scholarly journals Activity measurement in pediatric chronic fatigue syndrome

2020 ◽  
pp. 174239532094961
Author(s):  
Bernardo Loiacono ◽  
Madison Sunnquist ◽  
Laura Nicholson ◽  
Leonard A Jason
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Activity Patterns ◽  
Chronic Fatigue ◽  
Activity Level ◽  
Activity Measurement ◽  
Activity Levels ◽  
Healthy Children ◽  
Activity Data ◽  
Fatigue Syndrome ◽  
Delayed Initiation

Objectives Individuals with myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) experience debilitating symptoms, including post-exertional malaise, an intensification of symptoms after physical or cognitive exertion. Previous studies found differences in the activity levels and patterns of activity among individuals with ME and CFS, compared to healthy controls; however, limited research exists on the activity levels of pediatric patients. The objective of this study was to examine differences in activity between healthy children and youth with ME and CFS. Methods The present study examines the objective (i.e., ActiGraphy) and self-reported levels of activity among children (ages 5 to 17) enrolled in a community-based study of pediatric CFS. Results Children with ME and CFS evidenced lower activity levels than healthy control children. Moreover, participants with ME and CFS evidenced increased nighttime activity and delayed initiation of daytime activity. Participants’ self-reported activity data significantly correlated with their ActiGraph data, suggesting that children with ME and CFS are able to accurately describe their activity level. Discussion This study highlights differences in activity level and diurnal/nocturnal activity patterns between healthy children and those with ME and CFS. These differences should be considered in identifying appropriate supports and accommodations for children with ME and CFS.

Impaired oxygen delivery to muscle in chronic fatigue syndrome

1999 ◽  
Vol 97 (5) ◽  
pp. 603-608 ◽  
Author(s):  
Kevin K. MCCULLY ◽  
Benjamin H. NATELSON
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Time Constant ◽  
Oxidative Metabolism ◽  
Oxygen Delivery ◽  
Specific Effect ◽  
Chronic Fatigue ◽  
Medial Gastrocnemius ◽  
Resonance Spectroscopy ◽  
Activity Levels ◽  
Fatigue Syndrome

The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced oxygen delivery to muscles. Patients with CFS according to CDC (Center for Disease Control) criteria (n = 20) were compared with normal sedentary subjects (n = 12). Muscle oxygen delivery was measured as the rate of post-exercise and post-ischaemia oxygen-haem resaturation. Oxygen-haem resaturation was measured in the medial gastrocnemius muscle using continuous-wavelength near-IR spectroscopy. Phosphocreatine resynthesis was measured simultaneously using 31P magnetic resonance spectroscopy. The time constant of oxygen delivery was significantly reduced in CFS patients after exercise (46.5±16 s; mean±S.D.) compared with that in controls (29.4±6.9 s). The time constant of oxygen delivery was also reduced (20.0±12 s) compared with controls (12.0±2.8 s) after cuff ischaemia. Oxidative metabolism was also reduced by 20% in CFS patients, and a significant correlation was found between oxidative metabolism and recovery of oxygen delivery. In conclusion, oxygen delivery was reduced in CFS patients compared with that in sedentary controls. This result is consistent with previous studies showing abnormal autonomic control of blood flow. Reduced oxidative delivery in CFS patients could be specifically related to CFS, or could be a non-specific effect of reduced activity levels in these patients. While these results suggest that reduced oxygen delivery could result in reduced oxidative metabolism and muscle fatigue, further studies will be needed to address this issue.

scholarly journals Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study

Diagnostics ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 41 ◽  
Author(s):  
Nacul ◽  
de Barros ◽  
Kingdon ◽  
Cliff ◽  
Clark ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Cross Sectional Study ◽  
Myalgic Encephalomyelitis ◽  
Activity Levels ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fatigue Syndrome ◽  
Laboratory Test Results

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of a diagnostic biomarker, ME/CFS is diagnosed clinically, although laboratory tests are routinely used to exclude alternative diagnoses. In this analytical cross-sectional study, we aimed to explore potential haematological and biochemical markers for ME/CFS, and disease severity. We reviewed laboratory test results from 272 people with ME/CFS and 136 healthy controls participating in the UK ME/CFS Biobank (UKMEB). After corrections for multiple comparisons, most results were within the normal range, but people with severe ME/CFS presented with lower median values (p < 0.001) of serum creatine kinase (CK; median = 54 U/L), compared to healthy controls (HCs; median = 101.5 U/L) and non-severe ME/CFS (median = 84 U/L). The differences in CK concentrations persisted after adjusting for sex, age, body mass index, muscle mass, disease duration, and activity levels (odds ratio (OR) for being a severe case = 0.05 (95% confidence interval (CI) = 0.02–0.15) compared to controls, and OR = 0.16 (95% CI = 0.07–0.40), compared to mild cases). This is the first report that serum CK concentrations are markedly reduced in severe ME/CFS, and these results suggest that serum CK merits further investigation as a biomarker for severe ME/CFS.

