scholarly journals Pre-pregnancy parental BMI and offspring blood pressure in infancy

2019 ◽  
Vol 26 (15) ◽  
pp. 1581-1590 ◽  
Author(s):  
Maria Adriana Cornelia Jansen ◽  
Geertje W Dalmeijer ◽  
Siti RF Saldi ◽  
Diederick E Grobbee ◽  
Mohammad Baharuddin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
First Year ◽  
Maternal Body Mass Index ◽  
Middle Income ◽  
Oscillometric Device ◽  
First Year Of Life ◽  
The Impact

Aims A growing body of evidence suggests that a higher maternal pre-pregnancy body mass index results in higher offspring’s blood pressure, but there is inconsistency about the impact of father’s body mass index. Furthermore, evidence is limited with regard to low and middle income countries. We aimed to determine the association between parental pre-pregnancy body mass index and offspring’s blood pressure during the first year of life. Methods In 587 infants of the BReastfeeding Attitude and Volume Optimization (BRAVO) trial systolic and diastolic blood pressure were measured twice at the right leg in a supine position, using an automatic oscillometric device at day 7, month 1, 2, 4, 6, 9 and 12. Parental pre-pregnancy body mass index was based on self-reported weight and height. Linear mixed models were performed to investigate the associations between parental pre-pregnancy body mass index and offspring blood pressure patterns. Results Each unit increase in maternal body mass index was associated with 0.24 mmHg (95% confidence interval 0.05; 0.44) and 0.13 mmHg (0.01; 0.25) higher offspring’s mean systolic and diastolic blood pressure, respectively, during the first year of life. A higher offspring blood pressure with increased maternal pre-pregnancy body mass index was seen at birth and remained higher during the first year of life. The association with systolic blood pressure remained similar after including birth size and offspring’s weight and height over time. The association with diastolic blood pressure attenuated slightly to a non-significant result after including these variables. Paternal body mass index was not associated with offspring’s blood pressure. Conclusion Higher maternal pre-pregnancy body mass index, but not paternal pre-pregnancy body mass index, is associated with higher offspring blood pressure already from birth onwards.

scholarly journals Maternal body mass index, neonatal lung function and respiratory symptoms in childhood

2015 ◽  
Vol 46 (5) ◽  
pp. 1342-1349 ◽  
Author(s):  
Jacobien B. Eising ◽  
Cuno S.P.M. Uiterwaal ◽  
Cornelis K. van der Ent
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Body Mass ◽  
Maternal Obesity ◽  
First Year ◽  
Maternal Body Mass Index ◽  
Maternal Body ◽  
Increased Risk ◽  
Neonatal Lung ◽  
First Year Of Life

Recent studies have shown that maternal obesity is associated with increased risk of wheezing in the offspring. We assessed whether impaired neonatal lung function could explain this association.We measured neonatal lung function in 2606 children of our prospective birth cohort. Information about daily symptoms of wheezing was obtained using questionnaires. Consultations and prescriptions for wheezing illnesses were derived from general practitioner patient files.Higher maternal body mass index (BMI) was associated with increased risk of wheezing in the first year of life and more consultations and prescriptions for wheezing illnesses until the age of 5 years. Lung function could partially explain the association with wheezing in the first year of life. Adding respiratory resistance to the model decreased the incidence rate ratio from 1.023 (95% CI 1.008–1.039) to 1.015 (95% CI 0.998–1.032). Anthropometrics of the 5-year-olds largely explained the association with consultations. Intermediates or confounders could not explain the association with prescriptions.There is an association between higher maternal BMI and increased risk of wheezing illnesses. In the first year of life, it is largely explained by an impaired lung function in early life, especially in children of nonatopic mothers. At the age of 5 years, infant lung function is of minor influence in this association.

Abstract 18749: Body Mass Index, Leptin, and Recovery in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Esa Davis ◽  
Julie Damp ◽  
Rami Alharethi ◽  
Gregory Ewald ◽  
Michael Givertz ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Post Partum ◽  
Peptide Hormone ◽  
Peripartum Cardiomyopathy ◽  
Study Entry ◽  
First Year ◽  
Biomarker Analysis ◽  
Lv Remodeling ◽  
The Impact

