scholarly journals The role of Enterobacteria, TNF-α, IL-6, and IL-10 in the development of myocardial ischemia with type 2 diabetes mellitus

2018 ◽  
Vol 16 ◽  
pp. 205873921879232
Author(s):  
Yan Xiong ◽  
Jianhong Tao ◽  
Li Cai ◽  
Yijia Tang ◽  
Qiyong Li
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Myocardial Ischemia ◽  
Elderly Patients ◽  
Diabetic Group ◽  
Control Group ◽  
Tnf Α

This study is to observe the distribution of intestinal flora and the changes of inflammatory factors in elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus. A total of 106 elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus (complicated group), 106 elderly patients with simple type 2 diabetes mellitus (diabetic group), and 106 healthy elderly people (control group) were selected. The fasting blood glucose (FBG), 1-h postprandial blood glucose (1hPG), 2-h postprandial blood glucose (2hPG), 3-h postprandial blood glucose (3hPG), and hemoglobin A1c (HbA1c) in complicated group and the diabetic group were higher than those in the control group ( P < 0.05 or P < 0.01). The duration of diabetes, FBG, 3hPG, and HbA1c in the complicated group were higher than those in the diabetic group, while the 2hPG was lower than that in the diabetic group ( P < 0.05). Compared with control group, the number of Enterobacteria in the diabetic group and complicated group was increased, while the numbers of Bacteroides, Bifidobacteria, and Lactobacillus were decreased ( P < 0.05 or P < 0.01). Compared with the diabetic group, the number of Enterobacteria in complicated group was increased, while the numbers of Bacteroides, Bifidobacteria, and Lactobacillus were decreased ( P < 0.05 or P < 0.01). Compared with control group, the levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β), and C-reactive protein (CRP) decreased in the diabetic group and complicated group, and the lowest in the complicated group. Conversely, the levels of interleukin 10 (IL-10) and interleukin 12 (IL-2) increased in the diabetic group and complicated group, and the highest in the complicated group ( P < 0.05 or P < 0.01). Multiple logistic regression analysis showed that the duration of diabetes, HbA1c, Enterobacteria, TNF-α, IL-6, and IL-10 were the influencing factors of myocardial ischemia complicated with type 2 diabetes mellitus ( P < 0.05 or P < 0.01). In conclusion, in the elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus, the number of intestinal probiotics and the level of anti-inflammatory factors decreased, and the number of pathogenic bacteria and the level of inflammatory factors increased. Enterobacteria, TNF-α, IL-6, and IL-10 may play an important role in the development of myocardial ischemia in type 2 diabetes mellitus.

scholarly journals Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Yonghuan Bian ◽  
Changhao Liu ◽  
Zhaojiang Fu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Chronic Periodontitis ◽  
Root Planing ◽  
Tnf Α ◽  
Significant Difference ◽  
Hs Crp

Abstract Background Our study attempted to observe the value of periodontal curettage combined with root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes. Methods There involved 72 patients with type 2 diabetes mellitus complicated with moderate-to-severe chronic periodontitis who were diagnosed and treated in our hospital from January 2019 to December 2019. The patients enrolled were randomly divided into four groups using a computer-generated table: root planing and periodontal curettage combined group (n = 18), root planning group (n = 18), periodontal curettage group (n = 18) and cleansing group (n = 18). Blood glucose, plaque index (PI), gingival index (GI), probing depth (PD), attachment loss (AL), serum levels of inflammatory factors (Tumor Necrosis Factor Alpha [TNF- α] and hypersensitive C-reactive protein [hs-CRP]) were observed before and after treatment. The collecting dates were analyzed by the chi-square χ 2 test, repeated measurement analysis of variance, or t-test according to different data types and research objectives. Results Before treatment, there was no significant difference in PI, GI, PD and AL among the four groups (P> 0.05), while after 3-month treatment, the levels of PI, GI, PD and AL in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, with both root planing group and periodontal curettage group significantly lower than cleansing group (P< 0.05). The fasting blood glucose, 2-h postprandial blood glucose and glycosylated hemoglobin in the combined group, root planing group, periodontal curettage group and cleansing group were significantly lower than those before treatment (P < 0.05). Before treatment, there was no significant difference in TNF- α and hs-CRP among the four groups (P> 0.05), but the levels of TNF- α and hs-CRP in the four groups decreased significantly after 3-month treatment (P< 0.05). The levels of TNF- α and hs-CRP in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, and those in the root planing group and periodontal curettage group were significantly lower than those in the cleansing group (P< 0.05). Conclusion The combination therapy of periodontal curettage and root planing exerted beneficial effects on moderate-to-severe chronic periodontitis in patients with type 2 diabetes mellitus, which holds the potential to maintain the level of blood glucose and improve the quality of life of the patients.

