scholarly journals Fructose: Toxic effect on cardiorenal risk factors and redox state

2016 ◽  
Vol 4 ◽  
pp. 205031211668429 ◽  
Author(s):  
Fabiane V Francisqueti ◽  
Klinsmann C Santos ◽  
Artur JT Ferron ◽  
Angelo TC Lo ◽  
Igor O Minatel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Drinking Water ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Antioxidant Capacity ◽  
Prolonged Exposure ◽  
Control Group ◽  
Final Body Weight ◽  
Adiposity Index

Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.

scholarly journals Effect of Fresh Watermelon Consumption on Risk Factors for Cardiovascular Disease in Overweight and Obese Adults (P06-102-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Megan Connolly ◽  
Tiffany Lum ◽  
Amanda Marx ◽  
Shirin Hooshmand ◽  
Mark Kern ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Body Weight ◽  
Liver Function ◽  
Antioxidant Capacity ◽  
Lipid Profiles ◽  
Daily Consumption ◽  
Obese Adults ◽  
Waist To Hip Ratio

Abstract Objectives Watermelon has a great potential in preventing cardiovascular disease (CVD) due to its high levels of fiber, vitamins, minerals, and bioactive constituents such as L-citrulline, lycopene, and beta-carotene. Although previous studies have examined the effects of watermelon juice or extract on risk factors for CVD, it is unknown if the results can be extrapolated to fresh watermelon consumption. This study examined the effects of fresh watermelon consumption on risk factors for CVD in overweight and obese adults. Methods In a crossover design, 33 overweight or obese adults consumed two cups of watermelon or isocaloric low-fat cookies daily for four weeks with a two- to four-week washout period. Body weight, body composition, waist-to-hip ratio, blood pressure, glucose and insulin levels, inflammation, lipid profiles, antioxidant capacity, and liver function markers were measured at baseline and after the interventions. Results Watermelon consumption significantly (P ≤ 0.05) decreased body weight, body mass index (BMI), and systolic blood pressure and waist-to-hip ratio. Cookie consumption significantly increased blood pressure and body fat (P < 0.05). Watermelon intake reduced triglyceride, LDL cholesterol and thiobarbituric acid reactive substances and improved HDL cholesterol and total antioxidant capacity (P < 0.05). Serum glucose, insulin, C-reactive protein, total cholesterol, catalase, and liver function markers were not significantly different between the interventions. Conclusions These findings suggest that daily consumption of fresh watermelon improves lipid profiles and anthropometric measurements, reduces blood pressure, and increases antioxidant capacity, which may have implications for chronic diseases such as CVD. Funding Sources National Watermelon Promotion Board.

scholarly journals Comparative Evaluation of Aloe vera and Diclofenac on Body Weight, Blood Pressure and Renal Function of Hypertensive Rats

2021 ◽  
Vol 35 (1) ◽  
pp. 39-44
Author(s):  
Nadeem Yaqoob
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Aloe Vera ◽  
Treated Group ◽  
Control Group ◽  
Hypertensive Rats ◽  
Aloe Vera Gel ◽  
Group B

Introduction: NSAIDs are known to cause salt and water retention leading to hypertension and renal impairment. Aloe vera gel has been used in medicinal preparations for decades. Limited data is available regarding effect of Aloe vera on renal function. There is a need to search this aspect of Aloe vera, to use it judiciously. Aims & Objectives: To estimate and compare the effects of Aloe vera and diclofenac on systolic blood pressure and renal functions of hypertensive rats. Place and duration of study: This study was conducted at Post Graduate Medical Institute Lahore, Sargodha Medical College, Sargodha and Department of Pharmacy, University of Sargodha for the period of three months. Material & Methods: Male Sprague Dawley rats (n=24) were divided into four groups; Group A (Normal control), Group B (Hypertensive control), Group C (Aloe vera treated) and Group D (Diclofenac treated). Hypertension was induced in groups B, C and D by 20% sucrose diet in 8 weeks. After induction of hypertension, distilled water, dried Aloe vera gel 400 mg/kg and diclofenac 12 mg/kg were given orally to group B, C and D respectively for 2 weeks as a single morning dose. Body weight and systolic blood pressure were measured weekly, while serum creatinine, creatinine clearance and urinary proteins were estimated and compared at 0, 8 and 10 weeks. Data was analyzed using SPSS 23 and p value of ?0.05 was considered significant. Results: Diclofenac decreased body weight of rats non-significantly and increased systolic blood pressure significantly (p< 0.03) whereas Aloe vera increased body weight significantly (p<0.012) and had no significant effect on systolic blood pressure. Diclofenac treated group showed deterioration of renal function as compared to Aloe vera treated group numerically. Conclusion: Aloe vera may be safer anti-inflammatory agent than diclofenac for treatment of chronic inflammatory conditions if the patient also has hypertension or renal disease.

