scholarly journals Reply to letter to the editor: “The dosage of rifabutin in H. pylori eradication regimen should be appropriately determined in each area of the world”

2016 ◽  
Vol 4 (3) ◽  
pp. 476-477 ◽  
Author(s):  
Hideki Mori ◽  
Hidekazu Suzuki
Keyword(s):  
Letter To The Editor ◽  
The World ◽  
H Pylori

The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4639-4645 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Maryam Ghandehari ◽  
Fatemeh Goldani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressors ◽  
Ectopic Expression ◽  
Noncoding Rnas ◽  
World Population ◽  
Normal Flora ◽  
Small Noncoding Rnas ◽  
Control Gene Expression ◽  
The World ◽  
H Pylori

Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.

Letter to the Editor

PEDIATRICS ◽  
1969 ◽  
Vol 43 (5) ◽  
pp. 911-911
Author(s):  
Norman Kretchmer
Keyword(s):  
International Health ◽  
Basic Needs ◽  
Population Problem ◽  
Letter To The Editor ◽  
The World ◽  
Naive Approach

I think it is fairly well understood by most people interested in international health that the major underlying problem throughout the world is overpopulation. In my article it was not my intent to emphasize any one particular problem, but rather to give an anecdotal survey of my experience abroad. To think that merely solving the population problem will solve all of the world ills seems to me to be a naive approach. Each section of the world differs ill relation to its basic needs.

Letter to the Editor

2002 ◽  
Vol 17 (4) ◽  
pp. 192-192
Author(s):  
Ian Winspur
Keyword(s):  
Subject Matter ◽  
Performing Arts ◽  
Scientific Evidence ◽  
Performing Arts Medicine ◽  
Letter To The Editor ◽  
The World ◽  
The Subject ◽  
The Law

I enjoyed Alice Brandfonbrener’s editorial “But I Didn’t Ask to Be a Lawyer” in the June 2002 issue of MPPA [MPPA 2002;17(2):57]. I understand and sympathize with her. Many physicians who, like her, are involved in these cases for altruistic reasons rather than pure commercial—-and I believe that this is more common in the world of performing arts medicine—-must find themselves in the same predicament. However, in the words of an eminent English lawyer, who qualified and practiced as a gynecologist before turning to the law, when considering medical and scientific evidence (or in many cases, including performers, non-scientific evidence!): “However scientific the subject matter of the claim and however recondite the evidence and the argument, the legal definitions must apply in a Court of Law; the problem for the lawyer is in making the scientist understand a totally different concept of proof required by the court.” Therefore physicians involved, whether altruistic or not, must understand the basis of these claims.

scholarly journals Expanding Allelic Diversity of Helicobacter pylori vacA

1998 ◽  
Vol 36 (9) ◽  
pp. 2597-2603 ◽  
Author(s):  
Leen-Jan van Doorn ◽  
Céu Figueiredo ◽  
Ricardo Sanna ◽  
Salvador Pena ◽  
Peter Midolo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Direct Sequencing ◽  
Allelic Diversity ◽  
Pcr Primers ◽  
Epidemiological Studies ◽  
Sequence Alignments ◽  
Gene Encoding ◽  
The World ◽  
Probe Assay ◽  
H Pylori

The diversity of the gene encoding the vacuolating cytotoxin (vacA) of Helicobacter pylori was analyzed in 98 isolates obtained from different geographic locations. The studies focused on variation in the previously defined s and m regions ofvacA, as determined by PCR and direct sequencing. Phylogenetic analysis revealed the existence of four distinct types of s-region alleles: aside from the previously described s1a, s1b, and s2 allelic types, a novel subtype, designated s1c, was found. Subtype s1c was observed exclusively in isolates from East Asia and appears to be the major s1 allele in that part of the world. Three different allelic forms (m1, m2a, and m2b) were detected in the m region. On the basis of sequence alignments, universal PCR primers that allow effective amplification of the s and m regions from H. pyloriisolates from all over the world were defined. Amplimers were subsequently analyzed by reverse hybridization onto a line probe assay (LiPA) that allows the simultaneous and highly specific hybridization of the different vacA s- and m-region alleles and tests for the presence of the cytotoxin-associated gene (cagA). This PCR-LiPA method permits rapid analysis of the vacA andcagA status of H. pylori strains for clinical and epidemiological studies and will facilitate identification of any further variations.

scholarly journals RESISTANCE TO AMOXICILLIN, CLARITHROMYCIN AND CIPROFLOXACIN OF Helicobacter pylori ISOLATED FROM SOUTHERN BRAZIL PATIENTS

