scholarly journals Effect of high-intensity training on endothelial function in patients with cardiovascular and cerebrovascular disease: A systematic review

2016 ◽  
Vol 4 ◽  
pp. 205031211668225 ◽  
Author(s):  
Mia Kolmos ◽  
Rikke Steen Krawcyk ◽  
Christina Kruuse
Keyword(s):  
Systematic Review ◽  
Endothelial Function ◽  
Cerebrovascular Disease ◽  
High Intensity ◽  
Moderate Intensity ◽  
Continuous Exercise ◽  
High Intensity Training ◽  
Pubmed Database ◽  
Flow Mediated Dilatation ◽  
Intensity Training

Objectives: Exercise improves endothelial dysfunction, the key manifestation of cardiovascular and cerebrovascular disease, and is recommended in both cardiovascular and cerebrovascular rehabilitation. Disagreement remains, however, on the role of intensity of exercise. The purpose of this review was to gather current knowledge on the effects of high-intensity training versus moderate-intensity continuous exercise on endothelial function in cardiovascular and cerebrovascular patients. Methods: A systematic review was performed in PubMed database, Embase and Cochrane libraries and on PEDro using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were restricted to cardiovascular and cerebrovascular patients, and healthy subjects as general reference. Interventions comprised of high-intensity training alone, high-intensity training compared to moderate-intensity continuous exercise, or no training, with endothelial function as outcome measure. Endothelial function was measured either physiologically by flow-mediated dilatation and/or by systemic biomarkers. Data were analyzed descriptively due to non-comparability for a meta-analysis to be performed. Results: A total of 20 studies were included in the review. Although there was great heterogenecity in design, population and exercise protocols, all studies found high-intensity training to be safe. High-intensity training was equal to moderate-intensity continuous exercise through improvement in endothelial function in 15 of the 20 selected studies, as measured by flow-mediated dilatation, nitric oxide bioavailability and circulating biomarkers. Only a few studies examined high-intensity training in cerebrovascular patients, none with endothelial function as outcome. Conclusion: High-intensity training is promising as a time-efficient exercise strategy in cardiovascular rehabilitation, but data on endothelial effects in cerebrovascular rehabilitation are warranted. Agreement on a more uniform exercise protocol is essential to further investigate the optimal exercise mode for cerebrovascular rehabilitation.

scholarly journals Effects of high-intensity training on the quality of life of cancer patients and survivors: a systematic review with meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Myriam Lavín-Pérez ◽  
Daniel Collado-Mateo ◽  
Xián Mayo ◽  
Gary Liguori ◽  
Liam Humphreys ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Cancer Patients ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
High Intensity Training ◽  
Global Quality Of Life ◽  
Intensity Training

AbstractCancer and associated medical treatments affect patients' health-related quality of life (HRQoL) by decreasing functional dimensions of physical, social, cognitive, and emotional well-being, while increasing short and late-term symptoms. Exercise, however, is demonstrated to be a useful therapy to improve cancer patients' and survivors’ HRQoL, yet the effectiveness of high-intensity training (HIT) exercise is uncertain. This systematic review and meta-analysis aimed to analyse the effects of HIT on HRQoL dimensions in cancer patients and survivors as well as evaluate the optimal prescription of HIT. The search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and examined Web of Science and PubMed (Medline) databases. Data were analysed utilizing Review Manager Software. Twenty-two articles were included in the systematic review and 17 in the meta-analysis. Results showed HIT improved global quality of life, physical functioning, role functioning, social functioning, cognitive functioning, fatigue, pain, dyspnea, and insomnia, compared to an inactive control group, yet no differences were found between HIT and low to moderate-intensity exercise interventions. Particular improvements in HRQoL were observed during cancer treatment and with a training duration of more than eight weeks, a frequency of 2 days/week, and a volume of at least 120 min/week, including 15 min or more of HIT. Our findings whilst encouraging, highlight the infancy of the extant evidence base for the role of HIT in the HRQoL of cancer patients and survivors.

scholarly journals Low-to-Moderate-Intensity Resistance Exercise Is More Effective Than High-Intensity at Improving Endothelial Function in Adults: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (13) ◽  
pp. 6723
Author(s):  
Yong Zhang ◽  
Ya-Jun Zhang ◽  
Hong-Wei Zhang ◽  
Wei-Bing Ye ◽  
Mallikarjuna Korivi
Keyword(s):  
Systematic Review ◽  
Endothelial Function ◽  
Resistance Exercise ◽  
Brachial Artery ◽  
Effect Size ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Flow Mediated Dilatation ◽  
Online Library

