scholarly journals Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations

2020 ◽  
Vol 4 ◽  
pp. 239821282093946
Author(s):  
Maneesh V. Kuruvilla ◽  
David I. G. Wilson ◽  
James A. Ainge
Keyword(s):  
Entorhinal Cortex ◽  
Reference Frames ◽  
Spatial Information ◽  
Unit Recording ◽  
Egocentric Reference Frame ◽  
Spatial Frames Of Reference ◽  
Significant Difference ◽  
Cue Processing ◽  
The Impact

During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame.

scholarly journals The impact of passive immunisation against BMPRIB and BMP4 on follicle development and ovulation in mice

Reproduction ◽  
2015 ◽  
Vol 149 (5) ◽  
pp. 403-411 ◽  
Author(s):  
S Al-Samerria ◽  
I Al-Ali ◽  
J R McFarlane ◽  
G Almahbobi
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Primordial Follicle ◽  
Female Fertility ◽  
Passive Immunisation ◽  
Primordial Follicles ◽  
Treatment Groups ◽  
Significant Difference ◽  
Bmp Signalling ◽  
The Impact

The primordial follicle reserve is the corner stone of female fertility and determines the longevity and quality of reproduction. Complete depletion of this reserve will lead to primary infertility, and the key-limiting step of follicle depletion is the transition from primordial to primary follicles. It has been reported that this process is gonadotrophin-independent, but other conflicting reports are indicated otherwise and this discrepancy needs to be unequivocally clarified. The aim of this study was to investigate the role of bone morphogenetic proteins (BMPs) in the regulation of folliculogenesis in mice passively immunised against BMP receptor 1B (BMPRIB) and BMP4. While a stereological study revealed that the numbers of primordial follicles in immunised mice were significantly higher when compared with control animals, treatment with equine chorionic gonadotrophin showed no effect. In parallel, immunofluorescence microscopy revealed the presence of BMPRIB but not FSH receptor in primordial follicles. The number of primary follicles in immunised mice were also significantly increased when compared with control animals. After puberty, the rates of depletion of primordial and primary follicles were increased with age, particularly in treated animals; however, there was no significant difference between the treatment groups of the same age. Based on these results together with our previous reports in sheep and mice, we confirm that the attenuation of BMP signalling system can be an effective approach to sustain the primordial follicle reserve while promoting the development of growing follicles, ovulation and consequently overall female fertility.

Early reperfusion and clinical outcomes in patients with M2 occlusion: pooled analysis of the PROACT II, IMS, and IMS II studies

2014 ◽  
Vol 121 (6) ◽  
pp. 1354-1358 ◽  
Author(s):  
Ralph Rahme ◽  
Sharon D. Yeatts ◽  
Todd A. Abruzzo ◽  
Lincoln Jimenez ◽  
Liqiong Fan ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Functional Independence ◽  
Pooled Analysis ◽  
Modified Rankin Scale ◽  
Early Reperfusion ◽  
Glucose Levels ◽  
Significant Difference ◽  
Baseline Characteristics ◽  
The Impact