2014 ◽  
Vol 56 (3) ◽  
pp. 197-200 ◽  
Author(s):  
Simone Ulrich Picoli ◽  
Luiz Edmundo Mazzoleni ◽  
Heriberto Fernández ◽  
Laura Renata De Bona ◽  
Erli Neuhauss ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Eradication Therapy ◽  
Empirical Therapy ◽  
British Society ◽  
World Population ◽  
Southern Brazil ◽  
First Line ◽  
The World ◽  
Antibiotics Susceptibility ◽  
H Pylori

Introduction: Helicobacter pylori is a bacteria which infects half the world population and is an important cause of gastric cancer. The eradication therapy is not always effective because resistance to antimicrobials may occur. The aim of this study was to determine the susceptibility profile of H. pylori to amoxicillin, clarithromycin and ciprofloxacin in the population of Southern Brazil. Material and methods: Fifty four samples of H. pylori were evaluated. The antibiotics susceptibility was determined according to the guidelines of the British Society for Antimicrobial Chemotherapy and the Comité de l'Antibiogramme de la Société Française de Microbiologie. Results: Six (11.1%) H. pylori isolates were resistant to clarithromycin, one (1.9%) to amoxicillin and three (5.5%) to ciprofloxacin. These indices of resistance are considered satisfactory and show that all of these antibiotics can be used in the empirical therapy. Conclusion: The antibiotics amoxicillin and clarithromycin are still a good option for first line anti-H. pylori treatment in the population of Southern Brazil.

scholarly journals Helicobacter pyloriAntibiotic Resistance: Trends Over Time

2000 ◽  
Vol 14 (10) ◽  
pp. 895-899 ◽  
Author(s):  
Raymond G Lahaie ◽  
Christiane Gaudreau
Keyword(s):  
Bacterial Infections ◽  
Bacterial Resistance ◽  
Reliable Data ◽  
Asian Countries ◽  
Resistance To Antibiotics ◽  
Treatment Regimens ◽  
The World ◽  
Trends Over Time ◽  
H Pylori ◽  
Resistance Rates

Resistance to antibiotics can be a major problem in the treatment of bacterial infections. As the use of antibiotics increases, bacterial resistance to these agents is rising and in many cases is responsible for the failure of treatment regimens. Although the treatment ofHelicobacter pyloriinfection requires the use of more than one antibiotic to obtain adequate eradication rates, the efficacy of the currently used antibiotic combinations has been shown to be decreased by resistance to one of the antibiotics. The use of antibiotics in regimens for the treatment ofH pyloriis increasing in many countries, including Canada. This increase is both in the use of these antibiotics alone for the treatment of nongastrointestinal infections and in their use in association with proton pump inhibitors for the treatment ofH pyloriinfection. In several European and Asian countries, where resistance to antibiotics is being monitored, it has been demonstrated thatH pyloriresistance to metronidazole and to clarithromycin increased throughout the 1990s. Thus far, the data available in Canada do not show increased resistance to either of these antibiotics. As for other antibiotics used in the treatment ofH pyloriinfection, such as tetracycline and amoxicillin, the rate of resistance to these agents is still very low and does not constitute a significant problem. Because the efficacy of the regimens used in the treatment ofH pyloriinfection is compromised by resistance to the antibiotics used, it is important thatH pyloriresistance rates in Canada and throughout the world continue to be monitored. Only with such reliable data can the most optimal regimens be recommended.

scholarly journals Letter to the Editor—The Widespread Adoption of an Operational Policy and its Effect on the World as a Whole

1958 ◽  
Vol 6 (3) ◽  
pp. 447-448 ◽  
Author(s):  
Robert M. Stewart
Keyword(s):  
Widespread Adoption ◽  
Letter To The Editor ◽  
The World

scholarly journals Iran's Health Tourism Market during and after the Corona Pandemic and: Letter to the editor

2020 ◽  
Author(s):  
Hojjat Rahmani ◽  
Mohammad Arab ◽  
Jalal Saeedpour ◽  
Ghasem Rajabi Vasokolaei ◽  
Hiwa Mirzaii
Keyword(s):  
Health Care ◽  
Access To Health Care ◽  
Human Beings ◽  
Islamic Republic ◽  
Health Tourism ◽  
Seek Health Care ◽  
Letter To The Editor ◽  
Access To Health ◽  
The World ◽  
Islamic Republic Of Iran

The importance of maintaining and restoring health has always made human beings seek health care. Lack of proper access to health care, price and quality differences, as well as other factors among different countries have led to the formation of a long-standing industry called health tourism. Outbreak of coronavirus throughout the world has shocked and affected most countries. In this regard, the health tourism market of Islamic Republic of Iran was no an exception and was affected by this crisis. To meet this challenge, stakeholders of the health tourism market should determine their recession during this period, strengthen their weaknesses, and use the available opportunities. In this study, we intended to investigate effect of the coronavirus prevalence on the health tourism market of the Islamic Republic of Iran.

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