scholarly journals Alkaloids from an Endophytic Streptomyces sp. YIM66017

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Hao Zhou ◽  
Yabin Yang ◽  
Jucheng Zhang ◽  
Tianfeng Peng ◽  
Lixing Zhao ◽  
...  
Keyword(s):  
Culture Filtrate ◽  
Spectroscopic Analysis ◽  
Crystallographic Analysis ◽  
Natural Source ◽  
Streptomyces Sp ◽  
X Ray ◽  
Alpinia Oxyphylla ◽  
Endophytic Streptomyces ◽  
First Time ◽  
Mcf 7

Three alkaloids, flavensomycinoic acid (1), a linear polyketide, alpiniamide (2), and cyclo (L-Trp-L-Ala) (3), were isolated from the culture filtrate of endophytic Streptomyces sp. YIM66017 from Alpinia oxyphylla. Their structures were elucidated by spectroscopic analysis and the structure of 1 was confirmed by X-ray crystallographic analysis. Compound 1 was isolated from a natural source for the first time, and compound 2 is a new compound. Compound 1 showed cytotoxicity to MCF-7 with an IC 50 value of 17.0 μM.

scholarly journals Antimicrobial Metabolites from Endophytic Streptomyces sp. YIM61470

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Xueqiong Yang ◽  
Yun Liu ◽  
Shuquan Li ◽  
Fangfang Yang ◽  
Lixing Zhao ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Microbial Activity ◽  
Natural Source ◽  
Genus Streptomyces ◽  
Streptomyces Sp ◽  
Endophytic Streptomyces ◽  
Antimicrobial Metabolites ◽  
First Time

Six compounds were isolated from Streptomyces sp. YIM61470, and their structures elucidated by spectral analysis as ( R)-1- O-(phenylacetyl)glycerol (1), 4′,5-dihydroxy-6-(3,3–dimethylallyl)-7-methoxyflavanone (2), (32 R,33 R,34 S)-32,33,34,35-bacteriohopanetetrol (3), MKN-003C (4), cyclo (L-Pro-L-Gly) (5), and cyclo(L-Pro-L-Tyr) (6). Compound 1, an chiral monoacylglycerol, was isolated from a natural source for the first time. Compound 2 was first found in microorganisms, and compound 3, a bacteriohopanoid, was found first in the genus Streptomyces. Compounds 1-6 showed weak anti-microbial activity.

scholarly journals Diketopiperazine and Diphenylether Derivatives from Marine Algae-Derived Aspergillus versicolor OUCMDZ-2738 by Epigenetic Activation

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 6 ◽  
Author(s):  
Wen Liu ◽  
Liping Wang ◽  
Bin Wang ◽  
Yanchao Xu ◽  
Guoliang Zhu ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Specific Rotation ◽  
Crystallographic Analysis ◽  
Aspergillus Versicolor ◽  
X Ray ◽  
Naturally Occurring ◽  
Ic50 Values ◽  
New Compounds ◽  
First Time ◽  
Optically Pure

A chemical-epigenetic method was used to enhance the chemodiversity of a marine algicolous fungus. Apart from thirteen known compounds, (+)-brevianamide R ((+)-3), (‒)-brevianamide R ((‒)-3), (+)-brevianamide Q ((+)-4), (‒)-brevianamide Q ((‒)-4), brevianamide V ((+)-5), brevianamide W ((‒)-5), brevianamide K (6), diorcinol B (7), diorcinol C (8), diorcinol E (9), diorcinol J (10), diorcinol (11), 4-methoxycarbonyldiorcinol (12), two new compounds, (+)- and (‒)-brevianamide X ((+)- and (‒)- 2)), as well as a new naturally occurring one, 3-[6-(2-methylpropyl)-2-oxo-1H-pyrazin-3-yl]propanamide (1), were isolated from chemical-epigenetic cultures of Aspergillus versicolor OUCMDZ-2738 with 10 µM vorinostat (SAHA). Compared to cultures in the same medium without SAHA, compounds 1–4, 8, 9, 11, and 12 were solely observed under SAHA condition. The structures of these compounds were elucidated based on spectroscopic analysis, specific rotation analysis, ECD, and X-ray crystallographic analysis. (±)-3, (±)-4, and (±)-5 were further resolved into the corresponding optically pure enantiomers and their absolute configurations were determined for the first time. Compounds 11 and 12 showed selective antibacterial against Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 17.4 and 13.9 μM, respectively. Compound 10 exhibited better α-glucosidase inhibitory activity than the assay control acarbose with IC50 values of 117.3 and 255.3 μM, respectively.

scholarly journals HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1237 ◽  
Author(s):  
Xiao-Wei Luo ◽  
Cheng-Hai Gao ◽  
Hu-Mu Lu ◽  
Jia-Min Wang ◽  
Zi-Qi Su ◽  
...  
Keyword(s):  
Single Crystal ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Analysis ◽  
Chaetomium Globosum ◽  
X Ray ◽  
X Ray Crystallography ◽  
Ic50 Values ◽  
First Time ◽  
Mcf 7

Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC50 values ranging from 1.4 μM to 9.2 μM.

scholarly journals A Novel Steroid Derivative and a New Steroidal Saponin from Endophytic Fungus Xylaria sp

