Roth-like Spot in an Adult With Vitamin B6 Deficiency and Nonepileptic Seizures

2021 ◽  
pp. 247412642110287
Author(s):  
Diana Driscoll ◽  
David Callanan
Keyword(s):  
Differential Diagnosis ◽  
Adult Patient ◽  
Vitamin B6 ◽  
Vitamin B ◽  
Case Review ◽  
Single Patient ◽  
Retinal Lesion ◽  
History Of ◽  
Nonepileptic Seizures ◽  
Vitamin B6 Deficiency

Purpose: This work reports retinal findings in an adult patient with vitamin B6 deficiency. Methods: A case review of a single patient is presented. Results: A patient with a Roth-type retinal lesion and a history of nonepileptic seizures was found to have lymphocytic colitis. She was treated with pyridoxine, which resolved her seizures and the white-centered hemorrhage. Conclusions: Vitamin B6 deficiency should be considered in the differential diagnosis of patients presenting with white-centered hemorrhages and a history of nonepileptic seizures.

Cystic Hygroma with Multiple Benign bone Lymphangiomas in an Adult Patient: a rare Entity in the Differential Diagnosis of Multiple Osseous Lesions in Oncology Practice

2020 ◽  
Vol 17 ◽  
Author(s):  
Ferit Aslan ◽  
İnanç Güvenç ◽  
Aydın Aslan ◽  
Elif Günaydın
Keyword(s):  
Differential Diagnosis ◽  
Adult Patient ◽  
Cystic Hygroma ◽  
Cystic Lymphangioma ◽  
Bone Lesions ◽  
Lytic Bone Lesions ◽  
History Of ◽  
Oncology Practice ◽  
To Receive

: Cystic lymphangioma presenting with multiple bone lesions in an adult patient is a rare occurrence, with a limited number of reported cases in the literature. In this case report, we describe a 32-year old female patient with chronic neck and pelvic pain, and multiple lytic bone lesions on radiological imaging, which were eventually discovered to originate from cystic hygroma and widespread bone lymphangiomas that were present for more than 10 years. It should be kept in mind that there may be benign causes in the differential diagnosis in patients presenting with findings suggestive of diffuse bone metastasis.Because misdiagnosis may cause the patient to receive unnecessary treatments, especially radiotherapy. In this case, we reached the diagnosis of benign disease, diffuse bone lymphangiomatosis, and the long and stable medical history of the patient with the findings of BT, ultrasound and bone scintigraphy. We think that as long as there are no stable and serious results in the company with the clinical and radiological findings of the patient, it should be approached with medical follow-up without treatment.

BLOOD TRANSAMINASE ACTIVITIES IN VITAMIN B6 DEFICIENCY: EFFECT OF DEPLETION AND REPLETION ON THE ERYTHROCYTE ENZYMES

1967 ◽  
Vol 45 (2) ◽  
pp. 343-351 ◽  
Author(s):  
M. C. Cheney ◽  
Z. I. Sabry ◽  
G. H. Beaton
Keyword(s):  
Nutritional Status ◽  
Vitamin B6 ◽  
The State ◽  
Rapid Response ◽  
Vitamin B ◽  
Red Cell ◽  
Cell Turnover ◽  
Erythrocyte Enzymes ◽  
Liver Transaminases ◽  
Vitamin B6 Deficiency

To assess the usefulness of the erythrocyte transaminases, glutamic–oxaloacetic and glutamic–pyruvic, in the evaluation of vitamin B6 nutritional status, the response of these enzymes to repletion following 1, 4, and 10 weeks of vitamin B6 depletion was compared with that of the plasma and liver transaminases in the rat. The responses of the erythrocyte enzymes reflected the state of vitamin B6 nutrition most accurately and, unlike the plasma and liver transaminases, were not affected by other factors. Repletion produced a rapid response in the erythrocyte enzymes; however, restoration of control levels appeared to depend on red cell turnover, particularly after prolonged depletion periods. This finding suggests that the apoenzyme, as well as the coenzyme, is depleted during vitamin B6 deficiency.

