Assessment of Biomarkers for Clinical Diagnosis of Papillary Thyroid Carcinoma with Distant Metastasis

2010 ◽  
Vol 25 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Huasheng Liang ◽  
Yuhua Zhong ◽  
Zuojie Luo ◽  
Yu Huang ◽  
Huade Lin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinical Diagnosis ◽  
Distant Metastasis ◽  
Roc Curve ◽  
Curve Analysis ◽  
Papillary Thyroid ◽  
Roc Curve Analysis ◽  
Thyroid Carcinomas

Early diagnosis and treatment of thyroid cancers are critical for better prognosis and better survival rates. The purpose of this study was to identify potential diagnostic markers for papillary thyroid carcinomas with distant metastasis. Fifty-eight papillary thyroid tumor specimens (27 papillary thyroid carcinomas with distant metastasis and 31 without metastasis) were examined, and protein expression of pituitary tumor-transforming gene (PTTG), E-cadherin, p27kip1, vascular endothelial growth factor (VEGF)-C, metalloproteinase (MMP) 2, MMP9, chemokine receptor CXCR4, and basic fibroblast growth factor (bFGF) in these tumors was assessed by immunohistochemistry. The clinicopathological variables with diagnostic significance were determined by multivariate analysis, and their diagnostic values were evaluated by ROC curve analysis. PTTG, VEGF-C, MMP2, MMP9, CXCR4, and bFGF were overexpressed in metastatic papillary thyroid carcinomas, whereas p27kip1 expression was elevated only in carcinomas lacking metastasis. Multiple-factor binary ordinal logistic regression analysis revealed that PTTG, VEGF-C, MMP2, and bFGF were independently related to biological metastatic behavior in thyroid tumors, suggesting their potential use as biomarkers. ROC curve analysis showed that among these four proteins, VEGF-C and bFGF were the best diagnostic biomarkers. A VEGF-C and bFGF cluster was the most useful factor for the differential diagnosis between metastatic and non-metastatic papillary thyroid cancers. Thus, the combined use of VEGF-C and bFGF as biomarkers may improve the diagnostic accuracy of papillary thyroid carcinoma and may be useful in multimodal screening programs for the clinical diagnosis of papillary thyroid carcinoma and early detection of papillary thyroid carcinoma with distant metastasis.

scholarly journals Value of Quantitative Contrast-Enhanced Ultrasonography in Distinguishing Asymptomatic Subacute Thyroiditis from Papillary Thyroid Carcinoma

2021 ◽  
Vol 18 (3) ◽  
Author(s):  
Na Wang ◽  
Hongguang Sun ◽  
Tingyue Qi ◽  
Haiyan Cao ◽  
Nianfen Li ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Roc Curve ◽  
Control Area ◽  
Curve Analysis ◽  
Papillary Thyroid ◽  
Roc Curve Analysis ◽  
Diagnostic Efficacy ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Background: Asymptomatic subacute thyroiditis (aSAT) without inflammatory features is often difficult to distinguish from papillary thyroid carcinoma (PTC), even with ultrasonography. Under certain circumstances, a fine-needle aspiration biopsy (FNAB) is performed, which is known to increase the patient’s physical pain. Objectives: To investigate the value of quantitative contrast-enhanced ultrasonography (CEUS) in discriminating aSAT from PTC nodules. Methods: A total of 30 aSAT and 23 PTC patients were systematically reviewed. Quantitative CEUS parameters, including the rise time (RT), time to peak (TTP), maximum intensity (IMAX), as well as their extension indicators (ΔRT and ΔTTP), were determined in various nodule areas (total, central, peripheral, and control regions of nodules). Chi-square test and independent-samples t-test were performed to compare significant differences between PTC and aSAT. A receiver operating characteristics (ROC) curve analysis was also performed to assess the diagnostic efficacy of each parameter, as well as diagnostic efficacy indices, including sensitivity and specificity, in discriminating aSAT from PTC nodules. Results: Compared to the PTC group, patients with aSAT had a longer ∆RT1 (RT of the control area − RT of the whole area; 0.12 ± 0.69 vs. -0.2 ± 0.57, P = 0.03) and ∆RT3 (RT of the control area − RT of the central area; 0.43 ± 0.72 vs. 0.04 ± 0.94, P = 0.049). Besides, compared to the PTC group, the aSAT group had a shorter RT in the total area (RT1: 4.05 ± 1.56 vs. 4.91 ± 2.09, P = 0.045); a shorter TTP in the total (TTP1: 4.91 ± 1.76 vs. 7.30 ± 3.92, P = 0.005), peripheral (TTP2: 5.06 ± 1.97 vs. 7.00 ± 3.48, P = 0.01), and central (TTP3: 4.90 ± 1.68 vs. 7.57 ± 4.41, P = 0.004) areas; and a lower IMAX in the peripheral area (IMAX2: 0.74 ± 0.36 vs. 1.09 ± 0.57, P = 0.009). Based on the ROC curve analysis, the area under the curve was significantly larger for TTP1 as compared to RT1 (P = 0.027). Conclusion: Conventional ultrasound and CEUS examinations were inadequate in distinguishing PTC from aSAT. Overall, a quantitative analysis may indicate more biological characteristics of nodules, which can be helpful in the differential diagnosis.