scholarly journals IMPROVEMENT IN OXIDATIVE STRESS AFTER DUODENOJEJUNOSTOMY IN AN EXPERIMENTAL MODEL OF TYPE 2 DIABETES MELLITUS

2016 ◽  
Vol 29 (suppl 1) ◽  
pp. 3-7 ◽  
Author(s):  
Cacio Ricardo WIETZYCOSKI ◽  
João Caetano Dallegrave MARCHESINI ◽  
Sultan AL-THEMYAT ◽  
Fabiola Shons MEYER ◽  
Manoel Roberto Maciel TRINDADE
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Oral Glucose ◽  
Surgical Group

ABSTRACT Background: Type 2 Diabetes Mellitus is a multifactorial syndrome with severe complications. Oxidative stress is accepted as a causal factor of chronic complications Aim: To demonstrate alterations in oxidative stress after metabolic surgery. Methods: Twenty-four 2-day-old Wistar rats were used. In 16, Type 2 Diabetes Mellitus was induced by 100 mg/kg streptozotocin injection. The development of diabetes was confirmed after 10 weeks using an oral glucose tolerance test. Eight diabetic rats composed the diabetic surgical group; the remaining eight composed the diabetic group. Eight animals in which diabetes was not induced formed the clinical control group. The Marchesini technique was used in the diabetic surgical group. After 90 days, the rats were sacrificed, and the oxidative stress markers were measured. Results: Thiobarbituric acid reactive substances, superoxide dismutase and catalase were significantly reduced in the diabetic surgical group compared to the diabetic group. Conclusion: The duodenojejunostomy was effective in controlling the exacerbated oxidative stress present in diabetic rats.

scholarly journals Oral and Topical Centella asiatica in Type 2 Diabetes Mellitus Patients with Dry Skin: A Three-Arm Prospective Randomized Double-Blind Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Lili Legiawati ◽  
Kusmarinah Bramono ◽  
Wresti Indriatmi ◽  
Em Yunir ◽  
Siti Setiati ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Centella Asiatica ◽  
Control Group ◽  
Dry Skin ◽  
Sod Activity ◽  
Double Blind

Introduction. Uncontrolled diabetes mellitus (DM) is related to skin disorders, particularly dry skin. Pathogenesis of dry skin in type 2 diabetes mellitus (T2DM) rises from the chronic hyperglycemia causing an increase in advanced glycation end-products (AGEs), proinflammatory cytokines, and oxidative stress. Combination of oral and topical Centella asiatica (CA) is expected to treat dry skin in T2DM patients more effectively through decreasing N(6)-carboxymethyl-lysine (CML) and interleukin-1α (IL-1α) and increasing superoxide dismutase (SOD) activity. Methods. A three-arm prospective, double-blind, randomized, controlled study was performed to evaluate the efficacy of the oral and topical CA extract in 159 T2DM patients with dry skin. The subjects were divided into the CA oral (CAo) 2 × 1.100 mg + CA topical (CAt) 1% ointment group, oral placebo (Plo) + CAt group, and Plo and topical placebo (Plt) group. Dry skin assessment was performed on day 1, 15, and 29, while evaluation of CML, IL-1α, and SOD activity was on day 1 and 29. Result. Effectivity of CAo + CAt combination was assessed based on HbA1c and random blood glucose (RBG). In well-controlled blood glucose, on day 29, the percentage of SRRC decrement was greater in the CAo + CAt group compared to the control group (p=0.04). SCap value in the CAo + CAt group was greater than that in the control group (p=0.01). In the partially controlled blood glucose, increment of SOD activity in the CAo + CAt group was greater than that in the control group (p=0.01). There were medium-to-strong correlation between CML with SOD (r = 0.58, p<0.05) and IL-1α with SOD (r = 0.70, p<0.05) in well-controlled blood glucose. Systemic and topical adverse events were not significantly different between groups. Conclusion. CAo and CAt combination can be used to significantly improve dry skin condition through increasing SOD activity in T2DM patients with controlled blood glucose.

