WNT pathways and upper limb anomalies

2010 ◽  
Vol 36 (1) ◽  
pp. 9-22 ◽  
Author(s):  
M. M. Al-Qattan
Keyword(s):  
Upper Limb ◽  
Wnt Pathway ◽  
Apical Ectodermal Ridge ◽  
Joint Development ◽  
Limb Anomalies ◽  
Dorsal Ectoderm ◽  
Wnt Pathways ◽  
Nail Patella Syndrome ◽  
The Relationship ◽  
Duplication Syndrome

The various Wnt pathways that are related to upper limb anomalies are reviewed. Abnormalities in the Wnt7a pathway (located in the dorsal ectoderm) produce several clinically relevant conditions such as the palmar duplication syndrome, nail patella syndrome, ulnar ray deficiency, limb hypoplasia, polysyndactyly and the palmar nail syndrome. Abnormalities of the Wnt3/3a pathway (located in the apical ectodermal ridge) include tetra-amelia and loss of the distal phalanges/nails. Abnormalities of the Wnt5/5a pathway (located in the apical ectodermal ridge as well as in the mesoderm) will affect chondrogenesis of the developing limb and experimental Wnt5a−/− limbs have terminal adactyly. Chondrogenesis and limb muscle differentiation are both affected by several Wnt pathways and these will be reviewed in details. Abnormalities in LRP 5/6 (a co-receptor for Wnts) lead to congenital bone disease and Wnt4 is specifically involved in joint development. Finally, the relationship between the Wnt pathway and SALL4 (mutations of which cause Okihiro/Duane-radial ray deficiency in humans) are discussed.

scholarly journals THE RELATIONSHIP BETWEEN WNT (WINGLESS/INT) PATHWAYS REACTIVE OXYGEN SPECIES (ROS) AND CANCER

2019 ◽  
Vol 3 (2) ◽  
pp. 599
Author(s):  
Fitriannisa F. Zubaidi
Keyword(s):  
Reactive Oxygen Species ◽  
Wnt Pathway ◽  
Reactive Oxygen ◽  
Switching Effect ◽  
Oxygen Species ◽  
Cellular Death ◽  
Wnt Pathways ◽  
Canonical Wnt ◽  
The Relationship

Reactive oxygen species has been known to play a role in the formation of cancer and determination of cellular death. Less known, however, is its more recently studied role in regulating cellular physiologic functions. The mechanism of how ROS switches between these roles involves detailed interactions with different pathways. The Wnt pathway, specifically the canonical Wnt/β-catenin pathway, seems to be one that has this role switching effect, depending on the amount of ROS present in the cellular microenvirent. This review aims to revisit the regulation of ROS levels, their relationship to cancer, and how the Wnt pathways influence the effect of ROS.

Genetic Basis of Congenital Upper Limb Anomalies: Analysis of 487 Cases of a Specialized Clinic

2013 ◽  
Vol 97 (12) ◽  
pp. 798-805 ◽  
Author(s):  
Diana Carli ◽  
Tracy Fairplay ◽  
Paola Ferrari ◽  
Silvana Sartini ◽  
Mario Lando ◽  
...  
Keyword(s):  
Upper Limb ◽  
Genetic Basis ◽  
Limb Anomalies

The Relationship between Consistency of Propulsive Cycles and Maximum Angular Velocity during Wheelchair Racing

2008 ◽  
Vol 24 (3) ◽  
pp. 280-287 ◽  
Author(s):  
Yong “Tai” Wang ◽  
Konstantinos Dino Vrongistinos ◽  
Dali Xu
Keyword(s):  
Angular Velocity ◽  
Upper Limb ◽  
Wheelchair Propulsion ◽  
Upper Arm ◽  
Wheelchair Athletes ◽  
Angular Velocities ◽  
Limb Kinematics ◽  
Analysis System ◽  
The Right ◽  
The Relationship

The purposes of this study were to examine the consistency of wheelchair athletes’ upper-limb kinematics in consecutive propulsive cycles and to investigate the relationship between the maximum angular velocities of the upper arm and forearm and the consistency of the upper-limb kinematical pattern. Eleven elite international wheelchair racers propelled their own chairs on a roller while performing maximum speeds during wheelchair propulsion. A Qualisys motion analysis system was used to film the wheelchair propulsive cycles. Six reflective markers placed on the right shoulder, elbow, wrist joints, metacarpal, wheel axis, and wheel were automatically digitized. The deviations in cycle time, upper-arm and forearm angles, and angular velocities among these propulsive cycles were analyzed. The results demonstrated that in the consecutive cycles of wheelchair propulsion the increased maximum angular velocity may lead to increased variability in the upper-limb angular kinematics. It is speculated that this increased variability may be important for the distribution of load on different upper-extremity muscles to avoid the fatigue during wheelchair racing.

scholarly journals Unobtrusive Estimation of Cardiovascular Parameters with Limb Ballistocardiography

