scholarly journals Flare management in atopic dermatitis: from definition to treatment

2022 ◽  
Vol 13 ◽  
pp. 204062232110667
Author(s):  
Giampiero Girolomoni ◽  
Valentina Maria Busà
Keyword(s):  
Atopic Dermatitis ◽  
Patient Education ◽  
Inflammatory Disease ◽  
Unmet Needs ◽  
Current Knowledge ◽  
Appropriate Treatment ◽  
Immune Mediated ◽  
Acute Exacerbations ◽  
Definition Of

Atopic dermatitis (AD) is a skin immune-mediated inflammatory disease with a chronic-recurrent course. Acute exacerbations or flares are an integral part of the AD course and are generally defined as disease worsening, requiring escalation/intensification of treatment. Management of flares is crucial since their prevention is a key aim of long-term disease control. Nevertheless, difficulties related to this aspect are several, starting from the definition of flare itself, which is not always satisfactory or unambiguous, and needs clarification. Indeed, this hurdle may reduce clarity on treatment choice and generate difficulties when comparing data between studies. Deepening our knowledge on flares could be highly relevant to both clinicians and patients to provide adequate control of the disease through patient education and appropriate treatment. This review aims to summarize current knowledge on the management of AD flares from definition to treatment, highlighting aspects that are still unclear, and identifying any necessary unmet needs to better manage AD.

scholarly journals Post-COVID-19 arthritis: a case report and literature review

2021 ◽  
Author(s):  
M. Gasparotto ◽  
V. Framba ◽  
C. Piovella ◽  
A. Doria ◽  
Luca Iaccarino
Keyword(s):  
Molecular Mimicry ◽  
Current Knowledge ◽  
Pathological Condition ◽  
Severe Pneumonia ◽  
The Novel ◽  
Pathogenetic Mechanism ◽  
Short Term ◽  
Immunological Mechanism ◽  
Immune Mediated

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the novel pathogen responsible for the coronavirus disease 19 (COVID-19) outbreak. Researchers and clinicians are exploring the pathogenetic mechanisms of the viral-induced damage and growing interest is focusing on the short-term and long-term immune-mediated consequences triggered by the infection. We will focus on post-SARS-CoV2 infection arthritis which may arise as a new pathological condition associated with COVID-19. In this article, we describe a case of acute oligoarthritis occurring 13 days after a SARS-CoV2 severe pneumonia in a middle-aged Caucasian man and we go over a brief review of the current available literature. We hypothesize that molecular mimicry might be the basic immunological mechanism responsible for the onset of COVID-19-related arthritis based on the current knowledge of SARS-CoV2 and on the known pathogenetic mechanism of viral-induced arthritis.

scholarly journals Clinical Outcome of a Novel Anti-CD6 Biologic Itolizumab in Patients of Psoriasis with Comorbid Conditions

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Vinay Singh
Keyword(s):  
Clinical Outcome ◽  
Inflammatory Disease ◽  
Plaque Psoriasis ◽  
Systemic Therapy ◽  
Topical Therapy ◽  
Comorbid Conditions ◽  
Chronic Plaque Psoriasis ◽  
Immune Mediated ◽  
The World

Psoriasis is a common, chronic, immune mediated, inflammatory disease of skin characterized by red patches enclosed with white scales and affects 2-3% of people in the world. Topical therapy, phototherapy, and systemic therapy were employed for management of disease from many last decades. However, long term uses of these agents are associated with unwanted effects and toxicities. Recently, Itolizumab has been developed as world’s first anti-CD6 humanized monoclonal IgG1 antibody for the management of moderate-to-severe chronic plaque psoriasis in India. Here we are presenting the response indicated by Itolizumab in 7 Indian patients having moderate-to-severe psoriasis with severe comorbidities and who were intolerant/nonresponding to conventional therapies.

scholarly journals Atopic Dermatitis

2018 ◽  
Vol 60 (6) ◽  
pp. 26-33
Author(s):  
D. Engler ◽  
F. Makola ◽  
N. M. Magongwa
Keyword(s):  
Atopic Dermatitis ◽  
Patient Education ◽  
Disease Control ◽  
Significant Influence ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
First Line ◽  
Integral Role ◽  
Adherence To Therapy

The aetiology of atopic dermatitis is multi-faceted and affects our first line host defence, the skin. Atopic dermatitis has a significant influence on a patient’s social and occupational functioning and can have long-lasting effects. The signs and symptoms of AD includes pruritus, erythema, fissuring, and lichenification – these are reduced by the use of moisturizing agents. Guidelines on how to manage atopic dermatitis aims to improve symptoms and achieve long-term disease control. Patient education remains as important as other treatment strategies and the pharmacist plays an integral role in educating patients on the management of their condition and adherence to therapy.