scholarly journals Red wine polyphenols prevent cyclosporine-induced nephrotoxicity at the level of the intrinsic apoptotic pathway

2009 ◽  
pp. 511-519 ◽  
Author(s):  
R Rezzani ◽  
S Tengattini ◽  
F Bonomini ◽  
F Filippini ◽  
O Pecháňová ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Molecular Mechanisms ◽  
Red Wine ◽  
Control Group ◽  
Apoptotic Pathway ◽  
Biochemical Alterations ◽  
Wine Polyphenols ◽  
Apoptotic Effects

Flavonoids, polyphenol derivatives of plant origin, possess a broad range of pharmacological properties. A number of studies have found both pro/anti-apoptotic effects for many of these compounds. For these reasons we investigated whether ProvinolsTM, flavonoids obtained from red wine, have antiapoptotic properties. The investigations have been carried out in rats treated with Cyclosporine A (CsA). In particular, four groups of rats have been treated for 21 days with either olive oil (control group), with CsA, with ProvinolsTM, or with CsA and ProvinolsTM simultaneously. Oxidative stress, systolic blood pressure, body weight, biochemical parameters and different markers of pro/anti-apoptotic pathway were measured. CsA produced an increase of systolic blood pressure, a decrease in body weight, serum creatinine levels, urinary total protein concentration and creatinine clearance. Moreover, CsA induced renal alterations and the translocation of Bax and cytochrome c from cytoplasm to mitochondria and vice versa. These changes activated the caspase cascade pathway, that leads to morphological and biochemical features of apoptosis. ProvinolsTM restored morphological and biochemical alterations and prevented nephrotoxicity. In conclusion, this study may augment our current understanding of the controversial pro-/anti-apoptotic properties of flavonoids and their molecular mechanisms.

Carcinogenicity of Bromodichloromethane Administered in Drinking Water to Male F344/N Rats and B6C3F1 Mice

2002 ◽  
Vol 21 (3) ◽  
pp. 219-230 ◽  
Author(s):  
Michael H. George ◽  
Greg R. Olson ◽  
Donald Doerfler ◽  
Tanya Moore ◽  
Steve Kilburn ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Water Consumption ◽  
Body Weight Gain ◽  
Day Treatment ◽  
Life Time ◽  
Feed Consumption ◽  
Control Group ◽  
Renal Tubules ◽  
Final Body Weight

A life-time exposure study was conducted to assess the carcinogenicity of bromodichloromethane (BDCM) administered in the drinking water to male F344/N rats and B6C3F1 mice. In mouse, the calculated mean daily BDCM concentrations (measured concentrations corrected for on-cage loss of chemical) were 0.06, 0.28 and 0.49 g/l. Time-weighted water consumption of 135, 97, and 89 ml/kg/day resulted in mean daily doses of 8.1, 27.2, and 43.4 mg BDCM/kg/day. No changes in feed consumption, final body weight, or survival were observed. Kidney weights were significantly depressed at 27.2 and 43.4 mg BDCM/kg/day. There was no increase in neoplasia in the liver, kidney, spleen, testis, bladder, sections along the alimentary tract, excised lesions, or at any other organ site. In rat, the corrected mean daily BDCM concentrations were 0.06, 0.33, and 0.62 g/l. Time-weighted water consumption of 65, 63, and 59 ml/kg/day yielded 3.9, 20.6 and 36.3 mg BDCM/kg/day. No alterations in feed consumption, body weight gain, and survival were seen. Kidney weight was significantly depressed in the 36.3-mg/kg/day treatment group. There was a significantly enhanced prevalence and multiplicity of hepatocellular adenomas at 3.9 mg BDCM/kg/day (15.5% and 0.16/animal vs. 2.2% and 0.02/animal for the control). Hepatocellular carcinomas increased from 2.2% and 0.02/animal for the control and 3.9 mg BDCM/kg/day to 8.3% and 0.10/animal at 20.6 mg BDCM/kg/day. The combined neoplasms were enhanced at 3.9 and 20.6 mg BDCM/kg/day. Liver neoplasia was depressed to the control value at 36.3 mg BDCM/kg. The prevalence of basophilic and clear cell, but not eosinophilic cells, altered foci of cells declined with increasing dose. BDCM did not increase cancer in the large bowel, renal tubules, or in any of the other tissues examined. Renal tubular hyperplasia was observed at 36.3 mg BDCM/kg (15.8% vs. 8.7% for the control group). Under the conditions of the study, BDCM in the drinking water was not carcinogenic in the male B6C3F1 mouse, but was carcinogenic in the male F344/N rat based on an increased hepatocellular neoplasia.