Object The role of endovascular therapy in patients with acute ischemic stroke and a solitary M2 occlusion remains unclear. Through a pooled analysis of 3 interventional stroke trials, the authors sought to analyze the impact of successful early reperfusion of M2 occlusions on patient outcome. Methods Patients with a solitary M2 occlusion were identified from the Prolyse in Acute Cerebral Thromboembolism (PROACT) II, Interventional Management of Stroke (IMS), and IMS II trial databases and were divided into 2 groups: successful reperfusion (thrombolysis in cerebral infarction [TICI] 2–3) at 2 hours and failed reperfusion (TICI 0–1) at 2 hours. Baseline characteristics and clinical outcomes were compared. Results Sixty-three patients, 40 from PROACT II and 23 from IMS and IMS II, were identified. Successful early angiographic reperfusion (TICI 2–3) was observed in 31 patients (49.2%). No statistically significant difference in the rates of intracerebral hemorrhage (60.9% vs 47.6%, p = 0.55) or mortality (19.4% vs 15.6%, p = 0.75) was observed. However, there was a trend toward higher incidence of symptomatic hemorrhage in the TICI 2–3 group (17.4% vs 0%, p = 0.11). There was also a trend toward higher baseline glucose levels in this group (151.5 mg/dl vs 129.6 mg/ dl, p = 0.09). Despite these differences, the rate of functional independence (modified Rankin Scale Score 0–2) at 3 months was similar (TICI 2–3, 58.1% vs TICI 0–1, 53.1%; p = 0.80). Conclusions A positive correlation between successful early reperfusion and clinical outcome could not be demonstrated for patients with M2 occlusion. Irrespective of reperfusion status, such patients have better outcomes than those with more proximal occlusions, with more than 50% achieving functional independence at 3 months.

scholarly journals Usefulness of Anticoagulant Therapy in the Prevention of Embolic Complications in Patients with Acute Infective Endocarditis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Seung-Jae Lee ◽  
Sam-Sae Oh ◽  
Dal-Soo Lim ◽  
Suk-Keun Hong ◽  
Rak-Kyeong Choi ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Anticoagulant Therapy ◽  
Multivariate Logistic Regression Analysis ◽  
Hospital Death ◽  
Multivariate Logistic Regression ◽  
Cerebrovascular Events ◽  
Significant Difference ◽  
Time Of Admission ◽  
The Impact

Background. The use of anticoagulant therapy (ACT) in patients with acute infective endocarditis (IE) remains a controversial issue. Our study attempts to estimate the impact of ACT on the occurrence of embolic complications and the usefulness of ACT in the prevention of embolism in IE patients.Methods. The present authors analyzed 150 patients with left-sided IE. Embolisms including cerebrovascular events (CVE) and the use of ACT were checked at the time of admission and during hospitalization.Results. 57 patients (38.0%) experienced an embolic event. There was no significant difference in the incidence of CVE and in-hospital mortality between patients with and without warfarin use at admission, although warfarin-naïve patients were significantly more likely to have large (>1 cm) and mobile vegetation. In addition, there was no significant difference in the incidence of postadmission embolism and in-hospital death between patients with and without in-hospital ACT. On multivariate logistic regression analysis, ACT at admission was not significantly associated with a lower risk of embolism in patients with IE.Conclusions. The role of ACT in the prevention of embolism was limited in IE patients undergoing antibiotic therapy, although it seems to reduce the embolic potential of septic vegetation before treatment.

Effects of brand placement strength, prior game playing experience and game involvement on brand recall in advergames

2015 ◽  
Vol 7 (3) ◽  
pp. 292-312 ◽  
Author(s):  
Devika Vashisht ◽  
Sreejesh S
Keyword(s):  
Online Advertising ◽  
Individual Characteristics ◽  
Game Playing ◽  
Brand Placement ◽  
Content Type ◽  
Brand Recall ◽  
Significant Difference ◽  
Brand Placements ◽  
The Impact