scholarly journals glucose reducing effects of a physical regimen combining putu sila and tai chi in individuals with type 2 diabetes mellitus in the public health center of bima

2021 ◽  
Vol 7 (2) ◽  
pp. 63-70
Author(s):  
A. Haris ◽  
Jubair Jubair ◽  
Julhana Julhana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Tai Chi ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Glucose Levels

Diabetes mellitus hyperglycemia is a chronic disease characterized by the absence of insulin or a relative decrease in cell insensitivity to insulin that requires continuous treatment and ongoing self-management to prevent acute complications and reduce the risk of chronic complications. Type 2 diabetes mellitus is particularly by physical activity. This study aims to understand the difference between two exercise regimens on blood glucose levels reduction in patients with type 2 diabetes mellitus. This was a quasi-experimental study with a pre-test post-test control group design. 60 respondents were selected via random sampling and divided evenly into two groups of 30 individuals: 1) the treatment group; and 2) the control group. A Wilcoxon test performed on the treatment group yielded P-value = 0,005 < ? = 0,05 and a Wilcoxon test performed on the control group yielded P-value = 0,046 < ? = 0,05. The conclusion that can be drawn from this study is that physical activity has an effect of reducing blood glucose levels in patients with type 2 diabetes mellitus, and, when comparing the differences in blood glucose level reduction, a combined regimen of putu sila and Tai Chi is more effective than Tai Chi alone.

scholarly journals Effects of statins on cytokines levels in gingival crevicular fluid and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244806
Author(s):  
Huiyuan Zhang ◽  
Yameng Zhang ◽  
Xiaochun Chen ◽  
Juhong Li ◽  
Ziyang Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Patients ◽  
Gingival Crevicular Fluid ◽  
Inflammatory Factors ◽  
Tnf Α ◽  
Ifn Γ ◽  
Crevicular Fluid

Objective To analyze the effect of statins on cytokines levels in gingival crevicular fluid (GCF) and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus (T2DM). Methods Systemically healthy controls (C group, n = 62), T2DM patients not taking statins (D group, n = 57) and T2DM patients taking statins (S group, n = 24) were recruited. In each group, subjects (40–85 years) were subclassified into the h (periodontal health)group, the g (gingivitis)group or the p (periodontitis) group according to different periodontal conditions. 17 cytokines in gingival crevicular fluid (GCF) and saliva samples of each subject were measured utilizing the Luminex technology kit. Further, HbA1c (glycated hemoglobin), FPG (fasting plasma glucose), PD (probing depth), CAL (clinical attachment level), BOP (bleeding on probing), GI (gingival index) and PI (periodontal index) were recorded. Data distribution was tested through the Shapiro-Wilk test, upon which the Kruskal-Wallis test was applied followed by Mann-Whitney U test and Bonferroni’s correction. Results Levels of IFN-γ, IL-5, IL-10 and IL-13 in the saliva of the Dh group were significantly lower than those in the Ch group, while factor IL-4 was higher (p<0.05). Levels of MIP-3α, IL-7 and IL-2 in GCF of the Dh group were considerably higher than those in the Ch group (p<0.05), while that of IL-23 was considerably lower. Compared with the Cg group, levels of IFN-γ, IL-4, IL-5, IL-6, IL-10 and IL-13 were significantly lower in the saliva of the Dg group (p<0.05). Lower levels of IFN-γ, IL-5 and IL-10 were detected in the Sg group than those in the Cg group (p<0.05). At the same time, levels of IL-1β, IL-6, IL-7, IL-13, IL-17, IL-21 and MIP-3α in the gingival crevicular fluid of the Sg group were lower in comparison with the Dg group. In addition, lower levels of IL-4 and higher levels of IL-7 in GCF were identified in the Dg group than those in the Cg group, while in the Sg group, lower levels of IL-4, MIP-1αand MIP-3αwere observed than those in the Cg group (p<0.05). Lower levels of IFN-γ, IL-6, IL-10, IL-13 and I-TAC were found in the Sp group compared with those in the Cp group. The IFN-γ, IL-6 and IL-10 levels were lower in the Dp group than those in the Cp group (p<0.05). Meanwhile, in the Sp group, lower levels of pro-inflammatory factors IFN-γ, IL-1β, IL-2, IL-6, IL-7, IL-21 and TNF-α, in addition to higher levels of anti-inflammatory factors IL-4 and IL-5 in gingival crevicular fluid, were identified than those in the Dp group. Higher levels of IFN-γ,IL-1β,IL-2,IL-7,IL-21 and TNF-α and a lower level of IL-5 in the Dp group were identified than those in the Cp group (p<0.05). Moreover, statins were able to substantially reduce PD in T2DM patients with periodontitis, indicating an obvious influence on the levels of cytokines secreted by Th1 cells, Th2 cells and Th17 cells, as revealed by PCA (principal component analysis). Conclusion Statins are associated with reduced PD and cytokines levels in the GCF and saliva of T2DM patients with periodontitis.