scholarly journals Skipping breakfast leads to weight loss but also elevated cholesterol compared with consuming daily breakfasts of oat porridge or frosted cornflakes in overweight individuals: a randomised controlled trial

2014 ◽  
Vol 3 ◽  
Author(s):  
Allan Geliebter ◽  
Nerys M. Astbury ◽  
Roni Aviram-Friedman ◽  
Eric Yahav ◽  
Sami Hashim
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Weight Loss ◽  
Body Weight ◽  
Total Cholesterol ◽  
Controlled Trial ◽  
Control Group ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Skipping Breakfast

AbstractEating breakfast may reduce appetite, body weight and CVD risk factors, but the breakfast type that produces the greatest health benefits remains unclear. We compared the effects of consuming a high-fibre breakfast, a non-fibre breakfast, or no-breakfast control on body weight, CVD risk factors and appetite. A total of thirty-six overweight participants (eighteen men and eighteen women) (mean age 33·9 (sd7·5) years, mean BMI 32·8 (sd4·7) kg/m2) were randomly assigned to consume oat porridge (n = 12), frosted cornflakes (n = 12) or a water control (n = 12) breakfast daily for 4 weeks. Appetite ratings were collected on the first day and weekly thereafter. Before and after the intervention, body weight, composition, blood pressure and resting energy expenditure (REE) were measured and a fasting blood sample was collected. Across the 4 weeks, fullness was higher and hunger was lower in the oat porridge group compared with the control group (P < 0·05). Mean weight change over the intervention was significantly different in the control group (−1·18 (sd1·16) kg) compared with both the cornflakes (−0·12 (sd1·34) kg) and oat porridge (+0·26 (sd0·91) kg) groups (P < 0·05). However, the control group also showed elevated total cholesterol concentrations relative to the cornflakes and oat porridge groups (P < 0·05). There were no differences between groups in changes in body composition, blood pressure, REE or other CVD risk factors. In conclusion, although skipping breakfast led to weight loss, it also resulted in increased total cholesterol concentrations compared with eating either oat porridge or frosted cornflakes for breakfast.

scholarly journals Cardiac and Hepatic miRNAs Altered Expression in Rat Embryo after Bisphenol-A (BPA) Exposure and Their Histopathological Impact (In vivo Study)

2020 ◽  
pp. 74-86
Author(s):  
Ahmed S. Ahmed
Keyword(s):  
Blood Pressure ◽  
Drinking Water ◽  
Body Weight ◽  
Bisphenol A ◽  
Fetal Liver ◽  
Control Group ◽  
Histopathological Changes ◽  
Altered Expression ◽  
Mirnas Expression ◽  
The Impact