Purpose – The purpose of this paper is to explore the effect of brand placement strength on gamers’ brand recall as moderated by gamers’ prior game playing experience and game involvement in the context of advergames. Specifically, this research utilizes Limited Capacity Model of attention to explain how and under what conditions brand placements create attention, elaboration and subsequent brand recall. Design/methodology/approach – A 2 (brand placement strength: prominent versus subtle) × 2 (prior game playing experience: experienced versus inexperienced) × 2 (game involvement: high versus low involvement) between-subjects measures design is used. Empirical data were obtained from 220 undergraduate student gamers. A between-subjects measures ANOVA is used to test the hypotheses. Findings – There are several important findings that can be inferred from the results. First, inexperienced gamers report high brand recall in prominent brand placements than subtle brand placements, whereas for experienced gamers, no significant difference in recall rates is found between prominent brand placement and subtle brand placement. Second, inexperienced gamers with low game involvement playing an advergame with prominent brand placement report high brand recall compared to inexperienced gamers with high game involvement playing an advergame with prominent brand placement. Research limitations/implications – The study contributes to the advertising literature from a non-traditional advertising perspective, particularly in the context of online advergames, and explains the role of brand placement and its boundary conditions to create customers’ brand memory. Moreover, this research contributes to the marketing knowledge on how to locate and embed the brands effectively in advergames, taking into account the individual characteristics of each advergame. Practical implications – The findings are very important for advertising practitioners because selecting media that enhances the brand memory of the consumers through entertainment is a planning strategy that has been widely used by media planners today. Hence, advertising managers should think about designing advergames by taking into account the game involvement factor to make sure that the implementation has the strongest positive effect on consumers’ memory. Originality/value – This research contributes to the literature of online advertising, especially the advergames by exploring the impact of brand placement strength and prior gaming experience on gamers’ brand recall. In addition, this study is the first step toward understanding the moderating role of game involvement on Indian gamers recall in the context of online advertising.

The role of surgical resection for hepatocellular carcinoma in octogenarians: A population-based analysis.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 202-202
Author(s):  
Takintope Akinbiyi ◽  
Atuhani S. Burnett ◽  
Philip Ernst ◽  
Marisa Cevasco ◽  
Donald A. McCain ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Survival Benefit ◽  
The Elderly ◽  
Population Based ◽  
Seer Database ◽  
Significant Difference ◽  
Disease Stages ◽  
The Impact

202 Background: Hepatocellular carcinoma (HCC) is a significant source of morbidity and mortality amongst the elderly population. In appropriately selected patients, surgery is known to confer a survival advantage. Octagenarians, however, given their remaining life expectancy may receive limited benefit from surgery. Nevertheless, insufficient information is available in the literature on the survival benefit of surgery in octagenarians with HCC. Methods: Octogenarians with HCC were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2009. We evaluated patients who underwent surgical resection and those that declined to assess the impact surgery has on overall survival in this population. Results: A total of 8,614 with HCC were identified in the SEER database, of which surgery was recommended for 3,529 (41%). A total of 1,002 patients (28%) underwent surgery and 2,497 (71%) declined. Although there was a trend towards improved survival in the surgery group (7.91 months) vs the non-surgical group (7.03 months), there was no statistically significant difference in survival between the two groups (p = 0.09). Conclusions: Our study demonstrates that octagenarians as a whole do not experience a survival benefit from surgical resection for HCC. Subgroup analysis, however, may ultimately identify benefit in specific disease stages or patients with fewer comorbidities.

scholarly journals The Role of Social Parameters in the Choice of Address Forms used in Kinship domain in Punjab, Pakistan

2019 ◽  
Vol 4 (1) ◽  
pp. 73
Author(s):  
Ana Ramsha ◽  
Samrah Hidayat
Keyword(s):  
Social Class ◽  
Social Factors ◽  
Regional Differences ◽  
Language Use ◽  
Strong Connection ◽  
Address Forms ◽  
The Social ◽  
Significant Difference ◽  
The Impact

This study examines the role of social parameters in the choice of address forms used in kinship domain in Punjab, Pakistan. The study targeted 140 respondents in order to test the impact of social factors along with the regional differences in the choices of address forms in kinship domain. Statistical analyses are done by applying t-test for gender in relation to choices of address forms and ANOVA for age, income, education and social class. The study finds out that there is a strong connection of different social parameters not only with language use and practice but also in choices and use of address forms especially in kinship relationships.  Moreover, it is highlighted that gender does not influence in the choices of address forms, even the participants belonging to young and middle categories show no significant difference with regard to the choices of address form despite the fact that all the factors and parameters exert influence on the choices of address forms. Hence address forms as being one of the major traits of language and society is affected by all the social factors around and regional differences are also most important as they give identity and ethnicity to the society.

