scholarly journals Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia

2020 ◽  
Vol 18 ◽  
pp. 228080002097517
Author(s):  
Yuan-ming Geng ◽  
Dong-ni Ren ◽  
Shu-yi Li ◽  
Zong-yi Li ◽  
Xiao-qing Shen ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Low Cost ◽  
Low Elastic Modulus ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Alternative Material ◽  
Ct Analysis ◽  
Potential Alternative

Background: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK. Methods: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls. Results: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the μ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants. Conclusion: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.

Stress shielding and fatigue limits of poly-ether-ether-ketone dental implants

2012 ◽  
Vol 100B (4) ◽  
pp. 1044-1052 ◽  
Author(s):  
Woo-Taek Lee ◽  
Jai-Young Koak ◽  
Young-Jun Lim ◽  
Seong-Kyun Kim ◽  
Ho-Beom Kwon ◽  
...  
Keyword(s):  
Dental Implants ◽  
Stress Shielding ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Ether Ketone

scholarly journals Role of Stem Cells in Augmenting Dental Implant Osseointegration: A Systematic Review

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1035
Author(s):  
Mohammed E. Sayed ◽  
Maryam H. Mugri ◽  
Mazen A. Almasri ◽  
Manea Musa Al-Ahmari ◽  
Shilpa Bhandi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Bone Formation ◽  
Dental Implants ◽  
Mesenchymal Cells ◽  
Graft Material ◽  
Implant Surface ◽  
Oral Rehabilitation

Dental implants are a widely used treatment modality for oral rehabilitation. Implant failures can be a result of many factors, with poor osseointegration being the main culprit. The present systematic review aimed to assess the effect of stem cells on the osseointegration of dental implants. An electronic search of the MEDLINE, LILACS, and EMBASE databases was conducted. We examined quantitative preclinical studies that reported on the effect of mesenchymal stem cells on bone healing after implant insertion. Eighteen studies that fulfilled the inclusion criteria were included. Various surface modification strategies, sites of placement, and cell origins were analyzed. The majority of the selected studies showed a high risk of bias, indicating that caution must be exercised in their interpretation. All the included studies reported that the stem cells used with graft material and scaffolds promoted osseointegration with higher levels of new bone formation. The mesenchymal cells attached to the implant surface facilitated the expression of bio-functionalized biomaterial surfaces, to boost bone formation and osseointegration at the bone–implant interfaces. There was a promotion of osteogenic differentiation of human mesenchymal cells and osseointegration of biomaterial implants, both in vitro and in vivo. These results highlight the significance of biomodified implant surfaces that can enhance osseointegration. These innovations can improve the stability and success rate of the implants used for oral rehabilitation.

scholarly journals Coating Dental Implants with Synthetic Bone Mineral for Early New Bone Formation in Vivo

2021 ◽  
Vol 30 (4) ◽  
pp. 339-346
Author(s):  
Hiroshi Nakada ◽  
Takehiro Watanabe ◽  
Takahiro Takahashi ◽  
Hiroki Sato ◽  
Daisuke Isaji ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Bone Mineral ◽  
New Bone Formation ◽  
Synthetic Bone

A Novel Polymeric Approach by Utilizing Functionalized Poly(ether ether ketone) for Hydrogen Storage Applications

2009 ◽  
Vol 1216 ◽  
Author(s):  
Rolando Pedicini ◽  
Gaetano Squadrito ◽  
Giosuè Giacoppo ◽  
Ada Saccà ◽  
Enza Passalacqua
Keyword(s):  
Hydrogen Storage ◽  
Surface Area ◽  
Hydrogen Adsorption ◽  
Low Cost ◽  
Storage System ◽  
Hydrogen Chemisorption ◽  
Preliminary Results ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Ether Ketone

AbstractHydrogen is a reliable energy vector and its storage is strongly connected to the costs, performance and level of safety of the storage system components. Several materials for physical and chemical hydrogen storage have been proposed, but few research works were devoted to polymers, that generally are low cost and weight materials, easy to be managed and manufactured. In this work, a functionalised Poly(ether ether ketone) (PEEK) polymer was studied and chosen as a base polymeric matrix with the aim to produce both a low cost and low weight hydrogen storage material. The polymer was in situ functionalised starting from a manganese oxide precursor. The obtained oxide, bonded to the polymer chain, allows the hydrogen storage. In this work, the functionalisation process and preliminary results of the hydrogen storage capability are reported.From Scanning Electron Microscopy (SEM) and surface area measurements (BET), it has been verified that the metallic compound introduction modifies the morphology of the material, supplies an increased surface area for hydrogen chemisorption, revealing a 1.2%wt/wt hydrogen adsorption capability at 77 K. Preliminary results by Gravimetric Hydrogen Absorption measurements show that by increasing the temperature, the hydrogen storage capability is reduced and a value of 0.3%wt/wt at 50°C and 80 absolute bar was obtained. The reversibility cycles of hydrogen adsorption-desorption seem to be confirmed. For this reason such approach has been considered as a promising pathway and deeper studies are in progress.

scholarly journals In Vivo Evaluation of ß-TCP Containing 3D Laser Sintered Poly(ether ether ketone) Composites in Pigs