Introduction: The contribution of obesity and metabolic syndrome to the development of peripartum cardiomyopathy (PPCM) remains unknown. Leptin is a peptide hormone released by adipose tissue which may mediate impact of the obesity on cardiovascular function. We sought to evaluate their effect on myocardial recovery in PPCM in the multicenter Investigation of Pregnancy Associated Cardiomyopathy (IPAC) study. Methods: 100 women with new onset of PPCM were enrolled and serum obtained for biomarker analysis at entry. Myocardial function was assessed by echocardiography at entry, 2 months, 6 months and 12 months postpartum and LVEF calculated at a core lab. Leptin levels were measured by ELISA and the correlation of leptin with body mass index (BMI) and days post-partum evaluated. LVEF over the first year postpartum was compared by BMI at study entry (BMI >30 versus<=) and then compared by of Leptin levels (median). Results: The cohort was 30% black 65% white 5% other,age 30 + 6, mean BMI was 28.9 + 7.4 and LVEF 0.34 + 0.10 at study entry 31 + 25 days post-partum.Compared to those with a BMI<=30 women with a BMI > 30 had a similar LVEF at entry (LVEF BMI>30 vs < : 0.35 + 0.09 vs 0.34 + 0.10, p=0.60), but a lower LVEF at 2 month (0.39 + 0.12 vs 0.45 + 0.12, p=0.02), 6months (0.38 + 0.12 vs 0.53 + 0.09, p=0.02) and 12 months (0.50 + 0.13 vs 0.55 + 0.08, p=0.03). Leptin levels (mean 23.4 + 21.1 ng/ml, median 15.26 ng/ml) correlated with BMI (r=0.57, p<0.001). Higher leptin levels were associated with more remodeling (LVEDD for high/low leptin= 5.8 + 0.7/5.4 + 0.6, p=0.02) at entry and lower LVEF 2months (high/low= 0.40 + 0.12/ 0.46 + 0.11, p=0.02) which persisted at 12 months (high/low= 0.51 + 0.11/0.56 + 0.08, p=0.03). Leptin levels were significantly lower at entry in subjects who subsequently recovered to an LVEF>=0.50 (19.2 + 19.1 vs 31.8 + 22.9, p=0.006), and were higher in diabetics (p=0.01) and in blacks (p=0.03). Conclusions: In women with PPCM, obesity was associated with a lower LVEF at 6 and 12 months. Leptin levels correlated with BMI and were associated with greater LV remodeling at presentation and lower LVEF at 12 months. The impact of obesity and leptin on the development of cardiomyopathy warrants further investigation.

scholarly journals Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age

2021 ◽  
Author(s):  
Kozeta Miliku ◽  
Theo J. Moraes ◽  
Allan B. Becker ◽  
Piushkumar J. Mandhane ◽  
Malcolm R. Sears ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Breast Milk ◽  
Body Mass ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Maternal Body Mass Index ◽  
Lower Blood Pressure ◽  
Lower Blood ◽  
Underlying Mechanisms

Background Breastfeeding in infancy is associated with lower cardiovascular disease risk in adulthood; however, the amount of breastfeeding required to achieve this benefit is unknown. Methods and Results In the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study, we analyzed 2382 children with complete data on early life feeding and blood pressure. Infant feeding was documented from hospital records in the first few days of life and reported by mothers throughout infancy. Blood pressure was measured at 3 years of age. Analyses controlled for birth weight, gestational age, socioeconomic status, maternal body mass index, and other potential confounders. We found that nearly all children (2333/2382; 97.9%) were ever breastfed, of whom 98 (4.2%) only briefly received breast milk during their birth hospitalization (“early limited breastfeeding”). At 3 years of age, blood pressure was higher in children who were never breastfed (mean systolic/diastolic 103/60 mm Hg) compared with those who were ever breastfed (99/58 mm Hg), including those who received only early limited breastfeeding (99/57 mm Hg). These differences in systolic blood pressure persisted in adjusted models (ever breastfed: −3.47 mm Hg, 95% CI, −6.14 to −0.80; early limited breastfeeding: −4.24 mm Hg, 95% CI, −7.45 to −1.04). Among breastfed children, there was no significant dose‐response association according to the duration or exclusivity of breastfeeding. Associations were not mediated by child body mass index. Conclusions Although the benefits of sustained and exclusive breastfeeding are indisputable, this study indicates any breastfeeding, regardless of duration or exclusivity, is associated with lower blood pressure at 3 years of age. Further research examining the bioactive components of early breast milk, underlying mechanisms, and long‐term associations is warranted.

scholarly journals EFFECTS OF CONCURRENT TRAINING ON MORPHOFUNCTIONAL PARAMETERS AND BLOOD PRESSURE IN HYPERTENSIVE WOMEN