scholarly journals Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao He ◽  
Huan Wang ◽  
Jiangming Sun ◽  
Jie Wu ◽  
Fakuo Gong ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Curve Analysis ◽  
Healthy Controls ◽  
Papillary Thyroid ◽  
Roc Curve Analysis ◽  
Altered Expression ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Abstract Background Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. Methods In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and BTN patients were detected by qPCR. ROC curve analysis was performed for diagnostic analysis. Overexpression experiments were performed to analyze the interaction between DLG1-AS1 and miR-199a-3p. CCK-8 assay was performed to analyze cell proliferation. Results In this study, upregulation of DLG1-AS1 distinguished PTC patients from BTN patients and healthy controls. Plasma miR-199a-3p was downregulated in PTC patients compared with healthy controls and BTN patients. Plasma levels of miR-199a-3p were inversely correlated in PTC patients, but not in BTN patients and healthy controls. miR-199a-3p overexpression failed to significantly affect DLG1-AS1, while DLG1-AS1 overexpression resulted in downregulated miR-199a-3p, In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. miR-199a-3p overexpression played an opposite role and attenuated the effects of DLG1-AS1 overexpression. Conclusions Therefore, DLG1-AS1 may promote PTC by downregulating miR-199a-3p.

scholarly journals Temporal Bone Metastasis of Follicular Thyroid Carcinoma in an Asymptomatic Patient: A Rare Case

2019 ◽  
pp. 42
Author(s):  
Ahmad Khairi Mohamed ◽  
Irfan Mohamad ◽  
Norazlina Mat Nawi ◽  
Mohd Fazrin Mohd Rohani
Keyword(s):  
Computed Tomography ◽  
Papillary Thyroid Carcinoma ◽  
Bone Metastasis ◽  
Thyroid Carcinoma ◽  
Temporal Bone ◽  
Distant Metastasis ◽  
Follicular Thyroid Carcinoma ◽  
Whole Body ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas

Introduction: Thyroid carcinomas are classified according to their histological subtypes, namely: papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullar y carcinoma, undifferentiated carcinoma and poorly differentiated carcinoma. PTC usually spread to the lymph node which can be the presenting complaint, whereas FTC tends to have distant metastasis owing to its propensity of hematogenous spread. Differentiated thyroid carcinomas (DTC) such as papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) have a better prognosis compare to medullary and undifferentiated types. FTC constitutes around 10 to 25% of thyroid malignancies. Despite of its rarity compared to PTC, FTC tends to have distant metastases to lungs and bones. Usually long bones such as femur are more affected. Metastases to the skull and skull base are rare with only few reported cases. We report a case of temporal bone metastasis in an asymptomatic follicular thyroid carcinoma, which was detected on Iodine-131 (131I) scan and characterized on single-photon emission computed tomography/ computed tomography (SPECT/CT) scan.Conclusion: Temporal bone is a rare metastatic site of FTC. Early detection and prompt treatment play a vital role in patients’ survival and reducing the metastatic risk. In post total thyroidectomy patients, post ablation 131I whole body scan with SPECT/CT and serum thyroglobulin correlation is essential in detection of distant metastasis in asymptomatic patients.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 42

Epidermal growth factor receptor gene mutations in papillary thyroid carcinoma

2008 ◽  
Vol 124 (11) ◽  
pp. 2744-2749 ◽  
Author(s):  
Katsuhiro Masago ◽  
Ryo Asato ◽  
Shiro Fujita ◽  
Shigeru Hirano ◽  
Yoshihiro Tamura ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Papillary Thyroid Carcinoma ◽  
Epidermal Growth Factor ◽  
Thyroid Carcinoma ◽  
Receptor Gene ◽  
Growth Factor Receptor ◽  
Gene Mutations ◽  
Papillary Thyroid ◽  
Epidermal Growth

scholarly journals Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma

2015 ◽  
pp. 251 ◽  
Author(s):  
Mutahir Tunio ◽  
Mushabbab AlAsiri ◽  
Khalid H AL-Qahtani ◽  
Hanadi Fatani ◽  
Yasser Bayoumi
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Dura Mater ◽  
Distant Metastasis ◽  
Papillary Thyroid

Altered TEG Parameters Identify Hypercoagulablilty and are of Diagnosis Value for Papillary Thyroid Carcinoma Patients

2018 ◽  
Vol 128 (05) ◽  
pp. 297-302
Author(s):  
Songsong Lu ◽  
Rui Kang ◽  
Yongchao Wang ◽  
Mengjie Zhu ◽  
Lei Zhao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Correlation Analysis ◽  
Thyroid Carcinoma ◽  
Roc Curve ◽  
Nodular Goiter ◽  
Roc Curves ◽  
Control Group ◽  
Healthy Controls ◽  
Papillary Thyroid ◽  
Routine Coagulation

Abstract Objective The goal of this study was to clarify the changes and clinical significance of thromboelastography (TEG) parameters in papillary thyroid carcinomas and nodular goiters. Methods 62 nodular goiter (NG) patients and 53 papillary thyroid carcinoma (PTC) patients were included. Coagulation indicators, together with a series of TEG parameters were collected and analyzed, compared with results of 61 healthy controls (HC). Correlation analysis was conducted between routine coagulation indicators and TEG parameters. ROC curves were used to evaluate the potential diagnosis value of the TEG parameters that were altered in papillary thyroid carcinoma patients. Results APTT and PT in papillary thyroid carcinoma group were statistically significant higher than that in control group (p<0.05). MPV was found to be higher in PTC than NG and healthy controls.R, K and SP levels were significantly lower in PTC group than that in HC group; Angle, CI and TPI levels were significantly higher in PTC group than that in HC group. Areas under the ROC curve of CI, TPI, and angle were 0.725, 0.714, and 0.687 for distinguishing PTC from HC, 0.662, 0.668 and 0.591 for distinguishing PTC from NG. Conclusion TEG parameters are altered and indicate hypercoagulablilty status of papillary thyroid carcinoma patients; CI, TPI, and angle could be potential diagnosis indicators for detecting papillary thyroid carcinoma.

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