2009 ◽  
Vol 24 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Cornelius Von Wilmonsky ◽  
Rainer Lutz ◽  
Ulf Meisel ◽  
Safwan Srour ◽  
Stephan Rupprecht ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Ether Ketone

scholarly journals Osteogenic Cell Behavior on Titanium Surfaces in Hard Tissue

2019 ◽  
Vol 8 (5) ◽  
pp. 604 ◽  
Author(s):  
Jung-Yoo Choi ◽  
Tomas Albrektsson ◽  
Young-Jun Jeon ◽  
In-Sung Luke Yeo
Keyword(s):  
Electron Microscopy ◽  
Bone Formation ◽  
Dental Implants ◽  
Electron Microscopic Level ◽  
In Vivo Model ◽  
Electron Microscopic ◽  
Implant Surface ◽  
Cell Responses ◽  
Surrounding Bone

It is challenging to remove dental implants once they have been inserted into the bone because it is hard to visualize the actual process of bone formation after implant installation, not to mention the cellular events that occur therein. During bone formation, contact osteogenesis occurs on roughened implant surfaces, while distance osteogenesis occurs on smooth implant surfaces. In the literature, there have been many in vitro model studies of bone formation on simulated dental implants using flattened titanium (Ti) discs; however, the purpose of this study was to identify the in vivo cell responses to the implant surfaces on actual, three-dimensional (3D) dental Ti implants and the surrounding bone in contact with such implants at the electron microscopic level using two different types of implant surfaces. In particular, the different parts of the implant structures were scrutinized. In this study, dental implants were installed in rabbit tibiae. The implants and bone were removed on day 10 and, subsequently, assessed using scanning electron microscopy (SEM), immunofluorescence microscopy (IF), transmission electron microscopy (TEM), focused ion-beam (FIB) system with Cs-corrected TEM (Cs-STEM), and confocal laser scanning microscopy (CLSM)—which were used to determine the implant surface characteristics and to identify the cells according to the different structural parts of the turned and roughened implants. The cell attachment pattern was revealed according to the different structural components of each implant surface and bone. Different cell responses to the implant surfaces and the surrounding bone were attained at an electron microscopic level in an in vivo model. These results shed light on cell behavioral patterns that occur during bone regeneration and could be a guide in the use of electron microscopy for 3D dental implants in an in vivo model.

scholarly journals Histological and Histomorphometrical Evaluation of a New Implant Macrogeometry. A Sheep Study

2020 ◽  
Vol 17 (10) ◽  
pp. 3477 ◽  
Author(s):  
Sergio Alexandre Gehrke ◽  
Margherita Tumedei ◽  
Jaime Aramburú Júnior ◽  
Tiago Luis Eirles Treichel ◽  
Roni Kolerman ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Test Group ◽  
Titanium Implants ◽  
Control Group ◽  
New Bone Formation ◽  
Conventional Design ◽  
Random Fashion ◽  
Apical Direction

Decompression or healing chambers between the threads have been proposed to improve and accelerate the osseointegration process of dental implants. The aim of the present work was to test, in an in vivo sheep study, if healing chambers between the threads could produce a better osseointegration process. Thirty titanium implants (15 conventional design (control) and 15 implants with healing chambers (test)) were inserted in a random fashion in the tibia of 3 sheep. The animals were euthanized after 30 days of healing, and the retrieved specimens treated to obtain thin ground sections. Histological observations showed that the quantity of newly formed bone growing in an apical direction was lower in the control group (1095 µm) when compared to the Test group (1658 µm). This difference was statistically significant. Moreover, a layer of osteogenic matrix was present around the portion of implants immersed in the marrow spaces. This osteogenic tissue was thicker in the test group. In conclusion, the present study confirmed the very good results in implants with healing chambers that presented a higher percentage of new bone formation.

scholarly journals Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 940
Author(s):  
Tzu-Yu Peng ◽  
Dan-Jae Lin ◽  
Yuichi Mine ◽  
Chi-Yang Tasi ◽  
Po-Jung Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Viability ◽  
Dental Implants ◽  
Biofilm Formation ◽  
Antimicrobial Efficacy ◽  
Natural Material ◽  
Biofilm Removal ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Ether Ketone

Poly-ether-ether-ketone (PEEK) is an aesthetically pleasing natural material with good biocompatibility and shock absorption characteristics. The application of PEEK as a dental implant or abutment is expected to reduce the risk of failure and enhance aesthetics. Given that approximately one in 15 patients have allergic reactions to antibiotics, photodynamic therapy (PDT) has been gaining attention as an alternative treatment. Herein, the applicability of PEEK dental implants or abutments was investigated using material analyses, biofilm formation assay, and cell viability tests. The possible use of PDT for peri-implant mucositis was evaluated with the biofilm removal assay. The obtained data were analyzed based on the multivariate analysis of variance, paired t-tests, and the Pearson correlation coefficient (α = 0.05). The results revealed that PEEK was significantly less conducive to the formation of biofilms with S. mutans and A. actinomycetemcomitan (p < 0.001) but exhibited comparable MG-63 (human osteoblast-like) osteoblast cell viability (p > 0.05) to the other materials. PDT had similar antimicrobial efficacy and yielded similar biofilm removal effects to antibiotics. Altogether, these findings suggest that PEEK has attractive features and can serve as an alternative material for dental implants or abutments. In cases where peri-implant mucositis occurs, PDT can be used as an accessible therapeutic approach.

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