Karen L. Pedersen ◽  
Lisa A. Holstrom

In an era of tightening institutional budgets, ever increasing online enrollments and greater calls for accountability from multiple directions, the need for online program administrators to continually assess the quality of their overall operations has never been greater. But even vigilant administrators have had difficulty defining “quality” and were unable to benchmark to other programs, as standards for quality varied. To address this daunting task, a research-based standard assessment tool known as the Quality Scorecard for the Administration of Online Education Programs was developed. The primary goals of this case are to Provide a brief overview of the scorecard highlighting the key areas of the quality indicators and the scoring protocol and present practical applications for this research-based assessment tool as evidenced through the administration of the scorecard by three online administrators at four institutions. By focusing on the ways in which different administrators at diverse institutions (public and private, large and small) used the Quality Scorecard to benchmark their online operations against a standard, we are able to illustrate how continuous improvement opportunities, impacting on both learning effectiveness and program improvement, can be implemented at the program or institutional level.


2020 ◽  
Vol 24 (02) ◽  
pp. 54-64

The following topics are under this section: ASIA-PACIFIC — Collaborative research effort reveals chemical compound that kills drug-resistant bacteria ASIA-PACIFIC — Big Data Analytics used for Personalized Assessment Tool for Cancer Diagnosis ASIA-PACIFIC — Identifying the Molecular Mechanisms of Creating a Memory ASIA-PACIFIC — Funding for New Stem Cell Research provides Hope for Premature Born Babies ASIA-PACIFIC — Human Cortical Organoids used to Identify Mechanisms behind Epilepsy in Angelman Syndrome ASIA-PACIFIC — The Future of Contact Lenses: Self-Moisturising Technology ASIA-PACIFIC — Glycosylation of Protein Structure on Virus provide Insight to Molecular Understanding ASIA-PACIFIC — Comprehensive Mapping of the Human Brain using Synchrotron X-rays REST OF THE WORLD — Uncovering New Tricks for Old Drugs REST OF THE WORLD — Combination of Prenatal Smoking and Drinking adds on to Risk of SIDS REST OF THE WORLD — Blood Pressure Readings Could Provide Valuable Information on Early Warning Signs of Heart Disease REST OF THE WORLD — Study finds Households in the United States Wastes nearly a Third of the Food they Buy


1964 ◽  
Vol 19 (10) ◽  
pp. 929-935 ◽  
Author(s):  
Sigrid Hempel ◽  
Wolfgang Laskowski

A diploid Saccaromyces strain was treated with several doses of X-rays, UV and succinic acid peroxyde (BPO). The inactivation of the ability to form macroscopic colonies as well as the ability to form microcolonies of at least two cells to a few hundred cells has been compared with the inactivation of respiration and fermentation intensity. If the inactivation of macroscopic colony formation is taken as a measure of the effective dose applied, the formation of at least one daughter cell as well as respiration and fermentation intensity is reduced to approximately the same extent after BPO and X-ray treatment. In the latter case, however, much higher effective doses have to be applied and a distinct difference between respiration and fermentation sensitivity is observed. After UV-treatment the formation of at least one daughter cell is exceedingly more sensitive than the fermentation processes. The respiration processes behave most UV resistant. Possible reasons for the observed different relative sensitivities are discussed.


2020 ◽  
Author(s):  
Zeinab Siami ◽  
Alireza Soleimani ◽  
Armin Khavandegar

Abstract Background: The COViD-19 gold standard assessment tool remained the RT-PCR of upper respiratory tract specimen extracted by the nasopharyngeal swab. A positive result would dwindle through a three-week course and, eventually, would be undetectable. The most prolonged period of detectable viral RNA was 37 days. Besides, COViD-19 RT-PCR remained positive for 74 days in a patient suffering from lymphoma Case presentation: In this study, we have presented a 56-year-old Persian male patient, a known case of lymphoma since 2015, who experiences many episodes of chemotherapy with a five-month positive RT-PCR COViD-19 laboratory test and finally was intubated and then died of opportunistic pulmonary infections. Conclusion: COViD-19 patients who have concurrent lymphoma failed to remove the virus thoroughly, despite providing appropriate treatment regimens.


2021 ◽  
Vol 12 ◽  
Author(s):  
Barbara Hinterbuchinger ◽  
Nilufar Mossaheb

Assuming a continuum between psychotic experiences and psychotic symptoms aligned between healthy individuals and patients with non-psychotic and psychotic disorders, recent research has focused on subclinical psychotic experiences. The wide variety of definitions, assessment tools, and concepts of psychotic-like experiences (PLEs) might contribute to the mixed findings concerning prevalence and persistence rates and clinical impact. In this narrative review, we address the panoply of terminology, definitions, and assessment tools of PLEs and associated concerns with this multitude. Moreover, the ambiguous results of previous studies regarding the clinical relevance of PLEs are described. In conclusion, we address clinical implications and highly suggest conceptual clarity and consensus concerning the terminology and definition of PLEs. The development of an agreed upon use of a “gold standard” assessment tool seems essential for more comparable findings in future research.


