A New Triterpene Glucoside from Genista numidica
2018 ◽
Vol 13
(9)
◽
pp. 1934578X1801300
Keyword(s):
2D Nmr
◽
A new oleanolic acid triterpene glucoside, 3- O-β-D-glucopyranosyl-3β,21β,28-trihydroxy-olean-12-en-27-oic acid (1), has been isolated together with twelve known compounds from the chloroform and ethyl acetate extracts of Genista numidica Spach (Fabaceae) aerial parts. The structures were elucidated by spectroscopic and spectrometric analyses, mainly 1D-, 2D-NMR and MS data, and comparison with the literature. The antiproliferative activity of isolates was investigated on Jurkat, HeLa, and MCF7 cell lines. The most active triterpene, 3- O-β-D-glucopyranosyl-olean-12-en-3β,27,28,29-tetraol, showed activity in all cell lines. Further studies revealed that this compound induced in HeLa cells a cytostatic response.
2000 ◽
Vol 55
(1-2)
◽
pp. 40-43
◽
Keyword(s):
2016 ◽
Vol 11
(2)
◽
pp. 1934578X1601100
◽
2020 ◽
Vol 58
(3)
◽
pp. 356-356
Keyword(s):
Keyword(s):