Chronic fatigue syndrome: Assessing symptoms and activity level

1999 ◽  
Vol 55 (4) ◽  
pp. 411-424 ◽  
Author(s):  
Leonard A. Jason ◽  
Caroline P. King ◽  
Erin L. Frankenberry ◽  
Karen M. Jordan ◽  
Warren W. Tryon ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Activity Level ◽  
Fatigue Syndrome

scholarly journals Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case control study

2009 ◽  
Vol 3 (1) ◽  
pp. 7 ◽  
Author(s):  
Christopher Burton ◽  
Hans Knoop ◽  
Nikola Popovic ◽  
Michael Sharpe ◽  
Gijs Bleijenberg
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Case Control Study ◽  
Activity Patterns ◽  
Chronic Fatigue ◽  
Case Control ◽  
Fatigue Syndrome ◽  
Reduced Complexity ◽  
Control Study

scholarly journals Acute Effects of Thirty Minutes of Light-Intensity, Intermittent Exercise on Patients With Chronic Fatigue Syndrome

1999 ◽  
Vol 79 (8) ◽  
pp. 749-756 ◽  
Author(s):  
Lisa L Clapp ◽  
Mark T Richardson ◽  
Joe F Smith ◽  
Minqi Wang ◽  
Anthony J Clapp ◽  
...  
Keyword(s):  
Health Status ◽  
Chronic Fatigue Syndrome ◽  
Light Intensity ◽  
General Health ◽  
Intermittent Exercise ◽  
Chronic Fatigue ◽  
Activity Level ◽  
General Health Status ◽  
Fatigue Syndrome ◽  
Degree Of Disability

Abstract Background and Purpose. Currently, there is no consensus on exercise prescription for patients with chronic fatigue syndrome (CFS). This investigation examined whether light-intensity, intermittent physical activity exacerbated symptoms in patients with CFS immediately following exercise to 7 days following exercise. Subjects. Subjects were 9 women (mean age=44.2 years, SD=8.4, range=29-56; mean weight=74.2 kg, SD=18.8, range=56.36-110.91; and mean height=1.63 m, SD=0.8, range=1.55-1.78) and 1 man (age=48 years, weight=97.1 kg, and height=1.98 m) who met the Centers for Disease Control and Prevention's criteria for CFS. Methods. Subjects performed 10 discontinuous 3-minute exercise bouts (separated by 3 minutes of recovery) at a self-selected, comfortable walking pace on a treadmill. Oxygen consumption, minute ventilation, respiratory exchange ratio, and heart rate were measured every minute during the exercise session. To assess degree of disability, general health status, activity level, symptoms, and mood, subjects completed various questionnaires before and after exercise. Results. Results indicated that degree of disability, general health status, symptoms, and mood did not change immediately and up to 7 days following exercise. Conclusion and Discussion. Thirty minutes of intermittent walking did not exacerbate symptoms in subjects with CFS. The physiological data did not show any abnormal response to exercise. Although this study did not determine whether 30 minutes of continuous versus intermittent exercise would exacerbate symptoms, all 10 subjects felt that they could not exercise continuously for 30 minutes without experiencing symptom exacerbation. Despite this limitation, the results indicate that some individuals with CFS may be able to use low-level, intermittent exercise without exacerbating their symptoms.

Premorbid Functioning, Welfare Issues and Ethics in Chronic Fatigue Syndrome

2003 ◽  
Vol 11 (3) ◽  
pp. 312-318
Author(s):  
Chris Cantor ◽  
Kerryn Neulinger
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Ethical Issues ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Exercise Intolerance ◽  
Systematic Research ◽  
Activity Levels ◽  
Subjective Memory ◽  
Fatigue Syndrome ◽  
Premorbid Functioning

Objective: To assess former activity levels in chronic fatigue syndrome (CFS) subjects, identify differentiating variables and discuss ethical issues arising. Method: File review of 91 CFS patients from a private psychiatric practice, presenting multiple case reports, with limited case comparison data. Results: The CFS subjects appeared formerly more athletically inclined than controls. Other helpful differentiating variables included exercise intolerance, excessive need for sleep, hopefulness and subjective memory problems. Conclusions: Former exercise and other achievement levels warrant systematic research study and consideration in the assessment of CFS patients. Omissions of consideration of premorbid functioning in medicolegal evaluations raise ethical concerns.

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