2017 ◽  
Vol 25 (3) ◽  
pp. 60
Author(s):  
Renata Emilia Marques Aguiar ◽  
Cauê Vazquez La Scala Teixeira ◽  
Heverton Paulino ◽  
José Rodrigo Pauli ◽  
Alessandra Medeiros ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Total Cholesterol ◽  
Training Program ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Concurrent Training ◽  
Functional Fitness

Aerobic and resistance exercise have been prescript to prevention and non pharmacological treatment of hypertension. However, there is a lack of studies investigating the effects of concurrent training in hypertensive women. Thus, the aim of this study was to investigate the effects of concurrent training program on rest blood pressure, biochemical variables (blood glucose and total cholesterol) , anthropometric (body mass index and waist circumference) and functional fitness in hypertensive women. Eighteen hypertensive postmenopausal and untrained women (59±12 years old) started in the intervention, but only ten subjects finished. The voluntaries were enrolled in concurrent training, 60 min/day, 3 times a week, during 6 months. Systolic and diastolic blood pressure, blood glucose, total cholesterol, body mass index, waist circumference and functional fitness (AAPHERD) were measured pre and post experimental period. Data were analyzed using the Student’s t test with significance level set at 5% (P?0.05) and Cohen's Effect Size (ES). The results showed significant improvement in systolic and diastolic blood pressure at rest. The other variables did not show significantly changes, but the ES was medium and large for several variables (body mass index, blood glucose, total cholesterol, agility, coordination, aerobic fitness, strength endurance and general functional fitness index). In conclusion, this study confirms that 6 month of concurrent training program improved systolic and diastolic blood pressure in hypertensive women. In addition, the protocol suggests an improvement in anthropometric, biochemical and functional variables related to health.

Differences in Blood Pressure Level and Hypertension in Three Ethnic Groups of Northeastern India

2000 ◽  
Vol 12 (2) ◽  
pp. 71-78 ◽  
Author(s):  
N.C. Hazarika ◽  
D. Biswas ◽  
K. Narain ◽  
R.K. Phukan ◽  
H.C. Kalita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Ethnic Groups ◽  
Body Mass ◽  
Alcohol Intake ◽  
Blood Pressure Level ◽  
Tea Garden

A cross sectional study on hypertension was done on 294 subjects aged 30 years and above. 150 households were selected randomly representing 50 households from each locality inhabited exclusively by the rural Mizos, indigenous rural Assamese and the tea-garden workers respectively, in the northeastern region of India. Blood pressure was measured by sphygmo-manorneter in sitting posture. Anthro-pometric measurements were taken using standard procedure for measuring height, weight, waist and hip girth. Information on age, sex, ethnicity, literacy, alcohol intake, smoking pattern, physical activity, occupation, amount of salt consumption was collected using a standard and pre-tested questionnaire. Significant differences were observed in both the systolic and diastolic blood pressure levels among the three different ethnic groups selected for this study ( p<0.0001). Multiple regression analyses indicated that in Mizos, age, waist circumference and alcohol intake were independently associated with increase in systolic blood pressure whereas smoking was found to be negatively associated with systolic blood pressure ( R2=0.391, p<0.001). Factors, which were the best predictors of diastolic blood pressure, were age and body mass index [(kg/m2) ( R2=0.227, p<0.001)]. In the rural Assamese population, the best predictors of systolic blood pressure were age and waist circumference ( R2=0.263, p=0.018). For the diastolic blood pressure, age, alcohol intake and body mass index were important correlates ( R2 = 0.131, p<0.001). In the tea garden community, important predictors of systolic blood pressure were age, gender and marital status ( R2=0.187, p<0.001). On the other hand, age and alcohol intake were best predictors for diastolic blood pressure ( R2=0.09, p<0.001). Asia Pac J Public Health 2000,-12(2): 71-78

The Rate of Increase in Blood Pressure in Children 5 Years of Age Is Related to Changes in Aerobic Fitness and Body Mass Index

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 465-470
Author(s):  
Steven Shea ◽  
Charles E. Basch ◽  
Bernard Gutin ◽  
Aryeh D. Stein ◽  
Isobel R. Contento ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Aerobic Fitness ◽  
Medical Center ◽  
Multiple Regression Model ◽  
Age Related ◽  
Rate Of Increase