Sensors ◽  
2019 ◽  
Vol 19 (13) ◽  
pp. 2922 ◽  
Author(s):  
Yang Yao ◽  
Sungtae Shin ◽  
Azin Mousavi ◽  
Chang-Sei Kim ◽  
Lisheng Xu ◽  
...  
Keyword(s):  
Upper Limb ◽  
Lower Limb ◽  
Linear Regression Analysis ◽  
Peripheral Resistance ◽  
Physiological Mechanism ◽  
Multivariate Linear Regression Analysis ◽  
Time Intervals ◽  
Processing Procedure ◽  
Characteristic Features ◽  
The Relationship

This study investigates the potential of the limb ballistocardiogram (BCG) for unobtrusive estimation of cardiovascular (CV) parameters. In conjunction with the reference CV parameters (including diastolic, pulse, and systolic pressures, stroke volume, cardiac output, and total peripheral resistance), an upper-limb BCG based on an accelerometer embedded in a wearable armband and a lower-limb BCG based on a strain gauge embedded in a weighing scale were instrumented simultaneously with a finger photoplethysmogram (PPG). To standardize the analysis, the more convenient yet unconventional armband BCG was transformed into the more conventional weighing scale BCG (called the synthetic weighing scale BCG) using a signal processing procedure. The characteristic features were extracted from these BCG and PPG waveforms in the form of wave-to-wave time intervals, wave amplitudes, and wave-to-wave amplitudes. Then, the relationship between the characteristic features associated with (i) the weighing scale BCG-PPG pair and (ii) the synthetic weighing scale BCG-PPG pair versus the CV parameters, was analyzed using the multivariate linear regression analysis. The results indicated that each of the CV parameters of interest may be accurately estimated by a combination of as few as two characteristic features in the upper-limb or lower-limb BCG, and also that the characteristic features recruited for the CV parameters were to a large extent relevant according to the physiological mechanism underlying the BCG.

The relationship between upper limb activity and impairment in post-stroke hemiplegia

2009 ◽  
Vol 31 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Jane H. Burridge ◽  
Ruth Turk ◽  
Scott V. Notley ◽  
Ruth M. Pickering ◽  
David M. Simpson
Keyword(s):  
Upper Limb ◽  
Post Stroke ◽  
The Relationship

scholarly journals Documenting Combined Congenital Upper Limb Anomalies Using the Oberg, Manske, and Tonkin Classification: Implications for Epidemiological Research and Outcome Comparisons

2018 ◽  
Vol 43 (9) ◽  
pp. 869.e1-869.e11 ◽  
Author(s):  
Martijn Baas ◽  
Pieter R. Zwanenburg ◽  
Steven E.R. Hovius ◽  
Christianne A. van Nieuwenhoven
Keyword(s):  
Upper Limb ◽  
Epidemiological Research ◽  
Limb Anomalies

Convergent Validity of PODCI and PROMIS Domains in Congenital Upper Limb Anomalies

2020 ◽  
Vol 45 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Lindley B. Wall ◽  
Carley Vuillermin ◽  
Patricia E. Miller ◽  
Donald S. Bae ◽  
Charles A. Goldfarb
Keyword(s):  
Upper Limb ◽  
Convergent Validity ◽  
Limb Anomalies

scholarly journals Relationship between upper limb motor function and activities of daily living after removing the influence of lower limb motor function in subacute patients with stroke: A cross-sectional study

2020 ◽  
pp. 156918612092660
Author(s):  
Haruka Yamamoto ◽  
Kazuya Takeda ◽  
Soichiro Koyama ◽  
Keisuke Morishima ◽  
Yuichi Hirakawa ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Motor Function ◽  
Upper Limb ◽  
Lower Limb ◽  
Daily Living ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Motor Score ◽  
Cross Sectional ◽  
The Relationship

Background Previous studies have reported a relationship between upper limb motor function and activities of daily living. However, their relationship after removing the influence of lower limb motor function has not been clarified. Objective This study aimed to investigate the relationship between Fugl-Meyer assessment upper limb and total Functional Independence Measure motor score and between Fugl-Meyer assessment upper limb and each item contained in Functional Independence Measure motor score after eliminating the influence of the motor function of the affected lower limb. Methods This retrospective cross-sectional study included 58 subacute stroke patients. To investigate the relationship between the Fugl-Meyer assessment upper limb and total Functional Independence Measure motor score before and after removing the influence of Fugl-Meyer assessment lower limb, Spearman’s rank correlation coefficient and partial correlation analysis were used. Additionally, the relationship between Fugl-Meyer assessment upper limb and each item of Functional Independence Measure motor score after removing the influence was assessed. Results Before removing the influence of Fugl-Meyer assessment lower limb, Fugl-Meyer assessment upper limb was strongly correlated with total Functional Independence Measure motor score (r = 0.74, p < 0.001). However, it became weak after removing the influence (r = 0.27, p = 0.04). Regarding each item of Functional Independence Measure motor score, Fugl-Meyer assessment upper limb was correlated with grooming (r = 0.27, p = 0.04), bathing (r = 0.28, p = 0.03), dressing upper body (r = 0.33, p = 0.01), dressing lower body (r = 0.31, p = 0.02), and stair-climbing (r = 0.31, p = 0.02) after removing the influence. Conclusion These findings suggest that the relationship between the upper limb motor function and activities of daily living is strongly influenced by lower limb motor function.

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