scholarly journals The Effect of Music Therapy on Self-Reported Affect in Hospitalised Paediatric Patients

2021 ◽  
Author(s):  
◽  
Ruth Elizabeth Armstrong
Keyword(s):  
Music Therapy ◽  
Hospital Environment ◽  
Future Research ◽  
Psychosocial Needs ◽  
Clinical Notes ◽  
Significant Difference ◽  
Before And After ◽  
The Impact ◽  
Therapy Sessions

<p>The present research examines the effect of music therapy on the affect of hospitalised children. It took place on a paediatric ward of a New Zealand public hospital. This study aimed to investigate the role of music therapy in addressing patients' psychosocial needs. Literature on the impact of hospitalisation, and on the use of music therapy in hospitals and paediatrics was reviewed. The research involved an audit of the therapist's clinical notes from music therapy sessions over the course of seven months. The clinical notes included measurements of children's mood from the beginning and end of sessions, using McGrath's (1990) Affective Facial Scale. It was hypothesised that mood measures following music therapy would be higher than pre-music therapy scores. Statistical analysis of the facial scale data did not show a significant difference between 'before' and 'after' measures. These results were discussed with regard to a ceiling effect (this is, the measurements indicated patients were at the happy end of the scale before the music therapy session, so there was little room on the scale for mood to improve following music therapy). The measurement of emotion did not prove to be straightforward. The hospital environment may have influenced the patients' responses in a number of ways. These environmental influences are discussed with reference to examples from the clinical notes. The usefulness of facial scales in this context is discussed, as well as other limitations of the research. Suggestions for future research include the use of other mood measures, and the inclusion of measurements of parental mood and how this affects the child.</p>

scholarly journals The Effect of Music Therapy on Self-Reported Affect in Hospitalised Paediatric Patients

2021 ◽  
Author(s):  
◽  
Ruth Elizabeth Armstrong
Keyword(s):  
Music Therapy ◽  
Hospital Environment ◽  
Future Research ◽  
Psychosocial Needs ◽  
Clinical Notes ◽  
Significant Difference ◽  
Before And After ◽  
The Impact ◽  
Therapy Sessions

<p>The present research examines the effect of music therapy on the affect of hospitalised children. It took place on a paediatric ward of a New Zealand public hospital. This study aimed to investigate the role of music therapy in addressing patients' psychosocial needs. Literature on the impact of hospitalisation, and on the use of music therapy in hospitals and paediatrics was reviewed. The research involved an audit of the therapist's clinical notes from music therapy sessions over the course of seven months. The clinical notes included measurements of children's mood from the beginning and end of sessions, using McGrath's (1990) Affective Facial Scale. It was hypothesised that mood measures following music therapy would be higher than pre-music therapy scores. Statistical analysis of the facial scale data did not show a significant difference between 'before' and 'after' measures. These results were discussed with regard to a ceiling effect (this is, the measurements indicated patients were at the happy end of the scale before the music therapy session, so there was little room on the scale for mood to improve following music therapy). The measurement of emotion did not prove to be straightforward. The hospital environment may have influenced the patients' responses in a number of ways. These environmental influences are discussed with reference to examples from the clinical notes. The usefulness of facial scales in this context is discussed, as well as other limitations of the research. Suggestions for future research include the use of other mood measures, and the inclusion of measurements of parental mood and how this affects the child.</p>

scholarly journals The Role of Knowledge Management Infrastructure in Enhancing Job Satisfaction: A Developing Country Perspective

10.28945/4169 ◽  
2019 ◽  
Vol 14 ◽  
pp. 001-025 ◽  
Author(s):  
Ra'ed Masa'deh ◽  
Dmaithan Abdelkarim Almajali ◽  
Ala'aldin Alrowwad ◽  
Bader Obeidat
Keyword(s):  
Job Satisfaction ◽  
Developing Countries ◽  
Knowledge Management ◽  
Developing Country ◽  
Current Model ◽  
Future Research ◽  
Academic Rank ◽  
Significant Difference ◽  
The Impact

