Cytotoxicity against Cholangiocarcinoma and HepG2 Cell Lines of Lignans from Hernandia nymphaeifolia
2018 ◽
Vol 13
(1)
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pp. 1934578X1801300
Eleven lignans (1-11) were isolated from the seed of Hernandia nymphaeifolia. Most of the lignans exhibited strong to moderate cytotoxicity against cholangiocarcinoma KKU-M156 and HepG2 cell lines. Compounds 4 and 8 showed cytotoxicity against the KKU-M156 cell line with IC50 values of 5.2 μ M (Emax 96%) and 5.4 (Emax 59%) μM, respectively. In the cases of cytotoxicity against the HepG2 cell line, compounds 2, 3, 4, and 8 showed cytotoxicity with IC50 values of 1.7 M (Emax 84%), 4.1 μM (Emax 74%), 4.5 μM (Emax 68%), and 5.2 μM (Emax 78%), respectively.
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
2019 ◽
Vol 18
(11)
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pp. 1606-1616
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Keyword(s):
2015 ◽
Vol 10
(8)
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pp. 1934578X1501000
2021 ◽
Vol 22
(23)
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pp. 13135
Keyword(s):
2021 ◽
Vol 3
(2)
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pp. 231-244
Keyword(s):
2020 ◽
Vol 20
(4)
◽
pp. 486-494
Keyword(s):