scholarly journals Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1821 ◽  
Author(s):  
Hideya Shintani ◽  
Tomoya Shintani ◽  
Hisashi Ashida ◽  
Masashi Sato
Keyword(s):  
Glucose Metabolism ◽  
Calorie Restriction ◽  
Intracellular Signaling ◽  
Current Knowledge ◽  
Signaling Proteins ◽  
Human Lifespan ◽  
Sodium Glucose Cotransporter ◽  
Metabolism Inhibition ◽  
Definition Of

Calorie restriction (CR) can prolong the human lifespan, but enforcing long-term CR is difficult. Therefore, a compound that reproduces the effect of CR without CR is needed. In this review, we summarize the current knowledge on compounds with CR mimetic (CRM) effects. More than 10 compounds have been listed as CRMs, some of which are conventionally categorized as upstream-type CRMs showing glycolytic inhibition, while the others are categorized as downstream-type CRMs that regulate or genetically modulate intracellular signaling proteins. Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, particularly glucose metabolism modulation effects. The upstream-type CRMs reviewed include chitosan, acarbose, sodium-glucose cotransporter 2 inhibitors, and hexose analogs such as 2-deoxy-d-glucose, d-glucosamine, and d-allulose, which show antiaging and longevity effects. Finally, we discuss the molecular definition of upstream-type CRMs.

scholarly journals Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

2018 ◽  
Author(s):  
Hideya Shintani ◽  
Tomoya Shintani ◽  
Hisashi Ashida ◽  
Masashi Sato
Keyword(s):  
Energy Metabolism ◽  
Glucose Metabolism ◽  
Calorie Restriction ◽  
Intracellular Signaling ◽  
Current Knowledge ◽  
Signaling Proteins ◽  
Sodium Glucose Cotransporter ◽  
Metabolism Inhibition ◽  
Definition Of

Calorie restriction (CR) has been shown to prolong the lifespan of humans, but enforcing long-term CR is difficult. Therefore, a compound that reproduces the effect of CR without CR is needed. In this review, we summarize the current knowledge on compounds with CR mimetic (CRM) effects. More than 10 compounds have been listed as CRMs, some of which are conventionally categorized as upstream-type CRMs showing glycolytic inhibition while the others are categorized as downstream-type CRMs that regulate or genetically modulate intracellular signaling proteins. Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, particularly glucose metabolism modulation effects. The upstream-type CRMs reviewed include chitosan, acarbose, sodium-glucose cotransporter 2 inhibitors, and hexose analogs such as 2-deoxy-D-glucose, D-glucosamine, and D-allulose, which show anti-aging and longevity effects. Finally, we discuss the molecular definition of upstream-type CRMs.

scholarly journals New Biologics for the Treatment of Atopic Dermatitis: Analysis of Efficacy, Safety, and Paradoxical Atopic Dermatitis Acceleration

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Hong-jiao Qi ◽  
Lin-Feng Li
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Unmet Need ◽  
Term Therapy ◽  
Novel Treatments ◽  
Immune Mediated ◽  
Wide Range ◽  
Long Term Therapy ◽  
Shed Light

Atopic dermatitis (AD) is a chronic, inflammatory skin disease with an eczematous rash and itching. Due to undesired adverse effects of traditional systemic treatment, there is still an unmet need for safe and effective long-term therapy for refractory AD. As our understanding of the pathogenesis underlying AD grows, novel treatments targeting specific molecules have been developed. Here, we discuss the efficacy and safety profiles of these drugs in recent clinical trials. Among their adverse effects, of particular note is AD acceleration. Although there is still debate about whether certain adverse reactions can be said to be paradoxical adverse events (PAEs), a wide range of PAEs have been reported during biological treatment for chronic immune-mediated diseases. Close surveillance of novel biologics is crucial to detect new undescribed paradoxical reactions and to shed light on the convoluted pathogenesis of AD.

Central Otago - Built on gold, growing on grass.

2014 ◽  
Vol 76 ◽  
pp. 15-23
Author(s):  
Barrie J. Wills
Keyword(s):  
Economic Growth ◽  
Land Use ◽  
National Economy ◽  
Local Community ◽  
Central Government ◽  
Future Generations ◽  
Economic Potential ◽  
District Council ◽  
Definition Of

A warm welcome to our "World of Difference" to all delegates attending this conference - we hope your stay is enjoyable and that you will leave Central Otago with an enhanced appreciation of the diversity of land use and the resilient and growing economic potential that this region has to offer. Without regional wellbeing the national economy will struggle to grow, something Central Government finally seems to be realising, and the Central Otago District Council Long Term Plan 2012-2022 (LTP) signals the importance of establishing a productive economy for the local community which will aid in the economic growth of the district and seeks to create a thriving economy that will be attractive to business and residents alike. Two key principles that underpin the LTP are sustainability and affordability, with the definition of sustainability being "… development that meets the needs of the present without compromising the ability of future generations to meet their own needs."

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