Introduction: Plastic compound are widely used in modern life. Bisphenol-A is an essential component in high quality plastic containers such as bottles and food boxes. Beside its hormonal agonist and antagonist effects, Food and drug administration (FDA) had reported it is transmitted from mother to fetus through placental circulation causing mi-RNAs mutation. mi-RNAs regulate cellular morphology and functions through its essential role in genetic expression. The aim of the present study is to investigate the effect of exposure of BPA on maternal [placenta, body weight & blood pressure] and fetal [liver, heart & miRNAs expression] and the impact of miRNAs expression disorders on multiorgan development, namely cardiac and hepatic development. Materials and Methods: 60 healthy pregnant females’ rats were picked up since day one of gestation and divided into three groups (n=20). (c) control group gained access to drinking water containing only the vehicle (tween-80) 0.1/ml for three weeks.(10-BPA) group, gained access to drinking water containing 10 mg/L of BPA for three weeks.(20-BPA) group, gained access to drinking water containing 20 mg/L of BPA for three weeks. Placenta, liver and heart samples were collected and histopathological changes were recorded and mi-RNAs expression was investigated. Results: Histopathological changes were noticed in BPA related groups if compared to control group. mi-RNAs expression was found in same groups with variable extent. A significant increase was noticed in body weight and blood pressure of pregnant rats. Conclusion: Our data examined the impact of BPA exposure on different organs and their related miRNAs expression which showed a non-neglectable effect especially on the placenta of the mother and fetal heart and liver.

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

CARDIOVASCULAR RISKS IN OBSTRUCTIVE SLEEP APNEA SYNDROME WITH IMPROVED SASD07 COMPARE TO STARDUST II

2014 ◽  
pp. 77-86
Author(s):  
Anh Tien Hoang ◽  
Thi Y Nhi Nguyen ◽  
Luu Trinh Nguyen ◽  
Thi Hong Diep Phan ◽  
Huu Cat Nguyen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Sleep Apnea Syndrome ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Positive Correlation ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background : Sleep Apnea Syndrome (SAS) is a cause of hypertension, increasingcardiovascular risk and cardiovascular disease such as stroke, coronary artery disease, myocardial infarction, arrhythmias, heart failure, increasing the risk of death in patients with heart disease, independent of other causative factors. So far, in Vietnam there are very few studies on Obstructive Sleep Apnea Syndrome (OSAS) and cardiovascular risk factors . Self-making SASD07 is trustly for detecting OSAS with statistical significiant in comparision with StarDustII (gold criteria). Subjects and Methods: Cross sectional study, comparision with control group: 136 peoples (68 in disease group and 68 in control group). Patients were parallelly measured with StarDustII and SASD07 to detect OSAS and find the corellation with cardiovascular risk factors. Results: There is a positive correlation between SBP with the severity of OSAS (r = 0.459, p < 0.001), positive correlation between DBP with the severity of OSAS (r = 0.352, p < 0.003). No statistically significant differences between severe OSAS and fasting blood glucose, cholesterol, HDL Cholesterol, Non - HDL Cholesterol, LDL Cholesterol and TG median (p > 0.05). There is a positive correlation between AHI and neck circumference (r = 0.511, p < 0.001), waist circumference (r = 0.585, p < 0.001), BMI (r = 0.380, p < 0.01). SASD07 diagnostic value of detecting OSAS compared with StarDustII have Kappa = 0.72, (standard error 0.06, p <0.001). Conclusion: The risk factors related to OSAS in our study is neck circumference, waist circumference, systolic blood pressure, diastolic blood pressure. SASD07 have a good value in diagnosing of OSAS compared with polysomnography StarDustII. Key words: Sleep Apnea Syndrome, cardiovascular risk factor, SASD07.

Effect of Dietary Education on Cardiovascular risk Factors in Rheumatoid Arthritis Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Rahil Taheri ◽  
Shahram Molavynejad ◽  
Parvin Abedi ◽  
Elham Rajaei ◽  
Mohammad Hosein Haghighizadeh
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Statistical Tests ◽  
Intervention Group ◽  
Serum Levels ◽  
Control Group ◽  
Dietary Education

Aim: The aim of this study was to investigate the effect of dietary education on cardiovascular risk factors in patients with rheumatoid arthritis. Method: In this randomized clinical trial, 112 patients with rheumatoid arthritis were randomly assigned into two groups, intervention and control. Dietary education was provided for the intervention group in 4 sessions; anthropometric measurements, serum levels of RF, triglycerides, cholesterol, HDL, LDL, and fasting blood sugar were measured before and three months after intervention. Data was analyzed using SPSS software and appropriate statistical tests. Results: The mean of total cholesterol (p <0.001), triglycerides (p = 0.004), LDL (p <0.001), systolic blood pressure (p = 0.001), diastolic blood pressure (p = 0.003), FBS and BMI (p <0.001) were decreased significantly in the intervention group after education compared the control group. Conclusion: Traditional care for rheumatoid arthritis patients is not enough. Patients need more education in order to improve their situation.

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