BLOOD TRANSAMINASE ACTIVITIES IN VITAMIN B6 DEFICIENCY: EFFECT OF CONCURRENT THIAMINE AND RIBOFLAVIN DEFICIENCIES

1965 ◽  
Vol 43 (4) ◽  
pp. 591-599 ◽  
Author(s):  
M. C. Cheney ◽  
G. H. Beaton
Keyword(s):  
Body Weight ◽  
Nutritional Status ◽  
Factorial Design ◽  
Vitamin B6 ◽  
Vitamin B ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Vitamin B6 Deficiency ◽  
Design Experiments ◽  
Concurrent Variation

Factorial design experiments in rats revealed that blood transaminase activity was sensitive to vitamin B6 dosage and was not affected by concurrent variation in riboflavin or thiamine administration.The blood transaminase activity was a better index of vitamin B6 nutritional status than was body weight response or liver transaminase activity. Similarly, erythrocyte transketolase activity was found to reflect thiamine dosage, and plasma riboflavin level to reflect riboflavin dosage, regardless of manipulation of pyridoxine dosage.

scholarly journals Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass

2019 ◽  
Vol 12 (8) ◽  
pp. e230605
Author(s):  
Jared Freitas ◽  
Patrick Bliven ◽  
Robert Case
Keyword(s):  
Gastric Bypass ◽  
Vitamin B6 ◽  
Hypovolemic Shock ◽  
Serum Levels ◽  
The Body ◽  
Zinc Transporters ◽  
Acrodermatitis Enteropathica ◽  
Lower Back ◽  
History Of ◽  
Vitamin B6 Deficiency

A 39-year-old woman with a history of Roux-en-Y gastric bypass (RYGB) surgery and alcohol use presented with a confluent erythematous rash involving the perineum spreading outward to the abdomen, thighs and lower back. She had angular cheilitis and glossitis. The rash was painful and blistering in scattered areas. She was hypotensive and appeared to be in septic or hypovolemic shock at presentation. Serum levels of zinc and vitamin B6 were critically low and biopsy of her rash returned suggestive of a nutritional deficiency as its source. The rash slowly improved over the following 2 weeks with oral zinc and vitamin B6 replacement. The body rash resembled that of infants born with inherited defects in zinc transporters, referred to as acrodermatitis enteropathica (AE). This case may represent an acquired case of AE in the setting of prior RYGB.

Determination of Vitamin B6 Deficiency in Rainbow Trout (Salmo gairdneri) by Liver Enzyme Assay and HPLC Analysis

1987 ◽  
Vol 44 (1) ◽  
pp. 219-222 ◽  
Author(s):  
Ronald W. Hardy ◽  
Edmundo Casillas ◽  
Toshiro Masumoto
Keyword(s):  
Rainbow Trout ◽  
Vitamin B6 ◽  
Enzyme Assay ◽  
Clinical Signs ◽  
Salmo Gairdneri ◽  
Vitamin B ◽  
Deficient Diet ◽  
Vitamin B6 Deficiency ◽  
Stimulation Of

Rainbow trout (Salmo gairdneri), initially averaging 125 g, were fed a complete or a pyridoxine-deficient diet for 14 wk. Vitamin B6 status was evaluated biweekly by direct measurement of liver pyridoxine and pyridoxal levels by HPLC and by determining pyridoxal-5′-phosphate-enhanced liver aspartate aminotransferase (ASAT) activity. By 14 wk, mortality had severely reduced the number of fish remaining in the pyridoxine-deficient group. At 14 wk, no significant differences in liver pyridoxine and pyridoxal levels were detected between the trout fed the complete or pyridoxine-deficient diet. Significant differences between dietary groups are found in ASAT activity in liver and percent stimulation of liver ASAT by the addition of pyridoxal-5′-phosphate after 8 wk. Clinical signs of vitamin B6 deficiency including anorexia, listlessness, frantic and erratic swimming, and ataxia were observed after 11 wk of feeding a pyridoxine-deficient diet. This study shows that vitamin B6 deficiency in rainbow trout can be readily determined weeks before signs of clinical deficiency are apparent by measuring pyridoxine-enhanced liver ASAT activity. However, liver levels of pyridoxine and pyridoxal are not sensitive indicators of vitamin B6 status.