scholarly journals Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus

Genes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Maria Trapali ◽  
Dimitra Houhoula ◽  
Anthimia Batrinou ◽  
Anastasia Kanellou ◽  
Irini F. Strati ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Leptin Receptor ◽  
Genomic Region ◽  
Control Group ◽  
Control Subjects ◽  
Tnf Α ◽  
And Control

The objective of the present study was to identify the association of the TNF-α- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM). Methods: A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for the genomic region of TNF-α- 308G/A and LEPR Gln223Arg were carried out. Results: The frequency of LEPR Gln223Arg genotypes in T2DM and control groups showed significant differences in the distribution of genotypes (p < 0.05). The frequency also of TNF-α- 308G/A genotypes in T2DM and control subjects showed significant differences in the distribution of genotypes (p < 0.05). Conclusion: Our results indicate that there are significant differences in the distribution of genotypes and alleles between the individuals with T2DM and control subjects (p < 0.05).

scholarly journals Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Fanglin He ◽  
Zhanlin Zhao ◽  
Yan Liu ◽  
Linna Lu ◽  
Yao Fu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ocular Surface ◽  
Disease Duration ◽  
Surface Damage ◽  
Diabetic Group ◽  
Control Group ◽  
Breakup Time

Purpose. To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods. One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). Results. The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056  and  P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P<0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35  and  P<0.05). Conclusion. Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.

HYPOGLYCEMIC EFFECT OF INDOBUFEN,AN ANTIAGGREGATING AGENT,IN ELDERLY DIABETIC PATIENTS

1987 ◽  
Author(s):  
F Barzizza ◽  
G Belloni ◽  
E Trespi ◽  
A Venturini ◽  
I Richichi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Elderly Patients ◽  
Hypoglycemic Effect ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Atherosclerotic Vascular Disease

Inibition of platelet aggregation is of value in therapy for Transient Ischemic Attacks(TIA).We observed 2 consecutive elderly patients with type 2 diabetes mellitus(DM)and TIA,in whom chronic treatment with Indobufen(I) provoked a reduction of blood glucose levels; for this reason we started a cross-over study to assess the possible hypoglycemic effect of I in elderly patients with DM.Ten patients(5 males,mean age 75±5 years)with DM and TIA have been included in our study. After 1 month of diet treatment(1)all patients took either placebo tablets 2)or I 200mg every 12 hours for 4 weeks in a random cross-over fashion.After each period a daily blood glucose profile has been obteined. Results are the following:Indobufen in the dose of 200 mg every 12 hours has an hypoglycemic effect. This side effect can be dangerous in patients already treated with hypoglycemic agents, but can be usefull as a single drug therapy for aged patients with type 2 diabetes mellitus and atherosclerotic vascular disease.

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