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Wei Li ◽  
Xue-Qiong Yang ◽  
Ya-Bin Yang ◽  
Li-Xing Zhao ◽  
Qing-Yan Zhou ◽  
...  
Keyword(s):  
Cytotoxic Activities ◽  
Steroidal Saponin ◽  
Solid Culture ◽  
Single Crystal Diffraction ◽  
Nitric Oxide Inhibition ◽  
X Ray ◽  
First Time ◽  
Steroid Derivative ◽  
Oxide Inhibition ◽  
Mcf 7

Two new steroids, (24 R)-22, 23-dihydroxy-ergosta-4,6,8(14)-trien-3-one 23-β-D-glucopyranoside (1), and xylarester (2), together with 16 known compounds were isolated from the extract of endophytic Xylaria sp. solid culture. Their structures were elucidated by spectroscopic methods. Compound 2 has an unprecedent ergosta skeleton with a six-membered lactonic group in A ring. The X-ray single crystal diffraction data of 4,7-dihydroxy-13-tetradeca-2,5,8-trienolide (4) were also reported for the first time. The antibacterial, anti-acetylcholinesterase, nitric oxide inhibition and cytotoxic activities of 1–3 were investigated. Compound 1 showed cytotoxicity to MCF-7 with the ratio of inhibition at 72 % for a concentration at 40 μM.

scholarly journals Medelamine C, A New ω-Hydroxy Alkylamine Derivative from Endophytic Streptomyces sp. YIM 66142

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900
Author(s):  
Ju-Cheng Zhang ◽  
Ya-Bin Yang ◽  
Hao Zhou ◽  
Tian-Feng Peng ◽  
Fang-Fang Yang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Biosynthetic Pathway ◽  
2D Nmr ◽  
Sw480 Cell ◽  
Hydroxyl Group ◽  
Genus Streptomyces ◽  
Streptomyces Sp ◽  
Endophytic Streptomyces ◽  
Common Fatty Acid ◽  
Mcf 7

A new alkylamine derivative and a common fatty acid were isolated from Streptomyces sp. YIM 66142. On the basis of spectral data, including HRMS, NMR and 2D NMR, their structures were determined as medelamine C (1) and isomyristic acid (2). The ω-hydroxyl group in structure 1 is rare in a natural alkylamine. The possible biosynthetic pathway in the genus Streptomyces from isomyristic acid (2) to medelamines is proposed. Compound 1 showed no obvious cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, SW480 cell lines. The ω-hydroxyl and the acetyl at NH in compound 1 decreased its cytotoxicity in comparison with that of medelamine.

scholarly journals Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

2019 ◽  
Vol 2 (5) ◽  
pp. 63-67
Author(s):  
Huy Thuc Duong ◽  
Hao Xuan Bui
Keyword(s):  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Nmr Data ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Layer Chromatography ◽  
Mcf 7

The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

scholarly journals Isolation and Structure of Cordifolin, A Novel Insecticidal Oxygenated Chalcone, from the Stem of Tinospora Cordifolia Miers

2006 ◽  
Vol 1 (7) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Najam A. Shakil ◽  
Dinesh B. Saxena
Keyword(s):  
Spodoptera Litura ◽  
Chemical Structure ◽  
Spectroscopic Analysis ◽  
Ethanolic Extract ◽  
Natural Source ◽  
Tinospora Cordifolia ◽  
Regulatory Activity ◽  
Insect Growth ◽  
First Time

Cordifolin, a chalcone reported for the first time from a natural source, has been isolated from the ethanolic extract of the woody stem of Giloe (Tinospora cordifolia). The chemical structure was established as 1-(2′,3′,4′-trihydroxyphenyl)-3-(4′‘-methoxyphenyl)-propen-1-one by spectroscopic analysis. The compound exhibited good insect growth regulatory activity against larvae of Spodoptera litura.

scholarly journals Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 381
Author(s):  
Zhaoming Liu ◽  
Yuchan Chen ◽  
Saini Li ◽  
Qinglin Wang ◽  
Caiyun Hu ◽  
...  
Keyword(s):  
Deep Sea ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Tyrosine Phosphatase ◽  
Bioactive Metabolites ◽  
X Ray Diffraction ◽  
Antiproliferative Effects ◽  
X Ray ◽  
Ic50 Value ◽  
First Time

The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM.

scholarly journals Rapid Green Synthetic Protocol for Novel Trimetallic Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
B. Karthikeyan ◽  
B. Loganathan
Keyword(s):  
Electron Microscopy ◽  
Spectroscopic Analysis ◽  
Trisodium Citrate ◽  
Metallic Nanostructures ◽  
Structure Directing Agent ◽  
X Ray ◽  
Mw Irradiation ◽  
Xrd Techniques ◽  
First Time ◽  
Scanning Electron

Metallic nanocomposites and nanotubes can be rapidly prepared under microwave irradiation (MW) from an aqueous solution of metallic precursors in the presence of trisodium citrate as a reductant. For the nanotubes nanoparticles are stabilized by poly(N-vinyl-2-pyrrolidone) (PVP), a protecting agent. PVP is a typical capping and structure-directing agent used for the synthesis of various metallic nanostructures. In this work, we have demonstrated for the first time an MW irradiation approach for the synthesis of trimetallic nanocomposites and nanotubes. The resulting nanohybrids were characterized by UV-Vis spectroscopic analysis, high-resolution scanning electron microscopy (HR-SEM), energy dispersive X-ray spectroscopic analysis (EDX), and X-ray diffractometer (XRD) techniques.

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