Aim/Purpose: This research aims to examine the role of Knowledge Management (KM) infrastructure (technological, structural, and cultural) in enhancing job satisfaction in the context of developing countries, as exemplified by Jordan. Background: Despite the presence of job satisfaction studies conducted in educational institutions across the world, knowledge management issues have not been taken into consideration as influencing factors. Methodology: A total of 168 responses to a questionnaire survey were collected from the academic staff at Zarqa University in Jordan. Multiple regression analysis was conducted to test the research hypotheses. Contribution: This study offers deeper understanding about the role that knowledge management infrastructure plays in enhancing job satisfaction from a developing country perspective. The proposed model is tested the first time in Jordan. Findings: Results of the current study revealed that there are significant positive impacts of technological and cultural KM infrastructures on job satisfaction, whereas structural KM infrastructure does not have a significant impact on job satisfaction. Also, the results revealed significant gender difference in perception of the impact of knowledge management infrastructure on job satisfaction. On the other hand, an ANOVA test found no significant difference in the impact of knowledge management infrastructure on job satisfaction among groups by age, experience, and academic rank. Recommendation for Researchers: Our findings can be used as a base of knowledge for further studies about knowledge management infrastructure and job satisfaction following different criteria and research procedures. Future Research: The current model can be applied and assessed further in other sectors, including public universities and other services sectors in developed and developing countries.

Assessing the role of corrections included in the GRACE/GRACE-FO data in determination of hydrological and cryospheric signal in polar motion excitation

2021 ◽  
Author(s):  
Justyna Śliwińska ◽  
Małgorzata Wińska ◽  
Jolanta Nastula
Keyword(s):  
Angular Momentum ◽  
Polar Motion ◽  
Reference Frames ◽  
Temporal Variations ◽  
Terrestrial Reference Frames ◽  
Geophysical Processes ◽  
Terrestrial Water ◽  
Hydrological Angular Momentum ◽  
The Impact

&lt;p&gt;Assessing the impact of continental hydrosphere and cryosphere on polar motion (PM) variations is one of the crucial tasks in contemporary geodesy. The pole coordinates, as one of the Earth Orientation Parameters, are needed to define the relationship between the celestial and terrestrial reference frames. Therefore, the variations in PM should be monitored and interpreted in order to assess the role of geophysical processes in this phenomenon.&lt;/p&gt;&lt;p&gt;The role of hydrological and cryospheric signals in PM is usually examined by computing hydrological excitation (hydrological angular momentum, HAM) and cryospheric excitation (cryospheric angular momentum, CAM) of&amp;#160; PM, commonly treated together as HAM/CAM.&lt;/p&gt;&lt;p&gt;The Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) missions deliver temporal variations of the gravity field resulting from changes in global mass redistribution. The so-called GRACE/GRACE-FO Level-3 (L3) data delivers changes in terrestrial water storage (TWS) that can be used for computation of HAM/CAM.&lt;/p&gt;&lt;p&gt;For best possible representation of TWS, a number of corrections are introduced in the L3 data by computing centres. Such corrections are, among others, glacial isostatic adjustment (GIA) correction, geocenter correction and C&lt;sub&gt;20&lt;/sub&gt; coefficient correction.&lt;/p&gt;&lt;p&gt;The main goal of this study is to examine the impact of corrections included in GRACE/GRACE-FO data on HAM/CAM determined. More specifically, we test their influence on HAM/CAM trends, seasonal changes and non-seasonal variations. We also examine the change in compliance between HAM/CAM and hydrological plus cryospheric signal in geodetically observed excitation when the corrections are used. To achieve our goals, we use GRACE and GRACE-FO L3 datasets provided by Jet Propulsion Laboratory (JPL), Center for Space Research (CSR), and Goddard Space Flight Center (GSFC).&lt;/p&gt;

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