BLOOD TRANSAMINASE ACTIVITIES IN VITAMIN B6 DEFICIENCY: SPECIFICITY AND SENSITIVITY

1965 ◽  
Vol 43 (4) ◽  
pp. 579-589 ◽  
Author(s):  
M. C. Cheney ◽  
D. M. Curry ◽  
G. H. Beaton
Keyword(s):  
Vitamin B6 ◽  
B Vitamins ◽  
Xanthurenic Acid ◽  
Vitamin B ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Dietary Protein Level ◽  
Specificity And Sensitivity ◽  
Vitamin B6 Deficiency

The lowering of blood glutamic–oxaloacetic (GOT) and glutamic–pyruvic (GPT) transaminase activities was found to be specific for vitamin B6 deprivation among several B vitamins tested and in the presence of a simultaneous restriction of eight B vitamins, cortisone administration, or variation of dietary protein level. It was found that changes in blood transaminase activity did not always parallel those seen in liver transaminase activity. In the determination of vitamin B6 nutritional status, blood GPT activity appeared to be more sensitive than GOT activity and would seem to be as sensitive an indicator as xanthurenic acid excretion after a tryptophan load.

scholarly journals Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ashley M. Fields ◽  
Kevin Welle ◽  
Elaine S. Ho ◽  
Clementina Mesaros ◽  
Martha Susiarjo
Keyword(s):  
Cell Proliferation ◽  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Glucose Intolerance ◽  
Vitamin B6 ◽  
Serotonin Receptor ◽  
Dependent Manner ◽  
Β Cell ◽  
Vitamin B6 Deficiency ◽  
Maternal Glucose

AbstractIn pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell number, impaired insulin secretion, and gestational glucose intolerance in mice. Albeit the tryptophan-serotonin pathway is dependent on vitamin B6 bioavailability, how vitamin B6 deficiency impacts β-cell proliferation during pregnancy has not been investigated. In this study, we created a vitamin B6 deficient mouse model and investigated how gestational deficiency influences maternal glucose tolerance. Our studies show that gestational vitamin B6 deficiency decreases serotonin levels in maternal pancreatic islets and reduces β-cell proliferation in an HTR2B-dependent manner. These changes were associated with glucose intolerance and insulin resistance, however insulin secretion remained intact. Our findings suggest that vitamin B6 deficiency-induced gestational glucose intolerance involves additional mechanisms that are complex and insulin independent.

scholarly journals Giant Fibrovascular Polyp as an Unusual Cause of Globus Pharyngeus

2021 ◽  
pp. 014556132110039
Author(s):  
Jelena Sotirović ◽  
Ljubomir Pavićević ◽  
Stanko Petrović ◽  
Saša Ristić ◽  
Aleksandar Perić
Keyword(s):  
Differential Diagnosis ◽  
Asymptomatic Patient ◽  
Histopathological Examination ◽  
Complete Resection ◽  
Airway Compromise ◽  
Endoscopic Removal ◽  
Globus Sensation ◽  
Fibrovascular Polyp ◽  
History Of ◽  
Fatal Complications

Differential diagnosis of globus sensation in an otherwise asymptomatic patient should include hypopharyngeal fibrovascular polyp to avoid potentially fatal complications like airway compromise following regurgitation. We present a case of a 74-year-old man with a 13-cm long hypopharyngeal fibrovascular polyp with 9 months history of globus sensation. A narrow stalk of the giant polyp allowed endoscopic removal and complete resection with the CO2 laser. Histopathological examination was conclusive for the fibrovascular polyp.

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