Aerobic exercise has been confirmed to improve endothelial function (EF). However, the effect of resistance exercise (RE) on EF remains controversial. We conducted this systematic review and meta-analysis on randomized controlled trials (RCTs) to determine the effect of RE and its intensities on EF. We searched Web of Science, PubMed/MEDLINE, Scopus, and Wiley Online Library, and included 15 articles (17 trials) for the synthesis. Overall, RE intervention significantly improved flow-mediated dilatation (FMD) in brachial artery (SMD = 0.76; 95% CI: 0.47, 1.05; p < 0.00001), which represents improved EF. Meta-regression showed that the RE intensity was correlated with changes in FMD (Coef. = −0.274, T = −2.18, p = 0.045). We found both intensities of RE improved FMD, but the effect size for the low- to moderate-intensity (30–70%1RM) was bigger (SMD = 1.02; 95% CI: 0.60, 1.43; p < 0.0001) than for the high-intensity (≥70%1RM; SMD = 0.48; 95% CI: 0.21, 0.74; p = 0.005). We further noticed that RE had a beneficial effect (SMD = 0.61; 95% CI: 0.13, 1.09; p = 0.01) on the brachial artery baseline diameter at rest (BADrest), and the age variable was correlated with the changes in BADrest after RE (Coef. = −0.032, T = −2.33, p = 0.038). Young individuals (<40 years) presented with a bigger effect size for BADrest (SMD = 1.23; 95% CI: 0.30,2.15; p = 0.009), while middle-aged to elderly (≥40 years) were not responsive to RE (SMD = 0.07; 95% CI: −0.28, 0.42; p = 0.70). Based on our findings, we conclude that RE intervention can improve the EF, and low- to moderate-intensity is more effective than high-intensity.

scholarly journals Effects of High-Intensity Training on the Quality of Life of Cancer Patients and Survivors: A Systematic Review With Meta-Analysis

2021 ◽  
Author(s):  
Ana Lavín-Pérez ◽  
Daniel Collado-Mateo ◽  
Xián Mayo ◽  
Gary Liguori ◽  
Liam Humphreys ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Cancer Patients ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
High Intensity Training ◽  
Global Quality Of Life ◽  
Intensity Training

Abstract Cancer and associated medical treatments affect patients' health-related quality of life (HRQoL) by decreasing functional dimensions of physical, social, cognitive, and emotional well-being, while increasing short and late-term symptoms. Exercise, however, is demonstrated to be a useful therapy to improve cancer patients and survivors’ HRQoL, yet the effectiveness of high-intensity training (HIT) exercise is uncertain. This systematic-review and meta-analysis aimed to analyse the effects of HIT on HRQoL dimensions in cancer patients and survivors as well as evaluate the optimal prescription of HIT. The search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and examined Web of Science and PubMed (Medline) databases. Data was analysed utilizing Review Manager Software. Twenty-two articles were included in the systematic review and seventeen in the meta-analysis. Results showed HIT improved global quality of life, physical functioning, role functioning, social functioning, cognitive functioning, fatigue, pain, dyspnoea, and insomnia, compared to an inactive control group. Whereas no differences were found in contrast to low to moderate-intensity exercise compared to inactive controls. Particular improvements in HRQoL were observed during the cancer treatment and with the following prescription: a training duration of more than eight weeks, a frequency of 2 days/week, a volume of at least 120 minutes/week including 15 minutes or more of HIT. Our findings whilst encouraging, highlight the infancy of the extant evidence base for the role of HIT in the HRQoL of cancer patients and survivors.