Author(s):  
Rolina D van Gaalen ◽  
Wieke Altorf-van der Kuil ◽  
Marjolijn C A Wegdam-Blans ◽  
Jessica M Aguilar Diaz ◽  
Marie-Eve Beauchamp ◽  
...  

Abstract Objectives To obtain comprehensive insight into the association of ciprofloxacin use at different times in the past with the current risk of detecting resistance. Methods This retrospective nested case–control study of ciprofloxacin users used Dutch data from the PHARMO Database Network and one laboratory for the period 2003–14. Cases and controls were selected as patients with an antibiotic susceptibility test (AST) indicating ciprofloxacin resistance or susceptibility, respectively. We performed univariable and multivariable conditional logistic regression analyses, defining time-dependent exposure using standard definitions (current ciprofloxacin use, used 0–30, 31–90, 91–180 and 181–360 days ago) and a flexible weighted cumulative effect (WCE) model with four alternative time windows of past doses (0–30, 0–90, 0–180 and 0–360 days). Results The study population consisted of 230 cases and 909 controls. Under the standard exposure definitions, the association of ciprofloxacin use with resistance decreased with time [current use: adjusted OR 6.8 (95% CI 3.6–12.4); used 181–360 days ago: 1.3 (0.8–1.9)]. Under the 90 day WCE model (best-fitting model), more recent doses were more strongly associated with resistance than past doses, as was longer or repeated treatment. The 180 day WCE model, which fitted the data equally well, suggested that doses taken 91–180 days ago were also significantly associated with resistance. Conclusions The estimates for the association between ciprofloxacin use at different times and resistance show that ciprofloxacin prescribers should consider ciprofloxacin use 0–180 days ago to ensure that patients receive suitable treatment. The OR of ciprofloxacin resistance could be reduced by eliminating repeated ciprofloxacin prescription within 180 days and by treating for no longer than necessary.


Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Elena J Papadopoulos ◽  
Antoni Chan ◽  
Kathryn Rigler ◽  
Avaish Kachwaha ◽  
Jessica Gunn ◽  
...  

Abstract Background NICE guidelines (NG65) for diagnosis and management of spondyloarthritis (SpA) in over 16s provide evidence-based recommendations for provision of care and services for patients, with an aim to improving quality of care. There often appears to be misdiagnosis/under diagnosis of psoriatic arthritis (PsA), as well as unmet needs of achieving treatment to target and low disease activity. Our objective was to audit our PsA service against the guidelines to benchmark current service provision compared to the National recommendations, highlighting potential key areas to improve quality of SpA and PsA patient care and enable service development including our new electronic patient pathway. Methods The NICE baseline assessment tool was used to audit 100 patients diagnosed with PsA, attending the outpatient rheumatology clinic between 2017-2019. The mean age was 54, with a 3:2 female to male ratio. 30% of patients included were on a biologic disease modifying anti-rheumatic drug (bDMARD). Data was collected from clinic letters/medical/physiotherapy records. Data was collated to identify areas of compliance of our service against the guidelines, with the key outcomes scrutinised being assessment and diagnosis, imaging, information and support, pharmacological management and long-term condition management. Results 78% of patients with PsA had documentation of meeting the CASPAR or peripheral ASAS Criteria. 83% of patients who had symptomatic hands/feet obtained X-rays, and 82% had imaging of other peripheral or axial sites. 58% of patients with PsA had documented evidence of having received information on PsA. Out of 100% of patients that were started on a conventional synthetic DMARD (csDMARD), 83% that were on monotherapy were escalated to either an additional csDMARD or a bDMARD. Largely by month 3 the csDMARD was switched or the patient started combination therapy, in comparison to those that started a bDMARD which occurred largely around month 6. 100% of patients had access to flare management advice and flare clinic, but only 30% had documented discussions about cardiovascular (CV) and skin cancer risks on anti-TNF therapy. Subsequent action plans for service improvement included: a best practice pathway developed on the electronic patient records (EPR), including the CASPAR and ASAS criteria, the Group for Research and Assessment of Psoriasis (GRAPPA) 6 domains of PsA, CV and skin cancer risk. All patients are seen in the Nurse/therapist led education sessions for information on the disease. Conclusion Performing an audit of patients against the NG65 guidelines ensured that we were using real-world data to benchmark our service, enabling robust action plans to be developed to address low compliance areas. Consequently, the audit allowed us to justify changing and developing the service for improved patient care. Disclosures E.J. Papadopoulos: Other; Paid work with Novartis Pharmaceuticals. A. Chan: Member of speakers’ bureau; Novartis, Celgene, Janssen, Sanofi. Other; Advisory Board for: Novartis, Celgene, Lilly. K. Rigler: Other; aid work for Novartis Pharmaceuticals. A. Kachwaha: None. J. Gunn: None. N. Zabbey: None. E. Walsh: None.


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