Objective. To determine whether changes in aerobic fitness and body mass index are related to the age-related rise in blood pressure in healthy preschool children. Study design. Longitudinal analyses of 196 free-living children aged 5 years at baseline who were followed over a mean of 19:7 months. Aerobic fitness was assessed using a treadmill All measures were obtained on multiple occasions at scheduled visits as part of a longitudinal cohort study. Setting. An inner-city medical center. Outcome measures. Blood pressure was measured using an automated Dinamap device. Results. Mean systolic blood pressure was 95.3 mmHg (SD 8.38) at baseline and increased by 4.46 mmHg per year. Mean diastolic blood pressure was 53.9 mmHg (SD 5.81) at baseline and did not change significantly. Children in the highest quintile of increase in fitness had a significantly smaller increase in systolic blood pressure compared to children in the lowest quintile (2.92 vs 5.10 mmHg/year; P = .03). Children in the lowest quintile of increase in body mass index did not differ significantly in rate of increase in systolic blood pressure compared to children in the highest quintile (3.92 vs 4.96 mmHg/year). In a multiple regression model including baseline systolic blood pressure, fitness, height, body mass index, and other covariates, greater increase in fitness (P = .03) and lesser increase in body mass index (P &lt; .01) were associated with lower rates of increase in systolic blood pressure. In a similar multivariate analysis, an increase in fitness was also associated with a lower rate of increase in diastolic blood pressure (P = .02) Conclusion. Young children who increase their aerobic fitness or decrease their body mass index reduce the rate of the age-related increase in blood pressure. These observations may have implications for development of interventions directed at the primary prevention of hypertension.

scholarly journals Consistency between Self-Reported and Recorded Values for Clinical Measures

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Joseph Thomas III ◽  
Mindy Paulet ◽  
Jigar R. Rajpura
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Pearson Correlation ◽  
Recorded Data ◽  
Pearson Correlation Analysis ◽  
Reported Data ◽  
Clinical Measures

Objectives. This study evaluated consistency between self-reported values for clinical measures and recorded clinical measures.Methods. Self-reported values were collected for the clinical measures: systolic blood pressure, diastolic blood pressure, glucose level, height, weight, and cholesterol from health risk assessments completed by enrollees in a privately insured cohort. Body mass index (BMI) was computed from reported height and weight. Practitioner recorded values for the clinical measures were obtained from health screenings. We used bivariate Pearson correlation analysis and descriptive statistics to evaluate consistency between self-reported data and recorded clinic measurements.Results. There was high correlation between self-reported clinical values and recorded clinical measures for diastolic blood pressure (r=0.91,P=<0.0001), systolic blood pressure (r=0.93,P=<0.0001), cholesterol (r=0.97,P=<0.0001), body mass index (r=0.96,P=<0.0001), glucose (r=0.96,P=<0.0001), weight (r=0.98,P=<0.0001), and height (r=0.89,P=<0.0001).Conclusions. Self-reported clinical values for each of the eight clinical measures examined had good consistency with practitioner recorded data.

scholarly journals Impact of body mass index on blood pressure levels in patients with polycystic ovary syndrome

2007 ◽  
Vol 51 (7) ◽  
pp. 1104-1109 ◽  
Author(s):  
Cristiano R.G. Barcellos ◽  
Michelle P. Rocha ◽  
Sylvia A.Y. Hayashida ◽  
Décio Mion Junior ◽  
Silvia G. Lage ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Present Moment ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
The Impact

As there is controversy about the prevalence of hypertension in patients with polycystic ovary syndrome (PCOS) and, up to the present moment, no studies have evaluated the impact of body mass index (BMI) on blood pressure levels (BP) in these patients, we studied retrospectively sixty-nine patients with PCOS, with BMI of 29.0 ± 6.7 kg/m² and aged 25.6 ± 5.6 yr, subdivided into three groups according to BMI (normal, overweight and obese) and evaluated regarding BP (mercury sphygmomanometer), basal hormonal profile, fasting glucose, and insulin sensitivity (HOMA-IR). Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were normal (118.1 ± 17.0 and 74.7 ± 11.5 mmHg, respectively), with a hypertension prevalence of 20.3%. Of these patients, 78.6% were obese and 21.4% were overweight. When the groups were compared according to BMI, a significant increase in SBP and DBP was observed (higher in overweight and obese patients for SBP and higher in obese for DBP), as well as a significant progressive increase in glucose, insulin, homeostatic model assessment, and a significant progressive decline in LH levels. When the patients were subdivided as normotensive or hypertensive, a significant difference was observed only for BMI (28.2 ± 6.1 and 34.7 ± 8.6 kg/m², respectively; p = 0.007). In conclusion, we observed a significant and progressive impact of BMI on blood pressure levels in our patients with polycystic ovary syndrome.

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