Comparison of High-Intensity Training Versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness and Body Fat Percentage in Persons With Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
pp. 1-14
Author(s):  
Nivash Rugbeer ◽  
Demitri Constantinou ◽  
Georgia Torres
Keyword(s):  
Body Fat ◽  
High Intensity ◽  
Mean Difference ◽  
Moderate Intensity ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Continuous Training ◽  
High Intensity Training ◽  
Significant Difference ◽  
Intensity Training

Background: High-intensity training is comprised of sprint interval training (SIT) and high-intensity interval training (HIIT). This study compared high-intensity training with moderate-intensity continuous training (MICT) on cardiorespiratory fitness (CRF) and body fat percentage for overweight or obese persons. Methods: A systematic search of randomized controlled trials using the health science databases occurred up to April, 2020. Twenty-six studies were included for complete analysis. A total of 784 participations were analyzed. The unstandardized mean difference for each outcome measurement was extracted from the studies and pooled with the random effects model. Results: MICT was significantly better at improving CRF compared with SIT (mean difference = −0.92; 95% confidence interval, −1.63 to −0.21; P = .01; I2 = 10%). Furthermore, there was no significant difference between MICT versus HIIT on CRF (mean difference = −0.52; 95% confidence interval, −1.18 to 0.13; P = .12; I2 = 23%). There was no significant difference in body fat percentage between MICT versus HIIT and MICT versus SIT. Conclusions: MICT was significantly better at improving CRF than SIT in overweight or obese persons.

scholarly journals High-intensity training enhances executive function in children in a randomized, placebo-controlled trial

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
David Moreau ◽  
Ian J Kirk ◽  
Karen E Waldie
Keyword(s):  
Clinical Trial ◽  
Working Memory ◽  
Cognitive Control ◽  
High Intensity ◽  
Controlled Trial ◽  
Moderate Intensity ◽  
Promising Alternative ◽  
Trial Number ◽  
High Intensity Training ◽  
Intensity Training

Background:Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial.Methods:318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation. In the primary analysis, we compared improvements on six cognitive tasks representing two cognitive constructs (N = 305). Secondary outcomes included genetic data and physiological measurements.Results:The 6-week HIT regimen resulted in improvements on measures of cognitive control [BFM = 3.38, g = 0.31 (0.09, 0.54)] and working memory [BFM = 5233.68, g = 0.54 (0.31, 0.77)], moderated by BDNF genotype, with met66 carriers showing larger gains post-exercise than val66 homozygotes.Conclusions:This study suggests a promising alternative to enhance cognition, via short and potent exercise regimens.Funding:Funded by Centre for Brain Research.Clinical trial number:NCT03255499.

O075 Influence of high intensity training in endothelial function and oxidative stress in patients with heart failure

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e20
Author(s):  
Vitor G. Angarten ◽  
Almir Schmitt Netto ◽  
Anderson Z. Ulbrich ◽  
Sabrina W. Sties ◽  
Lourenço S. de Mara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Endothelial Function ◽  
High Intensity ◽  
High Intensity Training ◽  
Patients With Heart Failure ◽  
And Oxidative Stress ◽  
Intensity Training

High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart

2011 ◽  
Vol 111 (5) ◽  
pp. 1235-1241 ◽  
Author(s):  
A. D. Hafstad ◽  
N. T. Boardman ◽  
J. Lund ◽  
M. Hagve ◽  
A. M. Khalid ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
High Intensity ◽  
Interval Training ◽  
Substrate Utilization ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Cardiac Efficiency ◽  
High Intensity Training ◽  
High Intensity Interval ◽  
Intensity Training

Aims: although exercise training induces hypertrophy with improved contractile function, the effect of exercise on myocardial substrate metabolism and cardiac efficiency is less clear. High intensity training has been shown to produce more profound effects on cardiovascular function and aerobic capacity than isocaloric low and moderate intensity training. The aim of the present study was to explore metabolic and mechanoenergetic changes in the heart following endurance exercise training of both high and moderate intensity. Methods and Results: C57BL/6J mice were subjected to 10 wk treadmill running, either high intensity interval training (HIT) or distance-matched moderate intensity training (MIT), where HIT led to a pronounced increase in maximal oxygen uptake. Although both modes of exercise were associated with a 10% increase in heart weight-to-body weight ratio, only HIT altered cardiac substrate utilization, as revealed by a 36% increase in glucose oxidation and a concomitant reduction in fatty acid oxidation. HIT also improved cardiac efficiency by decreasing work-independent myocardial oxygen consumption. In addition, it increased cardiac maximal mitochondrial respiratory capacity. Conclusion: This study shows that high intensity training is required for induction of changes in cardiac substrate utilization and energetics, which may contribute to the superior effects of high compared with moderate intensity training in terms of increasing aerobic capacity.

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